Sleep disruption impairs haematopoietic stem cell transplantation in mice
Open accessAbstract
Many of the factors affecting the success of haematopoietic cell transplantation are still unknown. Here we show in mice that donor sleep deprivation reduces the ability of its haematopoietic stem cells (HSCs) to engraft and reconstitute the blood and bone marrow of an irradiated recipient by more than 50%. We demonstrate that sleep deprivation downregulates the expression of microRNA (miR)-19b, a negative regulator of the suppressor of cytokine signalling (SOCS) genes, which inhibit HSC migration and homing. Accordingly, HSCs from sleep-deprived mice have higher levels of SOCS genes expression, lower migration capacity in vitro and reduced homing to the bone marrow in vivo. Recovery of sleep after sleep deprivation restored the reconstitution potential of the HSCs. Taken together, this study provides insights into cellular and molecular mechanisms underlying the effects of sleep deprivation on HSCs, emphasizing the potentially critical role of donor sleep in the success of bone marrow transplantation. How can you increase the success of hematopoietic stem cell (HSC) transplantation? In mice, Rolls et al. identify sleep in the donor as an important factor, finding that less sleep leads to 50% lower HSC engraftment, via miR-19b and suppressor of cytokine signaling genes, which prevent HSC homing.
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From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [475]
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References 35 · Cited by 48
- Authors
- Rolls, A., Pang, W. W., Ibarra, I., Colas, D., Bonnavion, P., Korin, B., Heller, H. C., Weissman, I. L., & de Lecea, L.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Institute for Stem Cell Biology and Regenerative Medicine (US)
- Stanford University (US)
- Corresponding author
- Weissman, Irving L.
- ORCID
- Venue
- Nature Communications
- Published
- 2015-10-14
- Volume
- 6
- Issue
- 1
- Pages
- 8516-8516
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4621781
- OpenAlex
- W2267951826
- Cited by
- 48
- References
- 35
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 6
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- Funders
- Klarman Family Foundation
- National Institutes of Health (TG2-01159)
- National Heart, Lung, and Blood Institute (R01HL058770, U01-HL099999-03, U01HL099999)
- National Institute of Mental Health
- National Cancer Institute (R01CA086065)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep deprivation, hematopoietic stem cells, haematopoietic cell transplantation, bone marrow transplantation, HSC engraftment, HSC homing, HSC migration, microRNA-19b, suppressor of cytokine signaling
- MeSH terms
- Suppressor of Cytokine Signaling 3 Protein, Animals, Cell Movement, Hematopoietic Stem Cells, Mice, Inbred C57BL, Mice, Transgenic, Sleep Deprivation, Growth Hormone, Hematopoietic Stem Cell Transplantation, MicroRNAs, Suppressor of Cytokine Signaling Proteins
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