Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex

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Items 201–300 of 569

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2. Yersinia pseudotuberculosis Spatially Controls Activation and Misregulation of Host Cell Rac1
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3. Translocation of CrkL to Focal Adhesions Mediates Integrin-Induced Migration Downstream of Src Family Kinases
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4. Phagocytosis, an alternative model system for the study of cell adhesion
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5. p130Cas Couples the Tyrosine Kinase Bmx/Etk with Regulation of the Actin Cytoskeleton and Cell Migration
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6. Human Immunodeficiency Virus Type 1 Nef Recruits the Guanine Exchange Factor Vav1 via an Unexpected Interface into Plasma Membrane Microdomains for Association with p21-Activated Kinase 2 Activity
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7. A function of huntingtin in guanine nucleotide exchange on Rab11
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8. Competition between Blown Fuse and WASP for WIP Binding Regulates the Dynamics of WASP-Dependent Actin Polymerization In Vivo
   Peng Jin, Rui Duan, Fengbao Luo, Guofeng Zhang, Sabrina N. Hong, Elizabeth H. Chen · 2011 · Developmental Cell
9. Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2
   Madhu Mahankali, Hong‐Juan Peng, Karen M. Henkels, Mary C. Dinauer, Julián Gómez-Cambronero · 2011 · Proceedings of the National Academy of Sciences
10. ELMO1 increases expression of extracellular matrix proteins and inhibits cell adhesion to ECMs
    Atsuyuki Shimazaki, Yasushi Tanaka, Toshihiro Shinosaki, Minoru Ikeda, Hirotaka Watada, Takeshi Hirose, Ryuzo Kawamori, Shiro Maeda · 2006 · Kidney International
11. Integrative Omics Analysis of Rheumatoid Arthritis Identifies Non-Obvious Therapeutic Targets
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12. Gβγ subunits—Different spaces, different faces
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13. Clearance of Apoptotic Cells by Tissue Epithelia: A Putative Role for Hepatocytes in Liver Efferocytosis
    Scott P Davies, Gary M. Reynolds, Zania Stamataki · 2018 · Frontiers in Immunology
14. Dock4 regulates dendritic development in hippocampal neurons.
    Ueda, Shuhei, Fujimoto, Satoshi, Hiramoto, Kiyo, Negishi, Manabu, Katoh, Hironori · 2008 · Journal of Neuroscience Research
15. A Look Inside
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17. Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state
    Chang, Leifu, Yang, Jing, Jo, Chang Hwa, Boland, Andreas, Zhang, Ziguo, McLaughlin, Stephen H., Abu-Thuraia, Afnan, Killoran, Ryan C., Smith, Matthew J., Côté, Jean-Francois et al. · 2020 · Nature Communications
18. Mechanobiology of limb musculoskeletal development
    Varun Arvind, Alice H. Huang · 2017 · Annals of the New York Academy of Sciences
19. ELMO Domains, Evolutionary and Functional Characterization of a Novel GTPase-activating Protein (GAP) Domain for Arf Protein Family GTPases
    Michael P. East, J. Bradford Bowzard, Joel B. Dacks, Richard Kahn · 2012 · Journal of Biological Chemistry
20. High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy
    Catherine K. Hathaway, Albert S. Chang, Ruriko Grant, Hyung‐Suk Kim, Victoria J. Madden, C. Robert Bagnell, J. Charles Jennette, Oliver Smithies, Masao Kakoki · 2016 · Proceedings of the National Academy of Sciences
21. β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid
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22. Drosophila Myoblast Fusion: Invasion and Resistance for the Ultimate Union
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23. Caenorhabditis elegans Myotubularin MTM-1 Negatively Regulates the Engulfment of Apoptotic Cells
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24. Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites
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25. Integrin α9β1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase
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26. Involvement of adaptor protein Crk in malignant feature of human ovarian cancer cell line MCAS
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27. The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin
    Daniel Epting, Krasimir Slanchev, Christopher S. Boehlke, Sylvia Hoff, Niki T. Loges, Takayuki Yasunaga, Lara Indorf, Sigrun Nestel, Soeren S. Lienkamp, Heymut Omran et al. · 2014 · Development
28. Efferocytosis: An accomplice of cancer immune escape
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29. Fetal malformations and early embryonic gene expression response in cynomolgus monkeys maternally exposed to thalidomide
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30. The Rac activator DOCK2 regulates natural killer cell–mediated cytotoxicity in mice through the lytic synapse formation
