Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

Pan, Min, Reid, Michael A., Lowman, Xazmin H., Kulkarni, Rajan P., Tran, Thai Q., Liu, Xiaojing, Yang, Ying, Hernandez-Davies, Jenny E. +11 more·2016·Nature Cell Biology

Cited by (368)

Items 101–200 of 368

  1. Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation
    Parash Prasad, Sampurna Ghosh, Sib Sankar Roy · 2021 · Cellular and Molecular Life Sciences
  2. Symphony of epigenetic and metabolic regulation—interaction between the histone methyltransferase EZH2 and metabolism of tumor
    Tengrui Zhang, Yueqing Gong, Hui Meng, Chen Li, Lixiang Xue · 2020 · Clinical Epigenetics
  3. The “ART” of Epigenetics in Melanoma: From histone “Alterations, to Resistance and Therapies”
    Thomas Strub, Robert Ballotti, Corine Bertolotto · 2020 · Theranostics
  4. The role and prospect of JMJD3 in stem cells and cancer
    Xiaojiao Yin, Siyu Yang, Mingyue Zhang, Ying Yue · 2019 · Biomedicine & Pharmacotherapy
  5. Human Plasma-like Medium Improves T Lymphocyte Activation
    Michael Alexander Leney-Greene, Arun Kumar Boddapati, Helen C. Su, Jason R. Cantor, Michael J. Lenardo · 2019 · iScience
  6. Modulating ferroptosis sensitivity: environmental and cellular targets within the tumor microenvironment
    Yuze Hua, Sen Yang, Yalu Zhang, Jiayi Li, Mengyi Wang, Palashate Yeerkenbieke, Quan Liao, Qiaofei Liu · 2024 · Journal of Experimental & Clinical Cancer Research
  7. Intratumor heterogeneity in epigenetic patterns
    Yassen Assenov, David Brocks, Clarissa Gerhäuser · 2018 · Seminars in Cancer Biology
  8. A second Warburg‐like effect in cancer metabolism: The metabolic shift of glutamine‐derived nitrogen
    Manabu Kodama, Keiichi I. Nakayama · 2020 · BioEssays
  9. JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML
    Shanhe Yu, Kang-Yong Zhu, Juan Chen, Xiang-Zhen Liu, Peng‐Fei Xu, Wu Zhang, Yan Li, He‐Zhou Guo, Jiang Zhu · 2018 · Nature Communications
  10. Metabolic Dysregulations and Epigenetics: A Bidirectional Interplay that Drives Tumor Progression
    Fabiana Crispo, Valentina Condelli, Silvia Lepore, Tiziana Notarangelo, Alessandro Sgambato, Franca Esposito, Francesca Maddalena, Matteo Landriscina · 2019 · Cells
  11. Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1
    Pei-Yun Tsai, Min-Sik Lee, Unmesh Jadhav, Insia Naqvi, Shariq Madha, Ashley Adler, Meeta Mistry, Sergey Naumenko, Caroline A. Lewis, Daniel S. Hitchcock et al. · 2021 · Proceedings of the National Academy of Sciences
  12. Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes
    Thai Q. Tran, Mari B. Ishak Gabra, Xazmin H. Lowman, Ying Yang, Michael A. Reid, Min Pan, Timothy R O'Connor, Mei Kong · 2017 · PLoS Biology
  13. Metabolic control of collagen synthesis
    Julien Guillard, Simon Schwörer · 2024 · Matrix Biology
  14. Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cells
    Sean A. Misek, Kate M. Appleton, Thomas Steven Dexheimer, Erika Mathes Lisabeth, Roger S. Lo, Scott D. Larsen, Kathleen A. Gallo, Richard R. Neubig · 2019 · Oncogene
  15. The Bidirectional Relationship Between Cancer Epigenetics and Metabolism
    Luke Izzo, Hayley C. Affronti, Kathryn E. Wellen · 2020 · Annual Review of Cancer Biology
