Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Kettunen, Johannes, Demirkan, Ayşe, Würtz, Peter, Draisma, Harmen H.M., Haller, Toomas, Rawal, Rajesh, Vaarhorst, Anika, Kangas, Antti J. +42 more·2016·Nature Communications

DOI 10.1038/ncomms11122

Cited by (787)

Items 401–500 of 787

A genome-wide association analysis of 2,622,830 individuals reveals new pathogenic pathways in gout.
T. J. Major, R. Takei, H. Matsuo, M. Leask, R. Topless, Y. Shirai, Z. Li, A. Ji, M. Cadzow, N. Sumpter et al. · 2022 · medRxiv
Association between genetically proxied lipid-lowering drug targets, lipid traits, and amyotrophic lateral sclerosis: a mendelian randomization study
Zhaoqi Yan, Yifeng Xu, Keke Li, Liangji Liu · 2023 · Acta Neurologica Belgica
A metabolome-wide Mendelian randomization study prioritizes causal circulating metabolites for reproductive disorders including primary ovarian insufficiency, polycystic ovary syndrome, and abnormal spermatozoa
Shuang Chen, Shihao Sun, Mingshu Cai, Zhaokai Zhou, Yuan Ma, Zihan Zhou, Fang Wang, Jinhao Liu, Wenyan Song, Yu Liu et al. · 2024 · Journal of Ovarian Research
Cardiovascular Implications of Lipoprotein(a) and its Genetic Variants
Ayman Ahmed El-Menyar, Naushad Ahmad Khan, Wael A. Almahmeed, Jassim M. S. Al Suwaidi, Hassan Ali Saoud Al-Thani · 2025 · JACC Asia
Lipoprotein (a) in primary cardiovascular disease prevention is actionable today
Vibhu Parcha, Vera Bittner · 2025 · American Heart Journal Plus Cardiology Research and Practice
Circulating metabolites and depression: a bidirectional Mendelian randomization
Yankai Dong, Zengxiao Zou, Pin Deng, Xiaoping Fan, Chunlin Li · 2023 · Frontiers in Neuroscience
Genetic and phenotypic associations of frailty with cardiovascular indicators and behavioral characteristics
Yihan Chen, Siying Lin, Shuangyu Yang, Mengling Qi, Yu Ren, Chong Tian, Shitian Wang, Yuedong Yang, Jianzhao Gao, Huiying Zhao · 2024 · Journal of Advanced Research
The associations between dysregulation of human blood metabolites and lung cancer risk: evidence from genetic data
Gujie Wu, Jun Liu, Haochun Shi, Binyang Pan, Min Li, Xiaolin Wang, Yao Li, Lin Cheng, Weigang Guo, Yiwei Huang · 2024 · BMC Cancer
Personalized Profiling of Lipoprotein and Lipid Metabolism Based on 1018 Measures from Combined Quantitative NMR and LC-MS/MS Platforms
Siyu Zhao, Corey Giles, Kevin Huynh, Johannes Kettunen, Marjo‐Riitta Järvelin, Mika A. P. Kähönen, Jorma Viikari, Terho J. Lehtimäki, Olli Tuomas Raitakari, Peter J. Meikle et al. · 2024 · Analytical Chemistry
Using genetics to understand the role of antihypertensive drugs modulating angiotensin‐converting enzyme in immune function and inflammation
Jie V. Zhao, Catherine Mary Schooling, Gabriel Matthew Leung · 2020 · British Journal of Clinical Pharmacology
A latent mixture model for heterogeneous causal mechanisms in Mendelian randomization
Daniel Iong, Qingyuan Zhao, Yang Chen · 2024 · The Annals of Applied Statistics
Metabolic effects of PCSK9 inhibition with Evolocumab in subjects with elevated Lp(a)
Xiang Zhang, Lotte C.A. Stiekema, Erik S.G. Stroes, Albert Kornelis Groen · 2020 · Lipids in Health and Disease
Mendelian randomization reveals potential causal candidates for COVID-19 in 123 blood metabolites
Shizheng Qiu, Donghua Wang, Yu Zhang, Yang Hu · 2021 · Journal of Infection
Causal relationship between sleep apnea and non‐alcoholic fatty liver disease: A Mendelian randomization study
