Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance.

Healey, Kelley R., Zhao, Yanan, Perez, Winder B., Lockhart, Shawn R., Sobel, Jack D., Farmakiotis, Dimitrios, Kontoyiannis, Dimitrios P., Sanglard, Dominique +5 more·2016·Nature Communications
DOI 10.1038/ncomms11128

Cited by (277)

Items 201–277 of 277

  1. Nosocomial transmission of fluconazole-resistant Candida glabrata bloodstream isolates revealed by whole-genome sequencing
    In Ji Hwang, Yong Jun Kwon, Ha Jin Lim, Ki Ho Hong, Hyukmin Lee, Dongeun Yong, Eun Jeong Won, Seung A. Byun, Ga Yeong Lee, Soo Hyun Kim et al. · 2024 · Microbiology Spectrum
  2. Adhesive and biofilm‐forming Candida glabrata Lebanese hospital isolates harbour mutations in subtelomeric silencers and adhesins
    Nour Fattouh, Rola Husni, Marc Finianos, Ibrahim Bitar, Roy A. Khalaf · 2024 · Mycoses
  3. Brazilian Green Propolis Extract-Loaded Poly(Ε-Caprolactone) Nanoparticles Coated with Hyaluronic Acid: Antifungal Activity in a Murine Model of Vulvovaginal Candidiasis
    Aniely Dos Reis Teixeira, Amanda V. Quaresma, Renata Tupinambá Branquinho, Patrícia Capelari De Oliveira, Jorge Andrés García Suárez, Geraldo Célio Brandão, Ana Paula Moreira Barboza, Marcelo Gonzaga de Freitas Araújo, Juliana Teixeira de Magalhães, Sandra Aparecida Lima de Moura et al. · 2025 · AAPS PharmSciTech
  4. Rationalisation of Antifungal Properties of α-Helical Pore-Forming Peptide, Mastoparan B
    Edward Jianyang Lim, Eunice Goh Tze Leng, Nhan Dai Thien Tram, Mercy Halleluyah Periayah, Pui Lai Rachel Ee, Timothy Barkham, Zhi Sheng Poh, Navin Kumar Verma, Rajamani Lakshminarayanan · 2022 · Molecules
  5. Lighting Up Mutation: a New Unbiased System for the Measurement of Microbial Mutation Rates
    Kylie J. Boyce, Alexander Idnurm · 2019 · mBio
  6. Drug Resistance and Evolvability in an Emerging Human Fungal Pathogen
    R. Blake Billmyre · 2022 · mBio
  7. Stable hypermutators revealed by the genomic landscape of genes involved in genome stability among yeast species
    Gonçalves, Carla, Steenwyk, Jacob L, Rinker, David C, Opulente, Dana A, LaBella, Abigail L, Harrison, Marie-Claire, Wolters, John F, Zhou, Xiaofan, Shen, Xing-Xing, Covo, Shay et al. · 2025 · Molecular Biology and Evolution
  8. The putative error prone polymerase REV1 mediates DNA damage and drug resistance in Candida albicans
    Michelle R. Agyare-Tabbi, Deeva Uthayakumar, Desiree Francis, Laetitia Maroc, Chris Grant, Peter McQueen, Garret Westmacott, Hajer Shaker, Iwona Skulska, Isabelle Gagnon‐Arsenault et al. · 2024 · npj Antimicrobials and Resistance
  9. Factors that influence bidirectional long-tract homozygosis due to double-strand break repair in Candida albicans
    Timea Marton, Murielle Chauvel, Adeline Feri, Corinne Maufrais, Christophe d’Enfert, Mélanie Legrand · 2021 · Genetics
  10. Azole resistance: insights from Y132 substitutions in Candida sterol 14α-demethylase utilizing molecular dynamics simulations
    R. Shyama Prasad Rao, Larina Pinto, Renuka Suravajhala, Belle Damodara Shenoy, Vangal Krishnaswamy Sashindran, Sudeep Darbhe Ghate · 2025 · Journal of Biomolecular Structure and Dynamics
  11. A Soil-Isolated Streptomyces spororaveus Species Produces a High-Molecular-Weight Antibiotic AF1 against Fungi and Gram-Positive Bacteria
    Pu-Chieh Chang, Shao-Chung Liu, Ming-Chun Ho, Tzu‐Wen Huang, Chih‐Hung Huang · 2022 · Antibiotics
  12. Migration promotes mutator alleles in subdivided populations
    Yevgeniy Raynes, Paul Sniegowski, Daniel M. Weinreich · 2019 · Evolution
  13. Role of Antifungal Drugs in Combating Invasive Fungal Diseases