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31. GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance
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32. Phagocytosis: Hungry, Hungry Cells
    Matthew A. Gray, Roberto J. Botelho · 2016 · Methods in molecular biology
33. Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis
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34. Historical Overview of Rho GTPases
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35. The RhoG/ELMO1/Dock180 Signaling Module Is Required for Spine Morphogenesis in Hippocampal Neurons
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36. The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin
    Daniel Epting, Krasimir Slanchev, Christopher S. Boehlke, Sylvia Hoff, Niki T. Loges, Takayuki Yasunaga, Lara Indorf, Sigrun Nestel, Soeren S. Lienkamp, Heymut Omran et al. · 2015 · Development
37. A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells
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38. Basic Fibroblast Growth Factor Stimulates Activation of Rac1 through a p85 βPIX Phosphorylation-dependent Pathway
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39. Phospholipase C-γ1 is a guanine nucleotide exchange factor for dynamin-1 and enhances dynamin-1-dependent epidermal growth factor receptor endocytosis
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40. The Role of the Cytoskeleton in Regulating the Natural Killer Cell Immune Response in Health and Disease: From Signaling Dynamics to Function
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41. Elmo1 inhibits ubiquitylation of Dock180
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42. Phosphatidic Acid-dependent Recruitment and Function of the Rac Activator DOCK1 during Dorsal Ruffle Formation
    Fumiyuki Sanematsu, Akihiko Nishikimi, Mayuki Watanabe, Tsunaki Hongu, Yoshihiko Tanaka, Yasunori Kanaho, Jean‐François Côté, Yoshinori Fukui · 2013 · Journal of Biological Chemistry
43. Activation of Rac1 by the Guanine Nucleotide Exchange Factor Dck1 Is Required for Invasive Filamentous Growth in the PathogenCandida albicans
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44. Mechanical dynamics in live cells and fluorescence-based force/tension sensors
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45. The molecular basis of glandular trichome development and secondary metabolism in plants
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46. Temporal Dissection of β1-Integrin Signaling Indicates a Role for p130Cas-Crk in Filopodia Formation
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47. Identification of two signaling submodules within the CrkII/ELMO/Dock180 pathway regulating engulfment of apoptotic cells
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48. Arp2/3 and ‘The Shape of things to come’
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49. Essential Role of Elmo1 in Dock2-Dependent Lymphocyte Migration
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50. A model to die for: signaling to apoptotic cell removal in worm, fly and mouse
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51. Integrin-linked kinase in renal disease: connecting cell–matrix interaction to the cytoskeleton
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52. Opening up on ELMO regulation
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53. Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer
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54. Characterization of Recombinant ELMOD (Cell Engulfment and Motility Domain) Proteins as GTPase-activating Proteins (GAPs) for ARF Family GTPases
    Anna Ivanova, Michael P. East, Slee L. Yi, Richard Kahn · 2014 · Journal of Biological Chemistry
55. DOCK180 Is a Rac Activator That Regulates Cardiovascular Development by Acting Downstream of CXCR4
    Fumiyuki Sanematsu, Masanori Hirashima, Mélanie Laurin, Ryosuke Takii, Akihiko Nishikimi, Keiko Kitajima, Guo Ding, Mamiko Noda, Yuzo Murata, Yoshihiko Tanaka et al. · 2010 · Circulation Research
56. Abl Kinase Inhibits the Engulfment of Apopotic Cells in Caenorhabditis elegans
    Michael E. Hurwitz, Pamela J. Vanderzalm, Laird Bloom, Julia Goldman, Gian Garriga, Howard Robert Horvitz · 2009 · PLoS Biology
57. A novel syndrome of hypohidrosis and intellectual disability is linked to COG6 deficiency
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58. An Elmo–Dock complex locally controls Rho GTPases and actin remodeling during cadherin-mediated adhesion
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59. The Molecular Motor KIF21B Mediates Synaptic Plasticity and Fear Extinction by Terminating Rac1 Activation
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60. DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation
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61. C‐terminal SH3 domain of CrkII regulates the assembly and function of the DOCK180/ELMO Rac‐GEF
