Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Ryu, Jae Kyu, Petersen, Mark A., Murray, Sara G., Baeten, Kim M., Meyer-Franke, Anke, Chan, Justin P., Vagena, Eirini, Bedard, Catherine +8 more·2015·Nature Communications

Cited by (272)

Items 201–272 of 272

  1. Glycolysis-regulating polyphenol nanoparticles restore immune homeostasis and tolerance in autoimmune multiple sclerosis
    Ngoc Man Phan, Dong Kwang Min, Xin Wang Mo, Pilseon Im, Jaeyun Kim · 2025 · Chemical Engineering Journal
  2. Accumulation of Extracellular Matrix in Advanced Lesions of Canine Distemper Demyelinating Encephalitis
    F. Seehusen, S. Al-Azreg, B. Raddatz, V. Haist, C. Puff, I. Spitzbarth, R. Ulrich, W. Baumgärtner · 2016 · PLoS ONE
  3. Combination of Albumin/Fibrinogen Ratio and Admission Hunt-Hess Scale Score as an Independent Predictor of Clinical Outcome in Aneurysmal Subarachnoid Hemorrhage
    Hao Ran Wang, Jie Ma, Yi Zhuo Guo, Ke Feng Liu, Bin Han, Ming Hai Wang, Fei Hui Zou, Jian Wang, Zhen Tian, He Qi Qu et al. · 2023 · World Neurosurgery
  4. Fibrinogen degradation products exacerbate alpha-synuclein aggregation by inhibiting autophagy via downregulation of Beclin1 in multiple system atrophy
    Huanzhu Liu, Ruoyang Yu, Muwei Zhang, Xiaoyan Zheng, Lizi Zhong, Wanlin Yang, Yuqi Luo, Zifeng Huang, Jialing Zheng, Hui Zhong et al. · 2025 · Neurotherapeutics
  5. Striatal fibrinogen extravasation and vascular degeneration correlate with motor dysfunction in an aging mouse model of Alzheimer’s disease
    Hanna Berk-Rauch, Arnab Choudhury, Allison T. Richards, Pradeep Kumar Singh, Zu‐Lin Chen, Erin H. Norris, Sidney Strickland, Hyung Jin Ahn · 2023 · Frontiers in Aging Neuroscience
  6. Fibrinogen deposition promotes neuroinflammation and fibrin-derived γ377-395 peptide ameliorates neurological deficits after ischemic stroke
    Lu Han, Yaying Song, Weiwei Xiang, Ze Wang, Yishu Wang, Xiajun Zhou, Desheng Zhu, Yangtai Guan · 2024 · International Immunopharmacology
  7. Integrating chemokines and machine learning algorithms for diagnosis and bleeding assessment in primary immune thrombocytopenia: A prospective cohort study
    Qing Wen, Ting Sun, Jia Chen, Yang Li, Xiaofan Liu, Huiyuan Li, Rongfeng Fu, Wei Liu, Feng Xue, Mankai Ju et al. · 2024 · British Journal of Haematology
  8. Advances in Intravital Non-Linear Optical Imaging of the Central Nervous System in Rodents
    Geneviève N. Rougon, Sophie Brasselet, Franck Christian Debarbieux · 2016 · Brain Plasticity
  9. Alzheimer disease makes new blood contacts
    Mario Merlini, Katerina Akassoglou · 2017 · Blood
  10. Hemostasis Components as Therapeutic Targets in Autoimmune Demyelination
    Gianmarco Abbadessa, Caterina Mainero, Simona Bonavita · 2022 · Clinical Pharmacology & Therapeutics
  11. Are the integrin binding motifs within SARS CoV-2 spike protein and MHC class II alleles playing the key role in COVID-19?
