Genetic lineage tracing identifies endocardial origin of liver vasculature
Abstract
The hepatic vasculature is essential for liver development, homeostasis and regeneration, yet the developmental program of hepatic vessel formation and the embryonic origin of the liver vasculature remain unknown. Here we show in mouse that endocardial cells form a primitive vascular plexus surrounding the liver bud and subsequently contribute to a substantial portion of the liver vasculature. Using intersectional genetics, we demonstrate that the endocardium of the sinus venosus is a source for the hepatic plexus. Inhibition of endocardial angiogenesis results in reduced endocardial contribution to the liver vasculature and defects in liver organogenesis. We conclude that a substantial portion of liver vessels derives from the endocardium and shares a common developmental origin with coronary arteries.
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A proportion of HSECs may be derived from the endocardium and endoderm.
“though a proportion may be derived from the endocardium and endoderm”
From Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020) · cites this paper as Zhang et al., 2016
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References 37 · Cited by 105
- Authors
- Zhang, H., Pu, W., Tian, X., Huang, X., He, L., Liu, Q., Li, Y., Zhang, L., He, L., Liu, K., Gillich, A., & Zhou, B.
- Affiliations
- Chinese Academy of Sciences (CN)
- Stanford Medicine (US)
- Corresponding author
- Zhou, Bin
- ORCID
- Venue
- Nature Genetics
- Published
- 2016-03-28
- Volume
- 48
- Issue
- 5
- Pages
- 537-543
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2306878739
- Cited by
- 105
- References
- 37
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 9 · 2023: 4 · 2022: 10 · 2021: 13 · 2020: 12 · 2019: 11 · 2018: 14 · 2017: 10 · 2016: 5
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hospital for Sick Children
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- endocardium, liver vasculature, sinus venosus, liver organogenesis, coronary arteries, intersectional genetics
- MeSH terms
- Animals, Coronary Vessels, Endocardium, Heart Atria, Heart Ventricles, Liver, Liver Circulation, Morphogenesis, Neovascularization, Physiologic, Cell Lineage, NFATC Transcription Factors, Mice
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