    Shin Akakura, Bishnupriya Kar, Sukhwinder Singh, Leong Cho, Nitu Tibrewal, Reiko Sanokawa‐Akakura, Charles Reichman, Kodi S. Ravichandran, Raymond B. Birge · 2005 · Journal of Cellular Physiology
62. Regulation of circular dorsal ruffles, macropinocytosis, and cell migration by RhoG and its exchange factor, Trio
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63. The Granulocyte Receptor Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3 (CEACAM3) Directly Associates with Vav to Promote Phagocytosis of Human Pathogens
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64. Integrin Signaling as a Cancer Drug Target
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65. Identification and validation of DOCK4 as a potential biomarker for risk of bone metastasis development in patients with early breast cancer
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66. A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis
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69. Role of CrkII in Fcγ Receptor-mediated Phagocytosis
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70. The DOCK protein family in vascular development and disease
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72. Dock4 forms a complex with SH3YL1 and regulates cancer cell migration
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73. Breast Cancer Antiestrogen Resistance 3 (BCAR3) Promotes Cell Motility by Regulating Actin Cytoskeletal and Adhesion Remodeling in Invasive Breast Cancer Cells
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74. GRASP and IPCEF Promote ARF-to-Rac Signaling and Cell Migration by Coordinating the Association of ARNO/cytohesin 2 with Dock180
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75. Regulation of dendrite growth by the Cdc42 activator Zizimin1/Dock9 in hippocampal neurons
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76. Morphological changes and spatial regulation of diacylglycerol kinase‐ζ, syntrophins, and Rac1 during myoblast fusion
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77. The Development of The Drosophila Larval Body Wall Muscles
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78. Myoblast fusion in Drosophila
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79. In Vitro Guanine Nucleotide Exchange Activity of DHR‐2/DOCKER/CZH2 Domains
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80. Genome-Wide Association Study between Single Nucleotide Polymorphisms and Flight Speed in Nellore Cattle
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81. ELMO Recruits Actin Cross-linking Family 7 (ACF7) at the Cell Membrane for Microtubule Capture and Stabilization of Cellular Protrusions
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82. SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration inC. elegans
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83. Myoblast fusion: Experimental systems and cellular mechanisms
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84. Invasive Podosomes and Myoblast Fusion
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85. Surface apposition and multiple cell contacts promote myoblast fusion in Drosophila flight muscles
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86. DOCK2 is Required for Chemokine-Promoted Human T Lymphocyte Adhesion Under Shear Stress Mediated by the Integrin α4β1
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88. Dedicator of Cytokinesis 2 in Cell Signaling Regulation and Disease Development
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89. The CDM Superfamily Protein MBC Directs Myoblast Fusion through a Mechanism That Requires Phosphatidylinositol 3,4,5-Triphosphate Binding but Is Independent of Direct Interaction with DCrk
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90. RhoG regulates anoikis through a phosphatidylinositol 3-kinase-dependent mechanism
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92. CED-10/Rac1 Regulates Endocytic Recycling through the RAB-5 GAP TBC-2
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93. Elmo1 Helps Dock180 to Regulate Rac1 Activity and Cell Migration of Ovarian Cancer
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97. Specific Recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 Guanine Nucleotide Exchange Factors
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98. The role of Crk/Dock180/Rac1 pathway in the malignant behavior of human ovarian cancer cell SKOV3
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99. HGF-induced formation of the MET–AXL–ELMO2–DOCK180 complex promotes RAC1 activation, receptor clustering, and cancer cell migration and invasion
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100. DOCK2 contributes to endotoxemia-induced acute lung injury in mice by activating proinflammatory macrophages
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