    Marijan Gerenčer, Liam James McGuffin · 2023 · Frontiers in Immunology
  12. Protective Effects of Rivaroxaban on White Matter Integrity and Remyelination in a Mouse Model of Alzheimer’s Disease Combined with Cerebral Hypoperfusion
    Zhihong Bian, Xinran Hu, Xia Liu, Haibo Yu, Yuting Bian, Hongming Sun, Yusuke Fukui, Ryuta Morihara, Hiroyuki Ishiura, Toru Yamashita · 2023 · Journal of Alzheimer s Disease
  13. Proteomic analysis and experimental validation reveal the blood–brain barrier protective of Huanshaodan in the treatment of SAMP8 mouse model of Alzheimer’s disease
    Yunfang Su, Ningning Liu, Pan Wang, Congcong Shang, Ruiqin Sun, Jinlian Ma, Zhonghua Li, Huifen Ma, Yiran Sun, Zijuan Zhang et al. · 2024 · Chinese Medicine
  14. Age and Maturation Stage Linked Consequences of Fibrinogen on Human Oligodendroglia
    Gabriela J. Blaszczyk, Chao Weng, Abdulshakour Mohammadnia, Qiao‐Ling Cui, Arianna Giurleo, Adam M.R. Groh, Chloe Plouffe, Julien Sirois, Valerio E. C. Piscopo, Moein Yaqubi et al. · 2026 · Journal of Neuroscience Research
  15. The cause of multiple sclerosis is autoimmune attack of adenosyltransferase thereby limiting adenosylcobalamin production
    J.L. Boucher · 2017 · Medical Hypotheses
  16. Endothelial-derived exosomes demonstrate a link between endothelial innate inflammation and brain dysfunction and injury in aging
    Fanny M. Elahi, Danielle Jenine Harvey, Marie Altendahl, Kaitlin Blackstone Casaletto, N. Fernandes, Adam M. Staffaroni, Pauline Maillard, Jason D. Hinman, Bruce L. Miller, Charles S DeCarli et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  17. Histopathology-assisted proteogenomics provides foundations for stratification of melanoma metastases
    Magdalena Kuras, Lazaro Hiram Betancourt, Runyu Hong, Letícia Szadai, Jimmy Rodriguez Murillo, Peter L. Horvatovich, Indira Plá, Jonatan O. Eriksson, Beáta Szeitz, Bartłomiej Deszcz et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  18. Elevator‐Like Hollow Channels in Porous Scaffolds Accelerate Vascularized Bone Regeneration via NETs‐Fibrin‐Mediated Macrophage Recruitment
    Guifang Wang, Rongpu Liu, Huijing Ma, Shuhan Duan, Guangzheng Yang, Lingxi Meng, Yuqin Qiao, Dongqiang Song, Wenjie Zhang · 2025 · Advanced Science
  19. Clinical features of patients with MOG-IgG associated disorders and analysis of the relationship between fibrinogen-to-albumin ratio and the severity at disease onset
    Yue Li, Sai Wang, Panpan Liu, Jinxiu Ma, Xinjing Liu, Jing Yuan · 2023 · Frontiers in Neurology
  20. Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium
    Katerina Akassoglou, Dritan Agalliu, Christopher J. Chang, Dimitrios Davalos, Jaime Grutzendler, Elizabeth M. C. Hillman, Baljit S. Khakh, David Kleinfeld, Dorian B. McGavern, Sarah J. Nelson et al. · 2016 · Frontiers in Neuroscience
  21. Fibrinogen-to-albumin ratio percentage: An independent predictor of disease severity and prognosis in anti-N-methyl-D-aspartate receptor encephalitis
    Juan Du, Yingzhe Shao, Yajun Song, Kaixin Wang, Xuan Yang, Yanfei Li, Yaobing Yao, Zhe Gong, Yanjie Jia · 2023 · Frontiers in Neurology
  22. Cerebrospinal fluid/serum albumin ratio in patients with Lewy body disease: a systematic review and meta-analysis
    Moyu Li, Jinghuan Gan, Xia Yang, Shuai Liu, Yong Ji · 2024 · Frontiers in Aging Neuroscience