Ziqi Zhang, Meng Li, Guang Ji, Li Rita Zhang · 2023 · European Journal of Clinical Investigation
Causal association of smoking, blood lipids, and bladder cancer: Insights from a multivariable and mediation mendelian randomization investigation
Houyi Wei, Xiangqun Cheng, Gang Wang, Zhilong Li, Wenzhi Du, Lingao Ju, Danni Shan, Meng-xue Yu, Yayun Fang, Kaiyu Qian et al. · 2024 · Journal of Cancer
GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids
Yitang Sun, Huifang Xu, Kaixiong Ye · 2025 · Human Genetics and Genomics Advances
A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins
Sodbo Sharapov, Anna N. Timoshchuk, Olga O. Zaytseva, Denis E. Maslov, Anna G. Soplenkova, Elizaveta E. Elgaeva, Evgeny Tiys, Massimo Mangino, Clemens Wittenbecher, Lennart C. Karssen et al. · 2025 · Nature Communications
Lipoprotein(a) in clinical practice: Risk stratification and therapeutic strategies
Nadim Nasrallah, Atallah, Tarek Harb, Gary Gerstenblith, Thorsten Martin Leucker · 2025 · European Journal of Clinical Investigation
Inflammation, metabolic dysregulation, and depression profiles related to anhedonia and atypical, energy-related symptoms
J.C. Zwiep, Femke Lamers, Christiaan H. Vinkers, N.J.A. van der Wee, Brenda W.J.H. Penninx, Laura Nawijn, Yuri Milaneschi · 2025 · Brain Behavior and Immunity
Low and high serum IgG associates with respiratory infections in a young and working age population
Pia Holma, Paula Pesonen, Minna K. Karjalainen, Marjo‐Riitta Järvelin, Sara A. Väyrynen, Eeva Sliz, Anni Heikkilä, Mikko R. J. Seppänen, Johannes Kettunen, JUHA P. AUVINEN et al. · 2023 · EBioMedicine
How is Obstructive Sleep Apnea Associated with High Blood Pressure and Diabetes Mellitus Type 2? Clues from a Two-Step Mendelian Randomized Study
Yubin Shen, Hongwei Wang, Weiyu Zhang, X J Ou, Song Liu · 2023 · Nature and Science of Sleep
Causal effect of lipoprotein(a) level on chronic kidney disease of European ancestry: a two-sample Mendelian randomization study
Yunhui Zhu, Songzan Chen, Zhebin Chen, Yao Wang, Guosheng Fu, Wenbin Zhang · 2024 · Renal Failure
Identification of circulating metabolites linked to the risk of breast cancer: a mendelian randomization study
Xiaosheng Zhu, Huai Huang, Mengjie Zou, Honglin Luo, Tianqi Liu, Shaoliang Zhu, Bin Ye · 2024 · Frontiers in Pharmacology
Microbiome-metabolome analysis insight into the effects of high-salt diet on hemorheological functions in SD rats
Luming Qi, Yao Li, Zhixuan Chen, Changhong Wei, Xue Wen, Shuangyan Hu, Hang Wu, Zhuoheng Lv, Zhangmeng Xu, Lina Xia · 2024 · Frontiers in Nutrition
The Gut Microbiota and Its Metabolites and Their Association with the Risk of Autoimmune Thyroid Disease: A Mendelian Randomization Study
Chenyu Zhang, Weiping Teng, Chuyuan Wang, Zhongyan Shan · 2024 · Nutrients
Cognition, psychosis risk and metabolic measures in two adolescent birth cohorts
Hugh Ramsay, Jennifer H. Barnett, Graham K. Murray, Jouko Miettunen, Pirjo H. Mäki, Marjo‐Riitta Järvelin, George Davey Smith, Mika Ala‐Korpela, Juha M. Veijola · 2018 · Psychological Medicine
Repurposing Antihypertensive Drugs for the Prevention of Glaucoma: A Mendelian Randomization Study
Jingjing Liu, Shuang Li, Yang Hu, Shizheng Qiu · 2022 · Translational Vision Science & Technology
Unveiling the intricate causal nexus between pancreatic cancer and peripheral metabolites through a comprehensive bidirectional two-sample Mendelian randomization analysis
Rong Sun, Haoyu Xu, Feng Liu, Bin Zhou, Minli Li, Sun Xiangdong · 2023 · Frontiers in Molecular Biosciences
