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MYH9 is associated with nondiabetic end-stage renal disease in African Americans
Open accessAbstract
As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12. Each copy of the European ancestral allele conferred a relative risk of 0.50 (95% CI = 0.39–0.63) compared to African ancestry. Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans.
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Cites
A second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438
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Self-citationEvolving importance of kidney disease: from subspecialty to global health burden
Eckardt, K.-U., Coresh, J., Devuyst, O., Johnson, R. J., Köttgen, A., Levey, A. S., & Levin, A. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60439-0 · Cited by 1,159
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APOL1 Genetic Variants in Focal Segmental Glomerulosclerosis and HIV-Associated Nephropathy
Kopp, J. B., Nelson, G. W., Sampath, K., Johnson, R. C., Genovese, G., An, P., Friedman, D., Briggs, W., Dart, R., Korbet, S., et al. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011040388 · Cited by 855
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Metadata
- Authors
- on behalf of the Family Investigation of Nephropathy and Diabetes (FIND) Research Group, Kao, W. H. L., Klag, M. J., Meoni, L. A., Reich, D., Berthier-Schaad, Y., Li, M., Coresh, J., Patterson, N., Tandon, A., Powe, N. R., Fink, N. E., Sadler, J. H., Weir, M. R., Abboud, H. E., Adler, S. G., Divers, J., Iyengar, S. K., Freedman, B. I., Kimmel, P. L., Knowler, W. C., Kohn, O. F., Kramp, K., Leehey, D. J., Nicholas, S. B., Pahl, M. V., Schelling, J. R., Sedor, J. R., Thornley-Brown, D., Winkler, C. A., Smith, M. W., & Parekh, R. S.
- Venue
- Nature Genetics
- Published
- 2008-09-14
- Volume
- 40
- Issue
- 10
- Pages
- 1185-1192
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2160180886
- Cited by
- 649
- References
- 1
- FWCI
- 40.96
- Type
- journal article
- Language
- en
- Open access
- green
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