Fanconi anemia is associated with a defect in the BRCA2 partner PALB2

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Items 201–300 of 465

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2. Ovarian Surface Epithelial Neoplasms in the Pediatric Population
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4. Quality control of homologous recombination
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5. Exploring the roles of PALB2 at the crossroads of DNA repair and cancer
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6. Somatic variation and cancer: therapies lost in the mix
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7. Tumor Suppressor Tolerance: Reversion Mutations in BRCA1 and BRCA2 and Resistance to PARP Inhibitors and Platinum
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8. Novel germline PALB2 truncating mutations in African American breast cancer patients
   Yonglan Zheng, Jing Zhang, Qun Niu, Dezheng Huo, Olufunmilayo Ibironke Olopade · 2011 · Cancer
9. Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase
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10. Developments in Genetics: Better Management of Ovarian Cancer Patients
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11. FANCJ Helicase Operates in the Fanconi Anemia DNA Repair Pathway and the Response to Replicational Stress
    Yuliang Wu, Robert M. Brosh · 2009 · Current Molecular Medicine
12. Molecular analysis of PALB2‐associated breast cancers
    Jue Er Amanda Lee, Na Li, Simone M. Rowley, Dane Anthony Cheasley, Magnus Zethoven, Simone McInerny, Kylie L. Gorringe, Paul Andrew James, Ian Campbell · 2018 · The Journal of Pathology
13. Differential p53 Engagement in Response to Oxidative and Oncogenic Stresses in Fanconi Anemia Mice
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14. DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity
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15. Therapeutic options for triple-negative breast cancers with defective homologous recombination
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16. Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan
    Muhammad Usman Rashid, Noor Muhammad, Saima Faisal, Asim Amin, Ute Hamann · 2014 · Breast Cancer Research and Treatment
17. The Fanconi anemia/BRCA gene network in zebrafish: Embryonic expression and comparative genomics
    Tom A. Titus, Yi‐Lin Yan, CATHERINE A. WILSON, Amber M. Starks, Jonathan D. Frohnmayer, Ruth Bremiller, Cristian Cañestro, Adriana Rodríguez‐Marí, Xinjun He, John H. Postlethwait · 2008 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
18. The Fanconi anaemia/BRCA pathway and cancer susceptibility. Searching for new therapeutic targets
    María J. García, Javier J. Benitez · 2008 · Clinical & Translational Oncology
19. Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients
    K Obermeier, Juliane Sachsenweger, Thomas W. P. Friedl, Helmut Pospiech, Robert Winqvist, Lisa Wiesmüller · 2015 · Oncogene
20. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function
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21. Genotype-cancer association in patients with Fanconi anemia due to pathogenic variants in FANCD1 (BRCA2) or FANCN (PALB2)
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22. Constitutive role of the Fanconi anemia D2 gene in the replication stress response
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23. Pediatric renal tumor epidemiology: Global perspectives, progress, and challenges
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24. Mammary cancer susceptibility: human genes and rodent models
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25. PALB2: a novel inactivating mutation in a Italian breast cancer family
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26. Prevalence of PALB2 Mutations in Breast Cancer Patients in Multi-Ethnic Asian Population in Malaysia and Singapore
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27. Full in-frame exon 3 skipping of BRCA2 confers high risk of breast and/or ovarian cancer
    Sandrine M. Caputo, French COVAR group collaborators, Mélanie Léoné, Francesca Damiola, Åsa Ehlén, Aura Carreira, Pascaline Gaidrat, Alexandra Martins, Rita D. Brandão, Ana Peixoto et al. · 2018 · Oncotarget
28. High-risk human papillomavirus oncogenes disrupt the Fanconi anemia DNA repair pathway by impairing localization and de-ubiquitination of FancD2
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29. Growing Recognition of the Role for Rare Missense Substitutions in Breast Cancer Susceptibility
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30. PALB2 Variants: Protein Domains and Cancer Susceptibility
    Thales C. Nepomuceno, Marcelo Alex Carvalho, Amélie Rodrigue, Jacques Simard, Jean‐Yves Masson, Álvaro N.A. Monteiro · 2020 · Trends in cancer
31. Fanconi anemia and the cell cycle: new perspectives on aneuploidy
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32. Overlooked FANCD2 variant encodes a promising, portent tumor suppressor, and alternative polyadenylation contributes to its expression
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33. Discovering interactions among BRCA1 and other candidate genes associated with sporadic breast cancer
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34. Overnight transduction with foamyviral vectors restores the long-term repopulating activity of Fancc−/− stem cells
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35. Human Mus81 and FANCB independently contribute to repair of DNA damage during replication