Mechanistic insights from combining genomics with metabolomics
Fotios Drenos · 2017 · Current Opinion in Lipidology
Identification of novel non-synonymous variants associated with type 2 diabetes-related metabolites in Korean population
Tae Joo Park, Heun-Sik Lee, Young Jin Kim, Bong‐Jo Kim · 2019 · Bioscience Reports
Association Between Circulating Linoleic Acid and Risk of Ischemic Stroke
Ye Ding, Huijun Huang, David Wu, Wanting Zhang, Feixiang Zhou, Yu Qian, Ju‐Sheng Zheng, Yingying Mao · 2021 · Frontiers in Genetics
Effect of Metabolite Levels on Type 2 Diabetes Mellitus and Glycemic Traits: A Mendelian Randomization Study
Yue Sun, Ya‐Ke Lu, Haoyu Gao, Yuxiang Yan · 2021 · The Journal of Clinical Endocrinology & Metabolism
Genetically Determined Lifestyle and Cardiometabolic Risk Factors Mediate the Association of Genetically Predicted Age at Menarche With Genetic Predisposition to Myocardial Infarction: A Two-Step, Two-Sample Mendelian Randomization Study
Jilin Zheng, Ken Chen, Tao Huang, Chunli Shao, Ping Li, Jingjia Wang, Wenyao Wang, Kuo Zhang, Xiangbin Meng, Jun Lian Gao et al. · 2022 · Frontiers in Cardiovascular Medicine
Shared genetic influences between blood analyte levels and risk of severe COVID-19
Hamzeh Mesrian Tanha, Anita Sathyanarayanan, Divya Mehta, Dale R. Nyholt · 2022 · Cell Reports
Associations of human blood metabolome with optic neurodegenerative diseases: a bi-directionally systematic mendelian randomization study
Bin Tong, Chubing Long, Jing Zhang, Xin Zhang, Zhengyang Li, Haodong Qi, Kangtai Su, Deju Zhang, Yixuan Chen, Jitao Ling et al. · 2024 · Lipids in Health and Disease
Personalized nutrition to mitigate inflammation in genetically predisposed individuals: a secondary analysis of the Danish PREVENTOMICS intervention
Sebastiá Galmés, Andreu Palou-March, Kristina Pigsborg, Mona Adnan Aldubayan, Sophia M.O. Gormsen, Alberto Calleja, Joan Trabal, Vanesa Fernández Martínez, Biotza Gutierrez, Josep M Del Bas-Prior et al. · 2024 · Food Science and Human Wellness
Unsupervised Learning-Derived Complex Metabolic Signatures Refine Cardiometabolic Risk
Yujia Zhou, Boyang Xiang, Xiaoqin Yang, Yuxin Ren, Xiaosong Gu, Xiang Zhou · 2025 · JACC Advances
The interactions of Lipoprotein(a) with common cardiovascular risk factors in cardiovascular disease risk: evidence based on the UK Biobank
Linjun Ao, Raymond Noordam, J. Wouter Jukema, Diana van Heemst, Ko Willems van Dijk · 2025 · American Journal of Preventive Cardiology
Integrated Analyses to Identify the Roles of GPX1 in Frailty and Hypertension
Byron Huang, Qin Liu, Xing Yu, Yijun Chen, Ye-Bei Liang, Mengxue Yu, Yi-Fei Qiu, Fei-Yun Zhang, Jingxin Wang, Shihui Fu et al. · 2025 · Hypertension
PCK1 as a potential hub gene in distinguishing lactate metabolism between rheumatoid arthritis and osteoarthritis
Pengfei Xin, Shaoqiang Pei, Nanshan Ma, Lianbo Xiao · 2025 · PeerJ
Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics
Wenyi Xiao, Rachel D. Woodham, Yuhan Cui, Junhao Wen, Mathilde Antoniades, Dhivya Srinivasan, Yong Fan A, Güray Erus, José García, Stephen R. Arnott et al. · 2025 · Communications Medicine
Informative Bayesian Neural Network Priors for Weak Signals
Tianyu Cui, Aki Samuli Havulinna, Pekka Marttinen, Samuel Kaski A · 2021 · Bayesian Analysis
The associations of genetically predicted plasma alanine with coronary artery disease (CAD) and CAD risk factors: a Mendelian randomization study.
