The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia
Koh, Han Seok, Chang, Chi Young, Jeon, Sae-Bom, Yoon, Hee Jung, Ahn, Ye-Hyeon, Kim, Hyung-Seok, Kim, In-Hoo, Jeon, Sung Ho +2 more·2015·Nature Communications
Cited by (141)
Items 101–141 of 141
- Glutamine metabolism and ammonia death: targeted modulation for enhanced cancer immunotherapyFei Du, Linlin Xiao, Wang Guojun, Qian Dai, Junxin Li, Xin Zhao, Qimin Zhang, Lan Yang, Yujie Liu, Yidan Hu et al. · 2025 · Frontiers in Immunology
- Elevated Galectin-9 across the human brain correlates with HIV neuropathology and detrimental cognitive statesThomas A. Premeaux, Stephen T. Yeung, Satish K. Pillai, Lishomwa C. Ndhlovu · 2023 · Journal of NeuroVirology
- Hyperbaric Oxygen Therapy Attenuates Burn-Induced Denervated Muscle AtrophyChi‐An Chen, Yichen Huang, Jing-Jou Lo, Shih-Hung Wang, Shu‐Hung Huang, Sheng‐Hua Wu · 2021 · International Journal of Medical Sciences
- Tim-3 Deficiency Ameliorates Motor Deficits and Neuroinflammation in MPP+/MPTP-Induced Parkinson’s Disease Models via the NF-κB/NLRP3 PathwayXi Yin, Ge Li, Fei Ji, Miao Wang, Yang Gao, Fengzhu Li, Zhenfu Wang, Gencheng Han, Zhongbao Gao · 2024 · Molecular Neurobiology
- The lung-brain axis: elucidating the mechanisms of pulmonary-driven neurological disordersLongfei Wang, Fang Wang, Xingjun Wang, Xiangning Chen, Chengwei Li, Kaiyue Shan, Haipeng Zhou, Guanzhao Wu, Zhipeng Xu, Xiangyi Kong et al. · 2026 · Journal of Neuroinflammation
- Caveolin‐1 suppresses hippocampal neuron apoptosis via the regulation of HIF1α in hypoxia in naked mole‐ratsWenjing Yang, Wenqing Wu, Ying Zhao, Yu Li, Chengcai Zhang, Jingyuan Zhang, Chao Chen, Shufang Cui · 2022 · Cell Biology International
- Depletion of muscularis macrophages ameliorates inflammation-driven dysmotility in murine colitis modelS. Ferenczi, F. Mogor, Peter Takacs, T. Kovács, V. Toth, Z. Varga, Krisztina J. Kovács, Z. Lohinai, Koppány Csaba Vass, Nandor Nagy et al. · 2023 · Scientific Reports
- Supervised latent factor modeling isolates cell-type-specific transcriptomic modules that underlie Alzheimer’s disease progressionL. M. Hodgson, Yue Li, Yasser Iturria‐Medina, Jo Anne Stratton, Guy Wolf, Smita Krishnaswamy, David A. Bennett, Danilo Bzdok · 2024 · Communications Biology
- Promotion of a cancer-like phenotype, through chronic exposure to inflammatory cytokines and hypoxia in a bronchial epithelial cell line modelAnne‐Marie Baird, Steven G. Gray, Derek J. Richard, Kenneth John O'Byrne · 2016 · Scientific Reports
- Recent perspectives on the early expression immunohistochemical markers in post-mortem recognition of myocardial infarctionRadu Moldovan, Vlad Andrei Ichim, Vladimir Beliș · 2023 · Legal Medicine
- Iron Oxide Nanozyme as Reactive Oxygen and Nitrogen Species Scavenger to Regulate Microglial Homeostasis in StrokeYilin Qi, Chunxiao Wang, Yuqing Miao, Jiamin Li, Zengyu Xun, Di Sun, Fei Xu, Minrui Liu, Heping Wang, Galong Li et al. · 2026 · Advanced Science
- Immune Checkpoint InhibitorsPaweł Kaliński, Per H. Basse · 2018 · Elsevier eBooks
- Spatial protein profiling reveals active roles for astrocytes in the chronic active lesion core during multiple sclerosisBrandon C. Smith, Anthony M. Chomyk, Maria L. Habean, Benjamin C. Shaw, Rachel A. Tinkey, Bruce D. Trapp, Jessica L. Williams · 2025 · Acta Neuropathologica
- Correlation between the condition of patients with acute cerebral infarction and serum β2-microglobulin levelsZhi-Guo Li, Xia Zhou · 2016 · Journal of Acute Disease