    Kakoli Dutt · 2019 · Wiley eBooks
  14. Elevated mutation rates in the multi-azole resistant Aspergillus fumigatus clade drives rapid evolution of antifungal resistance
    Michael J. Bottery, Norman van Rhijn, Harry Chown, Johanna L. Rhodes, Brandi N. Celia-Sanchez, Marin T. Brewer, Michelle Momany, Matthew C. Fisher, Knight Cg, Michael Bromley · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Phylogenomic analysis and genetic mechanisms of antifungal resistance in clinical isolates of Candida glabrata ( Nakaseomyces glabratus ) from across Canada, 2013–2020
    Domenica G. De Luca, David C. Alexander, Tanis C. Dingle, Philippe J. Dufresne, Jeff Fuller, Greg J. German, David J. M. Haldane, Linda Hoang, Lei Jiao, Julianne V. Kus et al. · 2025 · Microbiology Spectrum
  16. Exploring the effects of culture conditions on Yapsin ( YPS ) gene expression in Nakaseomyces glabratus
    Aneta Bednarek, Agnieszka Kabut, Maria Rąpała‐Kozik, Dorota Satała · 2024 · Open Life Sciences
  17. Association of multilocus sequence typing, MSH2 gene mutations, and antifungal resistance in Candida glabrata: implications for clinical outcomes in Chinese hospitals
    Guanyi Zhang, Yisheng Chen, Jia Chen, Dongting Yao · 2024 · Annals of Clinical Microbiology and Antimicrobials
  18. Hypermutator fungal pathogens: from threat to meltdown
    Tobias Baril, Daniel Croll · 2025 · Trends in Microbiology
  19. Using Yeast to Discover Inhibitors of Multidrug Efflux in Candida albicans
    Brian C. Monk, Mikhail V. Keniya · 2017 · Springer eBooks
  20. Suppressed Protein Translation Caused by MSP‐8 Deficiency Determines Fungal Multidrug Resistance with Fitness Cost
    Mi Zhou, Ping Yu, Chengcheng Hu, Wenxia Fang, Cheng Jin, Shaojie Li, Xianyun Sun · 2024 · Advanced Science
  21. Membrane et paroi fongiques : des rôles clés dans la résistance aux antifongiques
    Cécile Garnaud, Muriel Cornet · 2020 · Revue Francophone des Laboratoires
  22. Evaluation of Synergistic Activity of Black Seed Extract (Nigella sativa), Honey and Zamzam Water on Candida albicans
    Ummasalma Saulawa Aliyu, Sani Liti Hamisu · 2018 · UMYU Journal of Microbiology Research (UJMR)
  23. Broadening the spectrum of cancer genes under selection in human populations
    Konstantinos Voskarides · 2021 · FASEB BioAdvances
  24. Patterns of genomic variation in the opportunistic pathogen Candida glabrata suggest the existence of mating and a secondary association to the human host
    Laia Carreté, Ewa Księżopolska, Cinta Pegueroles, Emilia Gómez-Molero, Ester Saus, Susana Iraola‐Guzmán, Damian Loska, Oliver Bader, Cécile Fairhead, Toni Gabaldón · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  25. Assessing the importance of resistance, persistence and hyper-mutation for antibiotic treatment success with stochastic modelling
    Christopher Witzany, Roland R. Regoes, Claudia Igler · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  26. Corrigendum: Molecular characterization and antifungal susceptibility testing of Candida nivariensis from blood samples – an Iranian multicentre study and a review of the literature
    Amir A. Arastehfar, Farnaz Daneshnia, Mohammadreza Salehi, Hossein Zarrinfar, Sadegh Khodavaisy, Pieter‐Jan Haas, Maryam Roudbary, Mohammad Javad Najafzadeh, Kamiar Zomorodian, Arezoo Charsizadeh et al. · 2019 · Journal of Medical Microbiology
  27. Mechanisms of Resistance to Antifungal Agents
    David S. Perlin · 2023 · ClinMicroNow
  28. Implication of genotypes for prognosis of Candida glabrata bloodstream infections
