Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation
Obregon, Demian, Hou, Huayan, Deng, Juan, Giunta, Brian, Tian, Jun, Darlington, Donna, Shahaduzzaman, Md, Zhu, Yuyuan, Mori, Takashi, Mattson, Mark P., Tan, Jun·2012·Nature Communications
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- Genetic Association Between APP, ADAM10 Gene Polymorphism, and Sporadic Alzheimer’s Disease in the Chinese PopulationFan Zeng, Cheng Shen, Yu-Hui Liu, Jing Li, Jie Zhu, Ye‐Ran Wang, Yan Jia-chuan, Chang-Yue Gao, Huadong Zhou, Juan Deng et al. · 2015 · Neurotoxicity Research
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- The thiol proteinase inhibitor E-64-d ameliorates amyloid-β-induced reduction of sAPPα secretion by reversing ceramide-induced protein kinase C down-regulation in SH-SY5Y neuroblastoma cellsFuminori Tanabe, Tomoko Nakajima, Masahiko Ito · 2013 · Biochemical and Biophysical Research Communications
- Effect of amyloid toxicity or chronic cerebral hypoperfusion on brain insulin resistance in a rat model with intracerebroventricular streptozotocinBo‐Ryoung Choi, Ju-Ha Seo, Dong Bin Back, Jung‐Soo Han, Dong‐Hee Choi, Kyoung Ja Kwon, Chan Young Shin, Jongmin Lee, Hahn Young Kim · 2020 · Brain Research Bulletin
- Tongluo Xingnao effervescent tablet reverses memory deficit and reduces plaque load in APPswe/PS1dE9 miceWenjun Fu, Yuan Dai, Tao Ma, Jiangping Wei, Huan Chen, Shijun Xu · 2018 · Experimental and Therapeutic Medicine
- NRF2 activation by 6-MSITC increases the generation of neuroprotective, soluble α amyloid precursor protein by inducing the metalloprotease gene ADAM17Daniel Carnicero-Senabre, José Jiménez-Villegas, Sofía Álvarez-Garrote, Maribel Escoll, Antonio Cuadrado, Ana Isabel Rojo · 2024 · Free Radical Biology and Medicine
- Glucose Metabolism, Lactate, Lactylation and Alzheimer’s DiseaseShuangshuang Hai, Yadan Hou, Meiyan Zhang, Xiaoyan Gao, Tuo Yang, Xiuli Shang, Xiaohong Sun · 2025 · Aging and Disease
- Autophagy-Dependent Increased ADAM10 Mature Protein Induced by TFEB Overexpression Is Mediated Through PPARαHongjie Wang, Mohan Kumar Muthu Karuppan, Madhavan Nair, Madepalli Krishnappa Lakshmana · 2021 · Molecular Neurobiology
- Dropping the BACE: Beta Secretase (BACE1) as an Alzheimer’s Disease Intervention TargetJustin L. Read, Cenk Suphioglu · 2013 · InTech eBooks
- Human Cord Blood Serum-Derived APP α-Secretase Cleavage Activity is Mediated by C1 ComplementAhsan Habib, Darrell R. Sawmiller, Huayan Hou, Manasa Kanithi, Jun Tian, Zeng Jin, Dan Zi, Zhixu He, Paul R. Sanberg, Jun Tan · 2018 · Cell Transplantation
- Therapeutic effects of a novel synthetic α-secretaseSung Bin Kim, Bo-Ram Mun, Sung Yoon Kim, Muthukumar Elangovan, Euy Jun Park, Won‐Seok Choi, Woo Jin Park · 2024 · Frontiers in Aging Neuroscience
- Different Expression Patterns of Amyloid-β Protein Precursor Secretases in Human and Mouse Hippocampal Neurons: A Potential Contribution to Species Differences in Neuronal Susceptibility to Amyloid-β PathogenesisZhiqiang Xu, Huang Huang, Yali Chen, Yun-Ying Gao, Jun Xu, Charles Marshall, Zhiyou Cai, Ming Xiao · 2016 · Journal of Alzheimer s Disease
- The Amyloid Precursor Protein: More than Just Amyloid- BetaStefan D. Jevtic, John Provias · 2019 · Journal of Neurology and Experimental Neuroscience
- HIV-Associated Insults Modulate ADAM10 and Its Regulator Sirtuin1 in an NMDA Receptor-Dependent MannerClaudia López Lloreda, Sarah Chowdhury, Shivesh Ghura, Elena Alvarez-Periel, Kelly L. Jordan‐Sciutto · 2022 · Cells
