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Cited by 104Memory and Neural MechanismsMemory Processes and InfluencesNeuroscience and Neuropharmacology Research

Behavioural memory reconsolidation of food and fear memories

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Flavell, Charlotte R., Barber, David J., Lee, Jonathan L.C.·2011·Nature Communications
DOI 10.1038/ncomms1515PMC PMC3516828
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Abstract

The reactivation of a memory through retrieval can render it subject to disruption or modification through the process of memory reconsolidation. In both humans and rodents, briefly reactivating a fear memory results in effective erasure by subsequent extinction training. Here we show that a similar strategy is equally effective in the disruption of appetitive pavlovian cue-food memories. However, systemic administration of the NMDA receptor partial agonist D-cycloserine, under the same behavioural conditions, did not potentiate appetitive memory extinction, suggesting that reactivation does not enhance subsequent extinction learning. To confirm that reactivation followed by extinction reflects a behavioural analogue of memory reconsolidation, we show that prevention of contextual fear memory reactivation by the L-type voltage-gated calcium channel blocker nimodipine interferes with the amnestic outcome. Therefore, the reconsolidation process can be manipulated behaviourally to disrupt both aversive and appetitive memories.

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  • At least in the hippocampus, memory destabilisation depends upon L-type voltage-gated calcium channels, blockade of which prevents the destabilisation of reactivated fear memories.

    “At least in the hippocampus, another potential neurochemical mechanism underlying memory destabilisation depends upon L-type voltage-gated calcium channels (LVGCCs), blockade of which prevents the destabilisation of reactivated fear memories (Suzuki et al., 2008; Flavell et al., 2011).”

    From Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between (2020) · cites this paper as Flavell et al., 2011

    The Abstract states that contextual fear-memory destabilisation depends on calcium influx through L-type voltage-gated calcium channels, and reports that the channel blocker nimodipine prevents the amnestic effect of reactivation followed by extinction. The Discussion identifies the hippocampus only as the likely locus of systemically administered nimodipine’s effect; this paper does not establish the hippocampal localization as definitively as the citing sentence suggests (pages unavailable in our copy). (LLM, conf=0.82)

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References 37 · Cited by 104

Research works printed but not linked: 30

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Authors
Flavell, C. R., Barber, D. J., & Lee, J. L. C.
Affiliations
University of Birmingham (GB)
Corresponding author
Lee, Jonathan L.C.
ORCID
Lee, Jonathan L.C.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2011-10-18
Volume
2
Issue
1
Pages
504-504
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms1515
PMC
PMC3516828
OpenAlex
W2047781016
Cited by
104
References
37
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 3 · 2020: 8 · 2019: 4 · 2018: 9 · 2017: 14 · 2016: 7 · 2015: 8 · 2014: 13 · 2013: 17 · 2012: 6
FWCI
5.85
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
Funders
Medical Research Council (G0700991)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
memory reconsolidation, fear memory, appetitive memory, memory extinction, memory retrieval, D-cycloserine, NMDA receptor, nimodipine, L-type calcium channels, contextual fear, drug addiction treatment
MeSH terms
Animals, Calcium Channel Blockers, Fear, Food, Male, Memory, Nimodipine, Calcium Channels, L-Type, Rats

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