The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
Open accessAbstract
A number of human diseases, such as arthritis and atherosclerosis, include characteristic pathology in specific anatomical locations. Here we show transcriptomic differences in synovial fibroblasts from different joint locations and that HOX gene signatures reflect the joint-specific origins of mouse and human synovial fibroblasts and synovial tissues. Alongside DNA methylation and histone modifications, bromodomain and extra-terminal reader proteins regulate joint-specific HOX gene expression. Anatomical transcriptional diversity translates into joint-specific synovial fibroblast phenotypes with distinct adhesive, proliferative, chemotactic and matrix-degrading characteristics and differential responsiveness to TNF, creating a unique microenvironment in each joint. These findings indicate that local stroma might control positional disease patterns not only in arthritis but in any disease with a prominent stromal component.
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Thorvaldsdottir, H., Robinson, J. T., & Mesirov, J. P. (2013) · Briefings in Bioinformatics · doi:10.1093/bib/bbs017 · Cited by 9,049
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290
Suppression of inflammation by a synthetic histone mimic
Nicodeme, E., Jeffrey, K. L., Schaefer, U., Beinke, S., Dewell, S., Chung, C.-W., Chandwani, R., Marazzi, I., Wilson, P., Coste, H., et al. (2010) · Nature · doi:10.1038/nature09589 · Cited by 1,563
Cited by
Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis
Buch, M. H., Eyre, S., & McGonagle, D. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-00541-7 · Cited by 312
PU.1 controls fibroblast polarization and tissue fibrosis
Wohlfahrt, T., Rauber, S., Uebe, S., Luber, M., Soare, A., Ekici, A., Weber, S., Matei, A.-E., Chen, C.-W., Maier, C., et al. (2019) · Nature · doi:10.1038/s41586-019-0896-x · Cited by 187
Self-citationA short field guide to fibroblast function in immunity
Buechler, M. B., & Turley, S. J. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2017.11.001 · Cited by 121
Wade, S. M., Trenkmann, M., McGarry, T., Canavan, M., Marzaioli, V., Wade, S. C., Veale, D. J., & Fearon, U. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.08.008 · Cited by 35
Self-citationM. S. Barron, A., Fabre, T., & De, S. (2024) · F1000Research · doi:10.12688/f1000research.143472.1 · Cited by 8
Metadata
- Authors
- Frank-Bertoncelj, M., Trenkmann, M., Klein, K., Karouzakis, E., Rehrauer, H., Bratus, A., Kolling, C., Armaka, M., Filer, A., Michel, B. A., Gay, R. E., Buckley, C. D., Kollias, G., Gay, S., & Ospelt, C.
- Venue
- Nature Communications
- Published
- 2017-03-23
- Volume
- 8
- Issue
- 1
- Pages
- 14852-14852
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2599500360
- Cited by
- 181
- References
- 3
- FWCI
- 13.71
- Type
- journal article
- Language
- en
- Open access
- gold
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- Frank-Bertoncelj, M., Trenkmann, M., Klein, K., Karouzakis, E., Rehrauer, H., Bratus, A., Kolling, C., Armaka, M., Filer, A., Michel, B. A., Gay, R. E., Buckley, C. D., Kollias, G., Gay, S., & Ospelt, C. (2017). Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions. Nature Communications. https://doi.org/10.1038/ncomms14852
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