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Comparative genomic analysis of three Leishmania species that cause diverse human disease
Open accessAbstract
Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only ∼200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader–associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage.
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Cites
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
Cited by
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Kaye, P., & Scott, P. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2608 · Cited by 988
Downing, T., Imamura, H., Decuypere, S., Clark, T. G., Coombs, G. H., Cotton, J. A., Hilley, J. D., de Doncker, S., Maes, I., Mottram, J. C., et al. (2011) · Genome Research · doi:10.1101/gr.123430.111 · Cited by 423
Self-citationRedox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism
Krauth-Siegel, R. L., & Comini, M. A. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.03.006 · Cited by 414
Leishmania infections: Molecular targets and diagnosis
Akhoundi, M., Downing, T., Votýpka, J., Kuhls, K., Lukeš, J., Cannet, A., Ravel, C., Marty, P., Delaunay, P., Kasbari, M., et al. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.11.012 · Cited by 363
Major Surface Protease of Trypanosomatids: One Size Fits All?
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Metadata
- Authors
- Peacock, C. S., Seeger, K., Harris, D., Murphy, L., Ruiz, J. C., Quail, M. A., Peters, N., Adlem, E., Tivey, A., Aslett, M., Kerhornou, A., Ivens, A., Fraser, A., Rajandream, M.-A., Carver, T., Norbertczak, H., Chillingworth, T., Hance, Z., Jagels, K., Moule, S., Ormond, D., Rutter, S., Squares, R., Whitehead, S., Rabbinowitsch, E., Arrowsmith, C., White, B., Thurston, S., Bringaud, F., Baldauf, S. L., Faulconbridge, A., Jeffares, D., Depledge, D. P., Oyola, S. O., Hilley, J. D., Brito, L. O., Tosi, L. R. O., Barrell, B., Cruz, A. K., Mottram, J. C., Smith, D. F., & Berriman, M.
- Venue
- Nature Genetics
- Published
- 2007-06-17
- Volume
- 39
- Issue
- 7
- Pages
- 839-847
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2170302951
- Cited by
- 768
- References
- 1
- FWCI
- 50.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Peacock, C. S., Seeger, K., Harris, D., Murphy, L., Ruiz, J. C., Quail, M. A., Peters, N., Adlem, E., Tivey, A., Aslett, M., Kerhornou, A., Ivens, A., Fraser, A., Rajandream, M.-A., Carver, T., Norbertczak, H., Chillingworth, T., Hance, Z., Jagels, K., . . . Berriman, M. (2007). Comparative genomic analysis of three Leishmania species that cause diverse human disease. Nature Genetics. https://doi.org/10.1038/ng2053
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
