A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Reynisdottir, Inga, Benediktsson, Rafn, Jonsdottir, Thorbjorg, Walters, G Bragi, Styrkarsdottir, Unnur, Gretarsdottir, Solveig +37 more·2007·Nature Genetics

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  1. Impact of Common Variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the Risk of Type 2 Diabetes in 5,164 Indians
    Ganesh Chauhan, Charles J. Spurgeon, Rubina Tabassum, Seema Bhaskar, Smita R. Kulkarni, Anubha Mahajan, Sreenivas Chavali, M. V. Kranthi Kumar, Swami Prakash, Om Prakash Dwivedi et al. · 2010 · Diabetes
  2. Reduced expression of the Kinesin-Associated Protein 3 ( KIFAP3 ) gene increases survival in sporadic amyotrophic lateral sclerosis
    John E. Landers, Judith Melki, Vincent Meininger, Jonathan D. Glass, Leonard H. van den Berg, Michael A. van Es, Peter C. Sapp, Paul W.J. van Vught, Diane M. McKenna-Yasek, Hylke M. Blauw et al. · 2009 · Proceedings of the National Academy of Sciences
  3. IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes
    Jan Christiansen, Astrid Marie Kolte, Thomas van Overeem Hansen, Finn Cilius Nielsen · 2009 · Journal of Molecular Endocrinology
  4. The pursuit of genome-wide association studies: where are we now?
    Chee‐Seng Ku, En Yun Loy, Yudi Pawitan Y, Kee Seng Chia · 2010 · Journal of Human Genetics
  5. Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium
    Peter Juergen Goebell, Margaret A. Knowles · 2010 · Urologic Oncology Seminars and Original Investigations
  6. Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
    Wei‐Min Chen, Michael R. Erdos, Anne Jackson, Richa Saxena, Serena Sanna, Kristi D. Silver, Nicholas John Timpson, Torben F. Hansen, Marco Orrù, Maria Grazia Piras et al. · 2008 · Journal of Clinical Investigation
  7. Genome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin Secretion in Human Pancreatic Islets
    Anders H. Olsson, Petr Volkov, Karl Bacos, Tasnim Dayeh, Elin Hall, Emma Nilsson, Claes Ladenvall, Tina Rönn, Charlotte Ling · 2014 · PLoS Genetics
  8. Genetics of type 2 diabetes: pathophysiologic and clinical relevance
    Christian Herder, Michael Roden · 2010 · European Journal of Clinical Investigation
  9. Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population
    Yong‐ho Lee, Eun Seok Kang, So Hun Kim, Seung Jin Han, Chul Hoon Kim, Hyeong Jin Kim, Chul Woo Ahn, Bong Soo, Moonsuk Nam, Chung Mo Nam et al. · 2008 · Journal of Human Genetics
  10. Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes With Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5,327 Nondiabetic Finnish Men
    Alena Stančáková, Teemu Kuulasmaa, Jussi Paananen, Anne Jackson, Lori L. Bonnycastle, Francis S. Collins, Michael Boehnke, Johanna Kuusisto, Markku Laakso · 2009 · Diabetes
  11. The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes
    Thomas Sparsø, G. Andersen, Trine Nielsen, Kristoffer Sølvsten Burgdorf, Anette P. Gjesing, Arne L. Nielsen, Anders Albrechtsen, Signe Sætre Rasmussen, Torben Jørgensen, K. Borch‐Johnsen et al. · 2007 · Diabetologia
