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Cited by 372

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Open access
Stolk, Lisette, Perry, John R B, Chasman, Daniel I, He, Chunyan, Mangino, Massimo, Sulem, Patrick, Barbalic, Maja, Broer, Linda, Byrne, Enda M, Ernst, Florian, Esko, Tõnu, Franceschini, Nora, Gudbjartsson, Daniel F, Hottenga, Jouke-Jan, Kraft, Peter, McArdle, Patrick F, Porcu, Eleonora, Shin, So-Youn, Smith, Albert V, van Wingerden, Sophie, Zhai, Guangju, Zhuang, Wei V, Albrecht, Eva, Alizadeh, Behrooz Z, Aspelund, Thor, Bandinelli, Stefania, Lauc, Lovorka Barac, Beckmann, Jacques S, Boban, Mladen, Boerwinkle, Eric, Broekmans, Frank J, Burri, Andrea, Campbell, Harry, Chanock, Stephen J, Chen, Constance, Cornelis, Marilyn C, Corre, Tanguy, Coviello, Andrea D, d'Adamo, Pio, Davies, Gail, de Faire, Ulf, de Geus, Eco J C, Deary, Ian J, Dedoussis, George V Z, Deloukas, Panagiotis, Ebrahim, Shah, Eiriksdottir, Gudny, Emilsson, Valur, Eriksson, Johan G, Fauser, Bart C J M, Ferreli, Liana, Ferrucci, Luigi, Fischer, Krista, Folsom, Aaron R, Garcia, Melissa E, Gasparini, Paolo, Gieger, Christian, Glazer, Nicole, Grobbee, Diederick E, Hall, Per, Haller, Toomas, Hankinson, Susan E, Hass, Merli, Hayward, Caroline, Heath, Andrew C, Hofman, Albert, Ingelsson, Erik, Janssens, A Cecile J W, Johnson, Andrew D, Karasik, David, Kardia, Sharon L R, Keyzer, Jules, Kiel, Douglas P, Kolcic, Ivana, Kutalik, Zoltán, Lahti, Jari, Lai, Sandra, Laisk, Triin, Laven, Joop S E, Lawlor, Debbie A, Liu, Jianjun, Lopez, Lorna M, Louwers, Yvonne V, Magnusson, Patrik K E, Marongiu, Mara, Martin, Nicholas G, Klaric, Irena Martinovic, Masciullo, Corrado, McKnight, Barbara, Medland, Sarah E, Melzer, David, Mooser, Vincent, Navarro, Pau, Newman, Anne B, Nyholt, Dale R, Onland-Moret, N Charlotte, Palotie, Aarno, Paré, Guillaume, Parker, Alex N, Pedersen, Nancy L, Peeters, Petra H M, Pistis, Giorgio, Plump, Andrew S, Polasek, Ozren, Pop, Victor J M, Psaty, Bruce M, Räikkönen, Katri, Rehnberg, Emil, Rotter, Jerome I, Rudan, Igor, Sala, Cinzia, Salumets, Andres, Scuteri, Angelo, Singleton, Andrew, Smith, Jennifer A, Snieder, Harold, Soranzo, Nicole, Stacey, Simon N, Starr, John M, Stathopoulou, Maria G, Stirrups, Kathleen, Stolk, Ronald P, Styrkarsdottir, Unnur, Sun, Yan V, Tenesa, Albert, Thorand, Barbara, Toniolo, Daniela, Tryggvadottir, Laufey, Tsui, Kim, Ulivi, Sheila, van Dam, Rob M, van der Schouw, Yvonne T, van Gils, Carla H, van Nierop, Peter, Vink, Jacqueline M, Visscher, Peter M, Voorhuis, Marlies, Waeber, Gérard, Wallaschofski, Henri, Wichmann, H Erich, Widen, Elisabeth, Wijnands-van Gent, Colette J M, Willemsen, Gonneke, Wilson, James F, Wolffenbuttel, Bruce H R, Wright, Alan F, Yerges-Armstrong, Laura M, Zemunik, Tatijana, Zgaga, Lina, Zillikens, M Carola, Zygmunt, Marek, Study, The LifeLines Cohort, Arnold, Alice M, Boomsma, Dorret I, Buring, Julie E, Crisponi, Laura, Demerath, Ellen W, Gudnason, Vilmundur, Harris, Tamara B, Hu, Frank B, Hunter, David J, Launer, Lenore J, Metspalu, Andres, Montgomery, Grant W, Oostra, Ben A, Ridker, Paul M, Sanna, Serena, Schlessinger, David, Spector, Tim D, Stefansson, Kari, Streeten, Elizabeth A, Thorsteinsdottir, Unnur, Uda, Manuela, Uitterlinden, André G, van Duijn, Cornelia M, Völzke, Henry, Murray, Anna, Murabito, Joanne M, Visser, Jenny A, Lunetta, Kathryn L·2012·Nature Genetics
DOI 10.1038/ng.1051
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Abstract

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10−8). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.

