Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer

Chan, Tsun Leung, Yuen, Siu Tsan, Kong, Chi Kwan, Chan, Yee Wai, Chan, Annie SY, Ng, Wai Fu, Tsui, Wai Yin, Lo, Michelle WS, Tam, Wing Yip, Li, Vivian SW, Leung, Suet Yi·2006·Nature Genetics
DOI 10.1038/ng1866

Cited by (321)

Items 201–300 of 321

  1. Methylation Analysis of DNA Mismatch Repair Genes Using DNA Derived from the Peripheral Blood of Patients with Endometrial Cancer: Epimutation in Endometrial Carcinogenesis
    Takashi Takeda, Kouji Banno, Megumi Yanokura, Masataka Adachi, Moito Iijima, Haruko Kunitomi, Kanako Nakamura, Miho Iida, Yuya Nogami, Kiyoko Umene et al. · 2016 · Genes
  2. Identification of a founder EPCAM deletion in Spanish Lynch syndrome families
    Pilar Mur, Marta Pineda, Atocha Romero, Jesús Del Valle, Ester Borràs, Alicia Canal, Matilde Navarro, Joan Brunet, Daniel Rueda, Teresa Ramón y Cajal et al. · 2013 · Clinical Genetics
  3. A New Frontier in Personalized Cancer Therapy: Mapping Molecular Changes
    Katayoon Kasaian, Steven J.M. Jones · 2011 · Future Oncology
  4. Alu in Lynch Syndrome: A Danger SINE?
    Megan Philippa Hitchins, John Burn · 2011 · Cancer Prevention Research
  5. Do Transgenerational Epigenetic Inheritance and Immune System Development Share Common Epigenetic Processes?
    Rwik Sen, Christopher Barnes · 2021 · Journal of Developmental Biology
  6. Multiple cancer susceptible genes sequencing in BRCA-negative breast cancer with high hereditary risk
    Guan‐Tian Lang, Jinxiu Shi, Liang Huang, A‐Yong Cao, Chenhui Zhang, Chuangui Song, Zhigang Zhuang, Xin Hu, Wei Huang, Zhi‐Ming Shao · 2020 · Annals of Translational Medicine
  7. Integrative Analysis of Hereditary Nonpolyposis Colorectal Cancer: the Contribution of Allele-Specific Expression and Other Assays to Diagnostic Algorithms
    Laura De Lellis, Gitana María Aceto, Maria Cristina Curia, Teresa Catalano, Sandra Mammarella, Serena Veschi, Fabiana Fantini, Pasquale Battista, Vittoria Stigliano, Luca Messerini et al. · 2013 · PLoS ONE
  8. Normal epigenetic inheritance in mice conceived by in vitro fertilization and embryo transfer
    Lei Li, Le Fang, Liya Wang, Xiangrong Xu, Hangying Lou, Yingming Zheng, Jiangzhong Sheng, Hefeng Huang, Fan Jin · 2011 · Journal of Zhejiang University SCIENCE B
  9. Reply to “Heritable germline epimutation is not the same as transgenerational epigenetic inheritance”
    Catherine M. Suter, David I. K. Martin · 2007 · Nature Genetics
  10. Population epigenetics, ecotoxicology, and human diseases
    Eugene L. Patkin, Генрих Александрович Софронов · 2013 · Russian Journal of Genetics Applied Research
  11. Identification of a Japanese Lynch syndrome patient with large deletion in the 3′ region of theEPCAMgene
    Hidetaka Eguchi, Kensuke Kumamoto, Okihide Suzuki, Masakazu Kohda, Yuhki Tada, Yasushi Okazaki, Hideyuki Ishida · 2015 · Japanese Journal of Clinical Oncology