  16. KDM6B is an androgen regulated gene and plays oncogenic roles by demethylating H3K27me3 at cyclin D1 promoter in prostate cancer
    Zhi Cao, Xiaolei Shi, Feng Tian, Fang Yu, Boyang Jason Wu, Stefan Mrđenović, Xinwen Nian, Jin Ji, Huan Xu, Kong Chen et al. · 2021 · Cell Death and Disease
  17. Reciprocal Regulation of Metabolic Reprogramming and Epigenetic Modifications in Cancer
    Xilan Yu, Rui Ma, Yinsheng Wu, Yansheng Zhai, Shanshan Li · 2018 · Frontiers in Genetics
  18. Hypoxia and Extracellular Acidification as Drivers of Melanoma Progression and Drug Resistance
    Ewelina Dratkiewicz, Aleksandra Simiczyjew, Justyna Mazurkiewicz, Marcin Ziętek, Rafał Matkowski, Dorota Nowak · 2021 · Cells
  19. Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance
    Zeribe C. Nwosu, Weronika Piorońska, Nadia Battello, Andreas David Zimmer, Bedair Dewidar, Mei Han, Sharon Pereira, Biljana Blagojevic, Darko Castven, Verodia Charlestin et al. · 2020 · EBioMedicine
  20. Integrating the Tumor Microenvironment into Cancer Therapy
    Sabina Sanegre, Federico Lucantoni, Rebeca Burgos‐Panadero, Luis de la Cruz‐Merino, Rosa Noguera, Tomás Álvaro Naranjo · 2020 · Cancers
  21. Kdm6a suppresses the alternative activation of macrophages and impairs energy expenditure in obesity
    Jun Chen, Xing Yue Xu, Yan Li, Li Fan, Jianjun Zhang, Qin Xu, Wantao Chen, Wei Xing Yan, Xu Wang · 2020 · Cell Death and Differentiation
  22. Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth
    Jiang‐Sha Zhao, Shuo Shi, Hai-Yan Qu, Zuzana Keckesova, Zi-Jian Cao, Lixian Yang, Xiaofu Yu, Limin Feng, Zhong Shi, Joanna Krakowiak et al. · 2022 · Nature Metabolism
  23. Phenotypic heterogeneity, stability and plasticity in tumor‐promoting carcinoma‐associated fibroblasts
    Yoshihiro Mezawa, Akira Orimo · 2021 · FEBS Journal
  24. Connections between metabolism and epigenetics: mechanisms and novel anti-cancer strategy
    Chen Chen, Zehua Wang, Yanru Qin · 2022 · Frontiers in Pharmacology
  25. Long noncoding RNA HEIH promotes melanoma cell proliferation, migration and invasion via inhibition of miR-200b/a/429
    Haiying Zhao, Guoping Xing, Yingying Wang, Zengxiang Luo, Guoyan Liu, Huijuan Meng · 2017 · Bioscience Reports
  26. Heterogeneity in Melanoma
    Mei Fong Ng, Jacinta L. Simmons, Glen M. Boyle · 2022 · Cancers
  27. The metabolic axis of macrophage and immune cell polarization
    Spencer Hobson-Gutierrez, Carlos Carmona‐Fontaine · 2018 · Disease Models & Mechanisms
  28. KDM6 Demethylases and Their Roles in Human Cancers
    Chunyan Hua, Jiaqing Chen, Shuting Li, Jianan Zhou, Jiahong Fu, Weijian Sun, Wenqian Wang · 2021 · Frontiers in Oncology
  29. Targeting mTORC2/HDAC3 Inhibits Stemness of Liver Cancer Cells Against Glutamine Starvation
    Hui‐Lu Zhang, Ping Chen, He‐Xin Yan, Gongbo Fu, Fei‐Fei Luo, Jun Zhang, Shi‐Min Zhao, Bo Zhai, Jianghong Yu, Lin Chen et al. · 2022 · Advanced Science
  30. Increased Amino Acid Uptake Supports Autophagy-Deficient Cell Survival upon Glutamine Deprivation
    Nan Zhang, Xin Ping Yang, Fengjie Yuan, Luyao Zhang, Yanan Wang, Lina Wang, Zebin Mao, Jianyuan Luo, Hongquan Zhang, Wei‐Guo Zhu et al. · 2018 · Cell Reports
  31. Epigenetics and metabolism at the crossroads of stress-induced plasticity, stemness and therapeutic resistance in cancer
