Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration
Jayatilaka, Hasini, Tyle, Pranay, Chen, Jonathan J., Kwak, Minsuk, Ju, Julia, Kim, Hyun Ji, Lee, Jerry S. H., Wu, Pei-Hsun +3 more·2017·Nature Communications
Cited by (175)
Items 101–175 of 175
- Negative Impact of Wound Complications on Oncologic Outcome of Soft Tissue Sarcomas of the Chest WallMehran Dadras, Pascal Koepp, Johannes Maximilian Wagner, Christoph Wallner, Maxi Sacher, Marcus Lehnhardt, Björn Behr, Kamran Harati · 2019 · Cancers
- Investigation of Fascin1, a Marker of Mature Dendritic Cells, Reveals a New Role for IL-6 Signaling in CCR7-Mediated ChemotaxisFumio Matsumura, Robin Polz, Sukhwinder Singh, Aya Matsumura, Jürgen Scheller, Shigeko Yamashiro · 2021 · The Journal of Immunology
- Advanced Cell Culture Models Illuminate the Interplay between Mammary Tumor Cells and Activated FibroblastsMartina Del Nero, Alessandro Colombo, Stefania Garbujo, Chiara Baioni, Linda Barbieri, Metello Innocenti, Davide Prosperi, Miriam Colombo, Luisa Fiandra · 2023 · Cancers
- Implications of microgravity-induced cell signaling alterations upon cancer cell growth, invasiveness, metastatic potential, and control by host immunityRandal K. Gregg · 2021 · International review of cytology
- Recyclable Periodic Nanostructure Formed by Sublimable Liquid Crystals for Robust Cell AlignmentMin Jeong Shin, San Hae Im, Wantae Kim, Hyungju Ahn, Tae Joo Shin, Hyun Jung Chung, Dong Ki Yoon · 2022 · Langmuir
- JP1 normalizes tumor vasculature to suppress metastasis and facilitate drug delivery by inhibiting IL-8Jiahua Cui, Zhen Che, Lu Zou, Dongyin Chen, Zhan Xie, Kun Ding, Huning Jiang, Aiping Li, Jianwei Zhou, Yongqian Shu · 2023 · JCI Insight
- A SERS-assisted 3D organotypic microfluidic chip for in-situ visualization and monitoring breast cancer extravasation processZiting Qian, Zuyao Wang, Kai Zhu, Kuo Yang, Lei Wu, Shenfei Zong, Zhuyuan Wang · 2024 · Talanta
- Loss of myosin light chain kinase induces the cellular senescence associated secretory phenotype to promote breast epithelial cell migrationDayoung Kim, Jonathan A. Cooper, David M. Helfman · 2024 · Scientific Reports
- An overview of multiplexed analyses of CAR T-cell therapies: insights and potentialBrittany Paige DePriest, Noah Vieira, Alan Bidgoli, Sophie Paczesny · 2021 · Expert Review of Proteomics
- Anti-Septic Potential of 7-α-Obacunyl Acetate Isolated from the Toona sinensis on Cecal Ligation/Puncture Mice via Suppression of JAK-STAT/NF-κB Signal PathwayDuo Li, Yibing Weng, Guan Wang, Genshen Zhen · 2021 · Infection and Drug Resistance
- Mechanism-Driven Design of Multispecific Antibodies for Targeted Disease TreatmentJustyn Fine, Bunyarit Meksiriporn, Jiacheng Tan, Jamie B. Spangler · 2024 · Annual Review of Chemical and Biomolecular Engineering
- Investigating the Role of Quercetin, an Active Ingredient in Bazhen Decoction, in Targeting CXCL8 to Inhibit Macrophage M2 Polarization and Reshape the Immunological Microenvironment of Colorectal CancerWenwu Wang, Fangfeng Lin, Shuping Shi, Yunqiu Yu, Mengyan Lin, Wenliang Lian, Biyin Chen, Xiaoyan Qi · 2025 · Chemical Biology & Drug Design
