APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma
Walker, Brian A., Wardell, Christopher P., Murison, Alex, Boyle, Eileen M., Begum, Dil B., Dahir, Nasrin M., Proszek, Paula Z., Melchor, Lorenzo +13 more·2015·Nature Communications
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Items 101–200 of 313
- APOBEC3: Friend or Foe in Human Papillomavirus Infection and Oncogenesis?Cody J. Warren, Mario L. Santiago, Dohun Pyeon · 2022 · Annual Review of Virology
- Reactivation of dormant anti-tumor immunity – a clinical perspective of therapeutic immune checkpoint modulationRichard Greil, Evelyn Hutterer, Tanja Nicole Hartmann, Lisa Pleyer · 2017 · Cell Communication and Signaling
- Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3BKe Shi, Özlem Demir, Michael A. Carpenter, Jeff Wagner, Kayo Kurahashi, Reuben S. Harris, Rommie E. Amaro, Hideki Aihara · 2017 · Scientific Reports
- Mate pair sequencing outperforms fluorescence in situ hybridization in the genomic characterization of multiple myelomaJames B. Smadbeck, Jess F. Peterson, Kathryn E. Pearce, Beth A. Pitel, Andrea Lebron Figueroa, Michael Timm, Dragan Jevremović, Min Shi, A. Keith Stewart, Esteban Braggio et al. · 2019 · Blood Cancer Journal
- The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road aheadMilaid Granadillo Rodríguez, Ben Flath, Linda Chelico · 2020 · Open Biology
- Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expressionNi Li, David C. Johnson, Niels Weinhold, James B. Studd, Giulia Orlando, Fabio Mirabella, Jonathan S. Mitchell, Tobias Meißner, Martin Kaiser, Hartmut Goldschmidt et al. · 2016 · Nature Communications
- Prognostic factors for multiple myeloma in the era of novel therapiesDimitrios C. Ziogas, Meletios Athanasios Dimopoulos, Efstathios Kastritis · 2018 · Expert Review of Hematology
- Landmark survival analysis and impact of anatomic site of origin in prospective clinical trials of biliary tract cancerMairead Geraldine McNamara, Andre Lopes, Harpreet Singh Wasan, David Malka, David Goldstein, Jenny Shannon, Takuji Okusaka, Jennifer Jane Knox, Dorothea Wagner, Thierry André et al. · 2020 · Journal of Hepatology
- Established and Novel Prognostic Biomarkers in Multiple MyelomaMark W. Bustoros, Tarek H. Mouhieddine, Alexandre Detappe, Irene M. Ghobrial · 2017 · American Society of Clinical Oncology Educational Book
- Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3BPieter A. Roelofs, Chai Yeen Goh, Boon Haow Chua, Matthew C. Jarvis, Teneale A. Stewart, Jennifer L. McCann, Rebecca M. McDougle, Michael A. Carpenter, John W.M. Martens, Paul N. Span et al. · 2020 · eLife
- The varied distribution and impact of RAS codon and other key DNA alterations across the translocation cyclin D subgroups in multiple myelomaCaleb K. Stein, Charlotte Pawlyn, Shweta S. Chavan, Leo Rasche, Niels Weinhold, Adam L. Corken, Amy F. Buros, Pieter Sonneveld, Graham Hunter Jackson, Ola Landgren et al. · 2017 · Oncotarget
- Reconstructing the evolutionary history of multiple myelomaFrancesco Maura, Even Holth Rustad, Eileen Mary Boyle, Gareth John Morgan · 2020 · Best Practice & Research Clinical Haematology
- Oncolytic Virotherapy as Promising Immunotherapy Against Cancer: Mechanisms of Resistance to Oncolytic VirusesNasser Hashemi Goradel, Arezoo Alizadeh, Shahnaz Hosseinzadeh, Mitra Taghipour, Zeinab Ghesmati, Arash Arashkia, Babak Negahdari · 2021 · Future Oncology
- Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomesBustoros, Mark, Anand, Shankara, Sklavenitis-Pistofidis, Romanos, Redd, Robert, Boyle, Eileen M., Zhitomirsky, Benny, Dunford, Andrew J., Tai, Yu-Tzu, Chavda, Selina J., Boehner, Cody et al. · 2022 · Nature Communications
- Genomic landscape of multiple myeloma and its precursor conditionsAlberge, Jean-Baptiste, Dutta, Ankit K., Poletti, Andrea, Coorens, Tim H. H., Lightbody, Elizabeth D., Toenges, Rosa, Loinaz, Xavi, Wallin, Sofia, Dunford, Andrew, Priebe, Oliver et al. · 2025 · Nature Genetics
- Current risk stratification and staging of multiple myeloma and related clonal plasma cell disordersSaurabh Zanwar, S. Vincent Rajkumar · 2025 · Leukemia
- Genomic Aberrations in Multiple MyelomaSalomon Manier, Karma Ziad Salem, Siobhan V. Glavey, Aldo Maria Roccaro, Irene M. Ghobrial · 2016 · Cancer treatment and research
- Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma CellsHiroyuki Yamazaki, Kotaro Shirakawa, Tadahiko Matsumoto, Shigeki Hirabayashi, Yasuhiro Murakawa, Masayuki Kobayashi, Anamaria Daniela Sarca, Yasuhiro Kazuma, Hiroyuki Matsui, Wataru Maruyama et al. · 2019 · Scientific Reports
- Aberrant BUB1 Overexpression Promotes Mitotic Segregation Errors and Chromosomal Instability in Multiple MyelomaYuto Fujibayashi, Reiko Isa, Daichi Nishiyama, Natsumi Sakamoto-Inada, Norichika Kawasumi, Junko Yamaguchi, Saeko Kuwahara‐Ota, Yayoi Matsumura‐Kimoto, Taku Tsukamoto, Yoshiaki Chinen et al. · 2020 · Cancers
- Metabolic Effects of Recurrent Genetic Aberrations in Multiple MyelomaTimon A. Bloedjes, Guus de Wilde, Jeroen E. J. Guikema · 2021 · Cancers
- Utilizing next-generation sequencing in the management of multiple myelomaMarta Lionetti, Antonino Neri · 2017 · Expert Review of Molecular Diagnostics
- Germline APOBEC3B deletion increases somatic hypermutation in Asian breast cancer that is associated with Her2 subtype, PIK3CA mutations and immune activationJia Wern Pan, Muhammad Mamduh Ahmad Zabidi, Boon‐Keat Chong, Mei‐Yee Meng, Pei-Sze Ng, Siti Norhidayu Hasan, Bethan Sandey, Saira Bahnu, Pathmanathan Rajadurai, Cheng Har Yip et al. · 2021 · International Journal of Cancer
- Activation induced cytidine deaminase: An old friend with new facesElif Çakan, Gürcan Günaydın · 2022 · Frontiers in Immunology
- Genomic and immune determinants of resistance to daratumumab-based therapy in relapsed refractory multiple myelomaBachisio Ziccheddu, Claudia Giannotta, Mattia D’Agostino, Giuseppe Bertuglia, Elona Saraci, Stefania Oliva, Elisa Genuardi, Marios Papadimitriou, Benjamin T. Diamond, Paolo Corradini et al. · 2024 · Blood Cancer Journal
- Neutral tumor evolution in myeloma is associated with poor prognosisDavid C. Johnson, Oleg Lenive, Jonathan S. Mitchell, Graham Hunter Jackson, Roger G. Owen, Mark Trehane Drayson, Gordon Cook, John R Jones, Charlotte Pawlyn, Faith E. Davies et al. · 2017 · Blood
- Treatment Strategies Considering Micro-Environment and Clonal Evolution in Multiple MyelomaKazuhito Suzuki, Kaichi Nishiwaki, Shingo Yano · 2021 · Cancers
- APOBEC and Cancer Viroimmunotherapy: Thinking the UnthinkableRichard G. Vile, Alan A. Melcher, Hardev Pandha, Kevin Joseph Harrington, José S. Pulido · 2021 · Clinical Cancer Research