    Pao‐Yu Chen, Yu‐Shan Huang, Yu‐Chung Chuang, Jann‐Tay Wang, Wang‐Huei Sheng, Yee‐Chun Chen, Shan‐Chwen Chang · 2024 · Journal of Antimicrobial Chemotherapy
  29. Design, synthesis and evaluation of antifungal activity of 8-hydroxyquinolin-5-ylidene thiosemicarbazone derivatives
    Haonan Zhang, Xiaochen Chi, Zhe Ji, Jiayin Wang, Futang Liu, Nan Chen, Qingli Guo, Yuanying Jiang, Tingjunhong Ni · 2025 · Current Research in Microbial Sciences
  30. Evaluation of antifungal activity of “green” Solidago canadensis extracts
    H. V. Yavorska, N. M. Vorobets · 2025 · The Journal of V N Karazin Kharkiv National University Series Biology
  31. Accelerated mutator phenotype in a clinical Aspergillus fumigatus isolate contributes to adaptive evolution
    Yinggai Song, Margriet Hokken, Jan Zoll, Hanka Venselaar, Paul E. Verweij, Willem J. G. Melchers, Johanna L. Rhodes · 2026 · Emerging Microbes & Infections
  32. Coenzyme A metabolism in fungi: a new frontier in antifungal therapy
    Jae‐Yeon Choi, Abigail Chiang, Choukri Ben Mamoun · 2026 · Clinical Microbiology Reviews
  33. Synthesis and Anticandidal Activities of Some Aryl (5-Chloro-Benzofuran- 2-yl) Ketoximes
    Ahmet Çağrı Karaburun · 2018 · Letters in Drug Design & Discovery
  34. Synthesis and Antifungal Activity of New Nitrobenzofuran Derivatives
    Ahmet Çağrı Karaburun · 2019 · Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi
  35. Trends of Antifungal Agent Susceptibility of Candida Strains Isolated from Blood Cultures in 2009~2018
    Yu-Yean Hwang, On‐Kyun Kang, Chang-Eun Park, Moo‐Sik Lee, Young-Kwon Kim, Hee Jae Huh, Nam Yong Lee · 2022 · Korean Journal of Clinical Laboratory Science
  36. Analysis of fks1 and fks2 gene mutations in invasive Candida glabrata strains from Pakistan
    Saba Memon, Najia Karim Ghanchi, Urooj Zafar, Joveria Qais Farooqi, Sadaf Zaka, Kauser Jabeen · 2022 · Mycoses
  37. Enzymatic and antifungal susceptibility profiles of Candida glabrata isolates from paediatric patients and their genetic diversity based on microsatellite length polymorphism
    Hadis Jafarian, Amir Kamal Hardani, Ali Amin Asnafi, Ali Zarei Mahmoudabadi · 2022 · Letters in Applied Microbiology
  38. A Stress Response that Allows Highly Mutated Eukaryotic Cells to Survive and Proliferate
    Rebecca A. Zabinsky, Jonathan Mares, Richard She, Michelle K. Zeman, Audrey Chang, James Talbot, E. Campbell, Tina Monzavi, Thomas R. Silvers, Daniel F. Jarosz · 2022 · SSRN Electronic Journal
  39. Azole resistance: Insights from Y132 substitutions in Candida sterol 14α-demethylase
    R. Shyama Prasad Rao, Larina Pinto, Renuka Suravajhala, Belle Damodara Shenoy, Sudeep Darbhe Ghate · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  40. Tn-seq of the Candida glabrata reference strain CBS138 reveals epigenetic plasticity, structural variation, and intrinsic mechanisms of resistance to micafungin
    Timothy J. Nickels, Andrew N. Gale, Abigail A. Harrington, Winston Timp, Kyle W. Cunningham · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  41. Antifungal Chemotherapy
    Keith E. Baptiste · 2024
  42. Mechanisms of Resistance to Antifungal Agents
    David S. Perlin · 2023 · ClinMicroNow
  43. Stable hypermutators revealed by the genomic landscape of DNA repair genes among yeast species
    Carla Gonçalves, Jacob Lucas Steenwyk, David C. Rinker, Dana A. Opulente, Abigail Leavitt LaBella, Marie‐Claire Harrison, John F. Wolters, Xiaofan Zhou, Xing‐Xing Shen, Shay Covo et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  44. Genetic determinants of antifungal resistance in Candida species
    Danielly Beraldo dos Santos Silva, Alexéia Barufatti, Mari Pires de Oliveira Kelly · 2016 · AFRICAN JOURNAL OF BIOTECHNOLOGY