    Dinoop Ravindran Menon, Heinz Hammerlindl, Joachim Torrano, Helmut Schaider, Mayumi Fujita · 2020 · Theranostics
  32. Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2
    Tsuyoshi Osawa, Teppei Shimamura, Kyoko Saito, Yoko Hasegawa, Naoko Ishii, Miyuki Nishida, Ritsuko Ando, Ayano Kondo, Muyassar Anwar, Rika Tsuchida et al. · 2019 · Cell Reports
  33. Glutamine Metabolism in Cancer Stem Cells: A Complex Liaison in the Tumor Microenvironment
    Francesco Pacifico, Antonio Leonardi, Elvira Crescenzi · 2023 · International Journal of Molecular Sciences
  34. Glutamine metabolism in cancer therapy
    Tra-Ly Nguyen, Raúl V. Durán · 2018 · Cancer Drug Resistance
  35. Immunosuppressive circuits in tumor microenvironment and their influence on cancer treatment efficacy
    Alessandra Tuccitto, Eriomina Shahaj, Elisabetta Vergani, Simona Ferro, Veronica Huber, Monica Rodolfo, Chiara Castelli, Licia Rivoltini, Viviana Vallacchi · 2018 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
  36. Arginine starvation elicits chromatin leakage and cGAS-STING activation via epigenetic silencing of metabolic and DNA-repair genes
    Sheng-Chieh Hsu, Chia‐Lin Chen, Mei‐Ling Cheng, Cheng-Ying Chu, Chun A. Changou, Yen‐Ling Yu, Shauh-Der Yeh, Tse-Chun Kuo, Cheng-Chin Kuo, Chih‐Pin Chuu et al. · 2021 · Theranostics
  37. Tumor microenvironment: Nurturing cancer cells for immunoevasion and druggable vulnerabilities for cancer immunotherapy
    Hongyang Yu, Jinyang Li, Shiyin Peng, Qin Liu, Dongfeng Chen, Zongsheng He, Junyu Xiang, Bin Wang · 2024 · Cancer Letters
  38. Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis
    Haocheng Lin, Yiyin Chung, Chun-Ting Cheng, Ching Ouyang, Yong Fu, Ching‐Ying Kuo, Kevin K. Chi, Maryam Sadeghi, Peiguo G. Chu, Hsing-Jien Kung et al. · 2018 · Autophagy
  39. Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective
    Géraldine Gentric, Fatima Mechta‐Grigoriou · 2021 · Cancers
  40. Glutamine addiction activates polyglutamine-based nanocarriers delivering therapeutic siRNAs to orthotopic lung tumor mediated by glutamine transporter SLC1A5
    Cuifeng Wang, Jiamin Wu, Zhongjuan Wang, Zeping Yang, Zhi Li, Huihui Deng, Long Li, Xiao Peng, Min Feng · 2018 · Biomaterials
  41. Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer
    Pasquale Saggese, Assunta Sellitto, Cesar A. Martinez, Giorgio Giurato, Giovanni Nassa, Francesca Maria Rizzo, Roberta Tarallo, Claudio Scafoglio · 2020 · Cancers
  42. The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation
    Katarzyna Parzych, Paula Saavedra-García, Gabriel N. Valbuena, Hibah A. Al-Sadah, Mark E. Robinson, Lucy Penfold, Desislava M. Kuzeva, Angie Ruiz-Tellez, Sandra Loaiza, Viktoria Holzmann et al. · 2019 · Oncogene
  43. Current understanding of epigenetics role in melanoma treatment and resistance
    Mohsen Karami Fath, Ali Azargoonjahromi, Asma Soofi, Faezeh Almasi, Shahnaz Hosseinzadeh, Saeed Khalili, Kamran Sheikhi, Saeid Ferdousmakan, Soroor Owrangi, Minoovash Fahimi et al. · 2022 · Cancer Cell International
  44. Supplementation with α-ketoglutarate improved the efficacy of anti-PD1 melanoma treatment through epigenetic modulation of PD-L1
