Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

Biancur, Douglas E., Paulo, Joao A., Małachowska, Beata, Quiles Del Rey, Maria, Sousa, Cristovão M., Wang, Xiaoxu, Sohn, Albert S. W., Chu, Gerald C. +5 more·2017·Nature Communications

Cited by (315)

Items 101–200 of 315

  1. Glutamine metabolic reprogramming in hepatocellular carcinoma
    Yanyan Ye, Bodong Yu, Hua Wang, F. Yi · 2023 · Frontiers in Molecular Biosciences
  2. Targeting of stress response pathways in the prevention and treatment of cancer
    Jaroslav Zelenka, Martina Koncošová, Tomáš Ruml · 2018 · Biotechnology Advances
  3. Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective
    Géraldine Gentric, Fatima Mechta‐Grigoriou · 2021 · Cancers
  4. Transporters at the Interface between Cytosolic and Mitochondrial Amino Acid Metabolism
    Keeley G. Hewton, Amritpal S Johal, Seth J. Parker · 2021 · Metabolites
  5. Blockade of glutamine-dependent cell survival augments antitumor efficacy of CPI-613 in head and neck cancer
    Liwei Lang, Fang Wang, Zhi‐Chun Ding, Xiangdong Zhao, Reid Loveless, Jin Xie, Chloe Shay, Peng Qiu, Yonggang Ke, Nabil F. Saba et al. · 2021 · Journal of Experimental & Clinical Cancer Research
  6. Targeting the Metabolic Rewiring in Pancreatic Cancer and Its Tumor Microenvironment
    Keisuke Yamamoto, Dosuke Iwadate, Hiroyuki Kato, Yousuke Nakai, Keisuke Tateishi, Mitsuhiro Fujishiro · 2022 · Cancers
  7. Glutaminase Inhibitors Induce Thiol-Mediated Oxidative Stress and Radiosensitization in Treatment-Resistant Cervical Cancers
    Ramachandran Rashmi, Kay Jayachandran, Jin Zhang, Vishnu Menon, Naoshad Muhammad, Michael C. Zahner, Fiona Ruiz, Sisi Zhang, Kevin Cho, Yuting Wang et al. · 2020 · Molecular Cancer Therapeutics
  8. Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease
    Irfana Soomro, Ying Sun, Li Zhai, Lonnette Diggs, Georgia Hatzivassiliou, Ajit G. Thomas, Rana Rais, Barbara Stauch Slusher, Stefan Somlo, Edward Y. Skolnik · 2017 · Nephrology Dialysis Transplantation
  9. Targeted Glucose or Glutamine Metabolic Therapy Combined With PD-1/PD-L1 Checkpoint Blockade Immunotherapy for the Treatment of Tumors - Mechanisms and Strategies
    Guofeng Ma, Chun Li, Zhilei Zhang, Ye Liang, Zhijuan Liang, Yuanbin Chen, Liping Wang, Dan Li, Manqin Zeng, Wenhong Shan et al. · 2021 · Frontiers in Oncology
  10. Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice
    Kishimoto, Shun, Brender, Jeffrey R, Crooks, Daniel R, Matsumoto, Shingo, Seki, Tomohiro, Oshima, Nobu, Merkle, Hellmut, Lin, Penghui, Reed, Galen, Chen, Albert P et al. · 2019 · eLife
  11. Pancreatic stellate cells exploit Wnt/β-catenin/TCF7-mediated glutamine metabolism to promote pancreatic cancer cells growth
    Hangqi Liu, Hui Zhang, Xiaoqian Liu, Wenting Guo, Qiaofei Liu, Longyun Chen, Junyi Pang, Xiaoding Liu, Ruiyu Li, Wei‐Min Tong et al. · 2022 · Cancer Letters
  12. Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis
    Shagun Sharma, Navneet Agnihotri, Sandeep Kumar · 2022 · Biochemical Pharmacology
  13. Increased glucose availability sensitizes pancreatic cancer to chemotherapy
    Ali Vaziri Gohar, Jonathan J. Hue, Ata Abbas, Hallie J. Graor, Omid Hajihassani, Mehrdad Zarei, George Titomihelakis, John Feczko, Moeez Ghani Rathore, Sylwia Chełstowska et al. · 2023 · Nature Communications
  14. Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes
