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A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
Open accessAbstract
We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 SNPs. We report a combined analysis of 2,240 gastric cancer cases, 2,115 ESCC cases and 3,302 controls drawn from five studies. In logistic regression models adjusted for age, sex and study, multiple variants at 10q23 had genome-wide significance for gastric cancer and ESCC independently. A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 × 10−9; per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 × 10−9; OR = 1.34). The association with gastric cancer differed by anatomic subsite. For tumors in the cardia the association was stronger (P = 4.19 × 10−15; OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China.
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Principal components analysis corrects for stratification in genome-wide association studies
Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006) · Nature Genetics · doi:10.1038/ng1847 · Cited by 10,248
The CHEK2-Breast Cancer Consortium (2002) · Nature Genetics · doi:10.1038/ng879 · Cited by 1,104
Practical aspects of imputation-driven meta-analysis of genome-wide association studies
de Bakker, P. I. W., Ferreira, M. A. R., Jia, X., Neale, B. M., Raychaudhuri, S., & Voight, B. F. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn288 · Cited by 531
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Rustgi, A. K., & El-Serag, H. B. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1314530 · Cited by 1,243
The Telomeres Mendelian Randomization Collaboration, Haycock, P. C., Burgess, S., Nounu, A., Zheng, J., Okoli, G. N., Bowden, J., Wade, K. H., Timpson, N. J., Evans, D. M., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2016.5945 · Cited by 513
Self-citationWu, C., Kraft, P., Zhai, K., Chang, J., Wang, Z., Li, Y., Hu, Z., He, Z., Jia, W., Abnet, C. C., et al. (2012) · Nature Genetics · doi:10.1038/ng.2411 · Cited by 270
Self-citationLi, W.-Q., Hu, N., Wang, Z., Yu, K., Su, H., Wang, L., Wang, C., Chanock, S. J., Burdett, L., Ding, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068999 · Cited by 24
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Metadata
- Authors
- Abnet, C. C., Freedman, N. D., Hu, N., Wang, Z., Yu, K., Shu, X.-O., Yuan, J.-M., Zheng, W., Dawsey, S. M., Dong, L. M., Lee, M. P., Ding, T., Qiao, Y.-L., Gao, Y.-T., Koh, W.-P., Xiang, Y.-B., Tang, Z.-Z., Fan, J.-H., Wang, C., Wheeler, W., Gail, M. H., Yeager, M., Yuenger, J., Hutchinson, A., Jacobs, K. B., Giffen, C. A., Burdett, L., Fraumeni, J. F., Tucker, M. A., Chow, W.-H., Goldstein, A. M., Chanock, S. J., & Taylor, P. R.
- Venue
- Nature Genetics
- Published
- 2010-08-22
- Volume
- 42
- Issue
- 9
- Pages
- 764-767
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1975600230
- Cited by
- 487
- References
- 3
- FWCI
- 19.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Abnet, C. C., Freedman, N. D., Hu, N., Wang, Z., Yu, K., Shu, X.-O., Yuan, J.-M., Zheng, W., Dawsey, S. M., Dong, L. M., Lee, M. P., Ding, T., Qiao, Y.-L., Gao, Y.-T., Koh, W.-P., Xiang, Y.-B., Tang, Z.-Z., Fan, J.-H., Wang, C., . . . Taylor, P. R. (2010). A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nature Genetics. https://doi.org/10.1038/ng.649
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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