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Cited by 647

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Multiple loci associated with indices of renal function and chronic kidney disease

Open access
Köttgen, Anna, Glazer, Nicole L, Dehghan, Abbas, Hwang, Shih-Jen, Katz, Ronit, Li, Man, Yang, Qiong, Gudnason, Vilmundur, Launer, Lenore J, Harris, Tamara B, Smith, Albert V, Arking, Dan E, Astor, Brad C, Boerwinkle, Eric, Ehret, Georg B, Ruczinski, Ingo, Scharpf, Robert B, Ida Chen, Yii-Der, de Boer, Ian H, Haritunians, Talin, Lumley, Thomas, Sarnak, Mark, Siscovick, David, Benjamin, Emelia J, Levy, Daniel, Upadhyay, Ashish, Aulchenko, Yurii S, Hofman, Albert, Rivadeneira, Fernando, Uitterlinden, André G, van Duijn, Cornelia M, Chasman, Daniel I, Paré, Guillaume, Ridker, Paul M, Kao, W H Linda, Witteman, Jacqueline C, Coresh, Josef, Shlipak, Michael G, Fox, Caroline S·2009·Nature Genetics
DOI 10.1038/ng.377
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Abstract

Chronic kidney disease (CKD) has a heritable component and is an important global public health problem because of its high prevalence and morbidity. We conducted genome-wide association studies (GWAS) to identify susceptibility loci for glomerular filtration rate, estimated by serum creatinine (eGFRcrea) and cystatin C (eGFRcys), and CKD (eGFRcrea < 60 ml/min/1.73 m2) in European-ancestry participants of four population-based cohorts (ARIC, CHS, FHS, RS; n = 19,877; 2,388 CKD cases), and tested for replication in 21,466 participants (1,932 CKD cases). We identified significant SNP associations (P < 5 × 10−8) with CKD at the UMOD locus, with eGFRcrea at UMOD, SHROOM3 and GATM-SPATA5L1, and with eGFRcys at CST and STC1. UMOD encodes the most common protein in human urine, Tamm-Horsfall protein, and rare mutations in UMOD cause mendelian forms of kidney disease. Our findings provide new insights into CKD pathogenesis and underscore the importance of common genetic variants influencing renal function and disease.

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Metadata

Authors
Köttgen, A., Glazer, N. L., Dehghan, A., Hwang, S.-J., Katz, R., Li, M., Yang, Q., Gudnason, V., Launer, L. J., Harris, T. B., Smith, A. V., Arking, D. E., Astor, B. C., Boerwinkle, E., Ehret, G. B., Ruczinski, I., Scharpf, R. B., Ida Chen, Y.-D., de Boer, I. H., Haritunians, T., Lumley, T., Sarnak, M., Siscovick, D., Benjamin, E. J., Levy, D., Upadhyay, A., Aulchenko, Y. S., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., van Duijn, C. M., Chasman, D. I., Paré, G., Ridker, P. M., Kao, W. H. L., Witteman, J. C., Coresh, J., Shlipak, M. G., & Fox, C. S.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2009-05-10
Volume
41
Issue
6
Pages
712-717
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.377
OpenAlex
W1967490910
Cited by
647
References
27
FWCI
24.42
Type
journal article
Language
en
Open access
green

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