The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.
The emerging landscape of breast cancer susceptibility
Abstract
The genetic basis of inherited predisposition to breast cancer has been assiduously investigated for the past two decades and has been the subject of several recent discoveries. Three reasonably well-defined classes of breast cancer susceptibility alleles with different levels of risk and prevalence in the population have become apparent: rare high-penetrance alleles, rare moderate-penetrance alleles and common low-penetrance alleles. The contribution of each component to breast cancer predisposition is still to be fully explored, as are the phenotypic characteristics of the cancers associated with them, the ways in which they interact, much of their biology and their clinical utility. These recent advances herald a new chapter in the exploration of susceptibility to breast cancer and are likely to provide insights relevant to other common, heterogeneous diseases.
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In the citing paper
“Instead, low-penetrant alleles likely require additional modifier alleles and/or secondary hits [57].”
From Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1 (2011) · cites this paper as [57]
In the citing paper
“Highly penetrant alleles will typically segregate with disease, whereas moderately penetrant alleles will not.”
From Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1 (2011) · cites this paper as [57]
Citations
Cites
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A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1
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Identification of the breast cancer susceptibility gene BRCA2
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Self-citationPatterns of somatic mutation in human cancer genomes
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Self-citationA Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase
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Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21
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Genome-wide association study identifies novel breast cancer susceptibility loci
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Self-citationLocalization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13
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Cited by
Sorted by citations
Genome-wide association studies for complex traits: consensus, uncertainty and challenges
McCarthy, M. I., Abecasis, G. R., Cardon, L. R., Goldstein, D. B., Little, J., Ioannidis, J. P. A., & Hirschhorn, J. N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2344 · Cited by 2,891
Common and rare variants in multifactorial susceptibility to common diseases
Bodmer, W., & Bonilla, C. (2008) · Nature Genetics · doi:10.1038/ng.f.136 · Cited by 1,131
Common disorders are quantitative traits
Plomin, R., Haworth, C. M. A., & Davis, O. S. P. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2670 · Cited by 670
RAD51B in Familial Breast Cancer
Pelttari, L. M., Khan, S., Vuorela, M., Kiiski, J. I., Vilske, S., Nevanlinna, V., Ranta, S., Schleutker, J., Winqvist, R., Kallioniemi, A. H., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153788 · Cited by 672
Genetics of breast cancer: a topic in evolution
Shiovitz, S., & Korde, L. A. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv022 · Cited by 577
Metadata
- Authors
- Stratton, M. R., & Rahman, N.
- Affiliations
- Institute of Cancer Research (GB)
- Venue
- Nature Genetics
- Published
- 2007-12-27
- Volume
- 40
- Issue
- 1
- Pages
- 17-22
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2067993067
- Cited by
- 487
- References
- 56
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 10 · 2023: 13 · 2022: 17 · 2021: 28 · 2020: 20 · 2019: 25 · 2018: 28 · 2017: 25 · 2016: 32 · 2015: 33 · 2014: 32 · 2013: 46 · 2012: 32
- FWCI
- 17.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Keywords
- breast cancer susceptibility, genetic susceptibility, low-penetrance alleles, cancer risk, genetic heterogeneity
- MeSH terms
- Alleles, Breast Neoplasms, Female, Humans, Mutation, Penetrance, Genetic Predisposition to Disease
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