- Cross-talk between non-ionizing electromagnetic fields and metastasis; EMT and hybrid E/M may explain the anticancer role of EMFsRomina Mehdizadeh, Alireza Madjid Ansari, Flora Forouzesh, Reyhane Ghadirian, Fatemeh Shahriari, Seyed Peyman Shariatpanahi, Mohammad Amin Javidi · 2023 · Progress in Biophysics and Molecular Biology
- Spatial Heterogeneity in Cytoskeletal Mechanics Response to TGF-β1 and Hypoxia Mediates Partial Epithelial-to-Mesenchymal Transition in Epithelial Ovarian Cancer CellsDeepraj Ghosh, Jeffrey Hsu, Kylen K.J. Soriano, Carolina Mejia Peña, Amy Huei‐Yi Lee, Don Steven Dizon, Michelle Dawson · 2023 · Cancers
- MicroRNAs, long non-coding RNAs, and circular RNAs and gynecological cancers: focus on metastasisAryan Rezaee, Sara Ahmadpour, Ameneh Jafari, Sarehnaz Aghili, Seyed Saeed Tamehri Zadeh, Ali Rajabi, Arash Raisi, Michael Richard Hamblin, Maryam Mahjoubin‐Tehran, Marzieh Derakhshan · 2023 · Frontiers in Oncology · Retracted
- Mechanistic computational modeling of monospecific and bispecific antibodies targeting interleukin-6/8 receptorsChristina M.P. Ray, Yang Hui-lin, Jamie B. Spangler, Feilim Mac Gabhann · 2024 · PLoS Computational Biology
- A solution to prevent secondary flow in adherent cell culturesPéter Száraz, Matthew Librach, Poonam Mander, Banafshe Hoseini, Max Librach, Farwah Iqbal, Clifford Lawrence Librach · 2019 · Biology Open
- Inhibition of Integrin αVβ3 Signaling Improves the Antineoplastic Effect of Bexarotene in Cutaneous T-Cell LymphomaFlorencia Cayrol, Maria Victoria Revuelta, Mercedes Debernardi, María Alejandra Paulazo, Jude M. Phillip, Nahuel Zamponi, Helena Sterle, María C. Díaz Flaqué, CYNTHIA M.J. MAGRO, Rossella Marullo et al. · 2022 · Molecular Cancer Therapeutics
- Inhibition of triple negative breast cancer-associated inflammation and progression by N- acylethanolamine acid amide hydrolase (NAAA)Othman Benchama, Michael S. Malamas, Kulkarni Praveen, Elizabeth C. Ethier, Mark K. Williams, Alexandros Makriyannis, Hava Karsenty Avraham · 2022 · Scientific Reports
- Long-wave Ultraviolet Ray Promotes Inflammation in Keloid-derived Fibroblasts by Activating P38-NFκB1 Signaling PathwayXingtang Niu, Xunxun Lin, Xiaoqian Chen, Shuqia Xu, Zhipeng Huang, Qing Tang · 2020 · Journal of Burn Care & Research
- High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironmentWenxuan Du, Bryan Zhou, André Forjaz, Sarah M. Shin, Fan Wu, Ashleigh J. Crawford, Praful R. Nair, Adrian C. Johnston, Hoku West‐Foyle, Ashley Tang et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Single-cell RNA sequencing reveals the therapeutic mechanism of Calvatia lilacina in promoting wound healing of anal fistulaTangtang He, Kewei Wang, Ruiwen Mo, Juntong Guo, Bin Jiang, Ruoyu Mu, Wen Min, Lifeng Zhu, Jun Chen · 2026 · Chinese Medicine
- The prohibitin-binding compound fluorizoline induces the pro-inflammatory cytokines interleukin-8 and interleukin-6 through the activation of JNK and p38 MAP kinasesIsmael Sánchez‐Vera, José Saura‐Esteller, Sonia Núñez‐Vázquez, Ana M. Cosialls, Ouldouz Ghashghaei, Rodolfo Lavilla, Gabriel Pons, Joan Gil, Daniel Iglesias‐Serret · 2023 · Biochemical Pharmacology
