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Cited by 836

The DOI matches its Crossref record; 230 of the 230 references it cites were found in a registry or an index.

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

Open access
LifeLines Cohort Study, Köttgen, Anna, CARDIoGRAM Consortium, DIAGRAM Consortium, ICBP Consortium, MAGIC Consortium, Albrecht, Eva, Teumer, Alexander, Vitart, Veronique, Krumsiek, Jan, Hundertmark, Claudia, Pistis, Giorgio, Ruggiero, Daniela, O'Seaghdha, Conall M, Haller, Toomas, Yang, Qiong, Tanaka, Toshiko, Johnson, Andrew D, Kutalik, Zoltán, Smith, Albert V, Shi, Julia, Struchalin, Maksim, Middelberg, Rita P S, Brown, Morris J, Gaffo, Angelo L, Pirastu, Nicola, Li, Guo, Hayward, Caroline, Zemunik, Tatijana, Huffman, Jennifer, Yengo, Loic, Zhao, Jing Hua, Demirkan, Ayse, Feitosa, Mary F, Liu, Xuan, Malerba, Giovanni, Lopez, Lorna M, van der Harst, Pim, Li, Xinzhong, Kleber, Marcus E, Hicks, Andrew A, Nolte, Ilja M, Johansson, Asa, Murgia, Federico, Wild, Sarah H, Bakker, Stephan J L, Peden, John F, Dehghan, Abbas, Steri, Maristella, Tenesa, Albert, Lagou, Vasiliki, Salo, Perttu, Mangino, Massimo, Rose, Lynda M, Lehtimäki, Terho, Woodward, Owen M, Okada, Yukinori, Tin, Adrienne, Müller, Christian, Oldmeadow, Christopher, Putku, Margus, Czamara, Darina, Kraft, Peter, Frogheri, Laura, Thun, Gian Andri, Grotevendt, Anne, Gislason, Gauti Kjartan, Harris, Tamara B, Launer, Lenore J, McArdle, Patrick, Shuldiner, Alan R, Boerwinkle, Eric, Coresh, Josef, Schmidt, Helena, Schallert, Michael, Martin, Nicholas G, Montgomery, Grant W, Kubo, Michiaki, Nakamura, Yusuke, Tanaka, Toshihiro, Munroe, Patricia B, Samani, Nilesh J, Jacobs, David R, Liu, Kiang, D'Adamo, Pio, Ulivi, Sheila, Rotter, Jerome I, Psaty, Bruce M, Vollenweider, Peter, Waeber, Gerard, Campbell, Susan, Devuyst, Olivier, Navarro, Pau, Kolcic, Ivana, Hastie, Nicholas, Balkau, Beverley, Froguel, Philippe, Esko, Tõnu, Salumets, Andres, Khaw, Kay Tee, Langenberg, Claudia, Wareham, Nicholas J, Isaacs, Aaron, Kraja, Aldi, Zhang, Qunyuan, Wild, Philipp S, Scott, Rodney J, Holliday, Elizabeth G, Org, Elin, Viigimaa, Margus, Bandinelli, Stefania, Metter, Jeffrey