Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Mahajan, Anubha, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium, Go, Min Jin, Zhang, Weihua +329 more·2014·Nature Genetics

DOI 10.1038/ng.2897

Cited by (1,001)

Items 601–700 of 1,001

Clinical worthlessness of genetic prediction of common forms of diabetes mellitus and related chronic complications
Raffaella Buzzetti, Sabrina Prudente, Massimiliano Copetti, Marco Dauriz, Simona Zampetti, Monia Garofolo, Giuseppe Penno, Vincenzo Trischitta · 2016 · Nutrition Metabolism and Cardiovascular Diseases
High Liver Enzyme Concentrations are Associated with Higher Glycemia, but not with Glycemic Variability, in Individuals without Diabetes Mellitus
Raymond Noordam, Debbie Vermond, Hermijntje Drenth, Carolien A. Wijman, Abimbola A. Akintola, Sabrina van der Kroef, Steffy W. M. Jansen, Neline C. Huurman, Bianca A. M. Schutte, Marian Beekman et al. · 2017 · Frontiers in Endocrinology
Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program
Kanika Kanchan, Kruthika Raman Iyer, Lisa R. Yanek, Ivan Carcamo‐Orive, Margaret A. Taub, Claire E Malley, Kristin K. Baldwin, Lewis C. Becker, Ulrich Broeckel, Linzhao Cheng et al. · 2020 · Stem Cell Research
Genetic variation in insulin‐induced kinase signaling
Isabel Xiaorong Wang, Girish Ramrattan, Vivian G. Cheung · 2015 · Molecular Systems Biology
Type 2 Diabetes Prevention: Implications of Hemoglobin A1c Genetics
Aaron Leong, James B. Meigs · 2015 · The Review of Diabetic Studies
Using whole genome scores to compare three clinical phenotyping methods in complex diseases
Wenyu Song, Hailiang Huang, Cheng‐Zhong Zhang, David Westfall Bates, Adam T. Wright · 2018 · Scientific Reports
Validation of Genome-Wide Association Studies (GWAS)-Identified Type 2 Diabetes Mellitus Risk Variants in Pakistani Pashtun Population
Asif Jan, Zakiullah, Fazli Khuda, Rani Akbar · 2022 · Journal of the ASEAN Federation of Endocrine Societies
Association of an intronic SNP rs9939609 in FTO gene with type 2 diabetes mellitus among Bangladeshi population: A case–control study combined with updated meta-analysis
Kumkum Kar, Md. Adnan Munim, Atqiya Fariha, Arpita Singha Roy, Md. Imranur Rahman, Shahana Akter, Mahafujul Islam Quadery Tonmoy, Mohammad Rahanur Alam, Ahmed Ifrad Bin Raunak, Shahjada Selim et al. · 2022 · Human Gene
Insight into genetic, biological, and environmental determinants of sexual-dimorphism in type 2 diabetes and glucose-related traits
Amel Lamri, Monica De Paoli, Russell J. de Souza, Geoff H. Werstuck, Sonia Savitri Anand, Marie Pigeyre · 2022 · Frontiers in Cardiovascular Medicine
Common and rare variants associated with cardiometabolic traits across 98,622 whole-genome sequences in the All of Us research program
Xin Wang, Justine H. Ryu, Jihoon Kim, Andrea H. Ramirez, Kelsey Mayo, Henry Robert Condon, Nataraja Sarma Vaitinadin, Lucila Ohno-machado A, Greg A. Talavera, Patrick T. Ellinor et al. · 2023 · Journal of Human Genetics
The impact of diabetes mellitus on the development of psychiatric and neurological disorders