  23. The hemostatic system in chronic brain diseases: A new challenging frontier?
    Mathias Chéa, Sylvie Bouvier, Jean‐Christophe Gris · 2024 · Thrombosis Research
  24. Alterations in the Blood–Brain Barrier in Mood Disorders and Neurodegenerative Diseases
    Ismaël Conejero, Mathias Chéa, Philippe Courtet, Sylvie Bouvier, Fabrício Pereira · 2025 · Seminars in Thrombosis and Hemostasis
  25. Ex vivo interaction between blood components and hormone-dependent breast cancer cells induces alterations associated with epithelial-mesenchymal transition and thrombosis
    Tanya Nadine Augustine, Kyrtania Pather, D. Mak, D. Klonaros, Kutlwano Rekgopetswe Xulu, Thérèse Dix‐Peek, Raquel A. B. Duarte, Wendy Jeannette van der Spuy · 2020 · Ultrastructural Pathology
  26. A Geroscience Approach to Preventing Pathologic Consequences of COVID-19
    Yan Dou, Soroosh Fatemi, Martin Darvas, Michael Gale, Warren Ladiges · 2020 · Journal of Interferon & Cytokine Research
  27. Distinct inflammatory and transcriptomic profiles in dominant versus subordinate males in mouse social hierarchies
    Won Lee, Tyler M Milewski, Madeleine F. Dwortz, Rebecca L. Young, Andrew D. Gaudet, Laura K. Fonken, Frances A. Champagne, James P. Curley · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  28. The Percentage of Neutrophils is Independently Associated with Blood-Brain Barrier(BBB) Disruption in Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease (MOGAD)
    Xuan Cheng, Yidi Sun, Yaoyao Wang, Wenchao Cheng, Haifeng Zhang, Yan Jiang · 2025 · Journal of Inflammation Research
  29. Pathological mechanisms of motor dysfunction in familial Danish dementia: insights from a knock-in rat model
    Arnab Choudhury, Metin Yeşiltepe, Tammaryn Lashley, Vishal Singh, Veertegh Minhas, Tao Yin, Anllely Fernández, Luciano D'adamio, Hyung Jin Ahn · 2025 · Journal of Neuroinflammation
  30. An experimental study to test the haemostatic effect of Aloe vera
    H Ramesh, C. H. Jyothi · 2019 · International Journal of Basic & Clinical Pharmacology
  31. Elevated plasma D-dimer levels in patients with anti-N-methyl-D-aspartate receptor encephalitis
    Yingzhe Shao, Juan Du, Yajun Song, Yanfei Li, Lijun Jing, Zhe Gong, Ranran Duan, Yaobing Yao, Yanjie Jia, Shujie Jiao · 2022 · Frontiers in Neurology
  32. Comparative Proteomics Reveals Prolonged Corneal Preservation Impaired Ocular Surface Immunity Accompanied by Fibrosis in Human Stroma.
    Pei-Shan Wu, Hsin-Yu Liu, Tzu-Hsuan Wong, Jui-Ti Lin, Fung-Rong Hu, Miao-Hsia Lin · 2023 · Journal of Proteome Research
  33. The Effect of Reduced Fibrinogen on Cerebrovascular Permeability during Traumatic Brain Injury in Fibrinogen Gene Heterozygous Knockout Mice
    Nurul Sulimai, Jason D. Brown, David G. Lominadze · 2024 · Biomolecules
  34. Fibrinogen contributes to myelin deficit and cognitive impairment in aged mice after anesthesia and surgery
    Xueji Wang, Sufang Jiang, Tianyu Cao, Peiying Huang, Lichao Di, Jiaqi Li, Lining Huang · 2025 · Journal of Cerebral Blood Flow & Metabolism
  35. The Complex and Integral Roles of Pericytes Within the Neurovascular Unit in Health and Disease
    Brad A. Sutherland · 2021 · Stem cell biology and regenerative medicine
  36. Measurement of D-dimer in cerebrospinal fluid using a luminescent oxygen channeling immunoassay
    Konstantin David Kohlhase, Jan Hendrik Schäefer, Wolfgang Miesbach, Gudrun Hintereder, Konstantin Kirchmayr, Birga Zwinge, Yavor Yalachkov, Christian Foerch, Martin Schaller · 2022 · Frontiers in Neurology
  37. Microglia
    Dimitrios Davalos, Katerina Akassoglou, Astrid E. Cardona · 2020 · Elsevier eBooks
  38. Serum Reactive Antibodies against the N-Methyl-D-Aspartate Receptor NR2 Subunit—Could They Act as Potential Biomarkers?