E, Lupo, Antonio, Trabetti, Elisabetta, Sorice, Rossella, Döring, Angela, Lattka, Eva, Strauch, Konstantin, Theis, Fabian, Waldenberger, Melanie, Wichmann, H-Erich, Davies, Gail, Gow, Alan J, Bruinenberg, Marcel, Stolk, Ronald P, Kooner, Jaspal S, Zhang, Weihua, Winkelmann, Bernhard R, Boehm, Bernhard O, Lucae, Susanne, Penninx, Brenda W, Smit, Johannes H, Curhan, Gary, Mudgal, Poorva, Plenge, Robert M, Portas, Laura, Persico, Ivana, Kirin, Mirna, Wilson, James F, Leach, Irene Mateo, van Gilst, Wiek H, Goel, Anuj, Ongen, Halit, Hofman, Albert, Rivadeneira, Fernando, Uitterlinden, Andre G, Imboden, Medea, von Eckardstein, Arnold, Cucca, Francesco, Nagaraja, Ramaiah, Piras, Maria Grazia, Nauck, Matthias, Schurmann, Claudia, Budde, Kathrin, Ernst, Florian, Farrington, Susan M, Theodoratou, Evropi, Prokopenko, Inga, Stumvoll, Michael, Jula, Antti, Perola, Markus, Salomaa, Veikko, Shin, So-Youn, Spector, Tim D, Sala, Cinzia, Ridker, Paul M, Kähönen, Mika, Viikari, Jorma, Hengstenberg, Christian, Nelson, Christopher P, Meschia, James F, Nalls, Michael A, Sharma, Pankaj, Singleton, Andrew B, Kamatani, Naoyuki, Zeller, Tanja, Burnier, Michel, Attia, John, Laan, Maris, Klopp, Norman, Hillege, Hans L, Kloiber, Stefan, Choi, Hyon, Pirastu, Mario, Tore, Silvia, Probst-Hensch, Nicole M, Völzke, Henry, Gudnason, Vilmundur, Parsa, Afshin, Schmidt, Reinhold, Whitfield, John B, Fornage, Myriam, Gasparini, Paolo, Siscovick, David S, Polašek, Ozren, Campbell, Harry, Rudan, Igor, Bouatia-Naji, Nabila, Metspalu, Andres, Loos, Ruth J F, van Duijn, Cornelia M, Borecki, Ingrid B, Ferrucci, Luigi, Gambaro, Giovanni, Deary, Ian J, Wolffenbuttel, Bruce H R, Chambers, John C, März, Winfried, Pramstaller, Peter P, Snieder, Harold, Gyllensten, Ulf, Wright, Alan F, Navis, Gerjan, Watkins, Hugh, Witteman, Jacqueline C M, Sanna, Serena, Schipf, Sabine, Dunlop, Malcolm G, Tönjes, Anke, Ripatti, Samuli, Soranzo, Nicole, Toniolo, Daniela, Chasman, Daniel I, Raitakari, Olli, Kao, W H Linda, Ciullo, Marina, Fox, Caroline S, Caulfield, Mark, Bochud, Murielle, Gieger, Christian·2013·Nature Genetics
DOI 10.1038/ng.2500
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Abstract