Olivia Kelly, Jillian Sullivan, Natalie Carris, Samantha Geci, Athena Martinez, Varvara Liashenko, James Colvin, Emily Misko, Gary Vanderlaan, Liu He et al. · 2024 · Brain Disorders
At the centre of things
Guang Ning · 2015 · Nature Reviews Endocrinology
Common Variants Associated with Type 2 Diabetes in a Black South African Population of Setswana Descent: African Populations Diverge
Tinashe Chikowore, Karin R. Conradie, Gordon Wayne Towers, Tertia van Zyl · 2015 · OMICS A Journal of Integrative Biology
The Role of TCF7L2 rs7903146 in Diabetes After Kidney Transplant
Marco Quaglia, Salvatore Terrazzino, Claudio Musetti, Sarah Cargnin, Guido Merlotti, Tiziana Cena, Piero Stratta, Armando A. Genazzani · 2015 · Transplantation
Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes
Susanne Jäger, Simone Wahl, Janine Kröger, Sapna Sharma, Per Hoffmann, Anna Floegel, Tobias Pischon, Cornelia P. Prehn, Jerzy Adamski, Martina Müller‐Nurasyid et al. · 2017 · Scientific Reports
Analysis of type 2 diabetes and obesity genetic variants in Mexican Pima Indians: Marked allelic differentiation among Amerindians at HLA
Wen‐Chi Hsueh, Peter H. Bennett, Julián Esparza‐Romero, René Urquídez-Romero, Mauro E. Valencia, Éric Ravussin, Robert C. Williams, William C. Knowler, Leslie J. Baier, Leslie Olmstead Schulz et al. · 2018 · Annals of Human Genetics
Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function
Mairéad Flynn, Laura Whitton, Gary J Donohoe, Ciaran G. Morrison, Derek W. Morris · 2019 · Human Molecular Genetics
Genetic risk score constructed from common genetic variants is associated with cardiovascular disease risk in type 2 diabetes mellitus
Chi‐Fung Cheng, Ying‐Ju Lin, Mei‐Chen Lin, Wen‐Miin Liang, Ching‐Chu Chen, Chien‐Hsiun Chen, Jer‐Yuarn Wu, Ting‐Hsu Lin, Chiu‐Chu Liao, Shao‐Mei Huang et al. · 2020 · The Journal of Gene Medicine
Using Genetic Variation to Predict and Extend Long-term Kidney Transplant Function
Matthew J. Simmonds · 2015 · Transplantation
Polymorphisms in PDLIM5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension
Daniel Owusu, Yue Pan, Changchun Xie, Sam Harirforoosh, Kesheng Wang · 2016 · Journal of Psychiatric Research
Pharmacogenetics of oral antidiabetes drugs: evidence for diverse signals at the IRS1 locus
Sabrina Prudente, Rosa Di Paola, Serena Pezzilli, Monia Garofolo, Olga Lamacchia, Tiziana Filardi, Gaia Chiara Mannino, Luana Mercuri, Federica Alberico, Maria Giovanna Scarale et al. · 2017 · The Pharmacogenomics Journal
Improved detection of genetic loci in estimated glomerular filtration rate and type 2 diabetes using a pleiotropic cFDR method
Huimin Liu, Jingyang He, Qıang Zhang, Wan‐Qiang Lv, Xin Xia, Changqing Sun, Weidong Zhang, Hong‐Wen Deng · 2017 · Molecular Genetics and Genomics
Regulatory and evolutionary signatures of sex-biased genes on both the X chromosome and the autosomes
Jiangshan Jane Shen, Ting-You Wang, Wanling Yang · 2017 · Biology of Sex Differences
Association between IL-15 and insulin plasmatic concentrations in patients with pulmonary tuberculosis and type 2 diabetes
Roberto Sánchez-Jiménez, Eduarda Cerón, Demetrio Arturo Bernal-Alcántara, Manuel de Jesús Castillejos-López, Eva González-Trujano, María Cristina Negrete-García, Noé Alvarado‐Vásquez · 2018 · Tuberculosis