- Paradoxes of tumour complexity: somatic selection, vulnerability by design, or infectious aetiology?Péter Apari, Viktor Müller · 2018 · Biological reviews/Biological reviews of the Cambridge Philosophical Society
- Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic leukemiaFangyi Dong, Li Chen, Chaoxian Zhao, Xiaoyang Li, Yun Tan, Huan Song, Wen Jin, Hongming Zhu, Yunxiang Zhang, Kai Xue et al. · 2022 · Frontiers of Medicine
- Exploring the influence of microgravity on chemotherapeutic drug response in cancer: Unveiling new perspectivesPreksha Manish Vora, Sudharshan Prabhu · 2024 · Journal of Cellular and Molecular Medicine
- CD142 plays a key role in the carcinogenesis of gastric adenocarcinoma by inhibiting BCL2-dependent autophagyWeifeng Xu, Beibei Chen, Dianshan Ke, Xiaobing Chen · 2021 · Biochemistry and Cell Biology
- Mechano-induced patterned domain formation by monocytesWenxuan Du, Jingyi Zhu, Yufei Wu, Hongyi Liu, Ashley L. Kiemen, Zeqi Wan, Eban A. Hanna, Hui Zhang, Sean X. Sun, Denis Wirtz · 2025 · Nature Materials
- Nonphosphorylatable PEA15 mutant inhibits epithelial-mesenchymal transition in triple-negative breast cancer partly through the regulation of IL-8 expressionJihyun Park, Moises J Tacam, Gaurav B. Chauhan, Evan N. Cohen, Maria Ester Gagliardi, LaKesla R. Iles, Naoto Tada Ueno, Venkata Lokesh Battula, Yoo‐Kyoung Sohn, Xiaoping Wang et al. · 2021 · Breast Cancer Research and Treatment
- Recent Developments in the Study of the Microenvironment of Cancer and Drug DeliveryBenu Chaudhary, Parveen Kumar, Preeti Arya, Deepak Singla, Virender Kumar, Davinder Kumar, S. Roshan, Sheetu Wadhwa, Monica Gulati, Sachin Kumar Singh et al. · 2022 · Current Drug Metabolism
- Structural analysis of healthy and cancerous epithelial-type breast cells by nanomechanical spectroscopy allows us to obtain peculiarities of the skeleton and junctionsAnahid Amiri, Florian D. Hastert, Lukas Stühn, Christian Dietz · 2019 · Nanoscale Advances
- TAM-ing the CIA—Tumor-Associated Macrophages and Their Potential Role in Unintended Side Effects of Therapeutics for Cancer-Induced AnemiaStefan Weiler, Manfred Nairz · 2021 · Frontiers in Oncology
- A 3D in vitro assay to study combined immune cell infiltration and cytotoxicityAshleigh J. Crawford, Adrian C. Johnston, Wenxuan Du, Eban A. Hanna, David Schell, Zeqi Wan, Ting-Hsi Chen, Fan Wu, Kehan Ren, Yeongseo Lim et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Cold, Hot, and Lethal—The Tumour Microenvironment and the Immunology of Head and Neck Squamous Cell CarcinomaSvatava Vyhnánková, Lukáš Lacina, Martin Chovanec, Jan Plzák, Karel Smetana, Jiří Netušil, Michal Kolář, Radek Sindelka E · 2025 · International Journal of Molecular Sciences
- It's a numbers game—density-dependent MMP activity mediates cancer cell migrationJude M. Phillip, Nahuel Zamponi, Madonna P. Phillip · 2018 · Oncotarget
- Metabolic fingerprinting by nuclear magnetic resonance of hepatocellular carcinoma cells during p53 reactivation‐induced senescencePhilipp Knopf, Jesús Pacheco‐Torres, Laimdota Zizmare, Noriko Mori, Flonné B. Wildes, Benyuan Zhou, Balaji Krishnamachary, Yelena Mironchik, Manfred Kneilling, Christoph Trautwein et al. · 2024 · NMR in Biomedicine
