Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat
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Mice with genetic leptin deficiency or leptin receptor deficiency exhibit hyperphagia, obesity, insulin resistance, and diabetes.
“Such animals exhibit not only hyperphagia and obesity, but insulin resistance and diabetes as well (37, 57, 181, 212).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [181]
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References 20 · Cited by 207
- Authors
- Takaya, K., Ogawa, Y., Hiraoka, J., Hosoda, K., Yamori, Y., Nakao, K., & Koletsky, R. J.
- Affiliations
- Kyoto University (JP)
- St. Luke's Hospital (US)
- Venue
- Nature Genetics
- Published
- 1996-10
- Volume
- 14
- Issue
- 2
- Pages
- 130-131
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2028605148
- Cited by
- 207
- References
- 20
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 6 · 2015: 6 · 2014: 10 · 2013: 11 · 2012: 9
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin receptor, nonsense mutation, obesity, spontaneously hypertensive rats, hypertension, leptin signaling, genetic obesity model
- MeSH terms
- Animals, Carrier Proteins, Mutation, Obesity, Rats, Inbred SHR, Receptors, Cell Surface, Polymorphism, Restriction Fragment Length, Receptors, Cytokine, Rats, Receptors, Leptin
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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