Xin Huang, Jie V. Zhao · 2023 · American Journal of Clinical Nutrition
Application and discoveries of metabolomics and proteomics in the study of female infertility
Junhua Shi, Xingjie Wu, Haiou Qi, Xin Xu, Shihao Hong · 2024 · Frontiers in Endocrinology
Biological agent exerts therapeutic effects by reversing abnormalities in amino acid metabolic pathways in psoriasis
Haijun Miao, Yaxing Bai, Shengxian Shen, Mengyang Chu, Chang Miao, Jundan Yang, Xia Li, Liang Li, Shuai Shao, Gang Wang et al. · 2024 · Experimental Dermatology
Blood metabolites, neurocognition and psychiatric disorders: a Mendelian randomization analysis to investigate causal pathways
Jing Guo, Ping Yang, Jiahao Wang, Shi-Hao Tang, Ji-Zhou Han, Shi Yao, Ke Yu, Congcong Liu, Shan‐Shan Dong, Kun Zhang et al. · 2024 · Translational Psychiatry
Associations between human blood metabolome and vascular dementia
Yiming Jia, Daoxia Guo, Yi Liu, Lulu Sun, Xinyue Chang, Yu He, Mengyao Shi, Guo‐Chong Chen, Yonghong Zhang, Hui Li et al. · 2024 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
A Comprehensive Evaluation of Cross-Omics Blood-Based Biomarkers for Neuropsychiatric Disorders
Weichen Song, Weidi Wang, Zhe Liu, Wenxiang Cai, Shunying Yu, Min Zhao, Guan Ning Lin · 2021 · Journal of Personalized Medicine
Causal effects of genetically predicted type 2 diabetes mellitus on blood lipid profiles and concentration of particle-size-determined lipoprotein subclasses: A two-sample Mendelian randomization study
Ken Chen, Jilin Zheng, Chunli Shao, Qing Zhou, Jie Yang, Tao Huang, Yi‐Da Tang · 2022 · Frontiers in Cardiovascular Medicine
Identification of potential causal metabolites associated with atopic dermatitis
Yiming Jia, Rong Wang, Lulu Sun, Daoxia Guo, Mengyao Shi, Kaixin Zhang, Pinni Yang, Yu Wang, Fanghua Liu, Guo-Chong Chen et al. · 2023 · Human Molecular Genetics
The role of blood metabolites in oral cancer: insights from a Mendelian randomization approach
Ziyang Hu, Zhe Xu, Yue Qu, Xuhong Pan, Ping Shi, Dandan Zhang, Jiexia Zhang, Runzhi Deng, Zitong Lin · 2024 · Frontiers in Oncology
Association of genetically predicted levels of circulating blood lipids with coronary artery disease incidence
Hasanga D. Manikpurage, Jasmin Ricard, Ursula Houessou, Jérôme Bourgault, Éloi Gagnon, Émilie Gobeil, Arnaud S. Girard, Zhonglin Li, Aïda Eslami, Patrick Mathieu et al. · 2024 · Atherosclerosis
The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites
Jessica O'Reilly, Faith Pangilinan, Karsten Hokamp, Per Magne Ueland, John T. Brosnan, Margaret E. Brosnan, Lawrence C. Brody, Anne Marie Molloy · 2018 · Molecular Genetics and Metabolism Reports
Associations between outdoor temperature and bright sunlight with metabolites in two population-based European cohorts
Boukje C. Eveleens Maarse, Nellie Y. Loh, Fredrik Karpe, Frits Richard Rosendaal, Diana van Heemst, Dennis O. Mook‐Kanamori, Ko Willems van Dijk, Patrick C.N. Rensen, Sander Kooijman, Constantinos Christodoulides et al. · 2020 · Nutrition Metabolism and Cardiovascular Diseases
DHA mediates the protective effect of fish consumption on new episodes of depression among women
John L. Reeves, Petr Otáhal, Costan G. Magnussen, Terence Dwyer, Antti J. Kangas, Pasi Soininen, Mika Ala‐Korpela, Alison Venn, Kylie J. Smith · 2017 · British Journal Of Nutrition
Functional Prediction of Chronic Kidney Disease Susceptibility Gene PRKAG2 by Comprehensively Bioinformatics Analysis
Ermin Wang, Hainan Zhao, Deyan Zhao, Lijing Li, Limin Du · 2018 · Frontiers in Genetics
Investigating Causality Between Blood Metabolites and Emotional and Behavioral Responses to Traumatic Stress: a Mendelian Randomization Study
Carolina Muniz Carvalho, Frank R. Wendt, Dan Joseph Stein, Murray B. Stein, Joel E. Gelernter, Sintia Iole Belangero, Renato A Polimanti · 2019 · Molecular Neurobiology
Reconstructing the blood metabolome and genotype using long-range chromatin interactions
Tayaza Fadason, William S. Schierding, Nikolai Kolbenev, Jiamou Liu, John R. Ingram, Justin Martin O'Sullivan · 2020 · Metabolism Open
Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data
Richard Howey, So-Youn Shin, Caroline Laura Relton, George Davey Smith, Heather J. Cordell · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics
María Gordillo‐Marañón, Magdalena Zwierzyna, Pimphen Charoen, Fotios Drenos, Sandesh Chopade, Tina Shah, Jorgen Engmann, Juan Pablo Casas, Nish Chaturvedi, Olia Papacosta et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Fifty-one novel and replicated GWAS loci for polyunsaturated and monounsaturated fatty acids in 124,024 Europeans
Michael Francis, Yitang Sun, Huifang Xu, James Thomas Brenna, Kaixiong Ye · 2022 · medRxiv
Real-life helping behaviours in North America: A genome-wide association approach.