    Nian Liu, Jianglin Zhang, Mingjie Yan, Lihui Chen, Jie Wu, Qian Tao, Bei Yan, Xiang Chen, Cong Peng · 2023 · Cell Death and Disease
  45. Glutamine metabolism: from proliferating cells to cardiomyocytes
    Yimin Shen, Yuhao Zhang, Wudi Li, Kaijie Chen, Meixiang Xiang, Hong Ma · 2021 · Metabolism
  46. Connecting Metabolic Rewiring With Phenotype Switching in Melanoma
    Paola Falletta, Colin R. Goding, Yurena Vivas · 2022 · Frontiers in Cell and Developmental Biology
  47. Metabolic reprogramming of the tumor microenvironment by p62 and its partners
    Miguel Reina‐Campos, Phillip M. Shelton, Maria Teresa Díaz-Meco, Jorge Moscat · 2018 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  48. HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple‐negative breast cancer
    Xin Guo, Aman Wang, Wen Wang, Ya Wang, Huan Chen, Xiaolong Liu, Tian Xia, Aijia Zhang, Di Chen, Huan Qi et al. · 2020 · Molecular Oncology
  49. Exosome application in treatment and diagnosis of B-cell disorders: leukemias, multiple sclerosis, and arthritis rheumatoid
    Mohsen Karami Fath, Jalil Azami, Niloofar Jaafari, Mahsa Akbari Oryani, Nafiseh Jafari, Alireza Karim poor, Ali Azargoonjahromi, Mohsen Nabi‐Afjadi, Zahra Payandeh, Hamidreza Zalpoor et al. · 2022 · Cellular & Molecular Biology Letters
  50. Metabolic Signaling to Epigenetic Alterations in Cancer
    Jung‐Ae Kim, Young Il Yeom · 2017 · Biomolecules & Therapeutics
  51. Pancreatic stellate cells exploit Wnt/β-catenin/TCF7-mediated glutamine metabolism to promote pancreatic cancer cells growth
    Hangqi Liu, Hui Zhang, Xiaoqian Liu, Wenting Guo, Qiaofei Liu, Longyun Chen, Junyi Pang, Xiaoding Liu, Ruiyu Li, Wei‐Min Tong et al. · 2022 · Cancer Letters
  52. Glucose Deprivation Promotes Pseudohypoxia and Dedifferentiation in Lung Adenocarcinoma
    Pasquale Saggese, Aparamita Pandey, Martín Alcaraz, Eileen Fung, Abbie Hall, Jane Yanagawa, Erika F. Rodriguez, Tristan Grogan, Giorgio Giurato, Giovanni Nassa et al. · 2023 · Cancer Research
  53. Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis
    Shagun Sharma, Navneet Agnihotri, Sandeep Kumar · 2022 · Biochemical Pharmacology
  54. Metabolites and Immune Response in Tumor Microenvironments
    Salvatore Cortellino, Valter Daniel Longo · 2023 · Cancers
  55. Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells
    Samantha J Linder, Tiziano Bernasocchi, Bárbara Martínez-Pastor, Kelly D. Sullivan, Matthew D. Galbraith, Caroline A. Lewis, Christina M. Ferrer, Ruben Boon, Giórgia Gobbi da Silveira, Hyo Min Cho et al. · 2023 · Nature Metabolism
  56. Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase
    Wei-Cheng Lin, Archan Chakraborty, Shih‐Chia Huang, Pei‐Yu Wang, Ya‐Ju Hsieh, Kun‐Yi Chien, Yen‐Hsien Lee, Chia‐Chun Chang, Hsiang-Yu Tang, Yu-Tsun Lin et al. · 2018 · Cell Reports
  57. Glutamine Deprivation Promotes the Generation and Mobilization of MDSCs by Enhancing Expression of G-CSF and GM-CSF
    Hong-Wei Sun, Wenchao Wu, Haitian Chen, Yi-Tuo Xu, Yanyan Yang, Jing Chen, Xing-Juan Yu, Zilian Wang, Zeyu Shuang, Limin Zheng · 2021 · Frontiers in Immunology
  58. Arginine limitation drives a directed codon-dependent DNA sequence evolution response in colorectal cancer cells
