UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

Goto, Yoko, Zeng, Lihua, Yeom, Chan Joo, Zhu, Yuxi, Morinibu, Akiyo, Shinomiya, Kazumi, Kobayashi, Minoru, Hirota, Kiichi +13 more·2015·Nature Communications
DOI 10.1038/ncomms7153

Cited by (231)

Items 201–231 of 231

  1. UCH-L1 in DLBCL: marker or target?
    Joseph Stephen Pagano, Julia Shackelford · 2016 · Blood
  2. Identification of novel genes with important functions in glioblastoma multiforme and acute myeloid leukemia
    Aditya Harisankar · 2018 · Figshare
  3. UCHL1-dependent control of Hypoxia-Inducible Factor Transcriptional Activity in Liver Disease
    Amy Collins, Rebecca Scott, Caroline L Wilson, Giuseppe Abbate, Gabrielle B. Ecclestone, Demi Biddles, Fiona Oakley, Jelena Mann, Derek A. Mann, Niall Steven Kenneth · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  4. Effect of Gene 33/Mig6/ERRFI1 on hexavalent chromium-induced transformation of human bronchial epithelial cells depends on the length of exposure
    Cen Li, Dina Edeni, Sarah Platkin, Raymond Liu, Jiangwei Li, Maheen Hossain, Mozibur Rahman, Humayun Kamal Islam, John L. Phillips, Dazhong Xu · 2022 · Journal of Environmental Science and Health Part C
  5. Establishing protocol for detecting methylation of Ubiquitin carboxyl terminal hydrolase 1 gene’s promoter in nasopharyngeal carcinoma
    Thiều Hồng Huệ, Huynh Thi Mong Tuyen, Nguyễn Văn Trưởng, Dao Duy Tin, Tran Minh Dang Khoa, Thuy Ai Huyen Le, Thuan Duc Lao · 2022 · HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY
  6. Chromosome 4
    Anindita Menon, Ravi Gor, Saurav Panicker, Satish Ramalingam · 2023 · BENTHAM SCIENCE PUBLISHERS eBooks
  7. N‐Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1
    Mirko Schmidt, Christian Grethe, Sarah Recknagel, Gian‐Marvin Kipka, Nikolas Klink, Malte Gersch · 2024 · Angewandte Chemie
  8. Construction and Validation of a Seven-Gene Signature for Predicting Prognosis and treatment response of Melanoma Based on Parkinson's Disease Family Genes
    Zhiqiang He, Weinan Zhang, Yanqi Li, Xiang Zhao, Jinqing Xie, Luoyingzi Xie, Hong Zheng · 2024 · Research Square
  9. Dynamic ubiquitination networks in liver cancer: decoding E3 ligases and deubiquitinases as gatekeepers of therapeutic resistance
    Nuo Xu, Yun Tong, Kexin Ma, Lihan Jiang, Wenjie Zheng · 2025 · Medical Oncology
  10. Additional file 3 of UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5
    Li, Juan, Liang, Yu, Zhou, Shijie, Chen, Jie, Wu, Chihua · 2024 · Figshare
  11. Additional file 1 of LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5
    Zheng Zhang, Hu, Xiaoxuan, Kuang, Jia, Liao, Jinmao, Yuan, Qi · 2020 · Figshare
  12. Additional file 2 of UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5
    Li, Juan, Liang, Yu, Zhou, Shijie, Chen, Jie, Wu, Chihua · 2024 · Figshare
  13. Additional file 5 of UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5
    Li, Juan, Liang, Yu, Zhou, Shijie, Chen, Jie, Wu, Chihua · 2024 · Figshare
  14. Additional file 6 of UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5
    Li, Juan, Liang, Yu, Zhou, Shijie, Chen, Jie, Wu, Chihua · 2024 · Figshare
  15. Additional file 9 of UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5
    Li, Juan, Liang, Yu, Zhou, Shijie, Chen, Jie, Wu, Chihua · 2024 · Figshare
  16. Additional file 10 of UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5