- Structure-Based Design of First-Generation Small Molecule Inhibitors Targeting the Catalytic Pockets of AID, APOBEC3A, and APOBEC3BJustin J. King, Faezeh Borzooee, Junbum Im, Mahdi Asgharpour, Atefeh Ghorbani, Cody P. Diamond, Heather Fifield, Lesley Berghuis, Mani Larijani · 2021 · ACS Pharmacology & Translational Science
- Emerging options in multiple myeloma: targeted, immune, and epigenetic therapiesShaji Kunnathu Kumar · 2017 · Hematology
- Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapyTimothy J. Kottke, Jason M. Tonne, Laura Evgin, Christopher B. Driscoll, Jacob P. van Vloten, Victoria A. Jennings, Amanda L. Huff, Brady N. Zell, Jill Thompson, Phonphimon Wongthida et al. · 2021 · Nature Communications
- m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesisMing Gao, Zijuan Qi, Wenya Feng, Hongyang Huang, Zhijie Xu, Zheng Dong, Ming Xu, Jinxiang Han, Jake A. Kloeber, Jinzhou Huang et al. · 2022 · Journal of Biological Chemistry
- Review of Multiple Myeloma Genetics including Effects on Prognosis, Response to Treatment, and Diagnostic WorkupJulia Erin Wiedmeier, Peter Leif Bergsagel · 2022 · Life
- Potent high-avidity neutralizing antibodies and T cell responses after COVID-19 vaccination in individuals with B cell lymphoma and multiple myelomaAndrea Keppler‐Hafkemeyer, Christine Greil, Paul R. Wratil, Khalid Shoumariyeh, Marcel Stern, Annika Hafkemeyer, Driti Ashok, Alexandra Hollaus, Gaia Lupoli, Alina Priller et al. · 2022 · Nature Cancer
- Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylationTadahiko Matsumoto, Kotaro Shirakawa, Masaru Yokoyama, Hirofumi Fukuda, Anamaria Daniela Sarca, Sukenao Koyabu, Hiroyuki Yamazaki, Yasuhiro Kazuma, Hiroyuki Matsui, Wataru Maruyama et al. · 2019 · Scientific Reports
- Designing Evolutionary-based Interception Strategies to Block the Transition from Precursor Phases to Multiple MyelomaFrancesco Maura, Ola Landgren, Gareth John Morgan · 2020 · Clinical Cancer Research
- Young Myeloma Patients: A Systematic Review of Manifestations and OutcomesMégane Tanguay, Christophe Dagenais, Richard LeBlanc, Imran Ahmad, Jean‐Sébastien Claveau, Jean Roy · 2023 · Current Oncology
- Understanding DNA Damage Response and DNA Repair in Multiple MyelomaCole Petrilla, Joshua Galloway, Ruchi Kudalkar, Aya Ismael, Francesca Cottini · 2023 · Cancers
- Multiple Myeloma Genomics: A Systematic ReviewCasey J. Weaver, Joseph D Tariman · 2017 · Seminars in Oncology Nursing
- A Journey Through Myeloma Evolution: From the Normal Plasma Cell to Disease ComplexityMatteo Da Vià, Bachisio Ziccheddu, Akihiro Maeda, Filippo Bagnoli, Giulia Perrone, Niccolò Bolli · 2020 · HemaSphere
- APOBEC3 Mediates Resistance to Oncolytic Viral TherapyAmanda L. Huff, Phonphimon Wongthida, Timothy J. Kottke, Jill Thompson, Christopher B. Driscoll, Matthew R. Schuelke, Kevin G. Shim, Reuben S. Harris, Amy M. Molan, José S. Pulido et al. · 2018 · Molecular Therapy — Oncolytics
- The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1Jennifer L. McCann, Madeline M. Klein, Evelyn M. Leland, Emily K. Law, William L. Brown, Daniel J. Salamango, Reuben S. Harris · 2019 · Journal of Biological Chemistry
- Drug Targeting of Genomic Instability in Multiple MyelomaMeral Beksaç, Sevinç Ballı, Dilara Akcora Yildiz · 2020 · Frontiers in Genetics
- Clonal Evolution of Multiple Myeloma—Clinical and Diagnostic ImplicationsAleksander Salomon‐Perzyński, Krzysztof Jamroziak, Eliza Głodkowska‐Mrówka · 2021 · Diagnostics
- Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple MyelomaParvathi Sudha, Aarif Ahsan, Cody Ashby, Tasneem Kausar, Akhil Khera, Mohammad H. Kazeroun, Chih-Chao Hsu, Lin Wang, Evelyn Fitzsimons, Outi Salminen et al. · 2022 · Clinical Cancer Research
- Germline Risk Contribution to Genomic Instability in Multiple MyelomaSiegfried Janz, Fenghuang Zhan, Fumou Sun, Yan Cheng, Michael D. Pisano, Ye Yang, Hartmut Goldschmidt, Parameswaran Hari · 2019 · Frontiers in Genetics
- Myc-Related Mitochondrial Activity as a Novel Target for Multiple MyelomaAlejandra Ortiz-Ruiz, Yanira Ruiz‐Heredia, María Luz Morales, Pedro Aguilar-Garrido, Almudena García-Ortiz, Antonio Valeri, Carmen Bárcena, Rosa García-Martín, Vanesa Garrido, Laura Moreno et al. · 2021 · Cancers
- Deciphering response dynamics and treatment resistance from circulating tumor DNA after CAR T-cells in multiple myelomaHitomi Hosoya, Mia A. Carleton, Kailee L. Tanaka, Brian J. Sworder, Shriya Syal, Bita Sahaf, Alisha M. Birk, Oscar Silva, Henning Stehr, Vanna N. Hovanky et al. · 2025 · Nature Communications
- Guidelines for the testing and reporting of cytogenetic results for risk stratification of multiple myeloma: a report of the Cancer Genomics Consortium Plasma Cell Neoplasm Working GroupXinyan Lu, Erica Andersen, Rahul Kumar Banerjee, Celeste Eno, Patrick R. Gonzales, Shaji Kunnathu Kumar, Angela M. Lager, Patricia Minehart Miron, Trevor J. Pugh, Fabiola Quintero‐Rivera et al. · 2025 · Blood Cancer Journal
- Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer PolymorphismLi Ni, David C. Johnson, Niels Weinhold, Scott T. Kimber, Sara E. Dobbins, Jonathan S. Mitchell, Ben Kinnersley, Amit Sud, Philip Law, Giulia Orlando et al. · 2017 · Cell Reports
- MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21Cip1Anna Huo-Chang Mei, Kaity Han-Yung Tung, Jessie Han, Deepak Perumal, Alessandro Laganà, Jonathan J. Keats, Daniel Auclair, Ajai Chari, Sundar Jagannath, Samir Sunil Parekh et al. · 2020 · Oncotarget
- Structure-Guided Design of a Potent and Specific Inhibitor against the Genomic Mutator APOBEC3AJuan Carlos Serrano, Dora von Trentini, Kiara N. Berríos, Aleksia Barka, Ivan J. Dmochowski, Rahul M. Kohli · 2022 · ACS Chemical Biology
- Old and Young Actors Playing Novel Roles in the Drama of Multiple Myeloma Bone Marrow Microenvironment Dependent Drug ResistanceSabrina Manni, Marilena Carrino, Gianpietro Semenzato, Francesco Piazza · 2018 · International Journal of Molecular Sciences
- Directly targeting c-Myc contributes to the anti-multiple myeloma effect of anlotinibYang Cao, Huizhuang Shan, Meng Liu, Jia Liu, Zilu Zhang, Xiaoguang Xu, Yue Liu, Hanzhang Xu, Hu Lei, Miao Yu et al. · 2021 · Cell Death and Disease
- Plasma cell myeloma: role of histopathology, immunophenotyping, and genetic testingMegan J. Fitzpatrick, Valentina Nardi, Aliyah R. Sohani · 2021 · Skeletal Radiology
- Suboptimal T-cell Therapy Drives a Tumor Cell Mutator Phenotype That Promotes Escape from First-Line TreatmentLaura Evgin, Amanda L. Huff, Timothy J. Kottke, Jill Thompson, Amy M. Molan, Christopher B. Driscoll, Matthew R. Schuelke, Kevin G. Shim, Phonphimon Wongthida, Elizabeth J. Ilett et al. · 2019 · Cancer Immunology Research
- Molecular Pathogenesis of Multiple MyelomaMaura, Francesco, Bergsagel, Peter Leif · 2024 · Hematology/Oncology Clinics of North America