    Dennis J. Hsu, Jenny Gao, Norihiro Yamaguchi, Alexandra M. Pinzaru, Qiushuang Wu, Mandayam O. Nandan, Maria V. Liberti, Søren Heissel, Hanan Alwaseem, Saeed Tavazoie et al. · 2023 · Science Advances
  59. The Warburg effect: The hacked mitochondrial-nuclear communication in cancer
    Haowen Jiang, Jiangbin Ye · 2025 · Seminars in Cancer Biology
  60. KDM5C Represses FASN-Mediated Lipid Metabolism to Exert Tumor Suppressor Activity in Intrahepatic Cholangiocarcinoma
    Bo Zhang, Binghai Zhou, Min Xiao, Hui Li, Lei Guo, Meng-xi Wang, Shanhe Yu, Qing‐Hai Ye · 2020 · Frontiers in Oncology
  61. Cooperative nutrient scavenging is an evolutionary advantage in cancer
    Gizem Guzelsoy, Setiembre D. Elorza, Manon Ros, Logan T. Schachtner, Makiko Hayashi, Spencer Hobson-Gutierrez, Parker Rundstrom, Julia S. Brunner, Ray Pillai, William E. Walkowicz et al. · 2025 · Nature
  62. Oncogenic KRAS Sensitizes Lung Adenocarcinoma to GSK-J4–Induced Metabolic and Oxidative Stress
    Beom-Jin Hong, Woo‐Yong Park, Hwa-Ryeon Kim, Jin Woo Moon, Ho Yeon Lee, Junhyung Park, Seon‐Kyu Kim, Youngbin Oh, Jae‐Seok Roe, Mi‐Young Kim · 2019 · Cancer Research
  63. ATM deficiency promotes progression of CRPC by enhancing Warburg effect
    Lingfan Xu, Enze Ma, Tao Zeng, Ruya Zhao, Yulei Tao, Xufeng Chen, Jeff Groth, Chang Yin Liang, Hailiang Hu, Jiaoti Huang · 2018 · Endocrine Related Cancer
  64. Targeting the Epigenome in Malignant Melanoma: Facts, Challenges and Therapeutic Promises
    Ioannis Anestopoulos, Sotiris Kyriakou, Venetia Tragkola, Ioannis Paraskevaidis, Eleni Tzika, Melina Mitsiogianni, Maria V. Deligiorgi, George Petrakis, Dimitrios T. Trafalis, Sotirios Botaitis et al. · 2022 · Pharmacology & Therapeutics
  65. Metabolic Flexibility Is a Determinant of Breast Cancer Heterogeneity and Progression
    Marina Fukano, Morag Park, Geneviève Deblois · 2021 · Cancers
  66. Combined tazemetostat and MAPKi enhances differentiation of papillary thyroid cancer cells harbouring BRAF V600E by synergistically decreasing global trimethylation of H3K27
    Hao Fu, Lin Cheng, Ri Sa, Yuchen Jin, Libo Chen · 2020 · Journal of Cellular and Molecular Medicine
  67. Glutamine deprivation counteracts hypoxia-induced chemoresistance
    Wappler, Jessica, Arts, Martijn, Röth, Anjali, Heeren, Ron M.A., Peter Neumann, Ulf, Olde Damink, Steven W., Soons, Zita, Cramer, Thorsten · 2020 · Neoplasia
  68. Genome‐Wide CRISPR/Cas9 Library Screening Revealed Dietary Restriction of Glutamine in Combination with Inhibition of Pyruvate Metabolism as Effective Liver Cancer Treatment
    Chunxue Yang, Derek Lee, Misty Shuo Zhang, Aki Pui‐Wah Tse, Lai Wei, Macus Hao‐Ran Bao, Bowie Po‐Yee Wong, Cerise Yuen‐Ki Chan, Vincent Wai‐Hin Yuen, Yi‐Ling Chen et al. · 2022 · Advanced Science
  69. Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation
    Youzi Kong, Mengting Wu, Xiaoyu Wan, Min Sun, Yankun Zhang, Zhuanchang Wu, Chunyang Li, Xiaohong Liang, Lifen Gao, Chunhong Ma et al. · 2023 · Redox Biology
  70. Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis
    Tobias T. Schmidt, Gloria Ximena Reyes, Kerstin Gries, Cemile Ümran Ceylan, Sushma Sharma, Matthias Meurer, Michael Knop, Andrei Chabes, Hans Hombauer · 2017 · Proceedings of the National Academy of Sciences