- Cancer-Associated Fibroblasts and Their Role in Cancer ProgressionLukáš Lacina, Pavol Szabó, Ivo Klepáček, Michal Kolář, Karel Smetana · 2022 · Interdisciplinary cancer research
- Cancer Metastasis: Dynamic Hetero-cellular Communications Between Cancer Cells and Host TissuesJessica L. Saliba, Maya El-Sabban, Abdullah A. Shaito, Mohammad El-Harakeh, Joëlle Obeid, Hiba El Hajj, Marwan Eid El-Sabban · 2023 · Springer eBooks
- The invadosome of stem-like cancer cells: metastasis machinery and targetable vulnerabilityKelvin K. Tsai · 2025 · Cancer and Metastasis Reviews
- A close unicellular animal relative and predator of schistosomes exhibits chemokinesis in response to proteins and peptides from its preySoniya R. Quick, Jason Singh Bains, Catherine Gerdt, B. H. Walker, Eleanor B. Goldstone, Theresa Jakuszeit, Andrew William Baggaley, Ottavio A. Croze, Joseph P. Gerdt · 2025 · PLoS Pathogens
- Targeting tumors and inflammation: A quinoline–chalcone ruthenium complex with therapeutic promiseKateřina Veselá, Ameneh Tatar, Zdeněk Kejík, Nikita Abramenko, Jan Čejka, Robert Kaplánek, Michal Masařík, Petr Babula, Pavel Martasek E, Milan Jakubek · 2025 · Biomedicine & Pharmacotherapy
- A 3D multi-compartment assembloid to study combined immune cell infiltration and cytotoxicityEban A. Hanna, Ashleigh J. Crawford, Wenxuan Du, Adrian C. Johnston, David Schell, Zeqi Wan, Ting-Hsi Chen, Fan Wu, Kehan Ren, Yeongseo Lim et al. · 2026 · Cell Reports Methods
- The role of macrophages and cytokines in the occurrence and development of MDSP J Li, Shuo Li, Dongmei Guan, Wenjie Xu, Jiakai Bian, Ju Deng, Hongwei Wang, Fanggang Ren · 2026 · Clinical and Experimental Medicine
- Reprogramming tumor angiogenesis in breast cancer: Mechanisms, challenges, and future directionsBarnalee Mishra, Suryendu Saha, Kavita Kumari, Samikshya Mahapatra, Sinjan Khanra, Diksha Malhotra, Gopal C. Kundu · 2026 · Biochemical and Biophysical Research Communications
- The Molecular Mechanisms Involved in Suppressing Triple Negative Breast Cancer Using Natural AgentsSaabira Banu Sahubar Sadik, Prathibha Sivaprakasam, Nishanthi Ramasami, Ashok Kumar Pandurangan · 2022 · Advances in medical diagnosis, treatment, and care (AMDTC) book series
- MicroRNAs as behind-the-scenes molecules in breast cancer metastasis and their therapeutic role through novel microRNA-based delivery strategiesMohamed J. Saadh, Ashok Kumar Bishoyi, Suhas Ballal, Abhayveer Singh, Radhwan Abdul Kareem, Anita Devi, Girish Chandra Sharma, K.Satyam Naidu, Fadhil Faez Sead · 2025 · Gene
- Interleukin-6 (IL-6), Interleukin-8 (IL-8), and Tumor Necrosis FactorAlpha (TNF-a): Their Role in the Development and Metastasis of Tumor CellsI Gede Angga Adnyana · 2019 · Sains Medika Jurnal Kedokteran dan Kesehatan
- Decoding the signaling pathway initiating cellular migration in cancer metastasisA. Thirumal Raj · 2017 · Oral Oncology