  45. Az antifungális rezisztencia és a virulencia összefüggésének vizsgálata Candida parapsilosis-ban
    Csaba Papp · 2019
  46. Targeting Casein Kinases in the Fungal Pathogen Candida albicans
    Sabrina Hyde · 2020 · TSpace (University of Toronto)
  47. Non Detection of Candida nivariensis and Candida bracarensis Among Candida glabrata Sensu Lato Isolates in the West Region of Cameroon
    Claude Nangwat, Aude Ngueguim Dougue, Cyrille Levis Kountchou, Alfred Itor Ekpo, Thierry Kammalac Ngouana, Jean Paul Dzoyem, Tume B. Christopher · 2020 · European Journal of Clinical and Biomedical Sciences
  48. Microbial Genetics in Mycology
    Johanna L. Rhodes · 2021 · Elsevier eBooks
  49. Faculty Opinions recommendation of A spontaneous mutation in DNA polymerase POL3 during in vitro passaging causes a hypermutator phenotype in Cryptococcus species.
    Joseph Heitman, Shelby J. Priest, Vikas Yadav · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  50. Peer Review #2 of "A rapid and accurate method for the detection of four aminoglycoside modifying enzyme drug resistance gene in clinical strains of Escherichia coli by a multiplex polymerase chain reaction (v0.1)"
    2020 · PeerJ
  51. Faculty Opinions recommendation of Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii.
    Jae‐Hyuk Yu, Hee-Soo Park · 2017 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  52. In the Literature
    2016 · Clinical Infectious Diseases
  53. Volume 40 Number 2
    2019 · Microbiology Australia
  54. Peer Review #1 of "A rapid and accurate method for the detection of four aminoglycoside modifying enzyme drug resistance gene in clinical strains of Escherichia coli by a multiplex polymerase chain reaction (v0.1)"
    2020 · PeerJ
  55. Analysis of genome instability and implications for the consequent phenotype in Plasmodium falciparum containing mutated MSH2-1 (P513T)
    Hajime Honma, Nobuyuki Takahashi, Nobuko Arisue, Tomohiko Sugishita · 2023 · Microbial Genomics
  56. Metabolic engineering of yeast for xylose utilization via the Weimberg pathway and for xylitol production
    Priti Regmi · 2023
  57. A role for the putative error-prone polymerase REV1 in DNA damage and antifungal drug resistance in Candida albicans
    Michelle R. Agyare-Tabbi, Deeva Uthayakumar, Desiree Francis, Laetitia Maroc, Chris Grant, Peter McQueen, Garret Westmacott, Hajer Shaker, Iwona Skulska, Isabelle Gagnon‐Arsenault et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Diverse Strategies and Evolutionary Histories of Fungal Pathogens
    Cene Gostinčar, Nina Gunde‐Cimerman · 2024 · Elsevier eBooks
  59. Candida albicans genome adaptation in azole resistant isolates from autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) patients
    Faten Al-Wathiqi, Sara Gago, Lilyann Novak Frazer, Riina Rautemaa‐Richardson, Paul Bowyer · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  60. Antifungal Agents
    Andreas H. Groll, Thomas J. Walsh · 2025 · Elsevier eBooks
  61. The Effect of Quercus robur Bark on Oral Candidiasis Caused by Candida albicans and Candida glabrata Isolated from a Pediatric Oral Infection as Comparison to Azole Antifungal
    Sura Sahab Naji, Maha Abdul-Kareem Mahmood, Hashim Mueen Hussein, Athraa Ali Mahmood, Hayder Baker · 2025 · Clinical Cosmetic and Investigational Dentistry
  62. Mechanism of azole resistance in Candida glabrata isolates from India: clinical vs. induced perspectives
    Kalpana Pawar, Ashutosh Kumar Singh · 2025 · Journal of Medical Microbiology
