The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
Open accessAbstract
Autoimmune diseases are thought to result from imbalances in normal immune physiology and regulation. Here, we show that autoimmune disease susceptibility and resistance alleles on mouse chromosome 3 (Idd3) correlate with differential expression of the key immunoregulatory cytokine interleukin-2 (IL-2). In order to test directly that an approximately twofold reduction in IL-2 underpins the Idd3-linked destabilization of immune homeostasis, we show that engineered haplodeficiency of Il2 gene expression not only reduces T cell IL-2 production by twofold but also mimics the autoimmune dysregulatory effects of the naturally occurring susceptibility alleles of Il2. Reduced IL-2 production achieved by either genetic mechanism correlates with reduced function of CD4+ CD25+ regulatory T cells, which are critical for maintaining immune homeostasis.
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Cited by
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Self-citationRobust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
Finland, G. O. T. 1. D. I., Todd, J. A., the Wellcome Trust Case Control Consortium, Walker, N. M., Cooper, J. D., Smyth, D. J., Downes, K., Plagnol, V., Bailey, R., Nejentsev, S., et al. (2007) · Nature Genetics · doi:10.1038/ng2068 · Cited by 1,456
Self-citationIL-12 family cytokines: immunological playmakers
Vignali, D. A. A., & Kuchroo, V. K. (2012) · Nature Immunology · doi:10.1038/ni.2366 · Cited by 1,297
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Metadata
- Authors
- Yamanouchi, J., Rainbow, D., Serra, P., Howlett, S., Hunter, K., Garner, V. E. S., Gonzalez-Munoz, A., Clark, J., Veijola, R., Cubbon, R., Chen, S.-L., Rosa, R., Cumiskey, A. M., Serreze, D. V., Gregory, S., Rogers, J., Lyons, P. A., Healy, B., Smink, L. J., Todd, J. A., Peterson, L. B., Wicker, L. S., & Santamaria, P.
- Venue
- Nature Genetics
- Published
- 2007-02-04
- Volume
- 39
- Issue
- 3
- Pages
- 329-337
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2002424665
- Cited by
- 368
- References
- 50
- FWCI
- 15.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Yamanouchi, J., Rainbow, D., Serra, P., Howlett, S., Hunter, K., Garner, V. E. S., Gonzalez-Munoz, A., Clark, J., Veijola, R., Cubbon, R., Chen, S.-L., Rosa, R., Cumiskey, A. M., Serreze, D. V., Gregory, S., Rogers, J., Lyons, P. A., Healy, B., Smink, L. J., . . . Santamaria, P. (2007). Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nature Genetics. https://doi.org/10.1038/ng1958
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