Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1

Karsunky, Holger, Zeng, Hui, Schmidt, Thorsten, Zevnik, Branko, Kluge, Reinhart, Schmid, Kurt Werner, Dührsen, Ulrich, Möröy, Tarik·2002·Nature Genetics

DOI 10.1038/ng831

Cited by (317)

Items 101–200 of 317

Implication of Inflammatory Macrophages, Nuclear Receptors, and Interferon Regulatory Factors in Increased Virulence of Pandemic 2009 H1N1 Influenza A Virus after Host Adaptation
Laurence Josset, Jessica A. Belser, Mary J. Pantin‐Jackwood, Jean H. Chang, Stewart T. Chang, Sarah E. Belisle, Terrence M. Tumpey, Michael G. Katze · 2012 · Journal of Virology
A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia
Diana Ordoñez‐Rueda, Friederike Jönsson, David A. Mancardi, Weidong Zhao, Aurélie Malzac, Yinming Liang, Elodie Bertosio, Pierre Grenot, Véronique Blanquet, Sybille Sabrautzki et al. · 2012 · European Journal of Immunology
Kostmann syndrome or infantile genetic agranulocytosis, part two: understanding the underlying genetic defects in severe congenital neutropenia
Göran Carlsson, Malin Melin, Niklas Dahl, Kim Göransdotter Ramme, Magnus Nordenskjöld, Jan E.W. Palmblad, Jan‐Inge Henter, Bengt Fadeel · 2007 · Acta Paediatrica
Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing
Florian Heyd, Gerdy ten Dam, Tarik Möröy · 2006 · Nature Immunology
Myeloid-Specific Deletion of Mcl-1 Yields Severely Neutropenic Mice That Survive and Breed in Homozygous Form
Janka Zsófia Csepregi, Anita Orosz, Erik Zajta, Orsolya Kása, Tamás Németh, Edina Simon, Szabina Fodor, Katalin Csonka, Balázs Barátki, Dorottya Kövesdi et al. · 2018 · The Journal of Immunology
Different Faces for Different Places: Heterogeneity of Neutrophil Phenotype and Function
Peiqing Yang, Yanhong Li, Yan Xie, Yi Liu · 2019 · Journal of Immunology Research
Growth Factor Independence-1B Expression Leads to Defects in T Cell Activation, IL-7 Receptor α Expression, and T Cell Lineage Commitment
Loretta L. Doan, Mary Kate Kitay, Qing Yu, Alfred Singer, Sabine Herblot, T Hoang, Susan E. Bear, Herbert C. Morse, Philip N. Tsichlis, H. Leighton Grimes · 2003 · The Journal of Immunology
An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development
Cecil Mayra Benitez, Kun Qu, 拓也杉山, Philip T. Pauerstein, Yinghua Liu, Jennifer Tsai, Xueying Gu, Amar Ghodasara, H. Efsun Arda, Jiajing Zhang et al. · 2014 · PLoS Genetics
HDACs and the epigenetic plasticity of cancer cells: target the complexity
Brancolini, Claudio, Gagliano, Teresa, Minisini, Martina · 2022 · Pharmacology & Therapeutics
The zinc finger transcription factor Growth factor independence 1 (Gfi1)
Tarik Möröy · 2004 · The International Journal of Biochemistry & Cell Biology
The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1
Maria De La Luz Sierra, Shuhei Sakakibara, Paola Gasperini, Ombretta Salvucci, Kan Jiang, Peter James McCormick, Marta Segarra, Jim Stone, Dragan Maric, Jinfang Zhu et al. · 2010 · Blood
Gfi-1 represses CDKN2B encoding p15 INK4B through interaction with Miz-1
Suchitra Basu, Qingquan Liu, Yaling Qiu, Fan Dong · 2009 · Proceedings of the National Academy of Sciences
The growth factor independence-1 transcription factor: New functions and new insights
Avedis A. Kazanjian, Eleanore A. Gross, H. Leighton Grimes · 2006 · Critical Reviews in Oncology/Hematology
Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNγ-dependent iNOS expression in the vasculature of healthy mice
J. Morton, B. Coles, K. Wright, A. Gallimore, J. Morrow, Erin S. Terry, Peter B. Anning, B. Morgan, V. Dioszeghy, Hartmut Kühn et al. · 2008 · Blood
Gfi/Pag-3/Senseless Zinc Finger Proteins: a Unifying Theme?
Hamed Jafar‐Nejad, Hugo Jozef Bellen · 2004 · Molecular and Cellular Biology
Role of Transcription Factors in Differentiation and Reprogramming of Hematopoietic Cells
Hideaki Nakajima · 2011 · The Keio Journal of Medicine
