Microbiota and host determinants of behavioural phenotype in maternally separated mice

De Palma, G.; Blennerhassett, P.; Lu, J.; Deng, Y.; Park, A. J.; Green, W.; Denou, E.; Silva, M. A.; Santacruz, A.; Sanz, Y.; Surette, M. G.; Verdu, E. F.; Collins, S. M.; Bercik, P.

doi:10.1038/ncomms8735

Microbiota and host determinants of behavioural phenotype in maternally separated mice

Early-life stress is a determinant of vulnerability to a variety of disorders that include dysfunction of the brain and gut. Here we exploit a model of early-life stress, maternal separation (MS) in mice, to investigate the role of the intestinal microbiota in the development of impaired gut func…