- The genetic landscape of 5T models for multiple myelomaKen Maes, Bram Boeckx, Philip Vlummens, Kim De Veirman, Eline Menu, Karin Vanderkerken, Diether Lambrechts, Elke De Bruyne · 2018 · Scientific Reports
- Where We Stand With Precision Therapeutics in Myeloma: Prosperity, Promises, and PipedreamsDarren Pan, Joshua Ryan Richter · 2022 · Frontiers in Oncology
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- Aberrant APOBEC3C expression induces characteristic genomic instability in pancreatic ductal adenocarcinomaYunzhen Qian, Yitao Gong, Xuan Zou, Yu Liu, Yusheng Chen, Ruijie Wang, Zhengjie Dai, Yesiboli Tasiheng, Xuan Lin, Xu Wang et al. · 2022 · Oncogenesis
- The FGF/FGFR/c-Myc axis as a promising therapeutic target in multiple myelomaArianna Giacomini, Sara Taranto, Giorgia Gazzaroli, Jessica Faletti, Davide Capoferri, Raffaella Marcheselli, Margherita Sciumé, Marco Presta, Antonio Sacco, Aldo Maria Roccaro · 2024 · Journal of Experimental & Clinical Cancer Research
- Targeting transcription factors in multiple myeloma: evolving therapeutic strategiesShirong Li, Sonia Vallet, Antonio Sacco, Aldo Maria Roccaro, Suzanne Lentzsch, Klaus Podar · 2019 · Expert Opinion on Investigational Drugs
- Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genesMolly Went, Ben Kinnersley, Amit Sud, David C. Johnson, Niels Weinhold, Asta Försti, Mark van Duin, Giulia Orlando, Jonathan S. Mitchell, Rowan Kuiper et al. · 2019 · Human Genomics
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- APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expressionHiroyuki Yamazaki, Kotaro Shirakawa, Tadahiko Matsumoto, Yasuhiro Kazuma, Hiroyuki Matsui, Yoshihito Horisawa, Emani Stanford, Anamaria Daniela Sarca, Ryutaro Shirakawa, Keisuke Shindo et al. · 2020 · PLoS ONE
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- Identification of key genes and construction of microRNA–mRNA regulatory networks in multiple myeloma by integrated multiple GEO datasets using bioinformatics analysisHongyu Gao, Huihan Wang, Wei Yang · 2017 · International Journal of Hematology
- Mutational load in carotid body tumorAnna V. Kudryavtseva, Elena Lukyanova, Dmitry Valerievich Kalinin, Andrew R. Zaretsky, Anatoly V. Pokrovsky, Alexander Leonidovich Golovyuk, Maria Fedorova, Elena A. Pudova, Sergey Kharitonov, Vladislav Pavlov et al. · 2019 · BMC Medical Genomics
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- Clinical Outcome-Related Cancer Pathways and Mutational Signatures in Patients With Unresectable Esophageal Squamous Cell Carcinoma Treated With ChemoradiotherapyLi Li, Jujie Sun, Ning Liu, Ruoying Yu, Junli Zhang, Jiaohui Pang, Qiuxiang Ou, Ying Yin, Jinfeng Cui, Xuling Yao et al. · 2022 · International Journal of Radiation Oncology*Biology*Physics
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- Determinants of Oligonucleotide Selectivity of APOBEC3BJeffrey Wagner, Özlem Demir, Michael A. Carpenter, Hideki Aihara, Daniel A. Harki, Reuben S. Harris, Rommie E. Amaro · 2018 · Journal of Chemical Information and Modeling
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- IgH translocation with undefined partners is associated with superior outcome in multiple myeloma patientsXuehan Mao, Junling Zhuang, Duoduo Zhao, Xiaoqing Li, Xin Du, Mu Hao, Yan Xu, Yuting Yan, Jiahui Liu, Huishou Fan et al. · 2020 · European Journal Of Haematology
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