  71. Can the Shape of Nanoparticles Enable the Targeting to Cancer Cells over Healthy Cells?
    Vu Thanh Cong, Wenqian Wang, Richard David Tilley, George Sharbeen, Phoebe A. Phillips, Katharina Gaus, J. Justin Gooding · 2021 · Advanced Functional Materials
  72. Deciphering the Warburg Effect: Metabolic Reprogramming, Epigenetic Remodeling, and Cell Dedifferentiation
    Albert Mao Li, Jiangbin Ye · 2023 · Annual Review of Cancer Biology
  73. The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade
    Yijian Qiu, Olivia T. Stamatatos, Qingting Hu, Jed de Ruiter Swain, Suzanne Russo, Ava Sann, Ana S.H. Costa, Sara Nunes Violante, David L. Spector, Justin R. Cross et al. · 2024 · Nature Metabolism
  74. Hypoxia and immunometabolism in the tumor microenvironment: insights into mechanisms and therapeutic potential.
    Cen Wu, Tian-Hua Xu, He-Yang Zhang, Yile Hu, Jing Jiao, Kun Qiu, J. Gu, Wen-Ya Li, Lei Sun · 2025 · Cancer Letters
  75. Therapeutic Values of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma: Facts and Hopes
    Yijun Wang, Tongyue Zhang, Mengyu Sun, Xiaoyu Ji, Meng Xie, Wenjie Huang, Limin Xia · 2021 · Cancers
  76. Hypoxic adaptation of mitochondria and its impact on tumor cell function
    Martin Benej, Ioanna Papandreou, Nicholas C. Denko · 2024 · Seminars in Cancer Biology
  77. IDH1 Targeting as a New Potential Option for Intrahepatic Cholangiocarcinoma Treatment—Current State and Future Perspectives
    Fabiana Crispo, Michele Pietrafesa, Valentina Condelli, Francesca Maddalena, Giuseppina Bruno, Annamaria Piscazzi, Alessandro Sgambato, Franca Esposito, Matteo Landriscina · 2020 · Molecules
  78. H3K4 Methylation in Aging and Metabolism
    Chia-Ling Hsu, Yi‐Chen Lo, Cheng-Fu Kao · 2021 · Epigenomes
  79. Noncoding RNAs as sensors of tumor microenvironmental stress
    Yue Lv, Yinghao Lv, Zhen Wang, Kefei Yuan, Yong Zeng · 2022 · Journal of Experimental & Clinical Cancer Research
  80. The Fe–S cluster assembly protein IscU2 increases α-ketoglutarate catabolism and DNA 5mC to promote tumor growth
    Xiaojun Ren, Jimei Yan, Qiongya Zhao, Xinzhu Bao, Xinyu Han, Zheng Chen, Yan Zhou, Lifang Chen, Bo Wang, Lina Yang et al. · 2023 · Cell Discovery
  81. Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors
    Melvin Pan, Christiane Zorbas, Maki Sugaya, Kensuke Ishiguro, Miki Kato, Miyuki Nishida, Haifeng Zhang, Marco M. Candeias, Akimitsu Okamoto, Takamasa Ishikawa et al. · 2022 · Nature Communications
  82. IKKβ activates p53 to promote cancer cell adaptation to glutamine deprivation
    Mari B. Ishak Gabra, Ying Yang, Xazmin H. Lowman, Michael A. Reid, Thai Q. Tran, Mei Kong · 2018 · Oncogenesis
  83. Immunosuppression Induced by Glutamine Deprivation Occurs via Activating PD-L1 Transcription in Bladder Cancer
    Liping Wang, Ting Xu, Xuecheng Yang, Zhijuan Liang, Jisheng Zhang, Dan Li, Yuanbin Chen, Guofeng Ma, Yonghua Wang, Ye Liang et al. · 2021 · Frontiers in Molecular Biosciences
  84. Glutamine regulates ovarian cancer cell migration and invasion through ETS1
    Parash Prasad, Sib Sankar Roy · 2021 · Heliyon
  85. Nutritional Epigenetics in Cancer
    María J. Barrero, Paloma Cejas, Henry W. Long, Ana Ramı́rez de Molina · 2022 · Advances in Nutrition
  86. When cancer drug resistance meets metabolomics (bulk, single-cell and/or spatial): Progress, potential, and perspective
    Zhiqiang Zhang, Chaohui Bao, Lu Jiang, Shan Wang, Kankan Wang, Chang Lu, Hai Fang · 2023 · Frontiers in Oncology
