Canonical and atypical E2Fs regulate the mammalian endocycle

Chen, Hui-Zi, Ouseph, Madhu M., Li, Jing, Pécot, Thierry, Chokshi, Veda, Kent, Lindsey, Bae, Sooin, Byrne, Morgan +24 more·2012·Nature Cell Biology
DOI 10.1038/ncb2595

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  51. Sunspace that saved a home
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