Coupling of receptor conformation and ligand orientation determine graded activity

Bruning, John B, Parent, Alexander A, Gil, German, Zhao, Min, Nowak, Jason, Pace, Margaret C, Smith, Carolyn L, Afonine, Pavel V, Adams, Paul D, Katzenellenbogen, John A, Nettles, Kendall W·2010·Nature Chemical Biology
DOI 10.1038/nchembio.451

Cited by (149)

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  12. Literature Search and Review
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  19. Flavanoids from Saraca asoca- Ideal Medication for Breast Cancer: A Molecular Simulation Approach
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  29. Literature Search and Review
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  31. Additional file 2 of The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract
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  32. Additional file 1 of The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract
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  34. A ternary switch determines ERα LBD conformation
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  36. Theoretical Studies of Anti-cancer Drug Tamoxifen and Estrogen Receptor Alpha
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  37. Additional file 3 of The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract
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  44. BindingDB Entry 50046753: Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity.
    BindingDB · 2016 · UC San Diego
  45. BindingDB Entry 50045108: Elements and modulation of functional dynamics.
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  46. BindingDB Entry 50044343: A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: active vitamin D analogues with 22R-alkyl group.
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  47. BindingDB Entry 50019968: Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors.
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  48. BindingDB Entry 50047049: Selective Human Estrogen Receptor Partial Agonists (ShERPAs) for Tamoxifen-Resistant Breast Cancer.
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  49. BindingDB Entry 50040720: Influence of chlorine or fluorine substitution on the estrogenic properties of 1-alkyl-2,3,5-tris(4-hydroxyphenyl)-1H-pyrroles.
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