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Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors
Open accessAbstract
Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.
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The Cancer Genome Atlas Research Network (2012) · Nature · doi:10.1038/nature11404 · Cited by 3,994
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Imielinski, M., Berger, A. H., Hammerman, P. S., Hernandez, B., Pugh, T. J., Hodis, E., Cho, J., Suh, J., Capelletti, M., Sivachenko, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.029 · Cited by 1,789
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Cited by
Mechanisms and consequences of Jak–STAT signaling in the immune system
Villarino, A. V., Kanno, Y., & O'Shea, J. J. (2017) · Nature Immunology · doi:10.1038/ni.3691 · Cited by 1,221
Intratumoral injection of Clostridium novyi -NT spores induces antitumor responses
Roberts, N. J., Zhang, L., Janku, F., Collins, A., Bai, R.-Y., Staedtke, V., Rusk, A. W., Tung, D., Miller, M., Roix, J., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008982 · Cited by 400
Nacev, B. A., Sanchez-Vega, F., Smith, S. A., Antonescu, C. R., Rosenbaum, E., Shi, H., Tang, C., Socci, N. D., Rana, S., Gularte-Mérida, R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30453-x · Cited by 232
Self-citationKarpathiou, G., Papoudou-Bai, A., Ferrand, E., Dumollard, J. M., & Peoc’h, M. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153477 · Cited by 116
Metadata
- Authors
- Chmielecki, J., Crago, A. M., Rosenberg, M., O'Connor, R., Walker, S. R., Ambrogio, L., Auclair, D., McKenna, A., Heinrich, M. C., Frank, D. A., & Meyerson, M.
- Venue
- Nature Genetics
- Published
- 2013-01-13
- Volume
- 45
- Issue
- 2
- Pages
- 131-132
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2170565367
- Cited by
- 606
- References
- 2
- FWCI
- 35.85
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. https://app.cochat.ai/papers/10.1038/ng.2522
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- Chmielecki, J., Crago, A. M., Rosenberg, M., O'Connor, R., Walker, S. R., Ambrogio, L., Auclair, D., McKenna, A., Heinrich, M. C., Frank, D. A., & Meyerson, M. (2013). Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nature Genetics. https://doi.org/10.1038/ng.2522
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