Primes, Georg, Fieder, Martin · 2018 · PLoS ONE
Genetic regulation and variation of fetal plasma metabolome in the context of sex, paternal breeds and variable fetal weight
Siriluck Ponsuksili, Eduard Muráni, Beate Fuchs, Christina E. Galuska, Henry Reyer, Muhammad Arsalan Iqbal, Shuaichen Li, Michael Oster, Klaus Wimmers · 2025 · Open Biology
Genetic architecture and analysis practices of circulating metabolites in the NHLBI Trans-Omics for Precision Medicine Program
Nannan Wang, Franklin P Ockerman, Laura Y. Zhou, Megan L. Grove, Taryn Alkis, John Barnard, Russell Paul Bowler, Clary B. Clish, Shinhye Chung, Emily Drzymalla et al. · 2025 · The American Journal of Human Genetics
Assessing the causal associations of different types of statins use and knee/hip osteoarthritis: A Mendelian randomization study
Xin Chen, Xin Huang, Youqun Liu, Zhiwei Zhang, Jiliang Chen · 2024 · PLoS ONE
Association between human blood metabolome and the risk of gastrointestinal tumors
Jiamin Lu, Yuqian Feng, Kaibo Guo, Leitao Sun, Shanming Ruan, Kai Zhang · 2024 · PLoS ONE
Effects of Longer-Term Mixed Nut Consumption on Lipoprotein Particle Concentrations in Older Adults with Overweight or Obesity
Kevin M.R. Nijssen, Marco A Chavez-Alfaro, Peter J. Joris, Jogchum Plat, Ronald P. Mensink · 2024 · Nutrients
Metabolome-wide Mendelian randomisation reveals causal links between circulating metabolites and type 1 diabetes
Basile Jumentier, Isabel Gamache, Dominika A. Michalek, Wei‐Min Chen, Suna Önengüt-Gümüşcü, Stephen S. Rich, Constantin Polychronakos, Despoina Manousaki · 2025 · EBioMedicine
Elucidation of disease etiology by trans-layer omics analysis
Yuya Shirai, Yukinori Okada · 2021 · Inflammation and Regeneration
Causal Associations Between Age at Diagnosis of Diabetes and Cardiovascular Outcomes: A Mendelian Randomization Study
Chaojie Ye, Lijie Kong, Yiying Wang, Hong Lin, Shuangyuan Wang, Zhiyun Zhao, Mian Li, Yu Xu, Jieli Lu, Yuhong Chen et al. · 2022 · The Journal of Clinical Endocrinology & Metabolism
Essential nutrients and cerebral small vessel diseases: a two-sample Mendelian randomization study
Jiayi Li, Kailin Xia, Zhengrui Wang, Yanru Liu, Yicheng Tong, Yuwei Wang, Yumou Zhou, Linjing Zhang, Lu Tang, Dongsheng Fan et al. · 2023 · Frontiers in Nutrition
Using proteomics and metabolomics to identify therapeutic targets for senescence mediated cancer: genetic complementarity method
Xiaolu Fang, Deyang Liu, Jianzhong Zhao, Xiaojia Li, Ting He, Baishan Liu · 2023 · Frontiers in Endocrinology
Association between human blood metabolome and the risk of pre-eclampsia
Yaling Ding, Mengxin Yao, Jiafeng Liu, Wanyi Fu, Xiaoyan Zhu, Yelin He, Qiuping Ma, Chunhua Zhang, Jieyun Yin · 2024 · Hypertension Research
Assessing the causal relationship between blood metabolites and low back pain: a Mendelian randomization study
Linsong Ji · 2024 · American Journal of Translational Research
Genotype-based “virtual” metabolomics in a clinical biobank identifies novel metabolite-disease associations
Minoo Bagheri, Andrei Bombin, Mingjian Shi, Venkatesh Locharla Murthy, Ravi V. Shah, Jonathan D. Mosley, Jane F. Ferguson · 2024 · Frontiers in Genetics