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.

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Authors
Study, L. C., Köttgen, A., CARDIoGRAM Consortium, DIAGRAM Consortium, ICBP Consortium, MAGIC Consortium, Albrecht, E., Teumer, A., Vitart, V., Krumsiek, J., Hundertmark, C., Pistis, G., Ruggiero, D., O'Seaghdha, C. M., Haller, T., Yang, Q., Tanaka, T., Johnson, A. D., Kutalik, Z., Smith, A. V., Shi, J., Struchalin, M., Middelberg, R. P. S., Brown, M. J., Gaffo, A. L., Pirastu, N., Li, G., Hayward, C., Zemunik, T., Huffman, J., Yengo, L., Zhao, J. H., Demirkan, A., Feitosa, M. F., Liu, X., Malerba, G., Lopez, L. M., van der Harst, P., Li, X., Kleber, M. E., Hicks, A. A., Nolte, I. M., Johansson, A., Murgia, F., Wild, S. H., Bakker, S. J. L., Peden, J. F., Dehghan, A., Steri, M., Tenesa, A., Lagou, V., Salo, P., Mangino, M., Rose, L. M., Lehtimäki, T., Woodward, O. M., Okada, Y., Tin, A., Müller, C., Oldmeadow, C., Putku, M., Czamara, D., Kraft, P., Frogheri, L., Thun, G. A., Grotevendt, A., Gislason, G. K., Harris, T. B., Launer, L. J., McArdle, P., Shuldiner, A. R., Boerwinkle, E., Coresh, J., Schmidt, H., Schallert, M., Martin, N. G., Montgomery, G. W., Kubo, M., Nakamura, Y., Tanaka, T., Munroe, P. B., Samani, N. J., Jacobs, D. R., Liu, K., D'Adamo, P., Ulivi, S., Rotter, J. I., Psaty, B. M., Vollenweider, P., Waeber, G., Campbell, S., Devuyst, O., Navarro, P., Kolcic, I., Hastie, N., Balkau, B., Froguel, P., Esko, T., Salumets, A., Khaw, K. T., Langenberg, C., Wareham, N. J., Isaacs, A., Kraja, A., Zhang, Q., Wild, P. S., Scott, R. J., Holliday, E. G., Org, E., Viigimaa, M., Bandinelli, S., Metter, J. E., Lupo, A., Trabetti, E., Sorice, R., Döring, A., Lattka, E., Strauch, K., Theis, F., Waldenberger, M., Wichmann, H.-E., Davies, G., Gow, A. J., Bruinenberg, M., Stolk, R. P., Kooner, J. S., Zhang, W., Winkelmann, B. R., Boehm, B. O., Lucae, S., Penninx, B. W., Smit, J. H., Curhan, G., Mudgal, P., Plenge, R. M., Portas, L., Persico, I., Kirin, M., Wilson, J. F., Leach, I. M., van Gilst, W. H., Goel, A., Ongen, H., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Imboden, M., von Eckardstein, A., Cucca, F., Nagaraja, R., Piras, M. G., Nauck, M., Schurmann, C., Budde, K., Ernst, F., Farrington, S. M., Theodoratou, E., Prokopenko, I., Stumvoll, M., Jula, A., Perola, M., Salomaa, V., Shin, S.-Y., Spector, T. D., Sala, C., Ridker, P. M., Kähönen, M., Viikari, J., Hengstenberg, C., Nelson, C. P., Meschia, J. F., Nalls, M. A., Sharma, P., Singleton, A. B., Kamatani, N., Zeller, T., Burnier, M., Attia, J., Laan, M., Klopp, N., Hillege, H. L., Kloiber, S., Choi, H., Pirastu, M., Tore, S., Probst-Hensch, N. M., Völzke, H., Gudnason, V., Parsa, A., Schmidt, R., Whitfield, J. B., Fornage, M., Gasparini, P., Siscovick, D. S., Polašek, O., Campbell, H., Rudan, I., Bouatia-Naji, N., Metspalu, A., Loos, R. J. F., van Duijn, C. M., Borecki, I. B., Ferrucci, L., Gambaro, G., Deary, I. J., Wolffenbuttel, B. H. R., Chambers, J. C., März, W., Pramstaller, P. P., Snieder, H., Gyllensten, U., Wright, A. F., Navis, G., Watkins, H., Witteman, J. C. M., Sanna, S., Schipf, S., Dunlop, M. G., Tönjes, A., Ripatti, S., Soranzo, N., Toniolo, D., Chasman, D. I., Raitakari, O., Kao, W. H. L., Ciullo, M., Fox, C. S., Caulfield, M., Bochud, M., & Gieger, C.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2012-12-23
Volume
45
Issue
2
Pages
145-154
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.2500
OpenAlex
W2147452548
Cited by
836
References
230
FWCI
30.02
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. https://app.cochat.ai/papers/10.1038/ng.2500
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Study, L. C., Köttgen, A., CARDIoGRAM Consortium, DIAGRAM Consortium, ICBP Consortium, MAGIC Consortium, Albrecht, E., Teumer, A., Vitart, V., Krumsiek, J., Hundertmark, C., Pistis, G., Ruggiero, D., O'Seaghdha, C. M., Haller, T., Yang, Q., Tanaka, T., Johnson, A. D., Kutalik, Z., . . . Gieger, C. (2013). Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics. https://doi.org/10.1038/ng.2500

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