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- A Novel scFv Anti-Aβ Antibody Reduces Pathological Impairments in APP/PS1 Transgenic Mice via Modulation of Inflammatory Cytokines and Aβ-related EnzymesMeng-Ming Hu, Jun Zhang, Junting Yang, Yue Cao, Jin‐Shun Qi · 2018 · Journal of Molecular Neuroscience
- A short peptide from sAPPα binding to BACE1-APP action site rescues Alzheimer-like pathologyXia Lai, Jie Hu, He Liu, Ling Lan, Yan Long, Xia Gao, Juan Deng · 2021 · Neuroscience Letters
- Blood-based therapies to combat neurodegenerative diseasesLee Jy, Mervyn Chen Xi Lim, Rhun Yian Koh, Min Tze Tsen, Soi Moi Chye · 2024 · Metabolic Brain Disease
- Tyrosine kinase receptor B isoforms alter APP and BACE1 endogenous levels independently of BDNFSara Ansaloni, Brian Chun Lok Leung, Aditi Dubey, Aleister J. Saunders · 2012 · Advances in Alzheimer s Disease
- Stem Cell Approaches for Treatment of Neurodegenerative DiseasesSaurabh Anand · 2014 · Clinical Pharmacology & Biopharmaceutics
- The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase ActivitiesRenato Brandimarti, Elena Irollo, Olimpia Meucci · 2022 · Molecular Neurobiology
- Novel social stimulation ameliorates memory deficit in Alzheimer's disease model through activating α-secretaseQiaoyun Ren, Susu Wang, Junru Li, Kun Cao, Mei Zhuang, Miao Wu, Junhua Geng, Zhengping Jia, Wei Xie, An Liu · 2024 · Journal of Neuroscience
- RAGE-Mediated Effects of Formaldehyde in Alzheimer’s DiseaseIlya G. Mikhailov, Milana S. Mikhailova, Аnton N. Shuvaev, Yana V. Gorina, Оlga S. Belozor · 2025 · Biochemistry (Moscow)
- Temporo-spatial cellular atlas of the regenerating alveolar niche in idiopathic pulmonary fibrosisPraveen Nilendra Weeratunga, Bethany Hunter, Martin J. Sergeant, Joshua A. Bull, Colin Clelland, Laura Denney, Chaitanya Vuppusetty, Rachel A. Burgoyne, Jeongmin Woo, Tian Hu et al. · 2024 · medRxiv
- Fucoxanthin suppresses amyloid-β and pyroglutamate-3-Aβ accumulation by modulating the PI3K/Akt/GSK-3β signaling pathwayNayoung Lee, Kumju Youn, Huiyoung Kwon, Jihye Lee, Eunhong Lee, Ji Wook Jung, Minho Moon, Dong‐Seok Lee, Dong Hyun Kim, Chi‐Tang Ho et al. · 2025 · Food & Function
- BDNF alters β-cleavage of APP and subcellular distribution of BACE1Ryan Douglas Hallam, Gregory Foran, Natasha K. Fletcher, Rebecca E. K. MacPherson, Aleksandar Necakov · 2026 · American Journal of Physiology-Cell Physiology
- A lipid-raft theory of Alzheimer's diseaseAri Rappoport · 2025 · Elsevier eBooks
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- Extension domain of amyloid processor protein inhibits amyloidogenic cleavage and balances neural activity in a traumatic brain injury mouse modelZhenxing Xie, Tianyu Li, Wei Cheng Su, Yanyun Lou, Yongsheng Zhang, Xiyuan Zhou, Zhanfei Li, Xiangjun Bai, Xinghua Liu · 2023 · CNS Neuroscience & Therapeutics
- Neuroplasticity and Alzheimer’s DiseaseAshkan Asgari Gashtrodkhani, Samaneh Ghorbani Shirkouhi, Seyed Sepehr Khatami, Farzin Kamari, Sarvenaz Ghaedi, Morten Blaabjerg, Sasan Andalib · 2026 · Journal of Integrative Neuroscience
- BACE1 Overexpression Reduces SH-SY5Y Cell Viability Through a Mechanism Distinct from Amyloid-β Peptide Accumulation: Beta Prime-Mediated Competitive Depletion of sAβPPαLauren Owens, Joshua Bracewell, Alexandre Benedetto, Neil Dawson, Christopher J. Gaffney, Edward T. Parkin · 2022 · Journal of Alzheimer s Disease
- THICAPA modulates amyloid precursor protein processing and alleviates oxidative stress in fibroblasts derived from patients with Familial Alzheimer’s diseaseDanesh Thangeswaran, Shaharum Shamsuddin, Venugopal Balakrishnan · 2025 · Molecular Biology Reports
