Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation.

Cheng, Jingdong, Yang, Huirong, Fang, Jian, Ma, Lixiang, Gong, Rui, Wang, Ping, Li, Ze, Xu, Yanhui·2015·Nature Communications

Cited by (165)

Items 101–165 of 165

  1. Expanding the ubiquitin code in pancreatic cancer
    Wenyan Yang, Shiqun Wang, Shengqiang Tong, Weidong Zhang, Jiang‐Jiang Qin · 2023 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  2. Insights into Conformational Dynamics and Allostery in DNMT1-H3Ub/USP7 Interactions
    Yu Zhu, Fei Ye, Ziyun Zhou, Wanlin Liu, Zhongjie T. Liang, Guang Hu · 2021 · Molecules
  3. Selective USP7 Inhibition Synergizes with MEK1/2 Inhibitor to Enhance Immune Responses and Potentiate Anti–PD-1 Therapy in NRAS-Mutant Melanoma
    Liya Su, Dinghao Wang, Timothy J. Purwin, Sophia Ran, Qi Yang, Qingrun Zhang, Weijia Cai · 2025 · Journal of Investigative Dermatology
  4. ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation
    Junpeng Meng, Hongkun Cai, Yan Sun, Shuang Wen, Heshui Wu, Dianyun Ren · 2022 · Cellular Oncology
  5. USP7 reduces the level of nuclear DICER , impairing DNA damage response and promoting cancer progression
    Xiaojia Liu, Runhui Lu, Qianqian Yang, Jianfeng He, Caihu Huang, Yingting Cao, Zihan Zhou, Jiayi Huang, Lian Li, Ran Chen et al. · 2023 · Molecular Oncology
  6. Consensus docking aid to model the activity of an inhibitor of DNA methyltransferase 1 inspired by de novo design
    Diana L. Prado‐Romero, Alejandro Gómez‐García, Raziel Cedillo-González, Hassan Villegas-Quintero, Juan F. Avellaneda-Tamayo, Edgar López‐López, Fernanda I. Saldívar‐González, Ana L. Chávez‐Hernández, José L. Medina‐Franco · 2023 · Frontiers in Drug Discovery
  7. Role of protein-protein interactions in allosteric drug design for DNA methyltransferases
    Zhongjie T. Liang, Yu Zhu, Xingyi Liu, Guang Hu · 2020 · Advances in protein chemistry and structural biology
  8. Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1
    Norimasa Iwanami, Kohei Takeshita, Divine-Fondzenyuy Lawir, Isao Suetake, Shoji Tajima, Katarzyna Sikora, Inês Trancoso, Connor P. O’Meara, Iliana Siamishi, Yousuke Takahama et al. · 2020 · iScience
  9. Acetylated DNMT1 Downregulation and Related Regulatory Factors Influence Metastatic Melanoma Patients Survival
    Xiaoqing Zhang, Matias Alberto Bustos, Yoshiaki Shoji, Romela Irene Ramos, Yuuki Iida, Rebecca Gentry, Teh‐Ling Takeshima, Dave S.�B. Hoon · 2021 · Cancers
  10. Quantitative analysis of USP activity in vitro
    Shreya Dharadhar, Robbert Q. Kim, Michael Uckelmann, Titia K. Sixma · 2019 · Methods in enzymology on CD-ROM/Methods in enzymology
  11. The role of USP7 in the Shoc2-ERK1/2 signaling axis and Noonan-like syndrome with loose anagen hair
    Patricia G. Wilson, Lina G. Abdelmoti, Rebecca G. Norcross, Eun Ryoung Jang, Malathy Palayam, Emilia Galperin · 2021 · Journal of Cell Science
  12. Therapeutic inhibition of USP7 promotes antitumor immune responses
    Angelika Muchowicz, Katarzyna Głuchowska, Marcin Mikołaj Grzybowski, Małgorzata Szostakowska-Rodzoś, Tomasz Piotr Rejczak, Agnieszka Belczyk-Ciesielska, Mieszko M. Wilk, Agnieszka Kikulska, Patrycja Marzęta-Assas, Agnieszka Zagożdżon et al. · 2025 · Journal for ImmunoTherapy of Cancer