  12. Constitutional Epimutations: From Rare Events Toward Major Cancer Risk Factors?
    Per Eystein Lønning, Oleksii Nikolaienko, Stian Knappskog · 2025 · JCO Precision Oncology
  13. Gene expression of the mismatch repair gene MSH2 in primary colorectal cancer
    Lars Henrik Jensen, Hidekazu Kuramochi, Dorthe Gylling Crüger, Jan Lindebjerg, Steen Kølvraa, Peter V. Danenberg, Kathleen D. Danenberg, Anders Kristian Moeller Jakobsen · 2011 · Tumor Biology
  14. Epigenetic epidemiology of age-related diseases
    Alexander M. Vaiserman, Vladimir P. Voitenko, Ludmila Mekhova · 2011 · Russian Journal of Developmental Biology
  15. Epigenetic mutations in CDKN2A in western Swedish families with hereditary malignant melanoma
    Charlotta Enerbäck, Frida Appelqvist, Anna Erlandson · 2008 · Molecular Medicine Reports
  16. Modulation of Epigenetics by Environmental Toxic Molecules
    Swati Swagatika, Raghuvir Singh Tomar · 2016 · Advances in molecular toxicology
  17. Absence of Germline Epimutation of the CDKN2A Gene in Familial Melanoma
    Remco van Doorn, Willem H. Zoutman, Nelleke A. Gruis · 2008 · Journal of Investigative Dermatology
  18. The TP53 gene promoter is not methylated in families suggestive of Li-Fraumeni syndrome with no germline TP53 mutations
    Alena Finková, Alzbeta Vazna, Ondrej Hrachovina, Šárka Bendová, Kamila Procházková, Zdeněk Sedláček · 2009 · Cancer Genetics and Cytogenetics
  19. Techniques to Study DNA Methylation and Histone Modification
    Ester Lara, Vincenzo Calvanese, Agustín F. Fernández, Mario F. Fraga · 2011 · Springer eBooks
  20. Identification of allelic expression imbalance genes in human hepatocellular carcinoma through massively parallel DNA and RNA sequencing
    Qiudao Wang, Yan An, Qing Yuan, Qi Yao, Ying Ou, Junhui Chen, Jian Jun Huang · 2016 · Medical Oncology
  21. Epigenetic Drift and Aging
    Ester Lara, Vincenzo Calvanese, Mario F. Fraga · 2009 · Springer eBooks
  22. Reply to “Heritable germline epimutation is not the same as transgenerational epigenetic inheritance”
    Suet Y Leung, Tsun Leung Chan, Siu Tsan Yuen · 2007 · Nature Genetics
  23. Gene Regulation in the Vascular Endothelium: Why Epigenetics Is Important for the Kidney
    Alisha N. Jamal, H. S. Jeffrey Man, Philip A. Marsden · 2012 · Seminars in Nephrology
  24. Population epigenetics, ecotoxicology and human diseases
    Eugene L. Patkin, Henry A Sofronov · 2012 · Ecological genetics
  25. Hereditary Endometrial Cancer: Lynch Syndrome
    Kouji Banno, Iori Kisu, Megumi Yanokura, Kiyoko Umene, Yuya Nogami, Kosuke Tsuji, Kenta Masuda, Arisa Ueki, Yusuke Kobayashi, Wataru Yamagami et al. · 2012 · Current Obstetrics and Gynecology Reports