Body mass index and the risk of mortality among Chinese adults with Type 2 diabetes
Huilin Xu, M. Zhang, D. Xu, Fan Zhang, Boshuang Yao, Yujie Yan, Na Zhao, Wanghong Xu, Guoyou Qin · 2018 · Diabetic Medicine
A critical evaluation of results from genome-wide association studies of micronutrient status and their utility in the practice of precision nutrition
Marie‐Joe Dib, Ruan M. Elliott, Kourosh R. Ahmadi · 2019 · British Journal Of Nutrition
Assessment of genetic risk of type 2 diabetes among Pakistanis based on GWAS-implicated loci
Bibi Sabiha, Attya Bhatti, Kang-Hsien Fan, Peter C. L. John, Muhammad Aslam, Johar Ali, Eleanor Feingold, F. Yesim Demirci, M. Ilyas Kamboh · 2021 · Gene
Admixture mapping and fine-mapping of type 2 diabetes susceptibility loci in African American women
José M. Uribe‐Salazar, Julie R. Palmer, Stephen A. Haddad, Lynn A. Rosenberg, Edward Ruiz-Narváez · 2018 · Journal of Human Genetics
Integrative cross tissue analysis of gene expression identifies novel type 2 diabetes genes
Jason Torres, Alvaro Barbeira, Rodrigo Bonazzola, Andrew P. Morris, Kaanan P. Shah, Heather E. Wheeler, Graeme I. Bell, Nancy Jean Cox, Hae Kyung Im · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis
Po‐Ru Loh, Gaurav Bhatia, Alexander Gusev, Hilary K. Finucane, Brendan K Bulik-Sullivan, Samuela J Pollack, Teresa R de Candia, Sang Lee, Naomi R. Wray, Kenneth S. Kendler et al. · 2015 · bioRxiv (Cold Spring Harbor Laboratory)
Bifunctional protein PCBD2 operates as a co‐factor for hepatocyte nuclear factor 1β and modulates gene transcription
Lotte E. Tholen, Caro Bos, Pascal W.T.C. Jansen, Hanka Venselaar, Michiel Vermeulen, Joost G.J. Hoenderop, Jeroen H. F. de Baaij · 2021 · The FASEB Journal
Transcriptional Regulation of the Pancreatic Islet: Implications for Islet Function
Michael L. Stitzel, Ina Kycia, Romy Kursawe, Duygu Ucar · 2015 · Current Diabetes Reports
Genetic risk scores for coronary artery disease and its traditional risk factors: Their role in the progression of coronary artery calcification—Results of the Heinz Nixdorf Recall study
Sonali Pechlivanis, Susanne Moebus, Nils Lehmann, Raimund Erbel, Amir Abbas Mahabadi, Per Hoffmann, Karl‐Heinz Jöckel, Markus Maria Nöthen, Hagen S. Bachmann, on behalf of the Heinz Nixdorf Recall Study Investigative Group · 2020 · PLoS ONE
MethHaplo: combining allele-specific DNA methylation and SNPs for haplotype region identification
Qiangwei Zhou, Ze Wang, Jing Li, Wing-Kin Ken Sung, Guoliang Li · 2020 · BMC Bioinformatics
Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice
Hui‐Young Lee, Hye Rim Jang, Hui Li, Varman T. Samuel, Karrie D. Dudek, Anna B. Osipovich, Mark A. Magnuson, Jeffrey Sklar, Gerald I. Shulman · 2022 · Proceedings of the National Academy of Sciences
CDKN2A-rs10811661 polymorphism, waist-hip ratio, systolic blood pressure, and dyslipidemia are the independent risk factors for prediabetes in a Vietnamese population
Trần Quang Bình, Nguyễn Thị Trung Thu, Phạm Trần Phương, Bùi Thị Nhung, Trịnh Thị Hồng Nhung · 2015 · BMC Genetics