Locus-specific DNA methylation in the placenta is associated with levels of pro-inflammatory proteins in cord blood and they are both independently affected by maternal smoking during pregnancy
Sanne D. van Otterdijk, Alexandra M. Binder, Karin B. Michels · 2017 · Epigenetics
Neutrophil Elastase Defects in Congenital Neutropenia
Zuzanna Rydzyńska, Bartłomiej Pawlik, Damian Krzyżanowski, Wojciech Michal Mlynarski, Joanna Madzio · 2021 · Frontiers in Immunology
A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia
Cyrus Khandanpour, Christian Thiede, Peter J.M. Valk, Ehssan Sharif‐Askari, Holger Nückel, Dietmar Rudolf Lohmann, Bernhard Horsthemke, Winfried Siffert, Andreas Neubauer, Karl‐Heinz Grzeschik et al. · 2010 · Blood
Gfi1 negatively regulates Th17 differentiation by inhibiting ROR t activity
Kenji Ichiyama, Masayuki Hashimoto, Takashi Sekiya, Ryusuke Nakagawa, Y. Wakabayashi, Y. Sugiyama, Kyoko Komai, Ingrid Saba, Tarik Möröy, Akihiko Yoshimura · 2009 · International Immunology
Novel genetic etiologies of severe congenital neutropenia
Kaan Boztuǧ, Christoph Klein · 2009 · Current Opinion in Immunology
GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene
Da-Yuan Huang · 2004 · Nucleic Acids Research
Targeting neutrophils as a novel therapeutic strategy after stroke
Chen Chen, Tingting Huang, Xiaozhu Zhai, Yezhi Ma, Lv Xie, Bingwei Lu, Yueman Zhang, Yan Li, Zengai Chen, Jiemin Yin et al. · 2021 · Journal of Cerebral Blood Flow & Metabolism
Genetic heterogeneity in severe congenital neutropenia: how many aberrant pathways can kill a neutrophil?
Alejandro A. Schäffer, Christoph Klein · 2007 · Current Opinion in Allergy and Clinical Immunology
Pathogenic mechanisms and clinical implications of congenital neutropenia syndromes
Fabian H. Hauck, Christoph Klein · 2013 · Current Opinion in Allergy and Clinical Immunology
GFI1 as a novel prognostic and therapeutic factor for AML/MDS
Judith Maria Hönes, Lacramioara Botezatu, Anne Helness, Charles Vadnais, Lothar Vaßen, François Robert, S M Hergenhan, Aniththa Thivakaran, Judith Schütte, Yahya Saleh Al-Matary et al. · 2016 · Leukemia
Gfi-1 Oncoproteins in Hematopoiesis
Zhijun Duan, Marshall S. Horwitz · 2003 · Hematology
Growth Factor Independence 1 Protects Hematopoietic Stem Cells Against Apoptosis but Also Prevents the Development of a Myeloproliferative-Like Disease
Cyrus Khandanpour, Christian Kosan, Marie‐Claude Gaudreau, Ulrich Dührsen, Josée Hébert, Hui Zeng, Tarik Möröy · 2010 · Stem Cells
Atoh1 in sensory hair cell development: constraints and cofactors
Aida Costa, Lynn Marie Powell, Sally Lowell, Andrew P. Jarman · 2016 · Seminars in Cell and Developmental Biology
MicroRNAs as regulators and effectors of hematopoietic transcription factors
Minjung Kim, Curt I. Civin, Tami J. Kingsbury · 2019 · Wiley Interdisciplinary Reviews - RNA
Increased CCAAT Enhancer-binding Protein ϵ (C/EBPϵ) Expression and Premature Apoptosis in Myeloid Cells Expressing Gfi-1 N382S Mutant Associated with Severe Congenital Neutropenia
Dazhong Zhuang, Yaling Qiu, Scott C. Kogan, Fan Dong · 2006 · Journal of Biological Chemistry
Association of Common C-Reactive Protein (CRP) Gene Polymorphisms With Baseline Plasma CRP Levels and Fenofibrate Response
Jian Shen, Donna K. Arnett, Laurence D. Parnell, James M. Peacock, Chao‐Qiang Lai, James E. Hixson, Michael Y. Tsai, Michael A. Province, Robert J. Straka, José María Ordovás · 2008 · Diabetes Care
The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice
Cyrus Khandanpour, Joseph Krongold, Judith Schütte, Frédérique C. M. Bouwman, Lothar Vaßen, Marie‐Claude Gaudreau, Riyan Chen, Fernando J. Calero‐Nieto, Evangelia Diamanti, Rebecca Hannah et al. · 2012 · Blood
Role of MicroRNAs in the development and function of innate immune cells
Selvaraj Manoj Kumar Kingsley, B. Vishnu Bhat · 2017 · International Reviews of Immunology
