Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

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Global reconstruction of the human metabolic network based on genomic and bibliomic data

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The Cystine/Glutamate Antiporter System x c − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

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Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

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Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

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Deuterium metabolic imaging phenotypes mouse glioblastoma heterogeneity through glucose turnover kinetics

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Impaired nitrogenous waste clearance promotes hepatocellular carcinoma

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Lysine‐372‐dependent SUMOylation inhibits the enzymatic activity of glutamine synthases

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Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures

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Green chemistry: Modern therapies using nanocarriers for treating rare brain cancer metastasis from colon cancer

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Amniotic membrane promotes doxorubicin potency by suppressing SH-SY5Y neuroblastoma cell angiogenesis

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Transcriptome profile of halofuginone resistant and sensitive strains of Eimeria tenella

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LINC02774 inhibits glycolysis in glioma to destabilize HIF‐1α dependent on transcription factor RP58

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Fluorination at the 4 position alters the substrate behavior of l-glutamine and l-glutamate: Implications for positron emission tomography of neoplasias

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Glutamine metabolism, the Achilles heel for medulloblastoma tumor

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A new approach to assess drug sensitivity in cells for novel drug discovery

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Plasma-Like Culture Medium for the Study of Viruses

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Chrysomycin A Reshapes Metabolism and Increases Oxidative Stress to Hinder Glioblastoma Progression

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Mitochondria and tumorigenesis: Molecular basis and therapeutic implications

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Ambient Mass Spectrometry Imaging Reveals Spatiotemporal Brain Distribution and Neurotransmitter Modulation by 1,8-Cineole: An Epoxy Monoterpene in Mongolian Medicine Sugmel-3

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Matrix composition and glucose availability cooperatively determine cancer spheroid bioenergetics in 3D hydrogels

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Ammonia reduces glutamine synthetase expression in astrocytes via activation of Hippo-YAP signaling pathways

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Strategies for uncovering stable isotope tracing patterns between cell populations

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Glioblastoma Sensitization to Therapeutic Effects by Glutamine Deprivation Depends on Cellular Phenotype and Metabolism

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Effects on Metabolism in Astrocytes Caused by cGAMP, Which Imitates the Initial Stage of Brain Metastasis

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Analysis of the Prognostic Significance and Immune Infiltration of the Amino Acid Metabolism-Related Genes in Colon Adenocarcinoma

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Glutamine metabolism-related genes predict prognosis and reshape tumor microenvironment immune characteristics in diffuse gliomas

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Depletion of L -Methionine in Foods with an Engineered Thermophilic Methionine γ-lyase Efficiently Inhibits Tumor Growth

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Genomic and metabolomic analysis of step-wise malignant transformation in human skin fibroblasts

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Caloric restriction alters lipid metabolism to contribute to tumor growth inhibitionPreprint

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Long-term 1,2-dimethylhydrazine triggers pathological remodeling of colon mucosa through repression of sestrin2, nuclear factor (erythroid-derived 2)-like 2, and sirtuin4 stimulating mitochondrial stress and metabolic reprogramming

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OCT4 Expression in Gliomas Is Dependent on Cell Metabolism

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A glutamatergic biomarker panel enables differentiating Grade 4 gliomas/astrocytomas from brain metastases

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Nutrition and Dietary Intervention in Cancer: Gaps, Challenges, and Future Perspectives

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Expression of IGFBP6, IGFBP7, NOV, CYR61, WISP1 and WISP2 genes in U87 glioma cells in glutamine deprivation condition

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Metabolic Plasticity of Tumor Cells: How They Do Adapt to Food Deprivation

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Analyzing the Metabolism of Metastases in Mice

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Short-term in vitro glutamine restriction differentially impacts the chromosomal stability of transformed and non-transformed cells

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Early metabolic reprogramming and carbonic anhydrase IX-mediated extracellular acidification drive radiotherapy-induced glioblastoma cell dedifferentiation

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BTSCs exosomes derived NamiRNA-enhancer network of miR-151a-3p mediates a positive feedback loop and promotes the progression of glioma via FAK phosphorylation

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SLC38A3 deficiency reveals a critical role of blood-derived glutamine in brain development

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Steroid-dependent metabolic rewiring reveals novel therapeutic and imaging approaches for glioblastoma

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Targeting Metabolic Vulnerabilities in Glioblastoma: a Framework for Multi-node Combination Therapy

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Glutamine synthetase: Spotlighting the emerging roles in tumor progression and therapeutic avenues

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The Nexus of Stemness, Telomere Stability, and Metabolic Reprogramming in Glioblastoma: Foundations of Tumor Persistence and Targets for Intervention

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Integrating Molecular Pathology, Tumor Microenvironment, and Novel Therapies to Overcome Resistance in Glioblastoma

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Proteomic and metabolomic analysis of the serum of patients with tick-borne encephalitis

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A proteomic approach supports the clinical relevance of TAT-Cx43266-283 in glioblastoma