  63. Evidence for long-standing mild-effect mutator alleles shaping genetic variation in S. cerevisiae populations
    Pengyao Jiang, Vidha Sudhesh, Megan My-Ngan Phan, Ishan Bansal, Cian Wheeler, Alan J. Herr, Maitreya J. Dunham, Kelley Harris · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  64. Additional file 3 of Genetic and environmental modulation of transposition shapes the evolutionary potential of Arabidopsis thaliana
    Pierre Baduel, Basile Leduque, Amandine Ignace, Isabelle Gy, José Gil, Olivier Loudet, Vincent Colot, Leandro Quadrana · 2021 · Figshare
  65. Additional file 10 of Genetic and environmental modulation of transposition shapes the evolutionary potential of Arabidopsis thaliana
    Pierre Baduel, Basile Leduque, Amandine Ignace, Isabelle Gy, Gil, José, Olivier Loudet, Vincent Colot, Leandro Quadrana · 2021 · Figshare
  66. The influence of genetic stability on Aspergillus fumigatus virulence and azole resistance
    Reis, Thaila Fernanda dos, Lilian Pereira Silva, Castro, Patrícia Alves, Pollyne Borborema Almeida de Lima, Rafaela Andrade do Carmo, Marjorie Mendes Marini, Silveira, José Franco da, Ferreira, Beatriz Henriques, Rodrigues, Fernando José dos Santos, Malavazi, Iran et al. · 2018 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
  67. Fongémies : épidémiologie, diagnostic et conduite à tenir
    Sarah Dellière, L. Chantelot, Cécile Garnaud, Muriel Cornet · 2026 · EMC - Biologie Médicale
  68. Novel Genomic Regions Associated with Multifungicide Resistance in Botrytis cinerea and Factors Impacting Greenhouse Population Structure
    Nicole T. Lukasko, Soumya S. Moonjely, M. K. Hausbeck · 2026 · Plant Disease
  69. Estudio proteómico y efecto de la modulación de la vía Calmodulina/Calcineurina en aislamientos de Candida glabrata resistentes a caspofungina
    Carlos Andres Ceballos Garzón · 2021
  70. Insights on molecular drivers of phenotypic plasticity in Candidozyma auris
    Shivani Solanki, Bharti Singh, Kartavya Mathur, Sadia Asif, Ashik Francis, Garima Gangwar, Anil S. Thakur, Rekha Puria · 2026 · World Journal of Microbiology and Biotechnology
  71. From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression
    Julia Robledo Jerez, Marcella Vieira Ambrosio, Marcela Eduarda Olegario Fernandes, Ewerton Garcia de Oliveira Mima · 2026 · MicrobiologyOpen
  72. Fungal DNA damage repair: from model to driver of virulence and AMR
    Callum Parkin, Adam G. Bainbridge, J.G.M. Rack · 2026 · Bioscience Reports
  73. Slt2 kinase of the cell wall integrity pathway is required for Fks2-specific echinocandin resistance in Candida glabrata
    Zubayeda Uddin, Saira Tahsin, Klára Valíčková, Tengfei Long, Laura Fruhauf De Macedo, Gabrielle Popencuk, Yanan Zhao, Kelley R. Healey · 2026 · Microbiology Spectrum
  74. Implications of oxidative stress on microbial evolution
    Ankita Kumari, Karuna Singh · 2026 · Elsevier eBooks
  75. Paths to pathogenicity: exploring the diversity and evolution of Cryptococcus neoformans
    Jake T. Leinas, Marina Ruzic, Zoë A. Hilbert · 2026 · npj Fungal Science
  76. Sub-consensus haploid variant calling in long-read sequencing technology
    Xavier Zair, Andreas Wilm, Miles C. Benton, Cheng Yong Tham, Lin Yang, Paola Flórez de Sessions, October Michael Sessions, Eng‐Hui Chew, Swapnil Mishra · 2026 · PLoS ONE
  77. Genomic Landscape Underlying Biofilm Formation Diversity in Nakaseomyces glabratus Clinical Isolates
    Inês Vieira Costa, Maria Zolotareva, Mafalda Cavalheiro, Dalila Mil‐Homens, Isabel Marcos Miranda, Kaname Sasamoto, Arsénio M. Fialho, Acácio Gonçalves Rodrigues, Hiroji Chibana, Miguel Cacho Teixeira · 2026 · MicrobiologyOpen