  13. Ubiquitin-Specific-Processing Protease 7 Regulates Female Germline Stem Cell Self-Renewal Through DNA Methylation
    Yongqiang Zhao, Xiaoyong Li, Geng G. Tian, Xinyan Zhao, Jiemin Wong, Yue Shen, Ji Wu · 2020 · Stem Cell Reviews and Reports
  14. Common mechanisms cannot explain time- and dose-dependent DNA methylation changes in earthworms exposed to cadmium
    Gerhard P. Aigner, Verena Pittl, Birgit Fiechtner, Bernhard Egger, Maja Šrut, Martina Höckner · 2021 · The Science of The Total Environment
  15. Elastic network models and molecular dynamic simulations reveal the molecular basis of allosteric regulation in ubiquitin-specific protease 7 (USP7)
    Jing Xu, Yiran Wang, Jiali Zhang, Amr Abbas Abdelmoneim, Zhongjie T. Liang, Lei Wang, Jia Jin, Qi Dai, Fei Ye · 2023 · Computers in Biology and Medicine
  16. Novel insights on post-translational modifications of nucleic acid methylation proteins in hepatic fibrosis
    Wenjie Sun, Minghui Li, Yang Yang, Qi-Qi Dong, Hui Tao, Chao Lu, H. J. Yang · 2025 · Pharmacological Research
  17. USP7 at the Crossroads of Ubiquitin Signaling, Cell Cycle, and Tumorigenesis
    Matteo Lusardi, Federica Rapetti, Andrea Spallarossa, Marta Massone, Elena Cichero, Chiara Brullo · 2025 · Molecules
  18. Intermittent ketogenic diet promotes Treg differentiation and alleviates Crohn’s disease via the β-hydroxybutyrate driven AHCY–DNMT1–Foxp3 axis
    Shaoqi Cheng, Chao Cheng, Chuanjiang Huang, Cuixia Liu, Feng Xun, Wenliang Jiang, Jie Zhao, Honggang Wang · 2026 · Journal of Crohn s and Colitis
  19. Ubiquitin signaling in pancreatic ductal adenocarcinoma
    Shengnan Lv, Jian Zhang, Xinyu Peng, Huan Liu, Yan Liu, Feng Wei · 2023 · Frontiers in Molecular Biosciences
  20. Nucleosomes specify co-factor access to p53
    Deyasini Chakraborty, Colby R. Sandate, Luke Isbel, Georg Kempf, Joscha Weiss, Simone Cavadini, Lukas Kater, Jan Seebacher, Zuzanna Kozicka, Lisa Stoos et al. · 2025 · Molecular Cell
  21. Functional spectrum of USP7 pathogenic variants in Hao–Fountain syndrome: Insights into the enzyme’s activity, stability, and allosteric modulation
    Emilie J. Korchak, Mona Sharafi, Isabella Jaen Maisonet, Andres F. Salazar‐Chaparro, Irina V. Semenova, Hamza Khan, Alison O’Neil, Pilar Caro, Christian P. Schaaf, Sara J. Buhrlage et al. · 2025 · Proceedings of the National Academy of Sciences
  22. The Molecular Basis of DNA Methylation
    Isao Suetake, Mikio Watanebe, Kohei Takeshita, Saori Takahashi, Peter Mark Carlton · 2017 · Cancer drug discovery and develogment/Cancer drug discovery and development
  23. Uncovering the acetylation sites of Dnmt3L that regulate protein stability and differentiation potency in embryonic stem cells
    Yun Ji Nam, Hyungu Kwon, Hyun Jun Im, Naimur Rahman, Humaira Lubna, S.-Y. Lee, Hee‐Sung Ahn, Gayoung Jang, YongHwan Kim, Hyein Ju et al. · 2026 · Experimental & Molecular Medicine
  24. Histone deacetylases in the regulation of cell death and survival mechanisms in resistant BRAF-mutant cancers
    Bernhard Biersack, Bianca Nitzsche, Michael Höpfner · 2025 · Cancer Drug Resistance
  25. Structures of USP7 in active and inactive states bound to DNMT1 revealed by cryo-EM
    Nao Nakamura, Sae Yoshimi, Amika Kikuchi, Hiroki Onoda, Satomi Kori, Makoto Nakanishi, Atsuya Nishiyama, Kyohei Arita · 2025 · Structure