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Hyaluronic Acid Influences Amino Acid Metabolism via Differential L‐Type Amino Acid Transporter 1 Expression in the U87‐Malignant Glioma Cell Line

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Role of Monocyte/Macrophages in the Pathogenesis of NeuroHIV

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Screening of the Candidate Metabolite to Evaluate the Mycelium Physiological Maturation of Lyophyllum decastes Based on Metabolome and Transcriptome Analysis

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cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish

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Glioblastoma - Current Evidence

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Oxaloacetate as a Holy Grail Adjunctive Treatment in Gliomas: A Revisit to Metabolic Pathway

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Assessing the Impact of the Nutrient Microenvironment on the Metabolism of Effector CD8+ T Cells

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Deuterium metabolic imaging phenotypes mouse glioblastoma heterogeneity through glucose turnover kineticsPreprint

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Overview of glutamine metabolism in stromal components of the tumor microenvironment and potential anti-tumor therapies

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miR-199a-5p/GPR89A axis modulates sorafenib resistance in hepatocellular carcinoma through glutamate metabolic reprogramming

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Emerging roles of ferroptosis in modulating the immune landscape of glial tumours

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Quantitation of macropinocytosis in glioblastoma based on high-content analysis

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Integrative transcriptomics-metabolomics approach to identify metabolic pathways regulated by glutamine synthetase activity

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The differential regulation of the urea cycle in tumors goes awry

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Interface of DNA Repair and Metabolism

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Radiation-Induced Rescue Effect: Insights from Microbeam Experiments

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FREQUENT SUBGRAPH MINING OF PERSONALIZED SIGNALING PATHWAY NETWORKS GROUPS PATIENTS WITH FREQUENTLY DYSREGULATED DISEASE PATHWAYS AND PREDICTS PROGNOSIS

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Induction of a Timed Metabolic Collapse to Overcome Cancer ChemoresistancePreprint

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Hippo's Q for a big liver

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GLUL Confers Perivascular Cancer‐Associated Fibroblasts With Pro‐Angiogenic Capacity to Promote Glioma Progression

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Comprehensive In Silico Investigation of L-Glutamine Transporters and Metabolism in Glioblastoma

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IRE1 KNOCKDOWN MODIFIES THE GLUTAMINE AND GLUCOSE DEPRIVATION EFFECT ON THE EXPRESSION OF NUCLEAR GENES ENCODING MITOCHONDRIAL PROTEINS IN U87 GLIOMA CELLS

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Cancer

Noakes, T. D., Kalamian, M., Seyfried, T. N., Mukherjee, P., D’Agostino, D. P., Arismendi-Morillo, G., Chinopoulos, C., Tettenborn, M., & Winters, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821617-0.00012-7 · Cited by 1

War on Glioblastoma Multiforme: 2-Pronged Siege on Glutamine

Panchanathan, R. S., Sittur, M. G., Aoun, R. J. N., Pines, A. R., Swanson, K. R., & Bendok, B. R. (2016) · World Neurosurgery · doi:10.1016/j.wneu.2016.04.074 · Cited by 1

Adenylosuccinate Lyase activity in the Purine recycling pathway is essential for developmental timing, germline maintenance and muscle integrity in C. elegansPreprint

Marsac, R., Pinson, B., Saint‐Marc, C., Olmedo, M., Artal‐Sanz, M., Daignan‐Fornier, B., & Gomes, J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/277640 · Cited by 1

Glutamate-ammonia ligase promotes lung cancer cell growth through an enzyme-independent upregulation of CaMK2G under a glutamine-sufficient conditionPreprint

Zhao, J., Zeng, X., & Hou, X. S. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/818575 · Cited by 1

Multiomics Integration Elucidates Metabolic Modulators of Drug Resistance in LymphomaPreprint

Choueiry, F., Singh, S. V., Sun, X., Zhang, S., Sircar, A., Hart, A., Alinari, L., Epperla, N., Baiocchi, R. A., Zhu, J., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.07.425721 · Cited by 1

Deuterium Metabolic Imaging Phenotypes Mouse Glioblastoma Heterogeneity Through Glucose Turnover KineticsPreprint

Simoes, R. V., Henriques, R. N., Olesen, J. L., Cardoso, B. M., Fernandes, F. F., Monteiro, M. A., Jespersen, S. N., Carvalho, T., & Shemesh, N. (2025) · eLife · doi:10.7554/elife.100570.2 · Cited by 1

Study of the Role of NRF2 in the Progression and Metabolic Adaptation of Glioblastoma

Moubarak, M. M. (2024) · theses.fr (ABES) · doi:10.70675/c7f50cd9za643z437dza037z13798faf9515 · Cited by 2

Terapia nutricional en el enfermo oncológico en estado crítico

Villarreal, A. Q., & Rodríguez, C. N. (2016) · Acta Colombiana de Cuidado Intensivo · doi:10.1016/j.acci.2016.07.002 · Cited by 1