Variants associated with type 2 diabetes identified by the transethnic meta-analysis study: assessment in American Indians and evidence for a new signal in LPP
Anup Kumar Nair, Yunhua L. Muller, Nellie A. McLean, Maryam Abdussamad, Paolo Piaggi, Sayuko Kobes, E. Jennifer Weil, Jeffrey M. Curtis, Robert G. Nelson, William C. Knowler et al. · 2014 · Diabetologia
Genome-Wide Studies of Type 2 Diabetes and Lipid Traits in Hispanics
Jennifer Elizabeth Below, Esteban Juan Parra · 2016 · Current Diabetes Reports
Gene expression signature: a powerful approach for drug discovery in diabetes
Smithamol Sithara, Tamsyn M. Crowley, Ken R. Walder, Kathryn Aston‐Mourney · 2016 · Journal of Endocrinology
Common and rare exonic MUC5B variants associated with type 2 diabetes in Han Chinese
Guanjie Chen, Zhenjian Zhang, Sally Nneoma Adebamowo, Guozheng Liu, Adebowale Adeyemo, Yanxun Zhou, Ayo Priscille Doumatey, Chuntao Wang, Jie Zhou, Wenqiang Yan et al. · 2017 · PLoS ONE
Serum resistin positively correlates with serum lipids, but not with insulin resistance, in first-degree relatives of type-2 diabetes patients
Xiaohong Niu, Li Li, Junyan Li, Qi Song, Miaomiao Jin, Jin-xia Liu · 2017 · Medicine
Diabetes area patent participation analysis – part II: years 2011-2016
Markus Boehm, Matthew Crawford, Jamie E. Moscovitz, Philip A. Carpino · 2017 · Expert Opinion on Therapeutic Patents
Contribution of Known Genetic Risk Variants to Dyslipidemias and Type 2 Diabetes in Mexico: A Population-Based Nationwide Study
Alicia Huerta‐Chagoya, Hortensia Moreno-Macías, Magdalena del Rocío Sevilla-González, Rosario Rodríguez-Guillén, María Luisa Ordóñez-Sánchez, Donají Gómez‐Velasco, Linda Liliana Muñóz-Hernández, Yayoi Segura-Kato, Olimpia Arellano‐Campos, Ivette Cruz‐Bautista et al. · 2020 · Genes
A rare missense variant in the milk fat globule-EGF factor 8 (MFGE8) increases T2DM susceptibility and cardiovascular disease risk with population-specific effects
Bishwa R. Sapkota, Dharambir K. Sanghera · 2020 · Acta Diabetologica
The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship
Qingqin S. Li, Chao Tian, David A. Hinds, Guy R. Seabrook · 2020 · PLoS ONE
Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion
Ming Hu, Inês Cebola, Gaëlle Carrat, Shuying Sue Jiang, Sameena Nawaz, Amna Khamis, Mickaël Canouil, Philippe Froguel, Anke Schulte, Michele Solimena et al. · 2021 · Cell Reports
Identification of novel functional CpG-SNPs associated with Type 2 diabetes and birth weight
Rui-Ke Liu, Lin Xu, Zun Wang, Jonathan Greenbaum, Chuan Qiu, Chun‐Ping Zeng, Yong-Yao Zhu, Jie Shen, Hong‐Wen Deng · 2021 · Aging
Integrating Common Risk Factors with Polygenic Scores Improves the Prediction of Type 2 Diabetes
Yanina Timasheva, Zhanna Balkhiyarova, Diana Shamilevna Avzaletdinova, И. Г. Рассолеева, Т. В. Моругова, Gulnaz Faritovna Korytina, Inga Prokopenko, Olga Vladimirovna Kochetova · 2023 · International Journal of Molecular Sciences
Risk Prediction Using Genome-Wide Association Studies on Type 2 Diabetes
Sungkyoung Choi, Sunghwan Bae, Taesung Park · 2016 · Genomics & Informatics
Genetic determinants of adiponectin regulation revealed by pregnancy