  26. Monoclonal Antibody-Based Treatment and Other New Agents for B-Lineage Acute Lymphoblastic Leukemia
    John C. Molina, Nirali N. Shah · 2022 · Springer eBooks
  27. HAUSP Is a Key Epigenetic Regulator of the Chromatin Effector Proteins
    Omeima Abdullah, Mahmoud Alhosin · 2021 · Genes
  28. Study on the mechanism of USP7 promoting endometriosis by regulating DNMT1 deubiquitination level
    Xiangming Gao, Li Liu, Xueqin Liu, Yanru Shen, Yang Fan · 2025 · Biochemistry and Cell Biology
  29. Recent Progress of Ubiquitin-Specific-Processing Protease 7 Inhibitors
    L. Chi, Hexiao Wang, F. Yu, C. Gao, H. Dai, Xi. Si, Lifang Liu, Zongyue Wang, Jun-Hui Zheng, Y. Ke et al. · 2023 · Russian Journal of Bioorganic Chemistry
  30. Deubiquitylase ubiquitin-specific protease 7 plays a crucial role in the lineage differentiation of preimplantation blastocysts
    Tong Yu, Xinyi Zhao, Yujie Tang, Yingbing Zhang, Bozhen Ji, Weijia Song, Jianmin Su · 2024 · Biology of Reproduction
  31. Quantitative analysis of acetylation in peste des petits ruminants virus-infected Vero cells
    Xuelian Meng, Xiangwei Wang, Xueliang Zhu, Rui Zhang, Zhidong Zhang, Yuefeng Sun · 2023 · Virology Journal
  32. Structural Biology of Epigenetic Targets: Exploiting Complexity
    Martin Marek, Tajith Baba Shaik, Christophe Romier · 2019 · Methods and principles in medicinal chemistry
  33. USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion
    Giulio Collotta, Maurizio Gatti, Irina-Maria Ungureanu, Vanessa van Ackeren, Emilie Rannou, Francesca Vivalda, Diego Gomez Vieito, Keri M. Fishwick, Christine von Aesch, Antônio Porro et al. · 2026 · Nature Communications
  34. From AlphaFold to site-selective inhibition of DNA methylation in glioblastoma multiforme
    Jean-Maxime Besson, Alain Chavanieu, Arulraj Nadaradjane, Pierre‐François Cartron, Marie Lopez · 2026 · RSC Medicinal Chemistry
  35. Honey activity on the proliferation and migration of oral squamous cell carcinoma: In vitro and bioinformatic analysis
    Macedo Sobrinho Santos Eliane, Hércules Otacílio Santos, Rezende Sá Miranda Gonçalves Juliana, Anna Christina de Almeida, Igor Viana Brandi, Sander Rodrigues Cangussu Alex, Nunes Alves Janainne, Ferreira de Jesus Sabrina, Jardim Neiva Ricardo, de Souza Costa Kattyanne et al. · 2018 · Scientific Research and Essays
  36. Papel de SLU7 en la regulación epigenética de la expresión génica: control de la estabilidad de DNMT1 y la metilación del DNA
    Miriam Recalde · 2022
  37. Mechanisms of USP7/MAGEL2 Complex Assembly and Its Mutational Disruption in Neurodevelopmental Diseases
    Emilie J. Korchak, Gabriela Soriano, Irina Semenova, Bing Hao, Denis Štepihar, Tara Bayat, Klementina Fon Tacer, Irina Bezsonova · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  38. Structural Insight into the Mechanisms of Activation and Substrate Specificity of Human Deubiquitinating Enzyme USP7
    Alexandra Pozhidaeva · 2016 · OpenCommons at University of Connecticut (University of Connecticut)
  39. Chromatin affinity purification coupled with mass spectrometry indetifies novel histone ubiquitylation interactors
    Stefan-Sebastian David · 2018
  40. DNA ‐modifying Enzymes
    Martin Roatsch, Dina Robaa, Michael Lübbert, Wolfgang Sippl, Manfred Jung · 2019 · Methods and principles in medicinal chemistry