    Maria S. Hadjiagapiou, George Krashias, Christina Christodoulou, Marios Pantzaris, Anastasia Lambrianides · 2023 · International Journal of Molecular Sciences
  39. Prevention of experimental autoimmune encephalomyelitis by targeting 6-sulfo sialyl Lewis X glycans involved in lymphocyte homing
    Qianqian Liu, Wei Xiong, Sachiyo Obara, Hirohito Abo, Hiroko Nakatsukasa, Hiroto Kawashima · 2024 · International Immunology
  40. Proteomics and Management of Multiple Sclerosis
    Au Vo, Kyle Wong, Amy Abram, Thu Thi Kim Le, Linh Ho · 2024 · Springer eBooks
  41. Coagulation system and its neurophysiology
    Shyam Vayyat, Sajal Clarence Singh, Priyadarshini Mishra · 2024 · Elsevier eBooks
  42. Matrix molecules associated with both regulation of inflammation and pathogenic outcomes associated with the surface of the lens in the eyes of EAU mice
    Phuong M. Le, JodiRae DeDreu, Mary Joseph Mattapallil, Rachel R Caspi, Ryan E. Tomlinson, Mary Ann Stepp, A. Sue Menko · 2025 · Experimental Eye Research
  43. Dynamics of plasma fibrinogen unveils hepatic initiating role in the pathogenesis of multiple sclerosis
    Jiaji Lin, Xinyan Han, Chenfu Zhao, Yanan Bai, Weitai He, Xiaoli Liu, Daidi Zhao, Hongzeng Li, Jun Guo · 2025 · Multiple Sclerosis and Related Disorders
  44. A central role for fibrinogen in promoting microglial repair of the hypoxia-disrupted blood-brain barrier
    Sebok K. Halder, Arjun Sapkota, Richard Milner · 2026 · Journal of Neuroinflammation
  45. Astrocytes play a crucial role in the formation and evolution of MS lesions – No
    Nicole Kerlero de Rosbo · 2018 · Multiple Sclerosis Journal
  46. The FDP/FIB Ratio and Blood FDP Level May Be Related to Seizures After Fever in Young Children
    Chun Li, Weining Ma, Shaoyi Li, Ya-Juan Zhao, Xuyang Zhao, Hua Wang · 2020 · Frontiers in Pediatrics
  47. Mutual regulation of CD4+ T cells and intravascular fibrin in infections
    Tonina T. Mueller, Mona Pilartz, Manovriti Thakur, Torben LangHeinrich, Junfu Luo, Rebecca Block, Jonathan K. L. Hoeflinger, Sarah Meister, Flavio Karaj, Laura García Pérez et al. · 2024 · Haematologica
  48. Characteristics of fibrin/fibrinogen degradation products in multiple sclerosis following SARS-CoV-2 infection
    Tetiana Halenova, Nataliia Raksha, Tetiana B. Vovk, Vitaliy Karbovskiy, Svitlana M. Sholomon, Volodymyr S. Melnyk, О. Savchuk · 2024 · INTERNATIONAL NEUROLOGICAL JOURNAL
  49. Gerinnungsfaktoren und Multiple Sklerose
    Kerstin Göbel, Christoph Kleinschnitz, Sven Guenther Meuth · 2018 · Der Nervenarzt
  50. Biochemical characterization of medaka (Oryzias latipes) fibrinogen gamma and its gene disruption resulting in anemia as a model fish
    Qi Meng, Yuko Watanabe, Hideki Tatsukawa, Hisashi Hashimoto, Kiyotaka Hitomi · 2022 · The Journal of Biochemistry
  51. Extensive and Persistent Extravascular Dermal Fibrin Deposition Characterizes Systemic Sclerosis
    Jeffrey L. Browning, Jag Bhawan, Anna E. Tseng, Nicholas A. Crossland, Andreea M. Bujor, Katerina Akassoglou, Shervin Assassi, Brian A. Skaug, Jonathan Dale Ho · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  52. Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer’s disease
    Min Joo Kim, Jessica R. Blumenfeld, Yaqiao Li, Oscar Yip, Leon Yao, Stephanie Ancheta, Samuel De Leon, Zoe Platow, Zherui Liang, David M. Shostak et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  53. Gerinnungsfaktoren bei MS als Immunmodulatoren
    Kerstin Göbel, Susann Pankratz, Christoph Kleinschnitz, Sven Guenther Meuth · 2016 · DNP - Der Neurologe und Psychiater
  54. Brain fibrinogen deposition plays a key role in MS pathophysiology – Commentary
    Tatiana Koudriavtseva, Marco Salvetti · 2019 · Multiple Sclerosis Journal
  55. Dysfibrinogenemia and multiple sclerosis: spuriously associated or causally linked?
    Vasilios Κ. Kimiskidis, Emmanouil S. Papadakis, Vasileios T. Papaliagkas, Sotirios Papagiannopoulos, Dennis K. Galanakis · 2017 · Europe PMC (PubMed Central)