- Brain damage in sleep-disordered breathing: the role of gliaIrina Filchenko, Л. С. Коростовцева, Бочкарев Михаил Викторович, Yu. V. Sviryaev · 2022 · S S Korsakov Journal of Neurology and Psychiatry
- Dual roles of ANGPTL4 in multiple inflammatory responses in stomatitis miceMiao-Miao Tian, Yishan Wang, Hong‐Bo Xiao · 2022 · Molecular Biology Reports
- Ozone Improves Oxygenation and Offers Organ Protection after Autologous Blood Transfusion in a Simulated Carbon Dioxide Pneumoperitoneal Environment in a Rabbit Hemorrhagic Shock ModelYu Gan, Xue Tian, Han Yao, Fei Huo, Yi Feng · 2023 · Transfusion Medicine and Hemotherapy
- Hypoxia-inducible Factor-1α Pathway in Cerebral Ischemia: From Molecular Mechanisms to Therapeutic TargetsVeerta Sharma, Thakur Gurjeet Singh · 2024 · CNS & Neurological Disorders - Drug Targets
- Markers of T cell activation and exhaustion in plasma are associated with persistent symptoms up to 18 months following mild SARS-CoV-2 infectionThor Ueland, Rebecca Jane Cox, Annika Elisabet Michelsen, Elisabeth Berg Fjelltveit, Kari Otterdal, Tuva Børresdatter Dahl, Fan Zhou, Rebecca Elyanow, Pål Aukrust, Bjørn Blomberg et al. · 2025 · Frontiers in Immunology
- The role of coinhibitory receptor-expressing non-T cells in inflammation and immunity: unsung heroes or peripheral players?Chaimae Khaled, Mijin Kim, Booki Min · 2025 · Experimental & Molecular Medicine
- The hypoxic tumor microenvironment: Functional and metabolic reprogramming of key immune populationsAmirhossein Faghih Ojaroodi, Samin Shokravi, Shabnam Eskandarzadeh, Armin Ghahremanzadeh, Fatemeh Alizadeh, Farinaz Amirikar, Golnaz Mobayen, Danial Mahrooghi, Masoud Lahouty, Karim Shamsasenjan et al. · 2026 · Pathology - Research and Practice
- Blocking of Tim‐3 Ameliorates Spinal Cord Ischemia‐Reperfusion Injury Through Inhibiting Neuroinflammation and Promoting M1‐to‐M2 Phenotypic Polarization of MicrogliaZhenxing Li, Binbin Zhou, Guanghui Chen, Xiangyu Yang, Han Su, Bolin Li · 2024 · Immunity Inflammation and Disease
- Chronic developmental hypoxia alters rat lung immune cell transcriptomes during allergic airway inflammationMichelle Chu, Huanling Gao, Patricia Esparza, Abigail Pajulas, Jocelyn Wang, Rakshin P Kharwadkar, Hongyu Gao, Mark H. Kaplan, Robert S. Tepper · 2023 · Physiological Reports
- TIM3 attenuates morphine antinociceptive tolerance and microglial neuroinflammation by suppressing the TRAF6/NF-κB pathway in male miceHuan Yang, Tong Shen, Zhi Qi, Zhong Yang, Mengyu Zhang, Jinhong Jiang, Zhuo Ran Sun, Chen Lu · 2025 · Neuropharmacology
- Single-cell sequencing analysis and machine learning model reveal aberrant TIM-3 expression in microglia during Alzheimer’s disease progressionZongtang Xu, MinShan Chen, Fengchu Liang, Siyuan Song, Jiawen Lei, Xingting Huang, Di Hu, Ling Tang, Pingyi Xu, l Zhi-Bing Lu · 2026 · Journal of Translational Medicine
- Expression, purification, and biophysical analysis of a part of the C-terminal domain of human hypoxia inducible factor-2α (HIF-2α)Aikaterini Diseri, George A. Stravodimos, Aikaterini I. Argyriou, Georgios A. Spyroulias, Demetres D. Leonidas, Panagiotis Liakos · 2024 · Biochemical and Biophysical Research Communications
- Pharmacological Properties of CDBT in Hypoxia-induced Neuronal Cell Injury and Their Underlying MechanismsSang-kyu Park, Eun-sun Jung, Ji-yoon Cha, Hyun-kyoung Cho, Ho-ryong Yoo, Yoon-sik Kim, In-Chan Seol · 2019 · The Journal of Internal Korean Medicine