- Causes and consequences of intratumoral cellular heterogeneity and the role of the melatonergic system in brain tumorsGabriela Sarti Kinker · 2020 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- Perioperative use of β-blockers in oncological patientsП.П. Сорочан, I. А. Hromakova, N. E. Prokhach, I. M. Роnomarev, I. S. Hromakova · 2021 · Український радіологічний та онкологічний журнал
- Association between Single-Nucleotide Polymorphisms in the Interleukin-6/Interleukin-6 Receptor/Janus Kinase/Signal Transducer and Activator of Transcription Pathway and the Risk of Brain Metastasis Among Patients with Non-Small Cell Lung CancerYalin Kang, Yu Tong Jin, Qianxia Li, Bili Wu, Li Ma, Lingyan Xiao, Guangyuan Hu, Xianglin Yuan · 2021 · SSRN Electronic Journal
- Análise dos marcadores de células tronco tumorais em linhagens tumorais resistentes ao estresse.Ana Carolina Lima Ralph · 2019
- Cancer biology and pathologyHymie Anisman, Alexander W. Kusnecov · 2022 · Elsevier eBooks
- Efeito citotóxico e anti-inflamatório da articaína-2-hidroxipropil-beta-ciclodextrina sobre células escamosas de carcinoma de línguaJonny Burga Sánchez · 2018
- Tumor cell density dependent IL-8 secretion induces the fluctuation of Tregs/CD8+ T cells infiltration in hepatocellular carcinoma: one prompt for the existence of density checkpointMengchao Yan, Jia Yao, Yan Lin, Jun Yan, Ye Xie, Yongqiang Zhou, Jiayun Wei, Xun Li · 2022 · Research Square
- Describing mechanisms supporting macrophage-promoted escape of PTEN-deficient prostate cancer cells to understand disease recurrenceSuzanne McCusker · 2023 · Queensland University of Technology
- Mechano-induced homotypic patterned domain formation by monocytesWenxuan Du, Jingyi Zhu, Yufei Wu, Ashley L. Kiemen, Sean X. Sun, Denis Wirtz · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Chemokinesis by a microbial predatorSoniya R. Quick, Jason Singh Bains, Catherine Gerdt, B. H. Walker, Eleanor B. Goldstone, Theresa Jakuszeit, Andrew William Baggaley, Ottavio A. Croze, Joseph P. Gerdt · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Density-dependent cell migration in the absence of social interactions: a case study of Acanthamoeba castellaniiNasser Ghazi, Mete Demircigil, Olivier Cochet‐Escartin, Amandine Chauviat, Sabine Favre‐Bonté, Christophe Anjard, Jean-Paul Rieu · 2025 · The European Physical Journal E
- Cancer Metastasis: Dynamic Hetero-cellular Communications Between Cancer Cells and Host TissuesJessica L. Saliba, Maya El-Sabban, Abdullah A. Shaito, Mohammad El-Harakeh, Joëlle Obeid, Hiba El Hajj, Marwan Eid El-Sabban · 2025 · Springer eBooks
- Additional file 2 of Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancerZhang, Yuanyuan, N. Li, 袁光文, Yao, Hongwen, Zhang, Die, Li, Nan, Zhang, Gongyi, Sun, Yangchun, Wang, Wenpeng, Zeng, Jia et al. · 2022 · Figshare
- Additional file 3 of Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancerZhang, Yuanyuan, Li, Ning, 袁光文, Yao, Hongwen, Zhang, Die, Li, Nan, Zhang, Gongyi, Sun, Yangchun, Wang, Wenpeng, Zeng, Jia et al. · 2022 · Figshare
- Additional file 4 of Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancerZhang, Yuanyuan, Li, Ning, 袁光文, Yao, Hongwen, Zhang, Die, Li, Nan, Zhang, Gongyi, Sun, Yangchun, Wang, Wenpeng, Zeng, Jia et al. · 2022 · Figshare