  56. Antimicrobial polymers : from theoretical studies to real-life applications
    Zheng Hou · 2020
  57. Gerinnungsfaktoren und Multiple Sklerose: Schlüsselfaktoren in der Pathogenese?
    Kerstin Göbel, Christoph Kleinschnitz, Sven Guenther Meuth · 2018 · Der Nervenarzt
  58. La quinasa ROCK2 regula el pronóstico funcional en los pacientes con hemorragias intraparenquimatosas
    María Dolores Calabria Gallego · 2021
  59. Faculty Opinions recommendation of A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling.
    Qingchun Tong · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  60. Bilateral jugular veins occlusion in mice: Clinical and histological findings
    Greco A, Luigi Auletta, Anna Rita Daniela Coda, Alfonso Baldi, Domenico Montanaro, Sandra Albanese, Sabina Pappatà, Marcello Mancini · 2020 · Journal of Translational Science
  61. Aortogenic emboli might play an important role in the development of delayed leukoencephalopathy after mechanical thrombectomy
    Takumi Ikeda, Takeo Sato, Teppei Komatsu, Kenichiro Sakai, Tadashi Umehara, Shusaku Omoto, Hidetomo Murakami, Hidetaka Mitsumura, Satoshi Matsushima, Rei Makishima et al. · 2023 · Neurology and Clinical Neuroscience
  62. Additional file 1 of Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury
    Fei Yao, Yang Luo, Yan-Chang Liu, Yi‐Hao Chen, Yi-Teng Li, Xuyang Hu, Xingyu You, Shuisheng Yu, Ziyu Li, Chen, Lei et al. · 2022 · Figshare
  63. Corrigendum to “Platelets and Hemostatic Proteins are Co-Localized with Chronic Neuroinflammation Surrounding Implanted Intracortical Microelectrodes” [Acta Biomaterialia. Volume 166, August 2023, Pages 278-290]
    Danny Lam, Anisha Javadekar, Nirav T. Patil, Marina H. Yu, Longshun Li, Dhariyat M. Menendez, Anirban Sen Gupta, Jeffrey R. Capadona, Andrew J. Shoffstall · 2024 · Acta Biomaterialia
  64. Multi-disciplinary investigation identifies increased potency of ethyl-parathion inhaled within a soil-dust matrix to cause acetylcholinesterase-dependent molecular impacts
    Kurt A. Gust, Saroj Kumar Amar, Chet P. Gut, Renée M. Styles, Ranju R. Karna, R. Arden James, David M. Holtzapple, Joshua Lysle Stricker, Shawn M. McInturf, Elizabeth A. Phillips et al. · 2024 · Environmental Toxicology and Pharmacology
  65. Plasma tissue factor as a promising marker in multiple sclerosis: Evidence from a two-sample Mendelian randomization study
    Rui Pan, Aiqi Wang, Yaqi Li, Qizhi Xie, Meihua Lin, Jiayi Li, Xiaolei Shi · 2025 · Translational Neuroscience
  66. The integrated stress response, a novel mediator of pro-inflammatory microglia
    Erica Kane, Nichola A. Cruickshanks, Lin Zhao, Sean P. Cregan, Shawn Narain Whitehead · 2025 · Research Square
  67. Neuronal APOE4 reduction with an APOE-I3-targeting ASO protects against neurodegeneration and neuroinflammation in an Alzheimer’s disease mouse model
    Oscar Yip, Leon Yao, Jessica R. Blumenfeld, Min Joo Kim, David M. Shostak, Zoe Platow, Kaylie Suan, Yaqiao Li, Claire Ellis, Alice An et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  68. The effects of bacterial and viral infections on microglia
    Sofya Ermolina, Dawn M. E. Bowdish · 2026 · Elsevier eBooks
  69. Dérégulation d'origine astrocytaire du système d'activation du plasminogène dans la sclérose en plaques
    Héloïse Lebas · 2018 · theses.fr (ABES)
  70. Hydrogel degradation products as immunomodulatory cues in neural injury: mechanisms and implications for neural repair
    Jugal Kishore, Fynn S. Owen La Boucan, Mohammad Foad Abazari, Karol Ann T. Baldo, Ifeoluwa Oluleke Awogbindin, Adeeb Akhavan, Marie‐Ève Tremblay, Stephanie M. Willerth · 2026 · Journal of Materials Chemistry B
  71. Controllability Analysis of Intercellular Protein–Protein Interaction Networks
    光 野崎, Keita Tsuchiya, Tatsuya Akutsu, Jose C. Nacher · 2026 · Computational and Structural Biotechnology Journal
  72. Targeting of demyelinated lesions in experimental models of multiple sclerosis using a fibrin binding peptide
    Sahar Farhangi, vahid sheibani, Mohammad Javan · 2025 · Physiology and Pharmacology