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Authors
Stolk, L., Perry, J. R. B., Chasman, D. I., He, C., Mangino, M., Sulem, P., Barbalic, M., Broer, L., Byrne, E. M., Ernst, F., Esko, T., Franceschini, N., Gudbjartsson, D. F., Hottenga, J.-J., Kraft, P., McArdle, P. F., Porcu, E., Shin, S.-Y., Smith, A. V., van Wingerden, S., Zhai, G., Zhuang, W. V., Albrecht, E., Alizadeh, B. Z., Aspelund, T., Bandinelli, S., Lauc, L. B., Beckmann, J. S., Boban, M., Boerwinkle, E., Broekmans, F. J., Burri, A., Campbell, H., Chanock, S. J., Chen, C., Cornelis, M. C., Corre, T., Coviello, A. D., d'Adamo, P., Davies, G., de Faire, U., de Geus, E. J. C., Deary, I. J., Dedoussis, G. V. Z., Deloukas, P., Ebrahim, S., Eiriksdottir, G., Emilsson, V., Eriksson, J. G., Fauser, B. C. J. M., Ferreli, L., Ferrucci, L., Fischer, K., Folsom, A. R., Garcia, M. E., Gasparini, P., Gieger, C., Glazer, N., Grobbee, D. E., Hall, P., Haller, T., Hankinson, S. E., Hass, M., Hayward, C., Heath, A. C., Hofman, A., Ingelsson, E., Janssens, A. C. J. W., Johnson, A. D., Karasik, D., Kardia, S. L. R., Keyzer, J., Kiel, D. P., Kolcic, I., Kutalik, Z., Lahti, J., Lai, S., Laisk, T., Laven, J. S. E., Lawlor, D. A., Liu, J., Lopez, L. M., Louwers, Y. V., Magnusson, P. K. E., Marongiu, M., Martin, N. G., Klaric, I. M., Masciullo, C., McKnight, B., Medland, S. E., Melzer, D., Mooser, V., Navarro, P., Newman, A. B., Nyholt, D. R., Onland-Moret, N. C., Palotie, A., Paré, G., Parker, A. N., Pedersen, N. L., Peeters, P. H. M., Pistis, G., Plump, A. S., Polasek, O., Pop, V. J. M., Psaty, B. M., Räikkönen, K., Rehnberg, E., Rotter, J. I., Rudan, I., Sala, C., Salumets, A., Scuteri, A., Singleton, A., Smith, J. A., Snieder, H., Soranzo, N., Stacey, S. N., Starr, J. M., Stathopoulou, M. G., Stirrups, K., Stolk, R. P., Styrkarsdottir, U., Sun, Y. V., Tenesa, A., Thorand, B., Toniolo, D., Tryggvadottir, L., Tsui, K., Ulivi, S., van Dam, R. M., van der Schouw, Y. T., van Gils, C. H., van Nierop, P., Vink, J. M., Visscher, P. M., Voorhuis, M., Waeber, G., Wallaschofski, H., Wichmann, H. E., Widen, E., Wijnands-van Gent, C. J. M., Willemsen, G., Wilson, J. F., Wolffenbuttel, B. H. R., Wright, A. F., Yerges-Armstrong, L. M., Zemunik, T., Zgaga, L., Zillikens, M. C., Zygmunt, M., Study, T. L. C., Arnold, A. M., Boomsma, D. I., Buring, J. E., Crisponi, L., Demerath, E. W., Gudnason, V., Harris, T. B., Hu, F. B., Hunter, D. J., Launer, L. J., Metspalu, A., Montgomery, G. W., Oostra, B. A., Ridker, P. M., Sanna, S., Schlessinger, D., Spector, T. D., Stefansson, K., Streeten, E. A., Thorsteinsdottir, U., Uda, M., Uitterlinden, A. G., van Duijn, C. M., Völzke, H., Murray, A., Murabito, J. M., Visser, J. A., & Lunetta, K. L.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2012-01-22
Volume
44
Issue
3
Pages
260-268
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.1051
OpenAlex
W2134788823
Cited by
372
References
22
FWCI
19.13
Type
journal article
Language
en
Open access
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Stolk, L., Perry, J. R. B., Chasman, D. I., He, C., Mangino, M., Sulem, P., Barbalic, M., Broer, L., Byrne, E. M., Ernst, F., Esko, T., Franceschini, N., Gudbjartsson, D. F., Hottenga, J.-J., Kraft, P., McArdle, P. F., Porcu, E., Shin, S.-Y., Smith, A. V., . . . Lunetta, K. L. (2012). Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics. https://doi.org/10.1038/ng.1051

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