- Additional file 1 of Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancerZhang, Yuanyuan, N. Li, 袁光文, Yao, Hongwen, Zhang, Die, Li, Nan, Zhang, Gongyi, Sun, Yangchun, Wang, Wenpeng, Zeng, Jia et al. · 2022 · Figshare
- Additional file 5 of Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancerZhang, Yuanyuan, Li, Ning, 袁光文, Yao, Hongwen, Zhang, Die, Li, Nan, Zhang, Gongyi, Sun, Yangchun, Wang, Wenpeng, Zeng, Jia et al. · 2022 · Figshare
- Additional file 1 of Tumor cell density dependent IL-8 secretion induces the fluctuation of tregs/CD8 + T cells infiltration in hepatocellular carcinoma: one prompt for the existence of density checkpointYan, Mengchao, Yao, Jia, Lin, Yan, Yan, Jun, Xie, Ye, Zongli Fu, Zhou, Yongqiang, Wei, Jiayun, Li, Xun · 2024 · Figshare
- Stiffness-mediated paracrine signaling enhances induction of EMT in oral squamous cell carcinomaSo Youn Moon, Marcelo Lazzaron Lamers, Adam Jeffrey Engler · 2025 · APL Bioengineering
- Accelerated discovery of cell migration regulators using label-free deep learning–based automated trackingTiffany Chu, Yeongseo Lim, Yufei Sun, Fan Wu, Carolina Castillo, Eban A. Hanna, Denis Wirtz, Pei-Hsun Wu · 2026 · Science Advances
- Etude mécanistique des propriétés anti-tumorales du glycéryl trinitrate (gtn) : impact du monoxyde d'azote dans des voies de signalisation induites par des cytokines pro-inflammatoires et dans la régulation de marqueurs de résistanceSarra Bouaouiche · 2018 · theses.fr (ABES)
- Un nouveau type d'anticorps bispécifique avec une activité de déplétion ciblée de facteurs solubles pro-tumoraux du microenvironnement tumoral pour la thérapie du cancerAdrien Laroche · 2019 · theses.fr (ABES)
- Machine Learning-Based Classification of Gliomas and Tumor Grades with SHAP-Guided Feature InterpretationGhaya Al-Rumaihi, Md. Shaheenur Islam Sumon, Ahmed Hassanein, Marwan Malluhi, Md. Sakib Abrar Hossain, Tahmid Zaman Raad, Muhammad E. H. Chowdhury, Rozaimi Razali, Shona Pedersen · 2026 · Genes
- TENG-Driven Electrotherapy: A Self-Powered Approach to Inducing Cancer Cell ApoptosisDandugudumula Ramu, Sugato Hajra, Swati Panda, Kushal Ruthvik Kaja, Yogendra Kumar Mishra, Hoe Joon Kim, Eunjoo Kim · 2026 · ACS Applied Bio Materials
- Intracellular Nanopharmacology of Trastuzumab Deruxtecan Reveals Lysosome-Centered Organelle Vulnerabilities in HER2-Positive Breast Cancer CellsErica Tagliatti, Maria Cristina Gagliani, Grazia Bellese, Shahnaz Salamat, Martina Crippa, Manuela Sollazzo, Andrea Abbona, Matteo Paccagnella, Pietro Arnaldi, Lucilla Rossi et al. · 2026 · ACS Nano Medicine
- Matrix stress relaxation drives glioblastoma cell response in viscoelastic biomaterialsSadegh Ghorbani, Michelle S. Huang, D.H. Zhang, Yueming Liu, Chris M. Long, Riley Zwetsloot, Esther A T Mozipo, Rameshwar R. Rao, Annika M. K. Enejder, Sarah C. Heilshorn · 2026 · Science Advances
- Targeting CDC7 overcomes gemcitabine resistance in cholangiocarcinoma by inducing cellular senescenceRong Xiao, Jing Han Hong, Peili Wang, Yi Zhong, Zhiwei Ye, Ziyu Hao, Jiuping Gao, Jiang Yu, Yu Peng, Siyu Chen et al. · 2026 · Cancer Letters