The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

Pomerantz, Mark M, Ahmadiyeh, Nasim, Jia, Li, Herman, Paula, Verzi, Michael P, Doddapaneni, Harshavardhan, Beckwith, Christine A, Chan, Jennifer A +18 more·2009·Nature Genetics

DOI 10.1038/ng.403

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Srilakshmi Srinivasan, Judith Ann Clements, Jyotsna Batra · 2015 · Critical Reviews in Clinical Laboratory Sciences
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M. J. Li, B. Yan, Pak Chung Sham, Junwen Wang · 2014 · Briefings in Bioinformatics
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Biddie, Simon C., John, Sam, Hager, Gordon L. · 2010 · Trends in Endocrinology & Metabolism
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Jinliang Xing, Shaogui Wan, Feng Zhou, Falin Qu, Bingshan Li, Ronald E. Myers, Xiaoying Fu, Juan Palazzo, Xianli He, Zhi‐Nan Chen et al. · 2012 · Cancer Epidemiology Biomarkers & Prevention
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Yupeng He, David U. Gorkin, Diane E. Dickel, Joseph R. Nery, Rosa Castanon, Ah Young Lee, Yin Shen, Axel Visel, Len A. Pennacchio, Bing Ren et al. · 2017 · Proceedings of the National Academy of Sciences
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Crosstalk mechanisms between the WNT signaling pathway and long non-coding RNAs
Vasiliki Zarkou, Αλέξανδρος Γαλάρας, Antonis Giakountis, Pantelis Hatzis · 2018 · Non-coding RNA Research
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Ying Ying, Yejun Wang, Xiaoyan Huang, Yanmei Sun, Junbao Zhang, Meiqi Li, Junhui Zeng, Maolin Wang, Wenjun Xiao, Lan Zhong et al. · 2019 · Oncogene
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Hongmei Nan, Teppei Morikawa, Miia Suuriniemi, Yu Imamura, Lillian L. Werner, Aya Kuchiba, Mai Yamauchi, David J. Hunter, Peter L. Kraft, Edward L. Giovannucci et al. · 2013 · JNCI Journal of the National Cancer Institute
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Wallerman, Ola, Motallebipour, Mehdi, Enroth, Stefan, Patra, Kalicharan, Bysani, Madhu Sudhan Reddy, Komorowski, Jan, Wadelius, Claes · 2009 · Nucleic Acids Research
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Risk SNP-induced lncRNA-SLCC1 drives colorectal cancer through activating glycolysis signaling
Tingting Yan, Chaoqin Shen, Penglei Jiang, Chenyang Yu, Fangfang Guo, Xianglong Tian, Xiaoqiang Zhu, Shiyuan Lu, Bingshe Han, Ming Zhong et al. · 2021 · Signal Transduction and Targeted Therapy
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Meijun Du, Tiezheng Yuan, Kala F. Schilter, Rachel L. Dittmar, Alexander Craig Mackinnon, Xiaoyi Huang, Michael Tschannen, Elizabeth A. Worthey, Howard J. Jacob, Shu Xia et al. · 2014 · Human Molecular Genetics
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Jiang Chang, Jianbo Tian, Yang Yang, Rong Zhong, Jiaoyuan Li, Kan Zhai, Juntao Ke, Jiao Lou, Wei Chen, Beibei Zhu et al. · 2018 · Cancer Research
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Fang Xiong, Chen Hsuan Wu, Xinyu Bi, Dianke Yu, Liming Huang, Jian Feng Xu, Tongwen Zhang, Kan Zhai, Jiang Chang, Wen Tan et al. · 2010 · Cancer Epidemiology Biomarkers & Prevention
Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis
Carolyn M. Hutter, Martha L. Slattery, David J Duggan, Jill Muehling, Karen P Curtin, Li Hsu, Shirley A.A. Beresford, Aleksandar Rajkovic, Gloria E. Sarto, James Roger Marshall et al. · 2010 · BMC Cancer
Allele-specific transcriptional regulation of IRF4 in melanocytes is mediated by chromatin looping of the intronic rs12203592 enhancer to the IRF4 promoter
Visser, Mijke, Palstra, Robert-Jan, Kayser, Manfred · 2015 · Human Molecular Genetics
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3D genome organization in health and disease: emerging opportunities in cancer translational medicine
Deepak Babu, Melissa J. Fullwood · 2015 · Nucleus
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Kashyap Dave, Inderpreet Sur, Jian Yan, Jilin Zhang, Eevi Kaasinen, Fan Zhong, Leander Blaas, Xiaoze Li, Shabnam Kharazi, Charlotte Gustafsson et al. · 2017 · eLife
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Dan E. Webster, Brook C. Barajas, Rose T. Bussat, Karen Yan, Poornima H. Neela, Ross J. Flockhart, Joanna R. Kovalski, Ashley M. Zehnder, Paul A. Khavari · 2014 · Genome Research
Cellular MYCro Economics: Balancing MYC Function with MYC Expression
David Levens · 2013 · Cold Spring Harbor Perspectives in Medicine
Identifying potential cancer driver genes by genomic data integration
Yong Chen, Jingjing Hao, Wei Jiang, Tong He, Xuegong Zhang, Tao Jiang, Rui Jiang · 2013 · Scientific Reports
The Genetics of Cancer Risk
Mark M. Pomerantz, Matthew L. Freedman · 2011 · The Cancer Journal
The Genome in Three Dimensions: A New Frontier in Human Brain Research
Amanda Mitchell, Rahul A. Bharadwaj, Catheryne Whittle, Winfried H. Krueger, Károly Mirnics, Yasmin L. Hurd, Theodore P. Rasmussen, Schahram Akbarian · 2013 · Biological Psychiatry
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Yi‐Ping Fu, Hege Edvardsen, Alpana Kaushiva, Juan P. Arhancet, Tiffany M. Howe, Indu Kohaar, Patricia A Porter-Gill, Anushi Shah, Hege Landmark‐Høyvik, Sophie D. Fosså et al. · 2010 · Molecular Cancer
Current Status of Long Non-Coding RNAs in Human Cancer with Specific Focus on Colorectal Cancer
Maria Anna Smolle, Stefan Uranitsch, Armin Gerger, Martin Pichler, Johannes Haybaeck · 2014 · International Journal of Molecular Sciences