Marie‐France Hivert, Denise M. Scholtens, Catherine Allard, Michael Nodzenski, Luigi Bouchard, Diane Brisson, Lynn P. Lowe, Ian C. McDowell, Tim Reddy, Zari Dastani et al. · 2017 · Obesity
Genetic Architecture of Type 2 Diabetes
Rashmi B. Prasad, Leif Groop · 2016 · Wiley eBooks
The causal relationship between metabolic factors, drinking, smoking and intrahepatic cholangiocarcinoma: a Mendelian randomization study
Shanshan Qin, Guoqiang Pan, Qun-bo Meng, Jinbo Liu, Ziyu Tian, Shou-jing Luan · 2023 · Frontiers in Oncology
C2CD4B Evokes Oxidative Stress and Vascular Dysfunction via a PI3K/Akt/PKCα–Signaling Pathway
Paola Di Pietro, Angela Carmelita Abate, Valeria Prete, Antonio Damato, Eleonora Venturini, Maria Rosaria Rusciano, Carmine Izzo, Valeria Visco, Michele Ciccarelli, Carmine Vecchione et al. · 2024 · Antioxidants
A genome-wide cross-trait analysis identifies shared loci and causal relationships of obesity and lipidemic traits with psoriasis
Wu Yuan, Mengfen Huang, Xueru Chen, Jingjing Wu, Li Li, Jianan Wei, Chuanjian Lu, Ling Han, Yue Lu · 2024 · Frontiers in Immunology
Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes
Magdalena del Rocío Sevilla-González, Kirk Smith, Ningyuan Wang, A. E. Jensen, ELIZABETH M. LITKOWSKI, Hyunkyung Kim, DANIEL A. DICORPO, Sarah C Hsu, Jinrui Cui, Ching‐Ti Liu et al. · 2025 · Nature Communications
Genome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biology
Nicola L. Beer, Anna L. Gloyn · 2016 · F1000Research
High-resolution metabolomics determines the mode of onset of type 2 diabetes in a 3-year prospective cohort study
Yeseung Lee, Aryo Dimas Pamungkas, Carl Angelo Medriano, Jinsung Park, Seri Hong, Sun Ha Jee, Youngja H. Park · 2017 · International Journal of Molecular Medicine
Genetics of type 2 diabetes and coronary artery disease and their associations with twelve cardiometabolic traits in the United Arab Emirates population
Wael Mohammed Osman, Ahmed Abdul Karim Hassoun, Herbert Franz Jelinek, Wael A. Almahmeed, Bachar O. Afandi, Guan K. Tay, Habiba S. AlSafar · 2020 · Gene
Human Pluripotent Stem Cells: A Unique Tool for Toxicity Testing in Pancreatic Progenitor and Endocrine Cells
Erin M. MacFarlane, Jennifer E. Bruin · 2021 · Frontiers in Endocrinology
Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes
Tue H. Hansen, Henrik Vestergaard, Marit E. Jørgensen, Marit E. Jørgensen, Torsten Lauritzen, Ivan Brandslund, Cramer Christensen, Oluf Borbye Pedersen, Torben Hansen, Anette P. Gjesing · 2015 · BMC Medical Genetics
Comparative Transcriptomes and EVO-DEVO Studies Depending on Next Generation Sequencing
Tiancheng Liu, Lin Yu, Lei Liu, Hong Li, Yixue Li · 2015 · Computational and Mathematical Methods in Medicine
Impaired glucose metabolism and type 2 diabetes in apparently healthy senior citizens
Pedro Medina Escobar, M Moser, Lorenz Risch, Martin Risch, U Nydegger, Zeno Giovanni Stanga · 2015 · Swiss Medical Weekly
Genetic markers of inflammation may not contribute to metabolic traits in Mexican children
Neeti Vashi, Carolina Stryjecki, Jesús Peralta‐Romero, Fernando Suarez, Jaime Héctor Gómez-Zamudio, Ana I. Burguete-García, Miguel Cruz, David Meyre · 2016 · PeerJ
