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Cited by 566

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy

Open access
Johnson, Douglas B., Estrada, Monica V., Salgado, Roberto, Sanchez, Violeta, Doxie, Deon B., Opalenik, Susan R., Vilgelm, Anna E., Feld, Emily, Johnson, Adam S., Greenplate, Allison R., Sanders, Melinda E., Lovly, Christine M., Frederick, Dennie T., Kelley, Mark C., Richmond, Ann, Irish, Jonathan M., Shyr, Yu, Sullivan, Ryan J., Puzanov, Igor, Sosman, Jeffrey A., Balko, Justin M.·2016·Nature Communications
DOI 10.1038/ncomms10582
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Abstract

Anti-PD-1 therapy yields objective clinical responses in 30–40% of advanced melanoma patients. Since most patients do not respond, predictive biomarkers to guide treatment selection are needed. We hypothesize that MHC-I/II expression is required for tumour antigen presentation and may predict anti-PD-1 therapy response. In this study, across 60 melanoma cell lines, we find bimodal expression patterns of MHC-II, while MHC-I expression was ubiquitous. A unique subset of melanomas are capable of expressing MHC-II under basal or IFNγ-stimulated conditions. Using pathway analysis, we show that MHC-II(+) cell lines demonstrate signatures of ‘PD-1 signalling’, ‘allograft rejection’ and ‘T-cell receptor signalling’, among others. In two independent cohorts of anti-PD-1-treated melanoma patients, MHC-II positivity on tumour cells is associated with therapeutic response, progression-free and overall survival, as well as CD4+and CD8+tumour infiltrate. MHC-II+tumours can be identified by melanoma-specific immunohistochemistry using commercially available antibodies for HLA-DR to improve anti-PD-1 patient selection.

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Metadata

Authors
Johnson, D. B., Estrada, M. V., Salgado, R., Sanchez, V., Doxie, D. B., Opalenik, S. R., Vilgelm, A. E., Feld, E., Johnson, A. S., Greenplate, A. R., Sanders, M. E., Lovly, C. M., Frederick, D. T., Kelley, M. C., Richmond, A., Irish, J. M., Shyr, Y., Sullivan, R. J., Puzanov, I., Sosman, J. A., & Balko, J. M.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2016-01-29
Volume
7
Issue
1
Pages
10582-10582
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms10582
OpenAlex
W2301707196
Cited by
566
References
18
FWCI
23.02
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy. https://app.cochat.ai/papers/10.1038/ncomms10582
The paper
Johnson, D. B., Estrada, M. V., Salgado, R., Sanchez, V., Doxie, D. B., Opalenik, S. R., Vilgelm, A. E., Feld, E., Johnson, A. S., Greenplate, A. R., Sanders, M. E., Lovly, C. M., Frederick, D. T., Kelley, M. C., Richmond, A., Irish, J. M., Shyr, Y., Sullivan, R. J., Puzanov, I., . . . Balko, J. M. (2016). Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy. Nature Communications. https://doi.org/10.1038/ncomms10582

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.