Impact of San-mediated Signaling on Glioblastoma and Neuroblastoma Metabolism

Silva, M. R. (2018) · FIU - Digital Commons (Florida International University) · doi:10.25148/etd.fidc006885

Tracking Metabolic Rewiring of Cancer Metabolism in Humans Using Isotope-Resolved NMR

Pichumani, K. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9690-2_10

Differential metabolic profiles mediated SLC1A2 confer resistance in glioblastoma therapies : stratification goals and implementation

Koh, L. (2019) · doi:10.32657/10356/138683

In vivo metabolite tracing of T cellsPreprint

Sheldon, R. D., Ma, E. H., DeCamp, L. M., Williams, K. S., & Jones, R. G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.21.261503

Tumor starvation by deprivation of glutamine and aspartate

Fried, R., Carlton, R. M., & Fried, D. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-824013-7.00008-0

Aggiornamenti sulla prima fase di Capua

Johannowsky, W. (2025) · Annali di archeologia e storia antica · doi:10.6093/1127-7130/12031

Faculty Opinions recommendation of HIV infection and latency induce a unique metabolic signature in human macrophages.

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Faculty Opinions recommendation of Dietary methionine influences therapy in mouse cancer models and alters human metabolism.

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DNA Damage Repair Related Genes in Cervical Cancer Radiotherapy

罗, 然. (2021) · Advances in Clinical Medicine · doi:10.12677/acm.2021.111019

Faculty Opinions recommendation of Glutamine deprivation alters the origin and function of cancer cell exosomes.

Guo, W., & Liu, D. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738401155.793579726

Glutamine synthetase : a potential therapeutic target in acute myeloid leukemia

Kreitz, J. (2022) · doi:10.21248/gups.68562

Potential Role of Cancer Stem Cells in Glioblastoma: A Therapeutic Aspect

Tiwari, M., Sharma, L. K., & Saxena, A. K. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.106332

A collaborative synthetase

Mazzone, M., & Castegna, A. (2022) · Nature Chemical Biology · doi:10.1038/s41589-022-01171-8

Data from Glutamine-Directed Migration of Cancer-Activated Fibroblasts Facilitates Epithelial Tumor Invasion

Mestre‐Farrera, A., Bruch‐Oms, M., Peña, R., Rodríguez-Morató, J., Alba‐Castellón, L., Comerma, L., Quintela-Fandiño, M., Duñach, M., Baulida, J., Pozo, Ó. J., et al. (2023) · doi:10.1158/0008-5472.c.6512562.v1

Data from Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth

Miller, K. D., Pniewski, K. A., Perry, C. E., Papp, S. B., Shaffer, J. D., Velasco‐Silva, J. N., Casciano, J. C., Aramburu, T. M., Srikanth, Y. V. V., Cassel, J. A., et al. (2023) · doi:10.1158/0008-5472.c.6512743.v1

Data from Metabolic and Nonmetabolic Functions of PSAT1 Coordinate Signaling Cascades to Confer EGFR Inhibitor Resistance and Drive Progression in Lung Adenocarcinoma

Luo, M., Zhou, Y., Gu, W.-M., Wang, C., Shen, N.-X., Dong, J.-K., Lei, H.-M., Tang, Y., Liang, Q., Zou, J.-H., et al. (2023) · doi:10.1158/0008-5472.c.6513966.v1

Data from Metabolic and Nonmetabolic Functions of PSAT1 Coordinate Signaling Cascades to Confer EGFR Inhibitor Resistance and Drive Progression in Lung Adenocarcinoma

Luo, M., Zhou, Y., Gu, W.-M., Wang, C., Shen, N.-X., Dong, J.-K., Lei, H.-M., Tang, Y., Liang, Q., Zou, J.-H., et al. (2023) · doi:10.1158/0008-5472.c.6513966

Abstract IA06: De novo purine biosynthesis dictates glutamine dependency of glioblastoma cells

Gottlieb, E. (2016) · Molecular Cancer Research · doi:10.1158/1557-3125.metca15-ia06

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622

Rethinking glutamine addiction

Krall, A. S., & Christofk, H. R. (2015) · Nature Cell Biology · doi:10.1038/ncb3278 · Cited by 37

Brain Tumor Stem Cell Dependence on Glutaminase Reveals a Metabolic Vulnerability through the Amino Acid Deprivation Response Pathway

Restall, I. J., Cseh, O., Richards, L. M., Pugh, T. J., Luchman, H. A., & Weiss, S. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3923 · Cited by 42

Oligodendroglioma Cells Lack Glutamine Synthetase and Are Auxotrophic for Glutamine, but Do not Depend on Glutamine Anaplerosis for Growth

Chiu, M., Taurino, G., Bianchi, M. G., Ottaviani, L., Andreoli, R., Ciociola, T., Lagrasta, C. A. M., Tardito, S., & Bussolati, O. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041099 · Cited by 31