Mouse Models of Human GWAS Hits for Obesity and Diabetes in the Post Genomic Era: Time for Reevaluation
Samantha Laber, Roger Cox · 2017 · Frontiers in Endocrinology
Lifestyle intervention modifies the effect of the MC4R genotype on changes in insulin resistance among women with prior gestational diabetes: Tianjin Gestational Diabetes Mellitus Prevention Program
Yuhang Chen, Huikun Liu, Leishen Wang, Tao Zhou, Zhaoxia Liang, Weiqin Li, Xiaoyun Shang, Junhong Leng, Yun Shen, Gang Hu et al. · 2019 · American Journal of Clinical Nutrition
Identification of two microRNA nodes as potential cooperative modulators of liver metabolism
Mette Yde Hochreuter, Ali Altıntaş, Christian Garde, Brice Emanuelli, C. Ronald Kahn, Juleen Rae Zierath, Sara G. Vienberg, Romain Barrès · 2019 · Hepatology Research
DNA Methylation and Type 2 Diabetes: the Use of Mendelian Randomization to Assess Causality
Diana L. Juvinao-Quintero, Marie‐France Hivert, Gemma C. Sharp, Caroline L. Relton, Hannah R. Elliott · 2019 · Current Genetic Medicine Reports
Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood
Yan Zheng, Tao Huang, Tiange Wang, Zhendong Mei, Zhonghan Sun, Tao Zhang, Christina Ellervik, Jin Fang Chai, Xueling Sim, Rob M. van Dam et al. · 2020 · European Journal of Epidemiology
TYK2 Promoter Variant Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients
Hitoe Mori, Hirokazu Takahashi, Keiichiro Mine, Ken Higashimoto, Kanako Inoue, Motoyasu Kojima, Shigetaka Kuroki, Takahisa Eguchi, Yasuhiro Ono, Sadataka Inuzuka et al. · 2021 · Genes
Examination on the risk factors of cholangiocarcinoma: A Mendelian randomization study
Lanlan Chen, Zhongqi Fan, Xiaodong Sun, Wei Qiu, Wentao Mu, Kaiyuan Chai, Yannan Cao, Guangyi Wang, Guoyue Lv · 2022 · Frontiers in Pharmacology
Diabetes in Population Isolates: Lessons from Greenland
Niels Grarup, Ida Moltke, Anders Albrechtsen, Torben F. Hansen · 2015 · The Review of Diabetic Studies
A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women
Stephen A. Haddad, Julie R. Palmer, Kathryn L. Lunetta, Maggie C.Y. Ng, Edward Ruiz-Narváez · 2017 · PLoS ONE
Genome-Wide Gene–Potassium Interaction Analyses on Blood Pressure
Changwei Li, Jiang He, Jing Chen, Jinying Zhao, Dongfeng Gu, James E. Hixson, D. C. Rao, Cashell E. Jaquish, Treva Rice, Yun Ju Sung et al. · 2017 · Circulation Cardiovascular Genetics
TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet
Sarah M. Graff, Arya Y. Nakhe, Prasanna K. Dadi, Matthew T. Dickerson, Jordyn R. Dobson, Karolina E. Zaborska, Chloe E. Ibsen, Regan B. Butterworth, Nicholas C. Vierra, David Aaron Jacobson · 2024 · Cell Reports
Polygenic Risk Score Assessment for Coronary Artery Disease in Asian Indians
Madhusmita Rout, Gurleen Kaur Tung, Jai Rup Singh, Narinder Kumar Mehra, Gurpreet Singh Wander, Sarju K. Ralhan, Dharambir K. Sanghera · 2024 · Journal of Cardiovascular Translational Research
Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans
Jacob M. Keaton, Jacklyn N. Hellwege, Maggie C.Y. Ng, Nicholette D. Palmer, James S. Pankow, Myriam Fornage, James G. Wilson, Adolfo Correa, Laura J. Rasmussen‐Torvik, Jerome I. Rotter et al. · 2016 · PLoS ONE
