The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Chirality-selected phase behaviour in ionic polypeptide complexes
Open accessAbstract
Polyelectrolyte complexes present new opportunities for self-assembled soft matter. Factors determining whether the phase of the complex is solid or liquid remain unclear. Ionic polypeptides enable examination of the effects of stereochemistry on complex formation. Here we demonstrate that chirality determines the state of polyelectrolyte complexes, formed from mixing dilute solutions of oppositely charged polypeptides, via a combination of electrostatic and hydrogen-bonding interactions. Fluid complexes occur when at least one of the polypeptides in the mixture is racemic, which disrupts backbone hydrogen-bonding networks. Pairs of purely chiral polypeptides, of any sense, form compact, fibrillar solids with a β-sheet structure. Analogous behaviour occurs in micelles formed from polypeptide block copolymers with polyethylene oxide, where assembly into aggregates with either solid or fluid cores, and eventually into ordered phases at high concentrations, is possible. Chirality is an exploitable tool for manipulating material properties in polyelectrolyte complexation.
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Cites
Kabsch, W., & Sander, C. (1983) · Biopolymers · doi:10.1002/bip.360221211 · Cited by 15,320
Block Copolymers in Solution: Fundamentals and Applications
Hamley, I. (2005) · doi:10.1002/9780470016985 · Cited by 479
Cited by
Zhao, Q., Lee, D. W., Ahn, B. K., Seo, S., Kaufman, Y., Israelachvili, J. N., & Waite, J. H. (2016) · Nature Materials · doi:10.1038/nmat4539 · Cited by 503
Phase Behavior and Salt Partitioning in Polyelectrolyte Complex Coacervates
Li, L., Srivastava, S., Andreev, M., Marciel, A. B., de Pablo, J. J., & Tirrell, M. V. (2018) · Macromolecules · doi:10.1021/acs.macromol.8b00238 · Cited by 357
Self-citationAumiller, W. M., Pir Cakmak, F., Davis, B. W., & Keating, C. D. (2016) · Langmuir · doi:10.1021/acs.langmuir.6b02499 · Cited by 325
Complex coacervate‐based materials for biomedicine
Blocher, W. C., & Perry, S. L. (2017) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1442 · Cited by 312
Self-citationFunctional Ambidexterity of an Ancient Nucleic Acid‐Binding Domain
Weil‐Ktorza, O., Naveh‐Tassa, S., Fridmann‐Sirkis, Y., Despotović, D., Cherukuri, K. P., Corlett, T., Levy, Y., Metanis, N., & Longo, L. M. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202505188 · Cited by 12
Metadata
- Authors
- Perry, S. L., Leon, L., Hoffmann, K. Q., Kade, M. J., Priftis, D., Black, K. A., Wong, D., Klein, R. A., Pierce, C. F., Margossian, K. O., Whitmer, J. K., Qin, J., de Pablo, J. J., & Tirrell, M.
- Venue
- Nature Communications
- Published
- 2015-01-14
- Volume
- 6
- Issue
- 1
- Pages
- 6052-6052
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1980248898
- Cited by
- 300
- References
- 2
- FWCI
- 14.07
- Type
- journal article
- Language
- en
- Open access
- gold
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- Perry, S. L., Leon, L., Hoffmann, K. Q., Kade, M. J., Priftis, D., Black, K. A., Wong, D., Klein, R. A., Pierce, C. F., Margossian, K. O., Whitmer, J. K., Qin, J., de Pablo, J. J., & Tirrell, M. (2015). Chirality-selected phase behaviour in ionic polypeptide complexes. Nature Communications. https://doi.org/10.1038/ncomms7052
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