The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia

Koh, Han Seok, Chang, Chi Young, Jeon, Sae-Bom, Yoon, Hee Jung, Ahn, Ye-Hyeon, Kim, Hyung-Seok, Kim, In-Hoo, Jeon, Sung Ho +2 more·2015·Nature Communications

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Items 101–141 of 141

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    Chi‐An Chen, Yichen Huang, Jing-Jou Lo, Shih-Hung Wang, Shu‐Hung Huang, Sheng‐Hua Wu · 2021 · International Journal of Medical Sciences
  4. Tim-3 Deficiency Ameliorates Motor Deficits and Neuroinflammation in MPP+/MPTP-Induced Parkinson’s Disease Models via the NF-κB/NLRP3 Pathway
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  5. The lung-brain axis: elucidating the mechanisms of pulmonary-driven neurological disorders
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  6. Caveolin‐1 suppresses hippocampal neuron apoptosis via the regulation of HIF1α in hypoxia in naked mole‐rats
    Wenjing Yang, Wenqing Wu, Ying Zhao, Yu Li, Chengcai Zhang, Jingyuan Zhang, Chao Chen, Shufang Cui · 2022 · Cell Biology International
  7. Depletion of muscularis macrophages ameliorates inflammation-driven dysmotility in murine colitis model
    S. Ferenczi, F. Mogor, Peter Takacs, T. Kovács, V. Toth, Z. Varga, Krisztina J. Kovács, Z. Lohinai, Koppány Csaba Vass, Nandor Nagy et al. · 2023 · Scientific Reports
  8. Supervised latent factor modeling isolates cell-type-specific transcriptomic modules that underlie Alzheimer’s disease progression
    L. M. Hodgson, Yue Li, Yasser Iturria‐Medina, Jo Anne Stratton, Guy Wolf, Smita Krishnaswamy, David A. Bennett, Danilo Bzdok · 2024 · Communications Biology
  9. Promotion of a cancer-like phenotype, through chronic exposure to inflammatory cytokines and hypoxia in a bronchial epithelial cell line model
    Anne‐Marie Baird, Steven G. Gray, Derek J. Richard, Kenneth John O'Byrne · 2016 · Scientific Reports
  10. Recent perspectives on the early expression immunohistochemical markers in post-mortem recognition of myocardial infarction
    Radu Moldovan, Vlad Andrei Ichim, Vladimir Beliș · 2023 · Legal Medicine
  11. Iron Oxide Nanozyme as Reactive Oxygen and Nitrogen Species Scavenger to Regulate Microglial Homeostasis in Stroke
    Yilin Qi, Chunxiao Wang, Yuqing Miao, Jiamin Li, Zengyu Xun, Di Sun, Fei Xu, Minrui Liu, Heping Wang, Galong Li et al. · 2026 · Advanced Science
  12. Immune Checkpoint Inhibitors
    Paweł Kaliński, Per H. Basse · 2018 · Elsevier eBooks
  13. Spatial protein profiling reveals active roles for astrocytes in the chronic active lesion core during multiple sclerosis
    Brandon C. Smith, Anthony M. Chomyk, Maria L. Habean, Benjamin C. Shaw, Rachel A. Tinkey, Bruce D. Trapp, Jessica L. Williams · 2025 · Acta Neuropathologica
  14. Correlation between the condition of patients with acute cerebral infarction and serum β2-microglobulin levels
    Zhi-Guo Li, Xia Zhou · 2016 · Journal of Acute Disease
  15. Brain damage in sleep-disordered breathing: the role of glia
    Irina Filchenko, Л. С. Коростовцева, Бочкарев Михаил Викторович, Yu. V. Sviryaev · 2022 · S S Korsakov Journal of Neurology and Psychiatry
  16. Dual roles of ANGPTL4 in multiple inflammatory responses in stomatitis mice
    Miao-Miao Tian, Yishan Wang, Hong‐Bo Xiao · 2022 · Molecular Biology Reports
  17. Ozone Improves Oxygenation and Offers Organ Protection after Autologous Blood Transfusion in a Simulated Carbon Dioxide Pneumoperitoneal Environment in a Rabbit Hemorrhagic Shock Model
    Yu Gan, Xue Tian, Han Yao, Fei Huo, Yi Feng · 2023 · Transfusion Medicine and Hemotherapy
  18. Hypoxia-inducible Factor-1α Pathway in Cerebral Ischemia: From Molecular Mechanisms to Therapeutic Targets
    Veerta Sharma, Thakur Gurjeet Singh · 2024 · CNS & Neurological Disorders - Drug Targets
  19. Markers of T cell activation and exhaustion in plasma are associated with persistent symptoms up to 18 months following mild SARS-CoV-2 infection
    Thor Ueland, Rebecca Jane Cox, Annika Elisabet Michelsen, Elisabeth Berg Fjelltveit, Kari Otterdal, Tuva Børresdatter Dahl, Fan Zhou, Rebecca Elyanow, Pål Aukrust, Bjørn Blomberg et al. · 2025 · Frontiers in Immunology
  20. The role of coinhibitory receptor-expressing non-T cells in inflammation and immunity: unsung heroes or peripheral players?
