Lysosomal recruitment of TSC2 is a universal response to cellular stress

Demetriades, Constantinos, Plescher, Monika, Teleman, Aurelio A.·2016·Nature Communications
DOI 10.1038/ncomms10662

Cited by (160)

Items 101–160 of 160

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  10. The role of integrin β1 in the heterogeneity of human embryonic stem cells culture
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  12. Inhibition of PIKfyve Leads to Lysosomal Disorders via Dysregulation of mTOR Signaling
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  13. Insulin Resistance, Secretion and Clearance –Taming the Three Effector Encounter of Type 2 Diabetes
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  16. GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi
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  17. The role of leucine in the activation of cellular metabolism: a large integrative review
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  18. Calmodulin enhances mTORC1 signaling by preventing TSC2-Rheb binding
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  19. Overexpression of the Tuberous sclerosis complex 2 (TSC2) gene inhibits goat myoblasts proliferation and differentiation in understanding the underlying mechanism of muscle development
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  22. TorS ‐ Reframing a rational for type 2 diabetes treatment
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  23. An Insight of Scientific Developments in TSC for Better Therapeutic Strategy
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  24. Chemical Biology Screening Identifies a Vulnerability to Checkpoint Kinase Inhibitors in TSC2-Deficient Renal Angiomyolipomas
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  25. Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid Availability
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  26. GRASP55 Safeguards Proper Lysosome Function by Controlling Sorting of Lysosomal Enzymes at the Golgi
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  27. Resilience and restoration from fasting-refeeding mediated by a nutrient-regulated linker histone
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  28. miR-675-5p regulation of autophagy by TSC2 promotes cisplatin resistance in ovarian cancer
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  29. Contractile and Genetic Characterization of Cardiac Constructs Engineered from Human Induced Pluripotent Stem Cells: Modeling of Tuberous Sclerosis Complex and the Effects of Rapamycin
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  30. Glutamine Synthetase-1 induces autophagy-lysosomal degradation of huntingtin aggregates and ameliorates animal motility in a Drosophila model for Huntington’s disease
    Luisa Vernizzi, Chiara Paiardi, Giusimaria Licata, Teresa Vitali, Stefania Santarelli, Martino Raneli, Vera Manelli, Manuela Rizzetto, Mariarosa Gioria, Maria E. Pasini et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  31. Single Serine on TSC2 Exerts Biased Control over mTORC1 Activation by ERK1/2 but Not Akt
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  35. mTORC1 signaling modulate microtubule tyrosination/detyrosination status to regulate lysosome dynamics
    Jeganath Ammavasai, Nitin Mohan · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  36. eIF4A moonlights as an off switch for TORC1
    Marta M. Swierczynska, Michael N. Hall · 2016 · The EMBO Journal
  37. Aberrant mTORC1 activation kills tubular cells by inactivating miR148b-3p
    Ken Inoki · 2016 · Kidney International
  38. Maintaining homeostasis and mitigating effects of harmful factors in the intrinsic or extrinsic environment
    Moyra Smith · 2020 · Elsevier eBooks
  39. Resolving the Communication GAPs Upstream of TORC1
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  40. Regulation | mTOR and its Substrates
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  43. Unravelling novel functions of the MTOR network across subcellular compartments
    Marti Cadena Sandoval · 2022 · University of Groningen research database (University of Groningen / Centre for Information Technology)
  44. Faculty Opinions recommendation of ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage.
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  45. Comprehensive Evaluation of Rapamycin’s Specificity as an mTOR Inhibitor
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  46. The Construction of Mathematical Model for the Mechanism of Protein Synthesis Involving mTORC1 from the AMPK Pathway
    Ari Kusumastuti, Mohammad Jamhuri, Dewi Firdaus, Nurul Anggraeni Hidayati · 2023 · International Journal of Computing Science and Applied Mathematics
  47. Analysis of the Clinicopathologic Characteristics of Colorectal Cancer with TSC2 Mutation
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  48. Targeting Ferroptosis in Tuberous Sclerosis Cell Line Models
    Tasmia Tahsin · 2025 · Cronfa (Swansea University)
  49. TSC1 phosphorylation by lysosomal mTORC1 establishes a minimal autoregulatory feedback loop
    Andreas A. Lamprakis, Constantinos Demetriades · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  50. Acides aminés et cancer : LAT1, un transporteur essentiel à l’activité mTORC1 et la croissance tumorale
    Yann Cormerais · 2016 · theses.fr (ABES)
  51. Role of p27/Kip1 in auphagy under metabolic stress conditions
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  55. Control of the invadopodia/MT1-MMP axis by mTORC1/TFEB signaling pathway in breast cancer cells
    David Remy · 2022 · theses.fr (ABES)
  56. Functional characterization of the GATOR1 complex in cisplatin resistance
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  57. Signal sensing and transmission of amino acids in mTORC1 regulation
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  58. Substrate selectivity as a paradigm shift in mTORC1 signaling
    Jiyoung Pan, Stephanie A. Fernandes, Riko Hatakeyama, Constantinos Demetriades · 2026 · Current Opinion in Cell Biology
  59. A conserved cargo recognition mechanism establishes TANGO1 as a selective extracellu lar matrix cargo receptor
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  60. Emergence of Rheb as a promising therapeutic target in the amelioration of diabetes
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