  87. Serine starvation silences estrogen receptor signaling through histone hypoacetylation
    Albert Mao Li, Bo He, Dimitris Karagiannis, Yang Li, Haowen Jiang, Preethi Srinivasan, Yaniel Ramirez, Meng-Ning Zhou, Christina N. Curtis, Joshua James Gruber et al. · 2023 · Proceedings of the National Academy of Sciences
  88. Glutamine Supplementation as an Anticancer Strategy: A Potential Therapeutic Alternative to the Convention
    Hayato Muranaka, Rasaq Akinsola, Sandrine Billet, Stephen Jacob Pandol, Andrew Eugene Hendifar, Neil A. Bhowmick, Jun Gong · 2024 · Cancers
  89. Unlocking the potential: Targeting metabolic pathways in the tumor microenvironment for Cancer therapy
    Siyuan Jia, Ann M. Bode, Xue Chen, Xiangjian Luo · 2024 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  90. Monocarboxylate Transporter-1 (MCT1)-Mediated Lactate Uptake Protects Pancreatic Adenocarcinoma Cells from Oxidative Stress during Glutamine Scarcity Thereby Promoting Resistance against Inhibitors of Glutamine Metabolism
    Nourhane Ammar, Maya Hildebrandt, Claudia Geismann, Christian Röder, Timo Gemoll, Susanne Sebens, Anna Trauzold, H. Schäfer · 2023 · Antioxidants
  91. Unveiling the crossroads of STING signaling pathway and metabolic reprogramming: the multifaceted role of the STING in the TME and new prospects in cancer therapies
    Siwei Wang, Lu Qin, Furong Liu, Zhanguo Zhang · 2025 · Cell Communication and Signaling
  92. Differential Fuel Requirements of Human NK Cells and Human CD8 T Cells: Glutamine Regulates Glucose Uptake in Strongly Activated CD8 T Cells
    Steven R. Presnell, Henry K Spear, Jerika Durham, Tyce Riddle, Austin Applegate, Charles T. Lutz · 2020 · ImmunoHorizons
  93. Targeting Alpha‐Ketoglutarate Disruption Overcomes Immunoevasion and Improves PD‐1 Blockade Immunotherapy in Renal Cell Carcinoma
    Le Li, Xing Zeng, Zheng Chao, Jing Luo, Wei Guan, Qiang Zhang, Yue Ge, Yanan Wang, Zezhong Xiong, Sheng Ma et al. · 2023 · Advanced Science
  94. Metabolic challengers selecting tumor-persistent cells
    Caterina Mancini, Giulia Lori, Erica Pranzini, Maria Letizia Taddei · 2023 · Trends in Endocrinology and Metabolism
  95. Canonical and Non-Canonical Roles of PFKFB3 in Brain Tumors
    Reinier Alvarez, Debjani Mandal, Prashant Chittiboina · 2021 · Cells
  96. Reprogramming glutamine metabolism enhances BCMA -CAR T-cell fitness and therapeutic efficacy in multiple myeloma
    Flor C. Navarro, Teresa Lozano, Andrea Fuentes-García, Inés Sánchez-Moreno, Marta Larráyoz, Pedro Justicia-Lirio, Beatriz Perucha, Maialen Martinez-Tabar, Rebeca Martínez-Turrillas, Noëlia Casares et al. · 2025 · Blood
  97. Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors
    Shuting Cao, Yu‐Wen Hung, Yi-Chang Wang, Yiyin Chung, Yue Qi, Ching Ouyang, Xiancai Zhong, Weidong Hu, Alaysia Coblentz, Ellie G. Maghami et al. · 2022 · Theranostics
  98. Glutamine Production by Glul Promotes Thermogenic Adipocyte Differentiation Through Prdm9-Mediated H3K4me3 and Transcriptional Reprogramming
    Xiaowen Pan, Lingxia Ye, Xiaozhen Guo, Weihua Wang, Ziyin Zhang, Qintao Wang, Jingjing Huang, Jingya Xu, Yanhan Cai, Xinxin Shou et al. · 2023 · Diabetes
  99. Specific regulation of epigenome landscape by metabolic enzymes and metabolites
    Xilan Yu, Shanshan Li · 2024 · Biological reviews/Biological reviews of the Cambridge Philosophical Society
  100. Metabolic regulation of immune responses to cancer
    Jannis Wißfeld, Anke Werner, Xin Yan, Nora ten Bosch, Guoliang Cui · 2022 · Cancer Biology and Medicine