A global assembly line for cyanobactins
Open accessAbstract
More than 100 cyclic peptides harboring heterocyclized residues are known from marine ascidians, sponges and different genera of cyanobacteria. Here, we report an assembly line responsible for the biosynthesis of these diverse peptides, now called cyanobactins, both in symbiotic and free-living cyanobacteria. By comparing five new cyanobactin biosynthetic clusters, we produced the prenylated antitumor preclinical candidate trunkamide in Escherichia coli culture using genetic engineering.
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References 15 · Cited by 279
Research works printed but not linked: 4
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- Authors
- Donia, M. S., Ravel, J., & Schmidt, E. W.
- Affiliations
- University of Utah (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Schmidt, Eric W
- Venue
- Nature Chemical Biology
- Published
- 2008-04-20
- Volume
- 4
- Issue
- 6
- Pages
- 341-343
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- PMC
- PMC2862271
- OpenAlex
- W1969209088
- Cited by
- 279
- References
- 15
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 11 · 2023: 11 · 2022: 11 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 14 · 2017: 11 · 2016: 23 · 2015: 14 · 2014: 20 · 2013: 25 · 2012: 17
- FWCI
- 17.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Chemical Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM071425, GM071425)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Synthesis and Biological Activity
- Keywords
- cyanobactins, cyclic peptides, biosynthetic gene clusters, anticancer agents, heterologous expression in Escherichia coli, marine cyanobacteria, marine natural products
- MeSH terms
- Cyanobacteria, Amino Acid Sequence, Escherichia coli, Genetic Engineering, Molecular Conformation, Molecular Sequence Data, Peptides, Cyclic, Stereoisomerism, Time Factors, Cluster Analysis
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