    José Manuel Matés, José Angel Campos-Sandoval, Juan de los Santos-Jiménez, Juan A. Segura, Francisco José Alonso, Javier Márquez · 2019 · Current Medicinal Chemistry
  15. The Role of Dysfunctional Adipose Tissue in Pancreatic Cancer: A Molecular Perspective
    Davide Brocco, Rosalba Florio, Laura De Lellis, Serena Veschi, Antonino Grassadonia, Nicola Tinari, Alessandro Cama · 2020 · Cancers
  16. Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis
    Chang Shao, Wenjie Lu, Ye Du, Wenchao Yan, Qiuyu Bao, Yang Tian, Guangji Wang, Hui Ye, Haiping Hao · 2020 · Redox Biology
  17. Exploiting the Achilles' heel of cancer: disrupting glutamine metabolism for effective cancer treatment
    Fan, Yuxin, Xue, Han, Li, Zhimin, Huo, Mingge, Gao, Hongxia, Guan, Xingang · 2024 · Frontiers in Pharmacology
  18. Targeting allosteric regulation of cancer metabolism
    Daniel M. Kremer, Costas Andreas Lyssiotis · 2022 · Nature Chemical Biology
  19. Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation
    Yong Yi, Guoqiang Wang, Wenhua Zhang, Shuhan Yu, Junjie Fei, Tingting An, Jianqiao Yi, Fengtian Li, Ting Huang, Jun Yang et al. · 2025 · Nature Communications
  20. Metabolic reprogramming dynamics in tumor spheroids: Insights from a multicellular, multiscale model
    Mahua Roy, Stacey D. Finley · 2019 · PLoS Computational Biology
  21. Molecular imaging of the tumor microenvironment reveals the relationship between tumor oxygenation, glucose uptake, and glycolysis in pancreatic ductal adenocarcinoma
    Yamamoto, Kazutoshi, Brender, Jeffrey R., Seki, Tomohiro, Kishimoto, Shun, Oshima, Nobu, Choudhuri, Rajani, Adler, Stephen S., Jagoda, Elaine M., Saito, Keita, Devasahayam, Nallathamby et al. · 2020 · Cancer Research
  22. Targets (Metabolic Mediators) of Therapeutic Importance in Pancreatic Ductal Adenocarcinoma
    Vikrant Rai, Swati Agrawal · 2020 · International Journal of Molecular Sciences
  23. NAD + depletion by type I interferon signaling sensitizes pancreatic cancer cells to NAMPT inhibition
    Alexandra M. Moore, Lei Zhou, Jing Cui, Luyi Li, Nanping Wu, Alice C. Yu, Soumya Poddar, Keke Liang, Evan R. Abt, Stephanie Kim et al. · 2021 · Proceedings of the National Academy of Sciences
  24. Targeting RAS mutants in malignancies: successes, failures, and reasons for hope
    Hang Sheng Yang, Xinyi Zhou, Dongliang Fu, Chenqin Le, Jiafeng Wang, Quan Zhou, Xiangrui Liu, Ying Yuan, Kefeng Ding, Qian Xiao · 2022 · 癌症:英文版
  25. Metabolic Remodeling as a Way of Adapting to Tumor Microenvironment (TME), a Job of Several Holders
    Jacinta Serpa · 2020 · Advances in experimental medicine and biology
  26. Glutaminase inhibition as potential cancer therapeutics: current status and future applications
    Rajath Cyriac, Kwang‐Ho Lee · 2023 · Journal of Enzyme Inhibition and Medicinal Chemistry
  27. Mitochondria at Center of Exchanges between Cancer Cells and Cancer-Associated Fibroblasts during Tumor Progression
    Lisa Nocquet, Philippe Paul Juin, Frédérique Souazé · 2020 · Cancers
  28. Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers
    Chengheng Liao, Cherise Ryan Glodowski, Cheng Fan, Juan Liu, Kevin Raynard Mott, Akash Kaushik, Hieu Vu, Jason W. Locasale, Samuel K. McBrayer, Ralph J. DeBerardinis et al. · 2021 · Cancer Research
  29. Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer
    Maria Chiara De Santis, Luca Gozzelino, Jean Piero Margaria, Andrea Costamagna, Edoardo Ratto, Federico Gulluni, Enza Di Gregorio, Erica Mina, Nicla Lorito, Marina Bacci et al. · 2022 · Gut
