Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1
Ligtenberg, Marjolijn J L, Kuiper, Roland P, Chan, Tsun Leung, Goossens, Monique, Hebeda, Konnie M, Voorendt, Marsha, Lee, Tracy Y H, Bodmer, Danielle, Hoenselaar, Eveline, Hendriks-Cornelissen, Sandra J B, Tsui, Wai Yin, Kong, Chi Kwan, Brunner, Han G, van Kessel, Ad Geurts, Yuen, Siu Tsan, van Krieken, J Han J M, Leung, Suet Yi, Hoogerbrugge, Nicoline·2009·Nature Genetics
DOI 10.1038/ng.283
Cited by (825)
Items 601–700 of 825
- Characterization of a germline variant MSH6 c. 4001G > C in a Lynch syndrome familyCiyu Yang, Maksym Misyura, Sarah R. Kane, Vikas Rai, Alicia J. Latham, Liying Zhang · 2023 · Molecular Genetics & Genomic Medicine
- Precision Medicine in the Era of Genetic Testing: Microsatellite Instability EvolvedDina Ioffe, Michelle J McSweeny, Michael J. Hall · 2023 · Clinics in Colon and Rectal Surgery
- Treatment of Microsatellite-Unstable Rectal Cancer in Sporadic and Hereditary SettingsCristan E. Anderson, David Liska · 2023 · Clinics in Colon and Rectal Surgery
- The role of epigenetics in rare diseasesBernhard Horsthemke · 2024 · Medizinische Genetik
- Gastrointestinal Malignancy: Genetic Implications to Clinical ApplicationsHannah E. Trembath, Jen Jen Yeh, Nicole Lopez · 2024 · Cancer treatment and research
- Host genetics-associated mechanisms in colorectal cancerAdriana González, Asier Fullaondo, Adrián Odriozola · 2024 · Advances in genetics
- Influence of Genetic Polymorphisms on the Age at Cancer Diagnosis in a Homogenous Lynch Syndrome Cohort of Individuals Carrying the MLH1:c.1528C>T South African Founder VariantLutricia Ndou, Ramadhani Chambuso, Ursula Algar, Paul A. Goldberg, Adam Boutall, Raj Ramesar · 2024 · Biomedicines
- Spectrum and genotyping strategies of “dark” genetic matter in germline susceptibility genes of tumor syndromesAnikó Bozsik, Henriett Butz, Vince Kornél Grolmusz, Tímea Pócza, Attila Patócs, J. Papp · 2024 · Critical Reviews in Oncology/Hematology
- A series of reviews in familial cancer: genetic cancer risk in context variants of uncertain significance in MMR genes: which procedures should be followed?Morghan C. Lucas, Thomas Keßler, Florentine Scharf, Verena Steinke‐Lange, Barbara Klink, Andreas Laner, Elke Holinski‐Feder · 2025 · Familial Cancer
- FROM FAMILIES SYNDROMES TO GENES… THE FIRST CLINICAL AND GENETIC CHARACTERIZATIONS OF HEREDITARY SYNDROMES PREDISPOSING TO CANCER: WHAT WAS THE BEGINNING?Charite Nicolette Ricker · 2017 · Revista Médica Clínica Las Condes
- Genomics of Colorectal CancerDaniel Gaston, Carman Anthony Giacomantonio · 2013 · Elsevier eBooks
- Lynch syndrome diagnostics: decision-making process for germ-line testingEnrique Lastra, María Asunción García-González, Beatriz Llorente, C. Bernuy, M. Jesús Barrio, Lucía Pérez‐Cabornero, Mercedes Durán, Carlos García Girón · 2012 · Clinical & Translational Oncology
- The ‘omics’ of cancerAd Geurts van Kessel · 2010 · Cancer Genetics and Cytogenetics
- Lymphocyte-rich Renal Cell CarcinomaFredrik Petersson, Radek Šíma, Māris Sperga, Dmitry V. Kazakov, Michal Michal, Milan Hora, Jiří Ferda, Miroslav Šulc, Petr Mičulka, Jiří Haferník et al. · 2011 · Applied immunohistochemistry & molecular morphology
- Role of microsatellite instability in colon cancerMikhail Yu. Fedyanin, Alexey Alexandrovich Tryakin, Sergey A. Tjulandin · 2015 · DOAJ (DOAJ: Directory of Open Access Journals)