    Chaimae Khaled, Mijin Kim, Booki Min · 2025 · Experimental & Molecular Medicine
  21. The hypoxic tumor microenvironment: Functional and metabolic reprogramming of key immune populations
    Amirhossein Faghih Ojaroodi, Samin Shokravi, Shabnam Eskandarzadeh, Armin Ghahremanzadeh, Fatemeh Alizadeh, Farinaz Amirikar, Golnaz Mobayen, Danial Mahrooghi, Masoud Lahouty, Karim Shamsasenjan et al. · 2026 · Pathology - Research and Practice
  22. Blocking of Tim‐3 Ameliorates Spinal Cord Ischemia‐Reperfusion Injury Through Inhibiting Neuroinflammation and Promoting M1‐to‐M2 Phenotypic Polarization of Microglia
    Zhenxing Li, Binbin Zhou, Guanghui Chen, Xiangyu Yang, Han Su, Bolin Li · 2024 · Immunity Inflammation and Disease
  23. Chronic developmental hypoxia alters rat lung immune cell transcriptomes during allergic airway inflammation
    Michelle Chu, Huanling Gao, Patricia Esparza, Abigail Pajulas, Jocelyn Wang, Rakshin P Kharwadkar, Hongyu Gao, Mark H. Kaplan, Robert S. Tepper · 2023 · Physiological Reports
  24. TIM3 attenuates morphine antinociceptive tolerance and microglial neuroinflammation by suppressing the TRAF6/NF-κB pathway in male mice
    Huan Yang, Tong Shen, Zhi Qi, Zhong Yang, Mengyu Zhang, Jinhong Jiang, Zhuo Ran Sun, Chen Lu · 2025 · Neuropharmacology
  25. Single-cell sequencing analysis and machine learning model reveal aberrant TIM-3 expression in microglia during Alzheimer’s disease progression
    Zongtang Xu, MinShan Chen, Fengchu Liang, Siyuan Song, Jiawen Lei, Xingting Huang, Di Hu, Ling Tang, Pingyi Xu, l Zhi-Bing Lu · 2026 · Journal of Translational Medicine
  26. Expression, purification, and biophysical analysis of a part of the C-terminal domain of human hypoxia inducible factor-2α (HIF-2α)
    Aikaterini Diseri, George A. Stravodimos, Aikaterini I. Argyriou, Georgios A. Spyroulias, Demetres D. Leonidas, Panagiotis Liakos · 2024 · Biochemical and Biophysical Research Communications
  27. Pharmacological Properties of CDBT in Hypoxia-induced Neuronal Cell Injury and Their Underlying Mechanisms
    Sang-kyu Park, Eun-sun Jung, Ji-yoon Cha, Hyun-kyoung Cho, Ho-ryong Yoo, Yoon-sik Kim, In-Chan Seol · 2019 · The Journal of Internal Korean Medicine
  28. Brain Damage in Sleep-Disordered Breathing: The Role of the Glia
    Irina Filchenko, Л. С. Коростовцева, Бочкарев Михаил Викторович, Yu. V. Sviryaev · 2022 · Neuroscience and Behavioral Physiology
  29. HIF-1α-mediated mitochondrial-glycolytic reprogramming controls the transition of precursor to terminally exhausted T cells
    Hao Wu, Xiufeng Zhao, Sophia M. Hochrein, Miriam Eckstein, Gabriela Farias Gubert, Konrad Knöpper, Ana Maria Mansilla, Arman Öner, Rémi Doucet-Ladevèze, Werner Schmitz et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  30. Long noncoding RNA H19 promotes leukocyte inflammation in ischaemic stroke by targeting the miR-29b/C1QTNF6 axis