  30. Screening in serum-derived medium reveals differential response to compounds targeting metabolism
    Keene L. Abbott, Ahmed Ali, Dominick E. Casalena, Brian T. Do, Raphaël Ferreira, Jaime H. Cheah, Christian K. Soule, Amy Deik, Tenzin Kunchok, Daniel R. Schmidt et al. · 2023 · Cell chemical biology
  31. Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma
    Lorey K. Smith, Tiffany J. Parmenter, Margarete Kleinschmidt, Eric P. Kusnadi, Jian Kang, Claire A. Martin, Peter K. H. Lau, Riyaben P. Patel, Julie Lorent, David J. Papadopoli et al. · 2022 · Nature Communications
  32. Targeting Pulmonary Fibrosis by SLC1A5-Dependent Glutamine Transport Blockade
    Malay Choudhury, Kyle J. Schaefbauer, Theodore J. Kottom, Eunhee S. Yi, Daniel J. Tschumperlin, ANDREW HAR LIMPER · 2023 · American Journal of Respiratory Cell and Molecular Biology
  33. Targeting amino acid-metabolizing enzymes for cancer immunotherapy
    Yvonne Grobben · 2024 · Frontiers in Immunology
  34. Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5α-dihydrotestosterone regulation
    Henrique J. Cardoso, Marília I. Figueira, Cátia Vicente Vaz, Tiago M. A. Carvalho, Luís A. Brás, Patrícia A. Madureira, Paulo Jorge Oliveira, Vilma A. Sardão, Sílvia Socorro · 2021 · Cellular Oncology
  35. Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types
    Andrea Nancy Chisari, Irene Golán, Sabrina Campisano, Caroline Gélabert, Aristidis Moustakas, Patricia Sancho, Laia Caja · 2021 · Frontiers in Pharmacology
  36. Cellular metabolism in pancreatic cancer as a tool for prognosis and treatment (Review)
    Michal Zuzčák, Ján Trnka · 2022 · International Journal of Oncology
  37. Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-Time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia
    Niki Marie Zacharias, Natalia Baran, Sriram S. Shanmugavelandy, Jae-Hyuk Lee, Juliana Vélez Luján, Prasanta Dutta, Steven W. Millward, Tianyu Cai, Christopher G. Wood, David R Piwnica-Worms et al. · 2019 · Molecular Cancer Therapeutics
  38. Targeting glutamine metabolism network for the treatment of therapy-resistant prostate cancer
    Lingfan Xu, Bing Zhao, William Butler, Huan Xu, Nan Song, Xufeng Chen, J. Spencer Hauck, Xia Gao, Hong Zhang, Jeff Groth et al. · 2022 · Oncogene
  39. A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells
    Geetha Venkateswaran, Paul C. McDonald, Shawn C. Chafe, Wells S. Brown, Zachary J. Gerbec, Shannon J. Awrey, Seth J. Parker, Shoukat Dedhar · 2022 · Molecular Cancer Therapeutics
  40. Dual rectification of metabolism abnormality in pancreatic cancer by a programmed nanomedicine
    Bowen Wu, Zhiqin Wang, Jingyuan Liu, Naishi Li, Xudong Wang, HaoChen Bai, Chunling Wang, Jian Ying Shi, Sai‐Yang Zhang, Jian Song et al. · 2024 · Nature Communications
  41. Amino acids in cancer: Understanding metabolic plasticity and divergence for better therapeutic approaches
    Linda K. Do, Hyun Min Lee, Yun‐Sok Ha, Chan‐Hyeong Lee, Jiyeon Kim · 2025 · Cell Reports
  42. Integrins meet complement: The evolutionary tip of an iceberg orchestrating metabolism and immunity
    Nicolas S. Merle, Parul Singh, Jubayer Rahman, Claudia Kemper · 2020 · British Journal of Pharmacology
  43. The Pharmacological TAILS of Matrix Metalloproteinases and Their Inhibitors
    Nabangshu Das, Colette Benko, Sean E. Gill, Antoine Dufour · 2020 · Pharmaceuticals
  44. Metabolomic Analysis of Small Extracellular Vesicles Derived from Pancreatic Cancer Cells Cultured under Normoxia and Hypoxia