  26. Do non-pathogenic variants of DNA mismatch repair genes modify neurofibroma load in neurofibromatosis type 1?
    Anja Harder · 2022 · Child s Nervous System
  27. Aberrant DNA Methylation
    Constance Regina Baer, C. Plass · 2014 · Elsevier eBooks
  28. Acquired Sperm DNA Modifications: Causes, Consequences, and Potential Solutions
    Jan Tesařík · 2019 · European Medical Journal
  29. Genome-wide analysis of constitutional DNA methylation in familial melanoma
    Catarina Salgado, Nelleke A. Gruis, Bastiaan T. Heijmans, Jan Oosting, Remco van Doorn · 2020 · Clinical Epigenetics
  30. Defectos de la metilación del ADN en el cáncer colorrectal esporádico y hereditario
    Rosa M. Xicola, Xavier Llor · 2012 · Gastroenterología y Hepatología
  31. Epigenetics and stroke risk – beyond the static DNA code
    Philip A. Marsden, Charles Christian Matouk, Paul J. Turgeon · 2012 · Advances in Genomics and Genetics
  32. Paternal Effects on Embryonic, Fetal and Offspring Health: The Role of Epigenetics in the ICSI and ROSI Era
    Jan Tesařík · 2019 · IntechOpen eBooks
  33. Transgenerational Epigenetic Inheritance in Drosophila
    Luan Wang, Xiangyi Lu, Douglas Mark Ruden · 2013 · Epigenetics and human health
  34. Pathology and Molecular Pathology of Colorectal Cancer
    Emily J. Poulin, Jeanne Shen, Jessica J. Gierut, Kevin M. Haigis · 2016 · Springer eBooks
  35. Unraveling noncoding DNA variants and epimutations: a paradigm shift in hereditary cancer research
    Maria Baz Ibrahim, James M. Flanagan, Tony Ibrahim, Étienne Rouleau · 2024 · Future Oncology
  36. DNA Methylation and Epigenetic Biomarkers in Cancer
    Michel Neidhart · 2015 · Elsevier eBooks
  37. Scrutinizing the Epigenetics Revolution
    Maurizio Meloni, Giuseppe Testa · 2017 · Palgrave Macmillan UK eBooks
  38. Intergenerational epigenetic inheritance mediated by MYS-2/MOF in the pathogenesis of Alzheimer’s disease
    Yuhong Li, Hua Bai, Wenwen Liu, Wenhui Zhou, Huan Gu, Pei‐Ji Zhao, Man Lu Zhu, Yixin Li, Xinyi Yan, Ninghui Zhao et al. · 2024 · iScience
  39. Historical Aspects of Lynch Syndrome
    Henry T. Lynch, Megan Philippa Hitchins, Trudy G. Shaw, Jane F. Lynch, Hemant K. Roy · 2010 · Springer eBooks
  40. Genetic Analysis of the PI3K/AKT/mTOR Signaling Pathway
    Janna Hutz · 2010 · Open Scholarship Institutional Repository (Washington University in St. Louis)
  41. Evidence for transgenerational transmission of epigenetic tumor susceptibility in Drosophila
    Xing Yalan, Song Shi, Long Le, Crystal Lee, Louise Silver-Morse, Willis X. Li · 2005 · PLoS Genetics
  42. A NovelMLH1Initiation Codon Mutation (c.3G>T) in a Large Chinese Lynch Syndrome Family with Different Onset Age and mRNA Expression Level
    Yanni Zhang, Huishuang Chen, Zhiyu Peng, Santasree Banerjee, Wei Li, Zhaolong Zhao, Jianbin Sun, Jian Lv, Hui Huang, Ru Bai et al. · 2018 · BioMed Research International
  43. Molecular profiling in colorectal cancer: current state of play and future directions
    Siddhartha Deb, Stephen B. Fox · 2014 · Colorectal Cancer
  44. Genomic mosaicism in colorectal cancer and polyposis syndromes: a systematic review and meta-analysis
    Francisco Cézar Aquino de Moraes, Nayara Rozalem Moretti, Vitor Kendi Tsuchiya Sano, Cristiane Wen Tsing Ngan, Rommel Mário Rodríguez Burbano · 2024 · International Journal of Colorectal Disease
  45. A series of reviews in familial cancer: genetic cancer risk in context variants of uncertain significance in MMR genes: which procedures should be followed?