Dietary Fat and the Genetic Risk of Type 2 Diabetes
Germán D. Carrasquilla, Hermina Jakupović, Tuomas O. Kilpeläinen · 2019 · Current Diabetes Reports
Burden of Type 2 Diabetes and Associated Cardiometabolic Traits and Their Heritability Estimates in Endogamous Ethnic Groups of India: Findings From the INDIGENIUS Consortium
Vettriselvi Venkatesan, Juan Carlos López-Alvarenga, Rector Arya, Deepika Ramu, Teena Koshy, Umarani Ravichandran, Amaresh Reddy Ponnala, Surendra Kumar Sharma, Sailesh Lodha, Krishna Kumar Sharma et al. · 2022 · Frontiers in Endocrinology
Circulating Vitamin D Concentrations and Risk of Atrial Fibrillation: A Mendelian Randomization Study Using Non-deficient Range Summary Statistics
Nan Zhang, Yueying Wang, Ziliang Chen, Daiqi Liu, Gary Tse, Panagiotis G. Korantzopoulos, Κonstantinos P. Letsas, Christos A. Goudis, Gregory Y.H. Lip, Guangping Li et al. · 2022 · Frontiers in Nutrition
Nontargeted Metabolomics Revealed Novel Association Between Serum Metabolites and Incident Acute Coronary Syndrome: A Mendelian Randomization Study
Gaokun Qiu, Yuhui Lin, Yang Ouyang, Mingrong You, Xinjie Zhao, Hao Wang, Rundong Niu, Wending Li, Xuedan Xu, Yan Qi et al. · 2023 · Journal of the American Heart Association
Pharmacogenetic Aspects of the Treatment of Type 2 Diabetes with the Incretin Effect Enhancers
Ivan Tkáč, Ivana Gotthardová · 2016 · Pharmacogenomics
GENOME-WIDE INTERACTION WITH SELECTED TYPE 2 DIABETES LOCI REVEALS NOVEL LOCI FOR TYPE 2 DIABETES IN AFRICAN AMERICANS
Jacob M. Keaton, Jacklyn N. Hellwege, Maggie C.Y. Ng, Nicholette D. Palmer, James S. Pankow, Myriam Fornage, James G. Wilson, Adolfo Correa, Laura J. Rasmussen‐Torvik, Jerome I. Rotter et al. · 2016 · Pacific Symposium on Biocomputing (PSB)
Cloud-based interactive analytics for terabytes of genomic variants data
Cuiping Pan, Gregory McInnes, Nicole A. Deflaux, Michael P. Snyder, Jonathan Bingham, Somalee Datta, Philip S. Tsao · 2017 · Bioinformatics
Identification of four genes as novel susceptibility loci for early‑onset type 2 diabetes mellitus, metabolic syndrome, or hyperuricemia
Yoshiji Yamada, Kimihiko Kato, Mitsutoshi Oguri, Hideki Horibe, Tetsuo Fujimaki, Yoshiki Yasukochi, Ichiro Takeuchi, Jun Sakuma · 2018 · Biomedical Reports
Genome-wide DNA methylation analysis of human peripheral blood reveals susceptibility loci of diabetes-related hearing loss
Jin Hao, Lin Hua, Xinxing Fu, Xuelian Zhang, Qijuan Zou, Yongxin Li · 2018 · Journal of Human Genetics
CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation
Naomi L. Cook, Milos Pjanic, Andrew Emmerich, Abhiram S. Rao, Susanne Hetty, Joshua W. Knowles, Thomas Quertermous, Casimiro Castillejo-López, Erik Ingelsson · 2019 · BMC Endocrine Disorders
A Preliminary Study Showing the Impact of Genetic and Dietary Factors on GC–MS-Based Plasma Metabolome of Patients with and without PROX1-Genetic Predisposition to T2DM up to 5 Years Prior to Prediabetes Appearance