- DNA Alterations in Lynch SyndromeMatjaž Vogelsang · 2013 · Springer eBooks
- Sebaceous Adenoma and SebaceomaLuís Requena, Lorenzo Cerroni · 2017 · Springer eBooks
- Colorectal CancerRoland P. Kuiper, Robbert D.A. Weren, Ad Geurts van Kessel · 2017 · Elsevier eBooks
- Molecular Mechanism of Lynch SyndromeKazuo Tamura · 2020 · Springer eBooks
- Hereditary CancerZoran Gatalica, Anatole Ghazalpour, Stan L. Lilleberg, Jeffrey J. Swensen, Henry T. Lynch · 2016 · Springer eBooks
- Hypermethylation of RAD9A intron 2 in childhood cancer patients, leukemia and tumor cell lines suggest a role for oncogenic transformationDanuta Galetzka, Julia Böck, Marcus Dittrich, Olesja Sinizyn, Marco Ludwig, Heidi Rossmann, Claudia Spix, Markus Radsak, Peter Scholz-Kreisel, Johanna Mirsch et al. · 2020 · PubMed Central
- Endometrial CarcinomaAnne M. Mills · 2019 · Springer eBooks
- Germline Genomic Copy Number Variation Contribution to Cancer PredispositionAmanda Gonçalves Silva, Tatiane Cristina Rodrigues, Peter Lees Pearson, Carla Rosenberg, Ana Cristina Victorino Krepischi · 2013 · Encyclopedia of Life Sciences
- Germline Copy Number Variation and Cancer RiskRicharda M. de Voer, Ramprasath Venkatachalam, Ad Geurts van Kessel, Roland P. Kuiper · 2012 · Wiley eBooks
- Population-wide Screening for Germline Variants of Hereditary Cancer Genes in 12K Unselected Japanese Colorectal Cancers and 27K ControlsMasashi Fujita, Xiaoxi Liu, Yusuke Iwasaki, Chikashi Terao, Sadaaki Takata, Chihiro Inai, Tomomi Aoi, Kazuhiro Maejima, Makoto Hirata, Yoshinori Murakami et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Microsatellite Instability in Stage II and III Colorectal Cancer: Patterns and ProfileA. P. Dubey, S Vishwanath, Nikhil Pathi, Anvesh Rathore, Abhishek Pathak, Rakesh Kumar · 2018 · Indian Journal of Medical and Paediatric Oncology
- Hereditary Colorectal Cancer: From Diagnosis to Surgical OptionsRami James N. Aoun, Matthew F. Kalady · 2024 · Clinics in Colon and Rectal Surgery
- Endometrial Carcinoma:Low-Grade Endometrioid CarcinomaElena Lucas, Anne M. Mills, Kelley S. Carrick · 2025 · Springer eBooks
- BRCA1 promoter hypermethylation is not associated with germline variants in Polish breast cancer patientsKarolina Prajzendanc, Paweł Domagała, Jolanta Hybiak, Wojciech Kluźniak, Cezary Cybulski, Katarzyna Białkowska, Alicja Ogrodniczak, Janusz Ryś, Aleksandra Sejda, Marek Szwiec et al. · 2025 · Hereditary Cancer in Clinical Practice
- Genetic Insights Into Nephrolithiasis and Renal Cancer Predisposition: Precision Medicine in Genes, Diagnosis, and TherapyChen‐Han Wilfred Wu, Yu-Ren Mike Huang, Hachem Ziadeh, Bor-En Jong, Prapti Dalal, Hsin-Ti Cindy Lin, Amar J. Majmundar, Yao‐Chou Tsai, Adonis Hijaz, Marshall L. Stoller et al. · 2025 · Seminars in Nephrology
- MLH1 c.27G>A (p.Arg9=) is a synonymous likely/pathogenic variant underlying variably mosaic constitutional MLH1 methylation in Lynch syndromeRocio Alvarez, Paula Climent‐Cantó, Gi Won Shin, Francesca Paola Aguirre, Lisa Zhou, Dennis J. Hazelett, Brent K. Larson, Covadonga Vara, Gabriel Capellá, Víctor Lorca Castellanos et al. · 2025 · Familial Cancer
- Living at genetic risk: The patient experience of Lynch syndromeNicola Reents, Georgina Hoffmann, Kelly Kohut · 2025 · International Journal of Cancer
- Distinctive Tumor Biology of MSI-High Colorectal CancerNeil Majithia, Benjamin R. Kipp, Axel AG Grothey · 2015 · Current Colorectal Cancer Reports