    Morghan C. Lucas, Thomas Keßler, Florentine Scharf, Verena Steinke‐Lange, Barbara Klink, Andreas Laner, Elke Holinski‐Feder · 2025 · Familial Cancer
  46. DNA Alterations in Lynch Syndrome
    Matjaž Vogelsang · 2013 · Springer eBooks
  47. Epigenetic Profiling of Gliomas
    Raman P. Nagarajan, J Costello · 2009 · Humana Press eBooks
  48. Epigenetics in nasopharyngeal carcinoma
    Di Sun · 2006 · Figshare
  49. Reply to Berg and Steigen
    Anshu Agrawal, Richard F. Murphy, Devendra K. Agrawal · 2008 · Modern Pathology
  50. Reply to Samowitz and Ogino
    Anshu Agrawal, Richard F. Murphy, Devendra K. Agrawal · 2008 · Modern Pathology
  51. Principles for the post-GWAS functional characterisation of risk loci
    Álvaro N.A. Monteiro, Gerhard A. Coetzee, Matthew L. Freedman, Mariella De Biasi, Graham Casey, Dave Duggan, Angela Risch, Christoph Plass, Pengyuan Liu, Michael A. James et al. · 2010 · Nature Precedings
  52. Principles for the post-GWAS functional characterisation of risk loci
    Graham Casey, Pengyuan Liu, Mariella De Biasi, Jay W. Tichelaar, Chris Carlson, Haris G. Vikis, Dave Duggan, Ming You, Ian Geoffrey Mills, Matthew L. Freedman et al. · 2011 · Nature Precedings
  53. Analyse des gènes du MisMatch Repair dans le syndrome de Lynch
    Sylviane Olschwang, François Eisinger · 2010 · Cancéro digest
  54. Allogeneic Transplantation and the Risk for Transmission of Genetic Disease: The Heritable Cancer Disorders
    Kenneth D. McMilin, Susmita Dasgupta · 2007 · Stem Cells and Development
  55. Mental Disorders and Transgenerational Epigenetics
    Takeo Kubota, Takae Hirasawa, Kunio Miyake · 2014 · Elsevier eBooks
  56. ЭПИГЕНЕТИЧЕСКАЯ РЕВОЛЮЦИЯ В ПРИСТАЛЬНОМ РАССМОТРЕНИИ
    Marisa Méloni, Дж. Теста · 2015 · Биосфера
  57. [Proteomic analysis and verification of protein expression after upregulation of human CD99 in Hodgkin lymphoma cell line L428].
    Lin Xl, Sun Qc, Lü Y, Han Xq, Tiantian Zhao, Zhou Xh · 2019 · PubMed Central
  58. The Complexity of Colorectal Cancer Biology — Putting Bricks on the Path to Personalized Medicine
    Emilia Balboa, Ángel Carracedo, Francisco Barros · 2014 · InTech eBooks
  59. The Role of Epimutations of the Mismatch Repair Genes in the Development of Lynch Syndrome Related Cancers
    Megan Philippa Hitchins · 2013 · Springer eBooks
  60. Health Consequences Due to Prenatal Endocrine-Disrupting Chemical Exposure
    Jayshree Annamalai, Namasivayam Vasudevan · 2017 · Springer eBooks
  61. The Emerging Role of the Sperm Epigenome and its Potential Role in Development
    Saher Sue Hammoud, Douglas T. Carrell · 2011 · Springer eBooks
  62. Hereditary Colon Cancer: Lynch Syndrome
    Eunice Lee Kwak, Daniel C. Chung · 2010 · Springer eBooks
  63. Patient and tumor characteristics may raise clinicians' awareness of familial colorectal cancer: A Norwegian population-based study
    Gerd Tranø, Hans H. Wasmuth, Wenche Sjursen, LARS JOHAN VATTEN · 2011 · Scandinavian Journal of Gastroenterology
  64. DNA methylation studies of preeclampsia and related conditions
    Blair, John · 2013 · cIRcle (University of British Columbia)
  65. Alternative Mechanisms to Germline CDH1 Mutations in Hereditary Diffuse Gastric Cancer
    Hugo Celso Pinheiro, Joana Carvalho, Carla Oliveíra · 2013 · Springer eBooks
  66. Interaction Between Genetics and Epigenetics in Cancer
    Amanda Ewart Toland · 2013 · Springer eBooks
  67. Molecular mechanisms of cancer predisposition in HNPCC/Lynch syndrome
    Annette Gylling · 2008 · Työväentutkimus Vuosikirja
  68. Epimutation in DNA Mismatch Repair (MMR) Genes
    Kouji Banno, Iori Kisu, Megumi Yanokura, Yuya Nogami, Kiyoko Umene, Kosuke Tsuji, Kenta Masuda, Arisa Ueki, Nobuyuki Susumu, Daisuke Aoki · 2013 · InTech eBooks
  69. Recognizing Lynch Syndrome by DNA Mismatch Repair Deficiency
    Minttu Kansikas · 2014 · Työväentutkimus Vuosikirja
  70. The Mutations and Their Relationships with the Genome and Epigenome, RNAs Editing and Evolution in Eukaryotes
    Daniel Frías-Lasserre · 2012 · InTech eBooks