    Guangwen Li, Xiaoqing Ma, Haiping Zhao, Junfen Fan, Tianwei Liu, Yumin Luo, Yunliang Guo · 2024
  31. TIM-3 blockade as a therapeutic approach for diffuse intrinsic pontine glioma
    Ausejo-Mauleón, I. (Iker) · 2023
  32. Investigating the impact of camel whey protein hydrolysate on cyp1a1 and keap1/nrf2 expression in hypoxic stress-affected liver tissue of Oreochromis niloticus
    Amany Abdel-Rahman Mohamed, Afaf A. Kishta, Elsayed M. Younis, Abdel‐Wahab A. Abdel‐Warith, Yasmina M. Abd‐Elhakim, Rowida E. Ibrahim, Mohamed M.M. Metwally, Tarek Khamis, Ali Osman, Simon J. Davies et al. · 2025 · Journal of Comparative Physiology B
  33. T-cell immunoglobulin and mucin-domain containing-3 orchestrates myeloid dysfunction across brain aging and disease
    Berta Segura‐Collar, Lucía Mondéjar-Ruescas, Carmen Jareño-Bonilla, Ricardo Gargini · 2026 · Neural Regeneration Research
  34. Hypoxia-inducible factor-1: A new neuroprotective agent for the treatment of hyperglycemia after stroke
    María Isabel Hernández, Jose Luis Zugaza, Abraham Martín · 2026 · Neural Regeneration Research
  35. Current advances and clinical perspectives of anti-angiogenic therapy combined with immune checkpoint inhibitors in digestive system malignancies
    Xiaoxuan Duan, Luqi Yan, Yingfei Wang, Xiaoshuo Dai, Chengjuan Zhang, Jing Lu · 2026 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  36. TIM3 alleviates microglia-mediated neuroinflammation in neuropathic pain by negatively regulating glycolysis-driven NLRP3 inflammasome activation
    J R Jiang, Yeqi Li, Mengyu Zhang, Cui Yin, Zhi Qi, Jie Xu, Chen Lu · 2026 · Acta Biochimica et Biophysica Sinica
  37. The role of microglial Tim-3 in neuroinflammation and functional recovery after spinal cord injury
    Renjie Ji, Yikun Fu, Fangjun Jiao, Mingkang Zhang, Cuiping Tian, Xiaonan Han, Liyan Yan, Hongwei Kou, Junmin Wang, Hongjian Liu et al. · 2026 · Frontiers in Neurology
  38. Astrocytes in Multiple Sclerosis: Getting to the Core
    Rachel A. Tinkey, Brandon C. Smith, Jessica Lynn Williams · 2026 · International Journal of Molecular Sciences
  39. Kaempferol attenuates microglial activation in Alzheimer's disease via inhibiting the cytosolic HK2-mediated NF-κB signaling pathway
    Mengyao Wang, Minsong Guo, Simeng Li, Liyu Song, Meihong Wu, Jiahui Zhao, Tengfei Xu, Yuan Zhou · 2026 · Phytomedicine
  40. The Role of Macrophages in the Immune Response to Peritoneal Infection with Dirofilaria immitis Larvae in the Mongolian Gerbil (Meriones unguiculatus)
    Elyssa J. Campbell, Catherine Pope, Katelin E. Greenway, Bridget C. Garner, Kaori Sakamoto, Andrew R. Moorhead · 2026 · Pathogens
  41. Prospects for treatment of cerebral ischemic stroke with Hydroxysafflower Yellow A
    Beibei Chen, Yuhan Zhang, Chengfang Zhai, Cungen Ma, Lijuan Song · 2026 · Pharmacology & Therapeutics