    Yuji Nomura, Noritaka Adachi, Hideki Koyama · 2007 · Genes to Cells
36. Fanconi anemia and breast cancer susceptibility
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37. Rad51C is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability
    Godelieve Smeenk, Anton J.L. de Groot, Ron J Romeijn, Paul P.W. van Buul, Małgorzata Z. Zdzienicka, Leon H.F. Mullenders, Albert Pastink, Barbara C. Godthelp · 2010 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
38. Screening for large genomic rearrangements in the FANCA gene reveals extensive deletion in a Finnish breast cancer family
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39. Evaluation of the Contribution of the Three Breast Cancer Susceptibility Genes CHEK2 , STK11 , and PALB2 in Non- BRCA1/2 French Canadian Families with High Risk of Breast Cancer
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40. Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair
    Maarten W. Paul, Arshdeep Sidhu, Yongxin Liang, Sarah E. van Rossum-Fikkert, Hanny Odijk, Alex N. Zelensky, Roland Kanaar, Claire Wyman · 2021 · eLife
41. FAVL impairment of the Fanconi anemia pathway promotes the development of human bladder cancer
    Jayabal Panneerselvam, Hwan Ki Park, Jun Zhang, Fred Duafalia Dudimah, Piyan Zhang, Hong Wang, Peiwen Fei · 2012 · Cell Cycle
42. Involvement of FANCD2 in Energy Metabolism via ATP5α
    Jayabal Panneerselvam, Chi Ma, Manoj K. Nepal, Yihang Shen, Raymond Che, James Turkson, Peiwen Fei · 2017 · Scientific Reports
43. A nervous predisposition to unrepaired DNA double strand breaks
    Reynolds, John J., Stewart, Grant S. · 2013 · DNA Repair
44. Selection and the Cell Cycle: Positive Darwinian Selection in a Well-Known DNA Damage Response Pathway
    Mary J. O’Connell · 2010 · Journal of Molecular Evolution
45. Towards a Molecular Understanding of the Fanconi Anemia Core Complex
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46. Prevalence of PALB2 mutation c.509_510delGA in unselected breast cancer patients from Central and Eastern Europe
    Monika Noskowicz, Natalia Viktorovna Bogdanova, Marina Bermisheva, Zalina Takhirova, Natalia Antonenkova, Э. К. Хуснутдинова, Michael Bremer, Hans Christiansen, Tjoung‐Won Park‐Simon, Peter Hillemanns et al. · 2013 · Familial Cancer
47. The involvement of FANCM, FANCI, and checkpoint proteins in the interstrand DNA crosslink repair pathway is conserved in C. elegans
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48. Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents
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49. Pediatric renal tumor epidemiology: Global perspectives, progress, and challenges
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50. Compensatory Functions and Interdependency of the DNA-Binding Domain of BRCA2 with the BRCA1–PALB2–BRCA2 Complex
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51. PALB2 mutations in BRCA1/2-mutation negative breast and ovarian cancer patients from Poland
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52. DNA Repair: Exploiting the Fanconi Anemia Pathway As a Potential Therapeutic Target
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53. The Fanconi Anemia Proteins FANCD2 and FANCJ Interact and Regulate Each Other's Chromatin Localization
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54. ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response
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55. Veliparib Alone or in Combination with Mitomycin C in Patients with Solid Tumors With Functional Deficiency in Homologous Recombination Repair
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56. Antiparallel Coiled-Coil Interactions Mediate the Homodimerization of the DNA Damage-Repair Protein PALB2
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57. Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells
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58. A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development
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59. Deficiency of the Fanconi anemia core complex protein FAAP100 results in severe Fanconi anemia
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60. Tumour morphology predicts PALB2 germline mutation status
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62. High expression of PALB2 predicts poor prognosis in patients with advanced breast cancer
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63. The Fanconi anemia protein interaction network: Casting a wide net
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72. DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress
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74. Evidence against PALB2 involvement in Icelandic breast cancer susceptibility
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76. The Fanconi anemia pathway: Insights from somatic cell genetics using DT40 cell line
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78. The Fanconi Anemia Core Complex Acts as a Transcriptional Co-regulator in Hairy Enhancer of Split 1 Signaling
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79. Lack of large genomic deletions in BRIP1, PALB2, and FANCD2 genes in BRCA1/2 negative familial breast cancer
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84. Frequency and molecular characteristics of PALB2 ‐associated cancers in Russian patients
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85. FANCD2 depletion sensitizes cancer cells repopulation ability in vitro
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