  71. Genetic etiology of hereditary colorectal cancer: new mechanisms and advanced mutation detection techniques
    Isabella Gazzoli · 2006 · Utrecht University Repository (Utrecht University)
  72. Investigation of genetic factors involved in colorectal cancer predisposition
    Tatjana Djureinovic · 2006 · Figshare
  73. Applying toponome imaging system for studying colon cancer
    Sayantan Bhattacharya · 2026 · Warwick Research Archive Portal (University of Warwick)
  74. Epigenetic Drivers of Genetic Alterations in Cancer
    Hiromu Suzuki · 2012 · Wiley eBooks
  75. Genetic Studies of Colorectal Cancer
    Johanna Skoglund · 2007 · Critical Reviews™ in Oncogenesis
  76. Tracking mutations in a family: Recognizing indicators of germline mutation in Lynch syndrome
    Païvi Peltomäki · 2007 · Current Colorectal Cancer Reports
  77. Role of histone methylation in paternal transmission of epigenetic information
    Urszula Brykczynska · 2010 · edoc (University of Basel)
  78. A mouse model for the overexpression of methyltransferases
    Nicholas Wagner · 2010 · DuEPublico (University of Duisburg-Essen)
  79. Epigenetic alterations in sporadic and familial cancers
    Emmi I. Joensuu · 2015 · Työväentutkimus Vuosikirja
  80. DNA Mismatch Repair and Lynch Syndrome
    Brittany C. Thomas, Matthew J. Ferber, Noralane M. Lindor · 2009 · Springer eBooks
  81. DNA Methylierung ausgewählter BRCA- und Fanconi Anämie-Gene beim familiären Mammakarzinom
    Robin Zazoff · 2014 · MACAU: Open Access Repository of Kiel University (University Library Kiel)
  82. DigitalCommons@Th e Texas Medical Center
    Yanis Boumber, Yutaka Kondo · 2008
  83. Mutations in Non-MMR Genes Modifying or Mimicking Lynch Syndrome Phenotype
    Mala Pande, Jinyun Chen, Chongjuan Wei, Yu-Jing Huang, Marsha L. Frazier · 2013 · Springer eBooks
  84. Functional characterization of MutL homologue mismatch repair proteins and their variants
    Mari K. Korhonen · 2009 · Työväentutkimus Vuosikirja
  85. Epigenetic Epidemiology of Cancer
    Angela Risch, Narek Sarkisyan, David Scherf, Hanna Jacobsson, Wolfgang Hagmann, Christoph Plass · 2011 · Springer eBooks
  86. Molekulare Analyse der epigenetischen Regulation der SMN2-Genaktivität in der Pathogenese der spinalen Muskelatrophie (SMA)
    Jan Hauke · 2009 · Kölner Universitäts PublikationsServer (Universität zu Köln)
  87. Who will Benefit from Epigenetic Drugs?
    Dominique Verhelle, David J. Shields · 2015 · Royal Society of Chemistry eBooks
  88. Allele-specific gene expression in carcinogenesis
    О. М. Кривцова, Natalia L. Lazarevich · 2016 · Advances in molecular oncology
  89. Molecular Biomarker Discovery in Psoriatic Arthritis
    Remy A. Pollock · 2016 · TSpace (University of Toronto)
  90. The Genetic Mechanisms Underlying Human Obesity
    Stephen J. Clark · 2012
  91. The HLA Complex Group 9 Gene Modification Study in Major Psychosis
    Mrinal Pal · 2015 · TSpace (University of Toronto)
  92. Comparative analysis of chromosome 8 copy number in paediatric solid tumours
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  93. DNA and Histone Methylation in Colon Cancer
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  94. KLLN as Tumor Suppressor in Cowden Syndrome and Sporadic Breast Cancers
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  95. Estudo da metilação em genes de reparo, mutação no gene BRAF e instabilidade de microssatélites em indivíduos com Câncer Colorretal
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  96. Genomic Instability and Epigenetic Alteration in Colorectal Carcinogenesis
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  97. Cancer Genomics
    Paul T. Spellman, J Costello, Joe W. Gray · 2008 · Elsevier eBooks
  98. Colorectal Cancer
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  99. Ovarian & endometrial cancers
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  100. DNA Methylation in Colorectal Cancer: Multiple Facets of Tumorigenesis
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