  12. Identification of Novel Candidate Genes for Type 2 Diabetes From a Genome-Wide Association Scan in the Old Order Amish
    Rampersaud, Evadnie, Damcott, Coleen M., Fu, Mao, Shen, Haiqing, McArdle, Patrick, Shi, Xiaolian, Shelton, John, Yin, Jing, Chang, Yen-Pei C., Ott, Sandra H. et al. · 2007 · Diabetes
  13. Matching tRNA modifications in humans to their known and predicted enzymes
    Valérie de Crécy‐Lagard, Pietro Boccaletto, Carl Grant Mangleburg, Puneet Sharma, Todd M. Lowe, Sebastian A. Leidel, Janusz Marek Bujnicki · 2019 · Nucleic Acids Research
  14. Singapore Genome Variation Project: A haplotype map of three Southeast Asian populations
    Yik‐Ying Teo, Xueling Sim, Rick Twee‐Hee Ong, Adrian K.S. Tan, Jieming Chen, Erwin Tantoso, Kerrin S. Small, Chee‐Seng Ku, Edmund J.D. Lee, Mark T. Seielstad et al. · 2009 · Genome Research
  15. Genetics of Type 2 Diabetes
    Ahlqvist, Emma, Ahluwalia, Tarunveer Singh, Groop, Leif · 2011 · Clinical Chemistry
  16. Isolated populations and complex disease gene identification
    Kati Kristiansson, Jussi Naukkarinen, Leena Peltonen · 2008 · Genome biology
  17. Genetics of type 2 diabetes: the GWAS era and future perspectives [Review]
    Minako Imamura, Shiro Maeda · 2011 · Endocrine Journal
  18. Polymorphisms within Novel Risk Loci for Type 2 Diabetes Determine β-Cell Function
    Harald Staiger, Fausto E Machicao, Norbert Stefan, Otto Tschritter, Claus Thamer, Kοnstantinos Kantartzis, Silke Schäfer, Kerstin Kirchhoff, Andreas Fritsche, Hans‐Ulrich Häring · 2007 · PLoS ONE
  19. Post Genome-Wide Association Studies of Novel Genes Associated with Type 2 Diabetes Show Gene-Gene Interaction and High Predictive Value
    Stéphane Cauchi, David Meyre, Emmanuelle Durand, Christine Cavalcanti-Proença, Michel Marre, Samy Hadjadj, Hélène Choquet, Franck De Graeve, Stefan Gaget, Frédéric Allegaert et al. · 2008 · PLoS ONE
  20. The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease
    Leonor Jacobo‐Albavera, Mayra Domínguez‐Pérez, Diana Jhoseline Medina-Leyte, Antonia González-Garrido, María Teresa Villarreal-Molina · 2021 · International Journal of Molecular Sciences
  21. Gene–Environment Interactions in the Etiology of Obesity: Defining the Fundamentals
    Claude Bouchard · 2008 · Obesity
  22. Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men
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  23. Zinc, a regulator of islet function and glucose homeostasis
    Nadeeja Wijesekara, Fabrice Chimienti, Michael B. Wheeler · 2009 · Diabetes Obesity and Metabolism
  24. The genetics of autoimmune diseases: a networked perspective
    Sergio E. Baranzini · 2009 · Current Opinion in Immunology
  25. Untitled work
    2007 · 10.1139/h06-102
  26. Type 2 Diabetes Genetics: Beyond GWAS
    Dharambir K. Sanghera, Piers R. Blackett · 2012 · Journal of Diabetes & Metabolism