Patrycja Mojsak, Katarzyna Miniewska, Adrian Godlewski, Edyta Adamska-Patruno, Paulina Samczuk, Fernanda Rey-Stolle, Witold Bauer, Coral Barbas, Adam Jacek Kretowski, Michał Ciborowski · 2021 · Current Issues in Molecular Biology
Bench Research Informed by GWAS Results
Nikolay V. Kondratyev, М. В. Алфимова, Arkadiy K. Golov, Вера Евгеньевна Голимбет · 2021 · Cells
Association Between Genetic Risk for Type 2 Diabetes and Structural Brain Connectivity in Major Depressive Disorder
Jonathan Repple, Amelie König, Siemon C. de Lange, Nils Opel, Ronny Redlich, Susanne Meinert, Dominik Grotegerd, Marco Mauritz, Tim Hahn, Tiana Borgers et al. · 2021 · Biological Psychiatry Cognitive Neuroscience and Neuroimaging
Evaluation of a Two‐Stage Approach in Trans‐Ethnic Meta‐Analysis in Genome‐Wide Association Studies
Jaeyoung Hong, Kathryn L. Lunetta, L. Adrienne Cupples, Josée Dupuis, Ching‐Ti Liu · 2016 · Genetic Epidemiology
Genetic and clinic predictors of new onset diabetes mellitus after transplantation
the Swiss Transplant Cohort Study, Núria Saigí-Morgui, Lina Quteineh, Pierre–Yves Bochud, Séverine Crettol, Zoltán Kutalik, Nicolas Johannes Mueller, Isabelle Binet, Christian van Delden, Jürg U. Steiger et al. · 2017 · The Pharmacogenomics Journal
A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese
Long Wang, Yu‐Ming Niu, Shishi Wu, Chao Zhang, Li Zhou, Hong‐Xia Zuo, Peng Wang · 2018 · Frontiers in Endocrinology
Polygenic scores for UK Biobank scale data
Timothy Shin Heng Mak, Robert M. Porsch, Shing Wan Choi, Pak Chung Sham · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
The Interaction of Genetic Predisposition and Socioeconomic Position With Type 2 Diabetes Mellitus: Cross-Sectional and Longitudinal Analyses From the Lifelines Cohort and Biobank Study
Sander K. R. van Zon, Sijmen A. Reijneveld, Peter J. van der Most, Morris A. Swertz, Ute Bültmann, Harold Snieder · 2018 · Psychosomatic Medicine
Genetics of mood instability and risk of cardiovascular diseases: A univariable and multivariable Mendelian randomization study
Miao Chen, Zhen Wang, Hongfei Xu, Weidong Li, Peng Teng, Liang Ma · 2023 · Journal of Affective Disorders
Genetically predicted mood swings increased risk of cardiovascular disease: Evidence from a Mendelian randomization analysis
Zirui Liu, Haocheng Wang, Zhengkai Yang, Yu Lu, Jikai Wang, Cao Zou · 2024 · Journal of Affective Disorders
Characterizing the genetic risk for Type 2 diabetes in a Malaysian multi‐ethnic cohort
Noraidatulakma Abdullah, Nor Azian Abdul Murad, John Attia, Christopher J. Oldmeadow, Ezanee Azlina Mohamad Hanif, Saiful Effendi Syafruddin, Nazihah Abd Jalal, Noorhassim Ismail, Muhiddin Ishak, Rahman Jamal et al. · 2015 · Diabetic Medicine
Identifying functional noncoding variants from genome-wide association studies for cardiovascular disease and related traits
Andrew J P Smith, Steve Eric Humphries, Philippa J. Talmud · 2015 · Current Opinion in Lipidology
Factors Motivating Individuals to Consider Genetic Testing for Type 2 Diabetes Risk Prediction
Jennifer Wessel, Jyoti Gupta, Mary de Groot · 2016 · PLoS ONE
Can genetic evidence help us to understand the fetal origins of type 2 diabetes?
Rachel M. Freathy · 2016 · Diabetologia