- Deficient mismatch repair in colorectal cancer: current perspectives on patient management and future directionsMatthew Burge, Barbara Leggett, Vicki Whitehall · 2015 · Colorectal Cancer
- Should Microsatellite Instability Be Tested in All Cases of Colorectal Cancer?Guy Rosner, Hana Strul · 2014 · Current Colorectal Cancer Reports
- Hereditäres kolorektales KarzinomMartina Kadmon, Matthias Kloor, Mirjam Tariverdian · 2011 · Der Onkologe
- Diagnosing lynch syndrome in absence of colorectal cancerHenry T. Lynch, Joseph A. Knezetic, Stephen J. Lanspa · 2012 · Expert Opinion on Medical Diagnostics
- Epigenetic modification and cancer: mark or stamp?William David Foulkes · 2012 · Endocrine Related Cancer
- The Role of Epimutations of the Mismatch Repair Genes in the Development of Lynch Syndrome Related CancersMegan Philippa Hitchins · 2013 · Springer eBooks
- Genetic Testing, an Optimal Strategy for Lynch Syndrome IdentificationPetra Hudler · 2013 · Springer eBooks
- DNA-MethylierungUlrich Lehmann · 2010 · Der Pathologe
- Cancer of the Colon and Gastrointestinal TractClement Richard Boland, Barbara Jung, John M. Carethers · 2013 · Elsevier eBooks
- ЭПИГЕНЕТИЧЕСКАЯ РЕВОЛЮЦИЯ В ПРИСТАЛЬНОМ РАССМОТРЕНИИMarisa Méloni, Дж. Теста · 2015 · Биосфера
- Next-Generation-Sequencing in der EpigenetikMichael Zeschnigk, Bernhard Horsthemke · 2019 · Medizinische Genetik
- Clinical Features of Lynch SyndromeKohji Tanakaya · 2020 · Springer eBooks
- Integrating Tumor Sequencing Into Clinical Practice for Patients With Mismatch Repair-Deficient Lynch Syndrome Spectrum CancersKatherine Dixon, Mary‐Jill Asrat, Angela C. Bedard, Kristin Binnington, Katie Compton, Carol Cremin, Nili Heidary, Zoe Lohn, Niki Lovick, Mary McCullum et al. · 2021 · Clinical and Translational Gastroenterology
- Familial SyndromesIsabelle Ferry, Saira B. Alli, James T. Rutka · 2018 · Springer eBooks
- Molecular Basis of Diseases of the Gastrointestinal TractAntonia R. Sepulveda, Armando J. Del Portillo · 2017 · Elsevier eBooks
- Hereditary Colon Cancer: Lynch SyndromeEunice Lee Kwak, Daniel C. Chung · 2010 · Springer eBooks
- Novel germline mutations in MLH1 and PMS2 in familial Lynch syndromeYuhan Cai, Xiaohan Chang, Congrong Liu, Qianqian Lin, Hua Li · 2022 · Gynecology and Obstetrics Clinical Medicine
- A Prospective Study to Evaluate the Prevalence of Microsatellite Instability in Endometrial Carcinoma by using Immunohistochemistry for Mismatch Repair Proteins as a Surrogate MarkerPrithviraj K. Solanki, Mahesh Mandolkar, Padmaj Sudhakar Kulkarni · 2024 · Indian Journal of Medical and Paediatric Oncology
- Oncogénétique colorectale : acquis récentsOlivier Caron, Émilie Consolino, Véronique Byrde, Brigitte Bressac–de Paillerets, David Malka · 2009 · Hépato-Gastro & Oncologie Digestive
- Les nouveautés dans les formes héréditaires des cancers colorectauxBruno Buecher, Diane Molière, Antoine De Pauw · 2009 · Côlon & Rectum
- Cancer Genetics and GenomicsJ. Whitworth, Eamonn Richard Maher · 2016 · Elsevier eBooks
- Hereditary Nonpolyposis Colorectal CancerBo Young Oh · 2017 · Ewha Medical Journal
- DE LAS FAMILIAS CON SÍNDROMES A LOS GENES. LAS PRIMERAS CARACTERIZACIONES CLÍNICAS Y GENÉTICAS DE DOS SÍNDROMES HEREDITARIOS CON PREDISPOSICIÓN AL CÁNCER: ¿CUÁL FUE EL COMIENZO?Charite Nicolette Ricker · 2017 · Revista Médica Clínica Las Condes
