TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus
Matsuda, Taito, Murao, Naoya, Katano, Yuki, Juliandi, Berry, Kohyama, Jun, Akira, Shizuo, Kawai, Taro, Nakashima, Kinichi·2015·Nature Communications
Cited by (142)
Items 101–142 of 142
- The role of epigenetics in the pathophysiology of epilepsySung Min Nam, Kyung‐Ok Cho · 2016 · Elsevier eBooks
- Endonuclease VIII-like 1 deficiency impairs survival of newly generated hippocampal neurons and memory performance in young-adult male miceYi-Ying Kuo, Yu-Chi Lin, Marcus J. Calkins, Pei‐Chun Chen · 2020 · Life Sciences
- Upregulation of Cathepsin S Expression Contributes to Neuronal Damage Following Kainic Acid–Induced Status EpilepticusHsin‐Ling Shih, Kuan‐Hsiang Cheng, Chin‐Hao Chen, Jang‐Yang Chang, Kuei‐Sen Hsu · 2025 · Journal of Neurochemistry
- cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsyYige Huang, Li Fan, Man Ying Wong, Zhuofan Lei, Balaji Krishnamachary, Daphne Zhu, Mika P. Cadiz, Ravi Kumar Nagiri, Pearly Ye, Kendra Norman et al. · 2026 · Nature Neuroscience
- Motor, Cognitive, and Behavioral Impairment in TLR3 and TLR9 Deficient Male Mice: Insights into the Non-Immunological Roles of Toll-Like ReceptorsHéctor Vargas-Calderón, Emmanuel Ortega‐Robles, Luísa Rocha, Philipp Yu, Óscar Arias-Carrión · 2024 · Archives of Medical Research
- NS-Pten knockout mice exhibit sex and hippocampal subregion-specific increases in microglia/macrophage densityDavid A. Narvaiz, Katherine J Blandin, D. Gregory Sullens, Paige D. Womble, Jacob B. Pilcher, Grace O’Neill, Taylor A. Wiley, Eliesse M. Kwok, Srikhar V. Chilukuri, Joaquín N. Lugo · 2024 · Epilepsy Research
- Marked differences in the effects of levetiracetam and its analogue brivaracetam on microglial, astrocytic, and neuronal density in the rat model of kainic acid-induced temporal lobe epilepsyKrisztina Kelemen, Máté Sárosi, Ágnes Csüdör, Károly Orbán-Kis, Hanga Kelemen, László Bába, Zsolt Gáll, Eszter Horváth, István Katona, T Szilágyi · 2025 · Frontiers in Pharmacology
- Controversies and insights into cytokine regulation of neurogenesis and behavior in adult rodentsRodrigo Daniel Sepúlveda-Cuéllar, Diego Alberto Soria-Medina, Irma Cañedo-Solares, Fernando Gómez‐Chávez, Liliana Monserrat Molina-López, Yolanda Cruz, Dolores Correa · 2025 · Frontiers in Immunology
- Targeting Toll-like Receptors 7, 8, and 9 Inhibition in Systemic Lupus Erythematosus: Therapeutic Advance and Future DirectionsXue Song, Motahareh Asgari, Guo-Qiang Lin, Hong Liu, Jie‐Fei Cheng, Yong Nian, Chen-guo Feng · 2026 · Journal of Medicinal Chemistry
- The role of epigenetics in the pathophysiology of epilepsyKyung‐Ok Cho · 2024 · Elsevier eBooks
- Bacterial Lipopolysaccharide Post-Conditioning in The kainic acid animal model of Temporal Lobe epilepsyMateus Eduardo Herpich, Leonardo de Oliveira Guarnieri, Antônio Carlos Pinheiro de Oliveira, Márcio Flávio Dutra Moraes · 2024 · Epilepsy & Behavior
- Therapeutic and Prophylactic Effects of Amphotericin B Liposomes on Chronic Social Defeat Stress-Induced Behavioral Abnormalities in MiceJiashu Lu, Chao Huang, Qun Lu, Xu Lu · 2022 · Frontiers in Pharmacology
- Central Role of Toll-like Receptor-9 Gene Function in Inflammation-Mediated Neuronal Plasticity: Implications for Long-Term Memory DevelopmentMega Obukohwo Oyovwi, Victor Oghenekparobo Emojevwe, Benneth Ben‐Azu, Ejayeta Jeroh · 2025 · Molecular Neurobiology
- Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING PathwayC F Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, J ZHU, Xin Wang, 张凯华 et al. · 2026 · Advanced Science
- Structural Plasticity Induced by Adult NeurogenesisGregory W. Kirschen, Kurt A. Sailor, Shaoyu Ge · 2017 · Elsevier eBooks
- The involvement of microglial CX3CR1 in heat acclimation-induced amelioration of adult hippocampal neurogenesis impairment in EMF-exposed miceGenlin He, Ze-Ze Wang, Xueting Yu, Tingting Shen, Zhen Luo, Ping Li, Xue Gang Luo, Yulong Tan, Peng Gao, Xuesen Yang · 2021 · Brain Research Bulletin
- Granzyme A Participates in the Pathogenesis of Infection-Associated Acute EncephalopathyGaku Yamanaka, Shinichiro Morıchı, Tomoko Takamatsu, Ryou Takahashi, Yusuke Watanabe, Yu Ishida, Mika Takeshita, Natsumi Morishita, Akiko Kasuga, Kanako Kanou et al. · 2019 · Journal of Child Neurology
- Glia in Epilepsy: An OverviewAastha Dheer, Aparna Banerjee Dixit, Manjari Tripathi, P. Sarat Chandra, Jyotirmoy Banerjee · 2022 · Springer eBooks
- Nucleic acid sensing in the central nervous system: Implications for neural circuit development, function, and degenerationJacob M. Stillman, Tsuyoshi Kiniwa, Dorothy P. Schafer · 2024 · Immunological Reviews
- Glial changes in the dentate gyrus of neuronal-specific PTEN knockout mice correlate with changes in cell proliferationSarah E. Latchney, Anjali C Raheja, Brayan R. Ruiz Lopez, Paige D. Womble, Katherine J Blandin, Joaquín N. Lugo · 2025 · Journal of Neuroimmunology
- The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta‐Analysis of Public Transcriptional Profiling Data From the Hippocampus and CortexEva M Geoghegan, Megan Hastings Hagenauer, Erin Hernandez, Sophia Espinoza, Elizabeth I. Flandreau, Phi T. Nguyen, Adrienne N. Santiago, Mubashshir Ra'eed Bhuiyan, Sophie Mensch, Stanley J. Watson et al. · 2026 · Journal of Neurochemistry
- From comorbidity to continuum: Alzheimer’s disease and epilepsy are connected-now what?Suélen Santos Alves, Patrícia Regina Manzine, Fernanda Marcelia dos Santos, Mariane Martins Migliaccio, Laís de Carvalho Alves, Rui Milton Patrício da Silva-Júnior, Lina Vanessa Becerra-Hernández, Carlos Arturo González-Acosta, Efraín Buriticá, Márcia Regina Cominetti et al. · 2026 · Neuroscience & Biobehavioral Reviews
- From insult to hyperexcitability: pharmacological targeting of MyD88 and JAK/STAT3 pathways in epilepsyAhmed M Abdelaziz, Mohamed N Fawzy, Mohamed K. Fathy, Mustafa M Shokr · 2026 · Inflammopharmacology
- Microglia in Epilepsy: From Molecular Mechanism to Therapeutic StrategyYam Nath Paudel, Efthalia Angelopoulou, Sai Kulkarni, Robert E. Blair, Laxmikant S. Deshpande · 2026 · Cells
- A self-perpetuating neuron-intrinsic GSDMD–mtDNA–AIM2 inflammasome axis drives neuronal pyroptosis and cognitive impairment after traumatic brain injuryT Li, Siyu Huang, Junjun Zhang, Xueer Liu, Lihong Zhu, Y K Li, Runmin Lin, Xiaoxuan Chen, Kangsheng Li, W Chen et al. · 2026 · Frontiers in Immunology
- Bidirectional communication between the innate immune and nervous systems for homeostatic neurogenesis in the adult hippocampusTaito Matsuda, Kinichi Nakashima · 2015 · Neurogenesis
- Neurogenesis in Cancun: where science meets the seaJenny Hsieh, Chunli Zhang · 2016 · Development
