Genetic dissection of the α-globin super-enhancer in vivo

Hay, Deborah, Hughes, Jim R, Babbs, Christian, Davies, James O J, Graham, Bryony J, Hanssen, Lars L P, Kassouf, Mira T, Oudelaar, A Marieke +15 more·2016·Nature Genetics

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  12. Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy
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  16. An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo
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  17. High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale
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  19. Transcription factor-dependent ‘anti-repressive’ mammalian enhancers exclude H3K27me3 from extended genomic domains
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  51. What is an enhancer?
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  53. Genomic dissection of enhancers uncovers principles of combinatorial regulation and cell type-specific wiring of enhancer–promoter contacts
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