- Clinical Diagnosis and Therapy of Colorectal Cancer2015 · OMICS International eBooks
- Ovarian metastases from ileum cancer in a patient with germline EPCAM gene deletion successfully treated with surgical resection and CAPOX chemotherapy: a case reportNarushi Iwata, Ayumi Shikama, Wataru Takao, Yoshihiko Hosokawa, Hiroya Itagaki, Nobutaka Tasaka, Azusa Akiyama, Hiroyuki Ochi, Takeo Minaguchi, Miwa Arita et al. · 2020 · BMC Medical Genetics
- Colorectal Cancer Genetics: An Overview of the Actionable Building BlocksKhalid El Bairi, Csongor György Lengyel, Antonio Marra, Saïd Afqir · 2020 · Springer eBooks
- Familial SyndromesIsabelle Ferry, Saira B. Alli, James T. Rutka · 2020 · Springer eBooks
- Hereditary CancersLorenzo Ceppi, Don Steven Dizon, Michael J. Birrer · 2019 · Springer eBooks
- Epimutations and Cancer SusceptibilityMathew A. Sloane, Luke B. Hesson, Robyn Lynne Ward · 2014 · Wiley eBooks
- Pathogenic mutations and novel variants in MLH1 and MSH2 in a South African colon cancer cohortKenneth Mark Davison · 2013 · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
- Epigenetic Mechanisms in Lynch SyndromeTaina Tuulikki Nieminen, Anni Niskakoski, Païvi Peltomäki · 2016 · Encyclopedia of Life Sciences
- Mutations Involving RBP4 and SOX3 Underlie Two Novel Forms of Congenital Eye Malformations.Christopher M. Chou · 2012 · Deep Blue (University of Michigan)
- Lynch SyndromeHenry T. Lynch · 2017 · Springer eBooks
- Occurrence of variants of unknown clinical significance in genetic testing for hereditary breast and ovarian cancer syndrome and Lynch syndrome - A Literature review and analytical observational retrospective cohort studyFelicia Adam, Muriel Fluri, Amina Scherz, Manuela Rabaglio · 2022 · Research Square
- Learning About Mismatch Repair From a Rare Cancer Syndrome: A LOGICal Step ForwardJunne Kamihara, Natalie Bucheimer Collins · 2022 · Journal of Clinical Oncology
- Malignant epithelial neoplasms of the large intestineShaun V. Walsh, Kieran D. Sheahan, Frank A. Carey · 2024 · Wiley eBooks
- Interaction Between Genetics and Epigenetics in CancerAmanda Ewart Toland · 2013 · Springer eBooks
- New Insights into Lynch Syndrome DiagnosisE. J. Coetzee, Ursula Algar, Paul A. Goldberg · 2013 · Springer eBooks
- Epimutation in DNA Mismatch Repair (MMR) GenesKouji Banno, Iori Kisu, Megumi Yanokura, Yuya Nogami, Kiyoko Umene, Kosuke Tsuji, Kenta Masuda, Arisa Ueki, Nobuyuki Susumu, Daisuke Aoki · 2013 · InTech eBooks
- Modifiable risk factors and colorectal adenomas among those at high risk of colorectal cancerAkke Botma · 2011
- Hereditary colorectal cancer syndromes: Epidemiological studies on Peutz-Jeghers syndrome & Lynch syndromeMargot G. van Lier · 2011
- Nuevas aportaciones a la caracterización molecular de los gliomasIrene Rodríguez Hernández · 2013 · Gredos (University of Salamanca)
- Functional Characterization of MutS Homologue Mismatch Repair Proteins and their VariantsJukka Kantelinen · 2012 · Työväentutkimus Vuosikirja
- Hereditary Endometrial CarcinomaJ. Salvador · 2012 · InTech eBooks
- Hereditäres kolorektales KarzinomMartina Kadmon, Matthias Kloor, Mirjam Tariverdian · 2012 · coloproctology
- Investigating the genetics and pharmacogenetics of bowel cancerHannah D. West · 2013 · ORCA Online Research @Cardiff (Cardiff University)
- Applying toponome imaging system for studying colon cancerSayantan Bhattacharya · 2026 · Warwick Research Archive Portal (University of Warwick)