- Brain Damage in Sleep-Disordered Breathing: The Role of the GliaIrina Filchenko, Л. С. Коростовцева, Бочкарев Михаил Викторович, Yu. V. Sviryaev · 2022 · Neuroscience and Behavioral Physiology
- HIF-1α-mediated mitochondrial-glycolytic reprogramming controls the transition of precursor to terminally exhausted T cellsHao Wu, Xiufeng Zhao, Sophia M. Hochrein, Miriam Eckstein, Gabriela Farias Gubert, Konrad Knöpper, Ana Maria Mansilla, Arman Öner, Rémi Doucet-Ladevèze, Werner Schmitz et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Long noncoding RNA H19 promotes leukocyte inflammation in ischaemic stroke by targeting the miR-29b/C1QTNF6 axisGuangwen Li, Xiaoqing Ma, Haiping Zhao, Junfen Fan, Tianwei Liu, Yumin Luo, Yunliang Guo · 2024
- TIM-3 blockade as a therapeutic approach for diffuse intrinsic pontine gliomaAusejo-Mauleón, I. (Iker) · 2023
- Investigating the impact of camel whey protein hydrolysate on cyp1a1 and keap1/nrf2 expression in hypoxic stress-affected liver tissue of Oreochromis niloticusAmany Abdel-Rahman Mohamed, Afaf A. Kishta, Elsayed M. Younis, Abdel‐Wahab A. Abdel‐Warith, Yasmina M. Abd‐Elhakim, Rowida E. Ibrahim, Mohamed M.M. Metwally, Tarek Khamis, Ali Osman, Simon J. Davies et al. · 2025 · Journal of Comparative Physiology B
- T-cell immunoglobulin and mucin-domain containing-3 orchestrates myeloid dysfunction across brain aging and diseaseBerta Segura‐Collar, Lucía Mondéjar-Ruescas, Carmen Jareño-Bonilla, Ricardo Gargini · 2026 · Neural Regeneration Research
- Hypoxia-inducible factor-1: A new neuroprotective agent for the treatment of hyperglycemia after strokeMaría Isabel Hernández, Jose Luis Zugaza, Abraham Martín · 2026 · Neural Regeneration Research
- Current advances and clinical perspectives of anti-angiogenic therapy combined with immune checkpoint inhibitors in digestive system malignanciesXiaoxuan Duan, Luqi Yan, Yingfei Wang, Xiaoshuo Dai, Chengjuan Zhang, Jing Lu · 2026 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- TIM3 alleviates microglia-mediated neuroinflammation in neuropathic pain by negatively regulating glycolysis-driven NLRP3 inflammasome activationJ R Jiang, Yeqi Li, Mengyu Zhang, Cui Yin, Zhi Qi, Jie Xu, Chen Lu · 2026 · Acta Biochimica et Biophysica Sinica
- The role of microglial Tim-3 in neuroinflammation and functional recovery after spinal cord injuryRenjie Ji, Yikun Fu, Fangjun Jiao, Mingkang Zhang, Cuiping Tian, Xiaonan Han, Liyan Yan, Hongwei Kou, Junmin Wang, Hongjian Liu et al. · 2026 · Frontiers in Neurology
- Astrocytes in Multiple Sclerosis: Getting to the CoreRachel A. Tinkey, Brandon C. Smith, Jessica Lynn Williams · 2026 · International Journal of Molecular Sciences
- Kaempferol attenuates microglial activation in Alzheimer's disease via inhibiting the cytosolic HK2-mediated NF-κB signaling pathwayMengyao Wang, Minsong Guo, Simeng Li, Liyu Song, Meihong Wu, Jiahui Zhao, Tengfei Xu, Yuan Zhou · 2026 · Phytomedicine
- The Role of Macrophages in the Immune Response to Peritoneal Infection with Dirofilaria immitis Larvae in the Mongolian Gerbil (Meriones unguiculatus)Elyssa J. Campbell, Catherine Pope, Katelin E. Greenway, Bridget C. Garner, Kaori Sakamoto, Andrew R. Moorhead · 2026 · Pathogens
- Prospects for treatment of cerebral ischemic stroke with Hydroxysafflower Yellow ABeibei Chen, Yuhan Zhang, Chengfang Zhai, Cungen Ma, Lijuan Song · 2026 · Pharmacology & Therapeutics