- Mycoplasma hyorhinis markedly degrades β-amyloid peptides in vitro and ex vivo: a novel biological approach for treating Alzheimer's disease?Ahsan Habib, Juan Deng, Huayan Hou, Qiang Zou, Brian N. Giunta, Yan‐Jiang Wang, Demian F. Obregon, Darrell R. Sawmiller, Song Li, Takashi Mori et al. · 2013 · Europe PMC (PubMed Central)
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- Evaluation of BACE1 silencing as a therapy against Alzheimer disease: implications for lipid metabolism and inflammatory responseJavier Gustavo Villamil-Ortiz · 2019 · University of Groningen research database (University of Groningen / Centre for Information Technology)
- How does neuroprotective sAPPα initiate its signalling cascadeJoshua R. Prendergast · 2016 · Otago University Research Archive (University of Otago)
- The effect of the combination of erythromycin with new beta-lactam antibiotics against gram-negative aerobic respiratory pathogens.Masao Nakatomi, Harold C. Neu · 1986 · PubMed
- Effects of anle138b treatment on amyloid-β neurotoxicityCarolina Thomas · 2020 · eDiss (Georg-August-Universität Göttingen)
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- Additional file 5 of Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathologyChao Song, Li, Shufang, Mai, Yingren, Li, Linpeng, Guoku Dai, Zhou, Yuan, Xiaosheng Liang, Olivia Meilan Zou, Wang, Ya, Libing Zhou et al. · 2024 · Figshare
- Additional file 3 of Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathologyChao Song, Li, Shufang, Mai, Yingren, Li, Linpeng, Guoku Dai, Zhou, Yuan, Xiaosheng Liang, Olivia Meilan Zou, Wang, Ya, Libing Zhou et al. · 2024 · Figshare
- Additional file 1 of Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathologyChao Song, Li, Shufang, Mai, Yingren, Li, Linpeng, Guoku Dai, Zhou, Yuan, Xiaosheng Liang, Olivia Meilan Zou, Wang, Ya, Zhou, Libing et al. · 2024 · Figshare
- Additional file 4 of Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathologyChao Song, Li, Shufang, Mai, Yingren, Li, Linpeng, Guoku Dai, Zhou, Yuan, Xiaosheng Liang, Olivia Meilan Zou, Wang, Ya, Libing Zhou et al. · 2024 · Figshare
- Additional file 2 of Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathologyChao Song, Li, Shufang, Mai, Yingren, Li, Linpeng, Guoku Dai, Zhou, Yuan, Xiaosheng Liang, Olivia Meilan Zou, Wang, Ya, Zhou, Libing et al. · 2024 · Figshare
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- Second Section: A single domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSFLiliana Napolitano · 2026 · Firenze University Press eBooks
- ReferencesLiliana Napolitano · 2026 · Firenze University Press eBooks
- DiscussionLiliana Napolitano · 2026 · Firenze University Press eBooks
- Third Section: Design of a dimeric-nanobody specific for Aβ42 oligomers: the Dimeric-DesAb-OLiliana Napolitano · 2026 · Firenze University Press eBooks
- A multidisciplinary approach for the early diagnosis of Alzheimer’s disease and potential therapeutic applicationsLiliana Napolitano · 2026 · Firenze University Press eBooks
- Material and MethodsLiliana Napolitano · 2026 · Firenze University Press eBooks
- First Section: Putative CSF biomarkers of Alzheimer’s disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohortLiliana Napolitano · 2026 · Firenze University Press eBooks
- IntroductionLiliana Napolitano · 2026 · Firenze University Press eBooks
- Conclusion and Future PerspectivesLiliana Napolitano · 2026 · Firenze University Press eBooks
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