- Epigenetic Drivers of Genetic Alterations in CancerHiromu Suzuki · 2012 · Wiley eBooks
- Mismatch Repair Deficient Tumors Lacking Known Sporadic Causes: Are They All Due to Lynch Syndrome?Katherine M. Dempsey · 2013 · Digital Commons-TMC (Texas Medical Center)
- Key genetic considerations in the management of suspected hereditary colorectal cancerP Barrow, Tara Clancy, D. Gareth Evans · 2013 · Colorectal Cancer
- Molecular Pathology Tools in Gastrointestinal PathologyFátima Carneiro · 2010 · International Journal of Surgical Pathology
- Diagnosis and Management of Lynch SyndromeFelipe Cavalcanti Carneiro da Silva, Mev Dominguez–Valentin, Érika Maria Monteiro Santos, Fabio O. Ferreira, Samuel Aguiar, Edenir Inêz Palmero, Benedito M. Rossi · 2011 · Recent Patents on Regenerative Medicine
- Thirty-Nine-Year-Old With Familial Colon Cancer, and Variant of Undetermined Significance in MSH6Christian S. Adonizio, Michelle Gazzillo, Joseph A. Knezetic, Carrie Snyder, Henry T. Lynch, Christina Rybak, Michael J. Hall, Kristina Lowstuter, Julie Malia Eggington, Gloria Joan Morris · 2012 · Seminars in Oncology
- Microsatellite instability profiling of Lynch syndrome-associated cancersAna M. Ferreira · 2009 · University of Groningen research database (University of Groningen / Centre for Information Technology)
- Epigenetic alterations in sporadic and familial cancersEmmi I. Joensuu · 2015 · Työväentutkimus Vuosikirja
- Microsatellite Instability and Intestinal TumorigenesisMeena A. Prasad, Barbara H. Jung · 2015 · Springer eBooks
- Analyse des gènes du MisMatch Repair dans le syndrome de Lynch MisMatch Repair genes and Lynch syndrome, recent updatesSylviane Olschwang, François Eisinger · 2010
- Hereditary CRC SyndromesManish K. Gala, Daniel C. Chung · 2015 · Springer eBooks
- Mutations in Non-MMR Genes Modifying or Mimicking Lynch Syndrome PhenotypeMala Pande, Jinyun Chen, Chongjuan Wei, Yu-Jing Huang, Marsha L. Frazier · 2013 · Springer eBooks
- Historical Development of Lynch SyndromeHenry T. Lynch, Stephen J. Lanspa, Carrie Snyder, Trudy G. Shaw, Patrick M. Lynch · 2013 · Springer eBooks
- Lynch-Syndrom, HNPCC und hereditäre Polyposis-SyndromeRalph Schneider, Claudia Schneider, Gabriela Möslein · 2015 · Elsevier eBooks
- Evaluation of Mismatch Repair Gene Polymorphisms and their Contribution to Colorectal Cancer and its SubsetsMiralem Mrkonjic · 2009 · TSpace (University of Toronto)
- Screening for Microsatellite Instability in Colorectal Cancer and Lynch Syndrome - A Mini ReviewMinhua Wang, Kazunori Kanehira, Frank Chen · 2016 · North American Journal of Medicine and Science
- The Role of MLH1 Constitutional Methylation in Lynch SyndromeDiana Touceira Pinto · 2015 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
- Risikogruppen mit einer erblichen Disposition für familiäre (polygene) kolorektale KarzinomeGabriela Möslein · 2016 · Der Onkologe
- Aspectos genético-moleculares asociados con el desarrollo del carcinoma colorrectalMábel Bohórquez, Ana Patricia Estrada-Florez, R Ángel Alexandro Criollo, S Rodrigo Prieto, María Magdalena Echeverry de Polanco, C Luis Guillermo Carvajal · 2015
- Évaluation de l'expression et de la valeur pronostique de PD-L1 dans les cancers colorectaux traités par chirurgie première : série rétrospective de 105 casGratiane Cogniet · 2016 · HAL