    Li, Juan, Liang, Yu, Zhou, Shijie, Chen, Jie, Wu, Chihua · 2024 · Figshare
  17. Additional file 1 of UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5
    Li, Juan, Liang, Yu, Zhou, Shijie, Chen, Jie, Wu, Chihua · 2024 · Figshare
  18. Additional file 4 of UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5
    Li, Juan, Liang, Yu, Zhou, Shijie, Chen, Jie, Wu, Chihua · 2024 · Figshare
  19. Additional file 7 of UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5
    Li, Juan, Liang, Yu, Zhou, Shijie, Chen, Jie, Wu, Chihua · 2024 · Figshare
  20. Additional file 8 of UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5
    Li, Juan, Liang, Yu, Zhou, Shijie, Chen, Jie, Wu, Chihua · 2024 · Figshare
  21. Pan-cancer perspectives on post-translational modifications and metastasis: Unraveling complex molecular mechanisms
    Qilu Yan, Shuya Jiang, Wangzheqi Zhang, Tonglin Sun, Ziyun Liu, Xuan Yin, Chagui Zheng, Ting Hu, Haoling Zhang, Yongjie Xie · 2026 · Critical Reviews in Oncology/Hematology
  22. Role of the bone microenvironment in systemic breast cancer growth and metastasis
    Yetki Aslan · 2020 · theses.fr (ABES)
  23. Impact du ciblage du domaine de liaison de HIF-1α avec HIF-1β sur le paysage immunitaire du mélanome
    Audrey Lequeux · 2020 · theses.fr (ABES)
  24. Pharmacological inhibition of deubiquitinase UCH-L1 by LDN57444 sensitises hepatocellular carcinoma to sorafenib by reverting drug-induced adaptive responses
    Elias Van De Vijver, Kylian Decroix, Delphine Burggraeve, Petra Van Wassenhove, Zenzi De Vos, Christophe Ampè, Lindsey Devisscher, Hans Van Vlierberghe, Marleen Van Troys · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  25. A risk stratification framework based on ammonia-induced cell death signatures for prognostic assessment and therapeutic insights in colorectal cancer
    Shuyan Sun, Yinuo Zhao, Zhiqiang Liu, Xiangying Ran · 2026 · Discover Oncology
  26. The Emerging Role of UCHL1 in Neurological and Musculoskeletal Diseases
    Ru Feng, Xiu Zhong, Jianjun Li, Adrian A. Achuthan · 2026 · Immunology and Cell Biology
  27. From epigenetics to metastasis: Multifaceted roles of lncRNAs in gastric cancer
    Mohamed J. Saadh, Ashok Kumar Bishoyi, R. Roopashree, K. Satyam Naidu, Lokesh Verma, Ojas Prakashbhai Doshi, Piyus Kumar Pathak, Suman Saini, Fadhil Faez Sead · 2026 · Biochemistry and Biophysics Reports
  28. UCHL1 Promotes Epithelial–Mesenchymal Transition Through E-Cadherin and N-Cadherin Switch in Endometrial Cancer
    Azusa Kobayashi, Kohshiro Nakao, Naoki Inoue, Tae Oike, Sadatomo Ikeda, Takashi Hirakawa, Orie Nakamura, Akira Iwase · 2026 · Biomedicines
  29. Systematic Identification of Candidate Substrates of the UCH Family of Deubiquitinases
    Juanma Ramírez, Gorka Prieto, Erik Paco Barrio, Ainhoa Atxa-Espiga, Natalia Presa, Olatz Arteaga-Cabeza, Ugo Mayor, Nerea Osinalde · 2026 · International Journal of Molecular Sciences
  30. BindingDB Entry 50013550: Design, synthesis, and target identification of new hypoxia-inducible factor 1 (HIF-1) inhibitors containing 1-alkyl-1H-pyrazole-3-carboxamide moiety.
    BindingDB · 2022 · UC San Diego
  31. BindingDB Entry 50015881: Activity-based protein profiling reveals deubiquitinase and aldehyde dehydrogenase targets of a cyanopyrrolidine probe.
    BindingDB · 2023 · UC San Diego