The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis
Open accessAbstract
The increased burden of chronic kidney and end-stage kidney diseases (ESKD) in populations of African ancestry has been largely unexplained. To identify genetic variants predisposing to idiopathic and HIV-1–associated focal segmental glomerulosclerosis (FSGS), we carried out an admixture-mapping linkage-disequilibrium genome scan on 190 African American individuals with FSGS and 222 controls. We identified a chromosome 22 region with a genome-wide logarithm of the odds (lod) score of 9.2 and a peak lod of 12.4 centered on MYH9, a functional candidate gene expressed in kidney podocytes. Multiple MYH9 SNPs and haplotypes were recessively associated with FSGS, most strongly a haplotype spanning exons 14 through 23 (OR = 5.0, 95% CI = 3.5–7.1; P = 4 × 10−23, n = 852). This association extended to hypertensive ESKD (OR = 2.2, 95% CI = 1.5–3.4; n = 433), but not type 2 diabetic ESKD (n = 476). Genetic variation at the MYH9 locus substantially explains the increased burden of FSGS and hypertensive ESKD among African Americans.
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The Structure of Haplotype Blocks in the Human Genome
Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M., et al. (2002) · Science · doi:10.1126/science.1069424 · Cited by 5,863
Prevalence of Chronic Kidney Disease in the United States
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A second generation human haplotype map of over 3.1 million SNPs
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Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men
Freedman, M. L., Haiman, C. A., Patterson, N., McDonald, G. J., Tandon, A., Waliszewska, A., Penney, K., Steen, R. G., Ardlie, K., John, E. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605832103 · Cited by 612
Discerning the ancestry of European Americans in genetic association studies
Price, A. L., Butler, J., Patterson, N., Capelli, C., Pascali, V. L., Scarnicci, F., Ruiz-Linares, A., Groop, L., Saetta, A. A., Korkolopoulou, P., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0030236 · Cited by 327
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Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans
Genovese, G., Friedman, D. J., Ross, M. D., Lecordier, L., Uzureau, P., Freedman, B. I., Bowden, D. W., Langefeld, C. D., Oleksyk, T. K., Uscinski Knob, A. L., et al. (2010) · Science · doi:10.1126/science.1193032 · Cited by 2,028
Self-citationEvolving importance of kidney disease: from subspecialty to global health burden
Eckardt, K.-U., Coresh, J., Devuyst, O., Johnson, R. J., Köttgen, A., Levey, A. S., & Levin, A. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60439-0 · Cited by 1,159
Self-citationAPOL1 Genetic Variants in Focal Segmental Glomerulosclerosis and HIV-Associated Nephropathy
Kopp, J. B., Nelson, G. W., Sampath, K., Johnson, R. C., Genovese, G., An, P., Friedman, D., Briggs, W., Dart, R., Korbet, S., et al. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011040388 · Cited by 855
Self-citationNew loci associated with kidney function and chronic kidney disease
Köttgen, A., Pattaro, C., Böger, C. A., Fuchsberger, C., Olden, M., Glazer, N. L., Parsa, A., Gao, X., Yang, Q., Smith, A. V., et al. (2010) · Nature Genetics · doi:10.1038/ng.568 · Cited by 804
Gadegbeku, C. A., Gipson, D. S., Holzman, L. B., Ojo, A. O., Song, P. X. K., Barisoni, L., Sampson, M. G., Kopp, J. B., Lemley, K. V., Nelson, P. J., et al. (2013) · Kidney International · doi:10.1038/ki.2012.428 · Cited by 342
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Metadata
- Authors
- Kopp, J. B., Smith, M. W., Nelson, G. W., Johnson, R. C., Freedman, B. I., Bowden, D. W., Oleksyk, T., McKenzie, L. M., Kajiyama, H., Ahuja, T. S., Berns, J. S., Briggs, W., Cho, M. E., Dart, R. A., Kimmel, P. L., Korbet, S. M., Michel, D. M., Mokrzycki, M. H., Schelling, J. R., Simon, E., Trachtman, H., Vlahov, D., & Winkler, C. A.
- Venue
- Nature Genetics
- Published
- 2008-09-14
- Volume
- 40
- Issue
- 10
- Pages
- 1175-1184
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2121965895
- Cited by
- 711
- References
- 6
- FWCI
- 61.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Kopp, J. B., Smith, M. W., Nelson, G. W., Johnson, R. C., Freedman, B. I., Bowden, D. W., Oleksyk, T., McKenzie, L. M., Kajiyama, H., Ahuja, T. S., Berns, J. S., Briggs, W., Cho, M. E., Dart, R. A., Kimmel, P. L., Korbet, S. M., Michel, D. M., Mokrzycki, M. H., Schelling, J. R., . . . Winkler, C. A. (2008). MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. Nature Genetics. https://doi.org/10.1038/ng.226
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