    Ryosuke Hayasaka, Sho Tabata, Masako Hasebe, Satsuki Ikeda, Sumiko Ohnuma, Masaru Mori, Tomoyoshi Soga, Masaru Tomita, Akiyoshi Hirayama · 2021 · Metabolites
  45. Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma
    Yang, Yandan, Bolomsky, Arnold, Oellerich, Thomas, Chen, Ping, Ceribelli, Michele, Häupl, Björn, Wright, George W., Phelan, James D., Huang, Da Wei, Lord, James W. et al. · 2022 · Nature Communications
  46. Interplay of Carbonic Anhydrase IX With Amino Acid and Acid/Base Transporters in the Hypoxic Tumor Microenvironment
    Geetha Venkateswaran, Shoukat Dedhar · 2020 · Frontiers in Cell and Developmental Biology
  47. Neurotransmitters: an emerging target for therapeutic resistance to tumor immune checkpoint inhibitors
    Jiyuan Yang, Yu Wu, Xinhui Lv, Sicong Liu, Ziwen Yuan, Ya‐Fang Chen, Xiangyu Ding, Li Zhong, Xudong Wang · 2025 · Molecular Cancer
  48. A glutamine ‘tug-of-war’: targets to manipulate glutamine metabolism for cancer immunotherapy
    Laura J. Pallett, Sarah Dimeloe, Linda V. Sinclair, Adam J. Byrne, Anna Schurich · 2021 · Immunotherapy Advances
  49. Crosstalk between metabolic remodeling and epigenetic reprogramming: A new perspective on pancreatic cancer
    Jie Ren, Bo Ren, Xiaohong Liu, Ming Cui, Yuan Fang, Xing Wang, Feihan Zhou, Minzhi Gu, Ruiling Xiao, Jialu Bai et al. · 2024 · Cancer Letters
  50. Dose Optimization for Anticancer Drug Combinations: Maximizing Therapeutic Index via Clinical Exposure-Toxicity/Preclinical Exposure-Efficacy Modeling
    Dean C. Bottino, Mayankbhai Patel, Ekta Kadakia, Jilai Zhou, Chirag Amrutlal Patel, Rachel B. Neuwirth, Natasha Iartchouk, Rachael L. Brake, Karthik Venkatakrishnan, Arijit Chakravarty · 2019 · Clinical Cancer Research
  51. Glutamine Supplementation as an Anticancer Strategy: A Potential Therapeutic Alternative to the Convention
    Hayato Muranaka, Rasaq Akinsola, Sandrine Billet, Stephen Jacob Pandol, Andrew Eugene Hendifar, Neil A. Bhowmick, Jun Gong · 2024 · Cancers
  52. Effective Treatment of Knee Osteoarthritis Using a Nano‐Enabled Drug Acupuncture Technology in Mice
    Wenjie Xu, Yu Xiao, Minzhi Zhao, Jiahui Zhu, Yu Wang, Wenbin Wang, Peng Wang, Huan Meng · 2023 · Advanced Science
  53. Spotlight on GOT2 in Cancer Metabolism
    Samuel A. Kerk, Javier García‐Bermúdez, Kıvanç Birsoy, Mara H. Sherman, Yatrik Madhukar Shah, Costas Andreas Lyssiotis · 2023 · OncoTargets and Therapy
  54. Complement and T Cell Metabolism: Food for Thought
    Erin E. West, Claudia Kemper · 2019 · Immunometabolism
  55. Hyperpolarized [5- 13 C,4,4- 2 H 2 ,5- 15 N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine
    Roozbeh Eskandari, Nathaniel Kim, Arsen Mamakhanyan, Michelle Saoi, Guannan Zhang, Marjan Berishaj, Kristin L. Granlund, Alex J. Poot, Justin R. Cross, Craig B. Thompson et al. · 2022 · Proceedings of the National Academy of Sciences
  56. Monocarboxylate Transporter-1 (MCT1)-Mediated Lactate Uptake Protects Pancreatic Adenocarcinoma Cells from Oxidative Stress during Glutamine Scarcity Thereby Promoting Resistance against Inhibitors of Glutamine Metabolism
    Nourhane Ammar, Maya Hildebrandt, Claudia Geismann, Christian Röder, Timo Gemoll, Susanne Sebens, Anna Trauzold, H. Schäfer · 2023 · Antioxidants
  57. Metabolic plasticity in pancreatic cancer: The mitochondrial connection
    Ghiglione Noemi, Damiano Abbo, Bushunova Anastasia, Andrea Costamagna, Paolo Ettore Porporato, Miriam Martini · 2024 · Molecular Metabolism
