A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

Brest, Patrick; Lapaquette, Pierre; Souidi, Mouloud; Lebrigand, Kevin; Cesaro, Annabelle; Vouret-Craviari, Valérie; Mari, Bernard; Barbry, Pascal; Mosnier, Jean-François; Hébuterne, Xavier; Harel-Bellan, Annick; Mograbi, Baharia; Darfeuille-Michaud, Arlette; Hofman, Paul

doi:10.1038/ng.762

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

Susceptibility to Crohn's disease, a complex inflammatory disease, is influenced by common variants at many loci. The common exonic synonymous SNP (c.313C>T) in IRGM, found in strong linkage disequilibrium with a deletion polymorphism, has been classified as non-causative because of the absence o…