  27. Genetics of diabetes – Are we missing the genes or the disease?
    Leif Groop, Flemming Pociot · 2013 · Molecular and Cellular Endocrinology
  28. Association Testing of Novel Type 2 Diabetes Risk Alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 Loci With Insulin Release, Insulin Sensitivity, and Obesity in a Population-Based Sample of 4,516 Glucose-Tolerant Middle-Aged Danes
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  29. Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study
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  30. Minireview: Meeting the Demand for Insulin: Molecular Mechanisms of Adaptive Postnatal ß-Cell Mass Expansion
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  31. Genome-wide association study identifies multiple loci associated with bladder cancer risk
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  32. Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity
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  33. Recommended Joint and Meta‐Analysis Strategies for Case‐Control Association Testing of Single Low‐Count Variants
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  34. A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study
    Hakon H. Hakonarson, Hui‐Qi Qu, Jonathan P. Bradfield, Luc Marchand, Cecilia Kim, Joseph Glessner, Rosemarie Grabs, Tracy Casalunovo, Shayne P. Taback, Edward C. Frackelton et al. · 2008 · Diabetes
  35. Replication of Genome-Wide Association Studies of Type 2 Diabetes Susceptibility in Japan
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  36. Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics
    Joseph L. McClay, Daniel E. Adkins, Karolina A. Åberg, T. Scott Stroup, Diana O. Perkins, Vladimir I. Vladimirov, Jeffrey Alan Lieberman, Patrick F. Sullivan, Edwin J. C. G. van den Oord · 2009 · Molecular Psychiatry
  37. Association Analysis in African Americans of European-Derived Type 2 Diabetes Single Nucleotide Polymorphisms From Whole-Genome Association Studies
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  38. Association Analysis of Variation in/NearFTO,CDKAL1,SLC30A8,HHEX,EXT2,IGF2BP2,LOC387761, andCDKN2BWith Type 2 Diabetes and Related Quantitative Traits in Pima Indians
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  39. Type 2 diabetes: genetic data sharing to advance complex disease research
    Jason A. Flannick, José C. Florez · 2016 · Nature Reviews Genetics
  40. What Can Genome-Wide Association Studies Tell Us about the Genetics of Common Disease?
    Mark Martin Iles · 2008 · PLoS Genetics
  41. Replication Study of Candidate Genes Associated With Type 2 Diabetes Based On Genome-Wide Screening
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  42. Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth
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  43. Genome-wide association studies: progress and potential for drug discovery and development
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  44. Identification of Eukaryotic and Prokaryotic Methylthiotransferase for Biosynthesis of 2-Methylthio-N6-threonylcarbamoyladenosine in tRNA
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  45. The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)–like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring
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  46. The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies
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  47. Genetic dissection of type 2 diabetes
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  48. Pathogenesis of Type 2 Diabetes Mellitus
    F Al-Saraj · 2015 · InTech eBooks
  49. A Genome-Wide Association Study of the Metabolic Syndrome in Indian Asian Men
    Delilah Zabaneh, David J. Balding · 2010 · PLoS ONE
  50. Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps
    Marlous J. Groenewoud, J. M. Dekker, Andreas Fritsche, Erwin Reiling, Giel Nijpels, Robert J. Heine, J. Antonie Maassen, Fausto E Machicao, Silke Schäfer, Hans‐Ulrich Häring et al. · 2008 · Diabetologia
  51. The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients—the EUGENE2 study
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  52. Pathomechanisms of Type 2 Diabetes Genes
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  53. Meta-Analysis of the Relationship between Common Type 2 Diabetes Risk Gene Variants with Gestational Diabetes Mellitus
    Mao, Hongyan, Li, Qin, Gao, Shujun · 2012 · PLoS ONE
  54. Genomewide Association Analysis Followed by a Replication Study Implicates a Novel Candidate Gene for Neuroticism
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  55. Recent advances in the molecular genetics of type 2 diabetes mellitus
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  56. Genetics and Genomics for the Prevention and Treatment of Cardiovascular Disease: Update
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  57. Learning From Molecular Genetics
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  58. Identification of Type 2 Diabetes Genes in Mexican Americans Through Genome-Wide Association Studies
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  59. Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain
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  60. Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics
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  61. Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data
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  62. Zinc, pancreatic islet cell function and diabetes: new insights into an old story
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  63. At-Risk Variant in TCF7L2 for Type II Diabetes Increases Risk of Schizophrenia
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  64. Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort
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  67. Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in Type 2 Diabetes in a Chinese population
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  68. Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc
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  69. Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes
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  70. A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits
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  73. tRNA-Derived Small RNAs: Biogenesis, Modification, Function and Potential Impact on Human Disease Development
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  90. A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations
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  92. Quantitative Trait Analysis of Type 2 Diabetes Susceptibility Loci Identified From Whole Genome Association Studies in the Insulin Resistance Atherosclerosis Family Study
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  99. Genetic Risk Score Constructed Using 14 Susceptibility Alleles for Type 2 Diabetes Is Associated With the Early Onset of Diabetes and May Predict the Future Requirement of Insulin Injections Among Japanese Individuals
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