  58. Advances in the Genetics and Biology of Pancreatic Cancer
    Andrew J. Aguirre, Eric Andrew Collisson · 2017 · The Cancer Journal
  59. Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition
    Victor Ruiz‐Rodado, Adrian Lita, Tyrone Dowdy, Orieta Celiku, Alejandra Cavazos Saldana, Herui Wang, Chunzhang Yang, Raj Chari, Aiguo Li, Wei Zhang et al. · 2020 · Cancer & Metabolism
  60. Role of amino acids in regulation of ROS balance in cancer
    Emilie Jaune, Sophie Vasseur · 2020 · Archives of Biochemistry and Biophysics
  61. NASH, Fibrosis and Hepatocellular Carcinoma: Lipid Synthesis and Glutamine/Acetate Signaling
    Yoshiaki Sunami · 2020 · International Journal of Molecular Sciences
  62. A genome-wide CRISPR screen reveals that antagonism of glutamine metabolism sensitizes head and neck squamous cell carcinoma to ferroptotic cell death
    Michael M. Allevato, Sally Trinh, Keiichi Koshizuka, Daniela Nachmanson, T Nguyen, Yumi Yokoyama, Xingyu Wu, Allen M. Andres, Zhiyong Wang, Jeramie D. Watrous et al. · 2024 · Cancer Letters
  63. Generation of a Key Synthon of Indole Alkaloid Synthesis by Palladium(II)‐Catalyzed Indole 2‐Methylenephosphorylation
    Yuan Niu, Peng‐Bo Bai, Qinxin Lou, Shang‐Dong Yang · 2020 · ChemCatChem
  64. Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS
    Dan Wang, Ya‐Wei Bi, Liang‐Hao Hu, Yongde Luo, Jun‐Tao Ji, Albert H. Mao, Craig D. Logsdon, Ellen Li, James L. Abbruzzese, Zhao‐Shen Li et al. · 2019 · Cell Communication and Signaling
  65. Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing
    Yan Liu, Fleur M. Ferguson, Lianbo Li, Miljan Kuljanin, Caitlin E. Mills, Kartik Subramanian, Wayne D. Harshbarger, Sudershan Reddy Gondi, Jinhua Wang, Peter Karl Sorger et al. · 2020 · Cell chemical biology
  66. Targeting PGM3 as a Novel Therapeutic Strategy in KRAS/LKB1 Co-Mutant Lung Cancer
    Hyunmin Lee, Feng Cai, Neil Kelekar, Nipun Velupally, Jiyeon Kim · 2022 · Cells
  67. Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer
    Ronald C. Bruntz, Alex C. Belshoff, Yan Zhang, Jéssica K. A. Macêdo, Richard M. Higashi, Andrew N. Lane, Teresa W.‐M. Fan · 2019 · PROTEOMICS
  68. Single-Cell and Subcellular Analysis Using Ultrahigh Resolution 21 T MALDI FTICR Mass Spectrometry
    Daniel C. Castro, Karl W. Smith, Miles D. Norsworthy, Stanislav S. Rubakhin, Chad R. Weisbrod, Christopher L. Hendrickson, Jonathan V. Sweedler · 2023 · Analytical Chemistry
  69. Rethinking the Roles of Cancer-Associated Fibroblasts in Pancreatic Cancer
    Ralph A. Francescone III, Howard C. Crawford, Debora Barbosa Vendramini Costa · 2024 · Cellular and Molecular Gastroenterology and Hepatology
  70. The role of GOT1 in cancer metabolism
    Huan Peng, Huihong Dou, shu he, Yuan Xie, Qinle Zhang, Jianqiu Zheng · 2024 · Frontiers in Oncology
  71. Organoids in recapitulating tumorigenesis driven by risk factors: Current trends and future perspectives
    Jie Zhang, Lei Wang, Qianqian Song, Mingbing Xiao, Jie Gao, Xiaolei Cao, Wenjie Zheng · 2022 · International Journal of Biological Sciences
  72. YAP governs cellular adaptation to perturbation of glutamine metabolism by regulating ATF4-mediated stress response
    Minjoong Kim, Sunsook Hwang, Byung-Joo Kim, Seungmin Shin, Seungyeon Yang, Jihye Gwak, Seung Min Jeong · 2023 · Oncogene
  73. Novel Liver X Receptor Ligand GAC0001E5 Disrupts Glutamine Metabolism and Induces Oxidative Stress in Pancreatic Cancer Cells