  41. Faculty Opinions recommendation of Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation.
    Anne D. Donaldson, Qianqian Dong · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  42. A commentary on “FAM135B sustains the reservoir of Tip60‐ATM assembly to promote DNA damage response”
    Matias Alberto Bustos, Yuta Kobayashi, Dave S.�B. Hoon · 2022 · Clinical and Translational Discovery
  43. Structural Plasticity Guides Functional Versatility of USP7 in Human Diseases: Mechanistic Insights and Therapeutic Targeting
    Xuanyu Xu, 张乃霞, Li Shi · 2025 · Health and Metabolism
  44. Additional file 4 of Quantitative analysis of acetylation in peste des petits ruminants virus-infected Vero cells
    Meng, Xuelian, Xiangwei Wang, Zhu, Xueliang, Zhang, Rui, Zhang, Zhidong, Sun YueFeng · 2024 · Figshare
  45. Additional file 5 of Quantitative analysis of acetylation in peste des petits ruminants virus-infected Vero cells
    Meng, Xuelian, Xiangwei Wang, Zhu, Xueliang, Zhang, Rui, Zhang, Zhidong, Sun YueFeng · 2024 · Figshare
  46. Additional file 2 of Quantitative analysis of acetylation in peste des petits ruminants virus-infected Vero cells
    Meng, Xuelian, Xiangwei Wang, Zhu, Xueliang, Zhang, Rui, Zhang, Zhidong, Sun YueFeng · 2024 · Figshare
  47. Additional file 1 of Quantitative analysis of acetylation in peste des petits ruminants virus-infected Vero cells
    Meng, Xuelian, Xiangwei Wang, Zhu, Xueliang, Zhang, Rui, Zhang, Zhidong, Sun YueFeng · 2024 · Figshare
  48. Additional file 7 of Quantitative analysis of acetylation in peste des petits ruminants virus-infected Vero cells
    Meng, Xuelian, Xiangwei Wang, Zhu, Xueliang, Zhang, Rui, Zhidong Zhang, Sun YueFeng · 2024 · Figshare
  49. Additional file 3 of Quantitative analysis of acetylation in peste des petits ruminants virus-infected Vero cells
    Meng, Xuelian, Xiangwei Wang, Zhu, Xueliang, Zhang, Rui, Zhang, Zhidong, Sun YueFeng · 2024 · Figshare
  50. Additional file 2 of E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1
    Zhang, Nannan, Gao, Xiaoliang, Yuan, Qiangqiang, Fu, Xin, Pengliang Wang, Cai, Fenglin, Liu, Hui, Zhang, Jing, Liang, Han, Nie, Yongzhan et al. · 2023 · Figshare
  51. Additional file 3 of E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1
    Zhang, Nannan, Gao, Xiaoliang, Yuan, Qiangqiang, Fu, Xin, Pengliang Wang, Cai, Fenglin, Liu, Hui, Zhang, Jing, Liang, Han, Nie, Yongzhan et al. · 2023 · Figshare
  52. Additional file 1 of E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1
    Zhang, Nannan, Gao, Xiaoliang, Yuan, Qiangqiang, Fu, Xin, Pengliang Wang, Cai, Fenglin, Liu, Hui, Zhang, Jing, Liang, Han, Nie, Yongzhan et al. · 2023 · Figshare
  53. Additional file 6 of Quantitative analysis of acetylation in peste des petits ruminants virus-infected Vero cells
    Meng, Xuelian, Xiangwei Wang, Zhu, Xueliang, Zhang, Rui, Zhidong Zhang, Sun YueFeng · 2024 · Figshare
  54. The molecular mechanisms regulating PAF15 chromatin association
    Ryota Miyashita · 2023 · Institutional Repositories DataBase (IRDB)
  55. UHRF1 inhibitors targeting the epigenetic patterns in cancer cells
    Liliyana Zaayter · 2018 · theses.fr (ABES)
  56. Méthylation de l'ADN : fonctions et ciblage au cours du développement chez la souris
    Thomas Dahlet · 2019 · theses.fr (ABES)
  57. Interaction mechanisms of epigenetic integrator UHRF1 with TIP60 acetyltransferase
    Waseem Ashraf · 2018 · theses.fr (ABES)
  58. Inhibition of UHRF1 protein by epigenetic partners and epi-drugs
    Tanveer Ahmad · 2019 · theses.fr (ABES)
  59. Epigenome deregulation in Epstein Barr virus-induced oncogenic B cell transformation
    Francesca Manara · 2023 · theses.fr (ABES)
  60. A role of protein conformational dynamics in mammalian DNA methylation
    Jikui Song · 2026 · Structural Dynamics
  61. Disease-Associated Mutations Impact DNA Methyltransferase 1 Function through Dynamic Allosteric Effects and Solvent Exposure
    Song Xie, Can Bora Yildiz, Paolo Ruggerone, Ke Zuo, Geraldine Zimmer‐Bensch, Paolo Carloni · 2026 · Journal of Chemical Theory and Computation
  62. Molecular mechanism of HUWE1-HAPSTR1-USP7-mediated ubiquitin chain amplification on nuclear proteins
    Stanislau Yatskevich, Jugal Mohapatra, Rana M Mroue, Lilian Phu, Alexander Leitner, Caleigh M. Azumaya, RICHARD L. VANDLEN, Tommy K. Cheung, Tik Hang Soong, Christopher M. Rose et al. · 2026 · Molecular Cell
  63. BindingDB Entry 50023269: Ubiquitin-Specific Protease 7 (USP7) as a Promising Therapeutic Target for Drug Discovery: From Mechanisms to Therapies.
    BindingDB · 2026 · UC San Diego
  64. BindingDB Entry 50017489: Discovery of Orally Bioavailable
    BindingDB · 2023 · UC San Diego
  65. BindingDB Entry 50001159: Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies.
    BindingDB · 2020 · UC San Diego