- Do minocycline and other suppressors of microglia reactivity have a future in prevention or treatment of epilepsy?Władysław Lasoń, Joanna Ślusarczyk, Magdalena Regulska, Monika Leśkiewicz, Agnieszka Basta‐Kaim · 2017 · Journal of Epileptology
- 4:てんかん脳におけるミクログリアの役割Toshimitsu Hiragi, Yuji Ikegaya, Ryuta Koyama · 2019 · てんかん研究
- Faculty Opinions recommendation of Noninflammatory changes of microglia are sufficient to cause epilepsy.Long‐Jun Wu, Ukpong B. Eyo · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Inhibition of the TLR4/NF-κB inflammatory pathway decreases the microglia-mediated overpruning of synapses to ameliorate the mechanism underlying brain injury after epileptic seizuresQiong Wu, Hua Wang, Xueyan Liu, Yajuan Zhao, Xin Zhao, Peng Su, Jianing Miao · 2022 · Research Square
- Microglial P2Y12 Receptor Signaling Governs Epilepsy-Associated Neurogenesis via Bidirectional Regulation of Distinct Microglial SubpopulationsMingshu Mo, Juan Ling, Lan Wang, Huishan Deng, Yilin Su, Lijian Wei, Yuting Tang · 2025 · Research Square
- Direct Reprogramming of Microglia into NeuronsKanae Matsuda‐Ito, Eriko Hatai, Takashi Irie, Taito Matsuda, Kinichi Nakashima · 2025 · Methods in molecular biology
- Additional file 1 of Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in miceBai, Xue, Wang, Bing, Yiduo Cui, Tian, Siqi, Zhang, Yi, You, Linhao, Chang, Yan-Zhong, Ge Gao · 2024 · Figshare
- Mitochondrial fission as a target for supressing aberrant neuroplasticity and degeneration in the hippocampusД. Н. Воронков, Evgenia N. Fedorova, Anastasia K. Pavlova, Maria S. Ryabova, Anna V. Egorova, Alla V. Stavrovskaya, Потапов Иван Александрович, Vladimir S. Sukhorukov · 2025 · Annals of Clinical and Experimental Neurology
- Astrocyte–microglia IL-3–IL-3Rα signaling drives JAK2/STAT5-dependent neuroinflammation and neurodegeneration after status epilepticusLiu Xie, Lian Liu, Xutao Wang, Xiao Wang, B. He, Tiantian Wang, Honghao Xu, Zhilin Li, Shuisheng Lei, Xiaoqin Zhu · 2026 · Experimental Brain Research
- Microglial HMGB2 mediates neuroinflammation and brain damage in Cx3cr1-creERT2 epileptic mice through astrocyte-derived CCL2Xinru Li, Yiting Wang, Dandan Sheng, Jing Liu, Bibi Yazgulyyeva, Bo Xiao, Luo Zhou, Weiping Liu · 2026 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
- STING restrains calcium-dependent microglial phagocytosis and protects against neuronal loss and cognitive impairment during epileptogenesisYuka Kasahara, Hideyuki Nakashima, Satoshi Miyashita, Taichi Umeyama, Yasuhiro Nakano, Soichiro Kumamoto, Kazuhiko Kawata, Keisuke Imabayashi, Yoshihiro Baba, Koji Kobiyama et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- RNAセンサーを起点とした抗ウイルス自然免疫応答制御メカニズムの解析 : 平成26-28年度成果報告書太郎 河合 · 2017 · Institutional Repositories DataBase (IRDB)
- Increased mitochondrial volume in dentate hilar microglia after kainic acid-induced seizuresRiho Shigeta, Kazuma Miyata, Ari Ogaki, Rena Kono, Megumi Andoh, Ryuta Koyama · 2026 · Epilepsy & Seizure
- Tibial bone compression promotes recovery after brain injury through osteocyte PIEZO1Zhiqing Cai, Zhimin Zhang, Yuxin Wang, Shencai Liu, Jiarong Leng, Yun Chu, Jihang Liu, Yingying Fang, Bochong Chen, Wenquan Liang et al. · 2026 · Nature Neuroscience
- Toll-like receptor signaling modulates AMPA receptor trafficking in homeostatic synaptic downscalingAkira Koga, 貴志 周平, Shinji Matsuda · 2026 · The Journal of Physiological Sciences