    Shivangi Srivastava, Scott Widmann, Charles Ho, Donovan Nguyen, Alexis Nguyen, Asitha Premaratne, Jan-Ακε Gustafsson, Chin‐Yo Lin · 2020 · International Journal of Molecular Sciences
  74. Screening of Focused Compound Library Targeting Liver X Receptors in Pancreatic Cancer Identified Ligands with Inverse Agonist and Degrader Activity
    Husna Karaboga, Wentao Huang, Shivangi Srivastava, Scott Widmann, Sridevi Addanki, Kasuni Thawalama Gamage, Zahra Mazhar, Jerry Osagie Ebalunode, James M. Briggs, Jan-Ακε Gustafsson et al. · 2020 · ACS Chemical Biology
  75. Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims
    Beata Małachowska, Weng‐Lang Yang, Andrea C. Qualman, Israel Muro, Devin M. Boe, Jed Noah Lampe, Elizabeth J. Kovacs, Juan‐Pablo Idrovo · 2023 · Communications Biology
  76. Targeting Metabolic Vulnerabilities to Combat Drug Resistance in Cancer Therapy
    Taranatee Khan, M. K. Nagarajan, Irene Kang, Chunjing Wu, Medhi Wangpaichitr · 2025 · Journal of Personalized Medicine
  77. Inhibition of Glutamate‐to‐Glutathione Flux Promotes Tumor Antigen Presentation in Colorectal Cancer Cells
    Tao Yu, Kevin Van der Jeught, Haiqi Zhu, Zhuolong Zhou, Samantha Sharma, Sheng Liu, Haniyeh Eyvani, Ka Man So, Naresh Singh, Jia Wang et al. · 2024 · Advanced Science
  78. Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression
    Ralph Francescone, Debora Barbosa Vendramini Costa, Janusz Franco-Barraza, Jessica Wagner, Alexander Muir, Allison N. Lau, Linara Gabitova, Tatiana Pazina, Sapna Gupta, Tiffany Luong et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  79. The Role of Stroma in Cancer Metabolism
    Alec C. Kimmelman, Mara H. Sherman · 2023 · Cold Spring Harbor Perspectives in Medicine
  80. Glutamine is critical for the maintenance of type 1 conventional dendritic cells in normal tissue and the tumor microenvironment
    Graham P. Lobel, Nanumi Han, William A. Molina Arocho, Michal Silber, Jason Shoush, Michael Noji, Tsun Ki Jerrick To, Li Zhai, Nicholas P. Lesner, Marie Celeste Simon et al. · 2024 · Proceedings of the National Academy of Sciences
  81. De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer
    Huan Zhang, Naiara Santana-Codina, Qijia Yu, Clara L. Poupault, Claudia Campos, Xingping Qin, Nicole Sindoni, Marina Ciscar, Aparna Padhye, Miljan Kuljanin et al. · 2025 · Nature Communications
  82. The trend toward more target therapy in pancreatic ductal adenocarcinoma
    Chiara Deiana, Margherita Agostini, Giovanni Brandi, Elisa Giovannetti · 2024 · Expert Review of Anticancer Therapy
  83. Amino acids metabolism: a potential target for cancer treatment
    Shiqi Ren, Xinyi Zhou, Zhen Wang, Kefei Yuan · 2025 · Molecular Cancer
  84. The role of glutamine metabolism in castration-resistant prostate cancer
    Bing Qiang Zhao, Jing Wang, Li Chen, Hong Wang, Chao-Zhao Liang, Jiaoti Huang, Lingfan Xu · 2023 · Asian Journal of Andrology
  85. Metabolomics-based phenotypic screens for evaluation of drug synergy via direct-infusion mass spectrometry
    Xiyuan Lu, G. Lavender Hackman, Achinto Saha, Atul Rathore, Meghan Collins, Chelsea A. Friedman, S. Stephen Yi, Fumio Matsuda, John DiGiovanni, Alessia Lodi et al. · 2022 · iScience
  86. Amino acid metabolism in primary bone sarcomas
    Jennifer A. Jiménez, Elizabeth R. Lawlor, Costas Andreas Lyssiotis · 2022 · Frontiers in Oncology
  87. Rerouting the drug response: Overcoming metabolic adaptation in KRAS-mutant cancers