Dissecting causal relationships between cortical morphology and neuropsychiatric disorders: a bidirectional Mendelian randomization study
Bochao Danae Lin, Yunzhi Li, Anastasia A. Goula, Xiao Chang, Katrina L. Grasby, Sarah Elizabeth Medland, Ole A. Andreassen, Bart P. F. Rutten, Sinan Gülöksüz, Dennis van der Meer et al. · 2025 · Nature Mental Health
Prioritising Risk Factors for Type 2 Diabetes: Causal Inference through Genetic Approaches
Laura B. L. Wittemans, Luca Andrea Lotta, Claudia Langenberg · 2018 · Current Diabetes Reports
Leveraging omics data to boost the power of genome-wide association studies
Zhaotong Lin, Katherine A. Knutson, Wei Pan · 2022 · Human Genetics and Genomics Advances
Causality of genetically determined blood metabolites on inflammatory bowel disease: a two-sample Mendelian randomization study
Xiongquan Long, Yuyang Zhang, Mingzhu Liu, Zihao Liu, Lvzhou Xia, Xiaoping Xu, Minghao Wu · 2024 · Scientific Reports
The Molecular Human – A Roadmap of Molecular Interactions Linking Multiomics Networks with Disease Endpoints
Anna Halama, Shaza B. Zaghlool, Gaurav Thareja, Sara Abdul Kader, Wadha Al Muftha, Marjonneke J. Mook-Kanamori, Hina Sarwath, Yasmin Ali Mohamoud, Sabine Ameling, Maja Pučić‐Baković et al. · 2022 · medRxiv
Exploring the Role of Glycine Metabolism in Coronary Artery Disease: Insights from Human Genetics and Mouse Models
Subarna Biswas, James R. Hilser, Nicholas C. Woodward, Zeneng Wang, Janet Gukasyan, Ina Nemet, William S. Schwartzman, Pin Huang, Yi Ying Han, Zachary Fouladian et al. · 2025 · Nutrients
Lipoprotein Subfractions Predict All-cause and Cardiovascular Mortality in CKD Patients Undergoing Hemodialysis: A Prospective Cohort Study Based on NMR Metabolomics
Qingxia Huang, Han Zhang, Ziyan Shen, Jing Chen, Xuesen Cao, Linghan Xu, Cheng Zhu, Shiqi Lv, Xixi Yu, Xiaoqiang Ding et al. · 2025 · Phenomics
Genome-wide association and multi-omics analyses provide insights into the disease mechanisms of central serous chorioretinopathy
Yuki Mori, Elon H. C. van Dijk, Masahiro Miyake, Yoshikatsu Hosoda, Anneke I. den Hollander, Suzanne Yzer, Akiko Miki, Li Jia Chen, Jeeyun Ahn, Ayako Takahashi et al. · 2025 · Scientific Reports
Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study
Wenyi Wang, Ko Willems van Dijk, Carolien A. Wijsman, Maarten Pieter Rozing, Simon P. Mooijaart, Marian Beekman, P. Eline Slagboom, J. Wouter Jukema, Raymond Noordam, Diana van Heemst · 2021 · Metabolomics
The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism
Sophia Metz, Nikolaj Thure Krarup, Thomas Bryrup, Julie Støy, Ehm Astrid Andersson Galijatovic, Christina Christoffersen, Matt J. Neville, Malene Revsbech Christiansen, Anna Elisabet Jonsson, Daniel R. Witte et al. · 2022 · Journal of the Endocrine Society
Crosstalk between Host Genome and Metabolome among People with HIV in South Africa
Chang Liu, Zicheng Wang, Qin Hui, Yiyun Chiang, Junyu Chen, Jaysingh Brijkumar, Johnathan A. Edwards, Claudia E. Ordóñez, Matthew R. Dudgeon, Henry Sunpath et al. · 2022 · Metabolites
Genetic estimation of correlations between circulating glutamine and cancer.