    Debbie Moss, Christopher K. McCann, Emma M. Kerr · 2022 · Science Signaling
  88. Crosstalk between the tumor immune microenvironment and metabolic reprogramming in pancreatic cancer: new frontiers in immunotherapy
    Taijin Shi, Xiaoyan Cui, Junlin Wang, Guangqia Liu, Jiayin Meng, Yingjie Zhang · 2025 · Frontiers in Immunology
  89. Regulation of metabolism in pancreatic ductal adenocarcinoma via nanotechnology-enabled strategies
    Zhiqin Wang, Bowen Wu, Guangjun Nie, Jingyan Wei, Yiye Li · 2023 · Cancer Letters
  90. ASCT2-mediated glutamine uptake of epithelial cells facilitates CCL5-induced T cell infiltration via ROS-STAT3 pathway in oral lichen planus
    Jingyi Lu, Zhangci Su, Wei Li, Zihang Ling, Bin Cheng, Xi Yang, Xiaoan Tao · 2023 · International Immunopharmacology
  91. Glutamine analogs for pancreatic cancer therapy
    Nada Y. Kalaany · 2024 · Nature Cancer
  92. A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer
    Manabu Kodama, Kiyotaka Oshikawa, Hideyuki Shimizu, Susumu Yoshioka, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Chisa Tateishi, Takeshi Tomonaga, Masaki Matsumoto et al. · 2020 · Nature Communications
  93. Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist
    Artur Wnorowski, Danuta Dudzik, Michel Bernier, Jakub Wójcik, Guido Keijzers, Alberto Díaz‐Ruiz, Karolina Mazur, Yongqing Zhang, Haiyong Han, Morten Scheibye‐Knudsen et al. · 2022 · Scientific Reports
  94. Simultaneous inhibition of PFKFB3 and GLS1 selectively kills KRAS-transformed pancreatic cells
    Selahattin Can Özcan, Aydan Mutlu, Tugba H. Altunok, Yunus Gurpinar, Aybike Sarıoğlu Bozkurt, Sabire Güler, Robertino J. Muchut, Alberto Á. Iglesias, Serap Çelikler, Paul M. Campbell et al. · 2021 · Biochemical and Biophysical Research Communications
  95. Effects of the IDH1 R132H Mutation on the Energy Metabolism: A Comparison between Tissue and Corresponding Primary Glioma Cell Cultures
    Lennard J. M. Dekker, Cassandra Verheul, Nicky Wensveen, William P. J. Leenders, Martine L.M. Lamfers, Sieger Leenstra, Theo M. Luider · 2022 · ACS Omega
  96. Metabolic Alterations in Pancreatic Cancer Detected by In Vivo 1H-MR Spectroscopy: Correlation with Normal Pancreas, PET Metabolic Activity, Clinical Stages, and Survival Outcome
    Chih-Kai Chang, Tiffany Ting‐Fang Shih, Yu‐Wen Tien, Ming‐Chu Chang, Yu‐Ting Chang, Shih‐Hung Yang, Mei‐Fang Cheng, Bang‐Bin Chen · 2021 · Diagnostics
  97. Targeting cellular adaptive responses to glutaminolysis perturbation for cancer therapy
    Minjoong Kim, Sunsook Hwang, Seung Min Jeong · 2024 · Molecules and Cells
  98. Establishment of patient-derived 3D in vitro models of sarcomas: literature review and guidelines on behalf of the FORTRESS working group
    Lore De Cock, Ieva Palubeckaitė, Francesca Bersani, Tobias Faehling, Sandro Pasquali, Sam Umbaugh, Michael T. Meister, Molly R Danks, Piotr J. Manasterski, Richard MIALLOT et al. · 2025 · Neoplasia
  99. Metabolic Alterations in Preneoplastic Development Revealed by Untargeted Metabolomic Analysis
    Henna Myllymäki, Jeanette Astorga Johansson, Estefania Grados Porro, Abigail M. Elliot, Tessa Moses, Yi Feng · 2021 · Frontiers in Cell and Developmental Biology
  100. Mitochondrial glutamine metabolism regulates sensitivity of cancer cells after chemotherapy via amphiregulin
    Sunsook Hwang, Seungyeon Yang, Minjoong Kim, Youlim Hong, Byung-Joo Kim, Eun Kyung Lee, Seung Min Jeong · 2021 · Cell Death Discovery