Kai Zhang, Hongjin Liang · 2023 · PubMed Central
ENPP2 /Autotaxin: The potential drug target for alcoholic liver disease identified through Mendelian randomization analysis
Peiqiong Luo, Xuefeng Yu · 2024 · Liver International
Causal relationship between serum metabolites and idiopathic pulmonary fibrosis: Insights from a two-sample Mendelian randomization study
Qiong‐Chao Zou, Jun-Pei Hu, Yan Cao, Chang She, Lihui Liang, Zhengyu Liu · 2024 · Heliyon
Effects of gut microbiota and metabolites on pancreatitis: a 2-sample Mendelian randomization study
Zhirong Zhao, Han Li, Baobaonai Tuerxunbieke, Lan Ming, Jiamin Ji, Yuan Chen, Ran Sun, Weiliang Tian, Fan Yang, Qian Huang · 2024 · Journal of Gastrointestinal Surgery
Causal relationships of circulating amino acids with sarcopenia-related traits: A bidirectional Mendelian randomization study
Chenyang Zhan, Zongjie Quan, Xiujin Huang, Jun Bu, Sheng Li · 2025 · Clinical Nutrition
Causal Pathways from Blood Pressure to Larger QRS Amplitudes: a Mendelian Randomization Study
M. Yldau van der Ende, Tom Hendriks, Dirk Jan van Veldhuisen, Harold Snieder, Niek Verweij, Pim van der Harst · 2018 · Scientific Reports
High-Density Lipoprotein Particle Subclasses in Statin-Treated Patients with Peripheral Artery Disease Predict Long-Term Survival
Bernhard Zierfuss, Clemens Höbaus, Carsten Thilo Herz, Renate Koppensteiner, Herbert Stangl, Gerit-Holger Schernthaner · 2022 · Thrombosis and Haemostasis
Lipoprotein(a) in systemic lupus erythematosus is associated with history of proteinuria and reduced renal function
Caoilfhionn Marie Connolly, Jessica L. Li, DANIEL W. GOLDMAN, Andrea Fava, Laurence S. Magder, Michelle Petri · 2022 · Lupus
Gene-metabolite annotation with shortest reactional distance enhances metabolite genome-wide association studies results
Cantin Baron, Sarah Cherkaoui, Sandra Therrien-Laperriere, Yann Ilboudo, Raphaël Poujol, Pamela Mehanna, Melanie E. Garrett, Marilyn J. Telen, Allison E. Ashley‐Koch, Pablo Bartolucci et al. · 2023 · iScience
Genetic correlation between circulating metabolites and chalazion: a two-sample Mendelian randomization study
Xin Zhang, Yuying Cai, Yaping Jiang, Wei Du, Weishu An, Qiang-Qiang Fu, Yihui Chen · 2024 · Frontiers in Molecular Biosciences
New Aquaculture Technology Based on Host-Symbiotic Co-metabolism
Miyuki Mekuchi, Taiga Asakura, Jun Kikuchi · 2019 · Springer eBooks
Genome-wide association studies of 74 plasma metabolites of German shepherd dogs reveal two metabolites associated with genes encoding their enzymes
Pamela X. Y. Soh, Juliana Maria Marin Cely, Sally Mortlock, Christopher J. Jara, Rachel Booth, Siria Natera, Ute Roessner, Ben Crossett, Stuart J. Cordwell, Mehar Singh Khatkar et al. · 2019 · Metabolomics
Genome-wide Association Study of the Postprandial Triglyceride Response Yields Common Genetic Variation in Hepatic Lipase (LIPC)
Dorina Ibi, Raymond Noordam, Jan Bert van Klinken, Ruifang Li‐Gao, Renée de Mutsert, Stella Trompet, Tim Christen, Lisanne L. Blauw, Diana van Heemst, Dennis O. Mook‐Kanamori et al. · 2020 · Circulation Genomic and Precision Medicine
Characteristics of a novel NMR-based metabolomics platform for dogs
Claudia Ottka, Katariina Vapalahti, Jenni Puurunen, Laura Vahtera, Hannes Lohi · 2019 · bioRxiv (Cold Spring Harbor Laboratory)