Neutrophil biology in injuries and diseases of the central and peripheral nervous systems
Brian M. Balog, Anisha Sonti, Richard E. Zigmond · 2023 · Progress in Neurobiology
Transcription Factor GFI1B in Health and Disease
Eduardo Anguita, Francisco Javier Candel, Alberto Chaparro, Juan José Roldán‐Etcheverry · 2017 · Frontiers in Oncology
Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia
Gretchen Johnston, Haley Elizabeth Ramsey, Qi Liu, Jing Wang, Kristy R. Stengel, Shilpa Sampathi, Pankaj Acharya, Maria Pia Arrate, Matthew C. Stubbs, Timothy C. Burn et al. · 2020 · Gene
Growth Factor Independence 1b (Gfi1b) Is Important for the Maturation of Erythroid Cells and the Regulation of Embryonic Globin Expression
Lothar Vaßen, Hugues Beauchemin, Wafaâ Lemsaddek, Joseph Krongold, Marie Trudel, Tarik Möröy · 2014 · PLoS ONE
Transcriptional regulation of haematopoietic transcription factors
Nicola K. Wilson, Fernando J. Calero‐Nieto, Rita Ferreira, Berthold Göttgens · 2011 · Stem Cell Research & Therapy
Genetics and Pathophysiology of Severe Congenital Neutropenia Syndromes Unrelated to Neutrophil Elastase
Kaan Boztuǧ, Christoph Klein · 2012 · Hematology/Oncology Clinics of North America
Growth factor‐independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate
Ahmet H Elmaagacli, Michael Koldehoff, Johannes L. Zakrzewski, Nina K. Steckel, Hellmut Dietmar Ottinger, Dietrich Wilhelm Beelen · 2006 · British Journal of Haematology
Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions
Kira Behrens, Ioanna Triviai, Maike Schwieger, Nilgün Solak Tekin, Malik Alawi, Michael Spohn, Daniela Indenbirken, Marion Ziegler, Ursula Müller, Warren S. Alexander et al. · 2016 · Blood
Congenital Neutropenia Syndromes
Kaan Boztuǧ, Karl Welte, Cornelia Zeidler, Christoph Klein · 2008 · Immunology and Allergy Clinics of North America
The Dominant Role of Sp1 in Regulating the Cystathionine β-Synthase –1a and –1b Promoters Facilitates Potential Tissue-specific Regulation by Kruppel-like Factors
Kenneth N. Maclean, Eva Kraus, Jan Peter Kraus · 2004 · Journal of Biological Chemistry
The MYB proto-oncogene suppresses monocytic differentiation of acute myeloid leukemia cells via transcriptional activation of its target gene GFI1
Liang Zhao, Ping Ye, Thomas J. Gonda · 2013 · Oncogene
Therapeutic targeting of neutrophil exocytosis
Sergio Daniel Catz, Kenneth R. McLeish · 2020 · Journal of Leukocyte Biology
High-mobility group protein HMGB2 regulates human erythroid differentiation through trans-activation of GFI1B transcription
Benoît Laurent, Voahangy Randrianarison-Huetz, Vincent Maréchal, Patrick Mayeux, Isabelle Dusanter‐Fourt, Dominique Dumènil · 2009 · Blood
Contributions to Neutropenia from PFAAP5 (N4BP2L2), a Novel Protein Mediating Transcriptional Repressor Cooperation between Gfi1 and Neutrophil Elastase
Stephen J. Salipante, Meghan E. B. Rojas, Brice Korkmaz, Zhijun Duan, Jeremy Wechsler, Kathleen F. Benson, Richard Person, H. Leighton Grimes, Marshall S. Horwitz · 2009 · Molecular and Cellular Biology
Tumor-Infiltrating Myeloid Cells Activate Dll4/Notch/TGF-β Signaling to Drive Malignant Progression
Hidetaka Ohnuki, Kan Jiang, Dunrui Wang, Ombretta Salvucci, Hyeongil Kwak, David Sánchez‐Martín, Dragan Maric, Giovanna Tosato · 2014 · Cancer Research
CCAAT-binding factor regulates expression of the β 1 subunit of soluble guanylyl cyclase gene in the BE2 human neuroblastoma cell line
Iraida G. Sharina, Emil Martin, Anthony Thomas, Karen Uray, Ferid Murad · 2003 · Proceedings of the National Academy of Sciences
Differential impact of the transcriptional repressor Gfi1 on mature CD4 + and CD8 + T lymphocyte function
Denise Pargmann, Raif Yücel, Christian Kosan, Ingrid Saba, Ludger Klein‐Hitpaß, Simone Schimmer, Florian Heyd, Ulf Dittmer, Tarik Möröy · 2007 · European Journal of Immunology
Differential Transcriptional Regulation of meis1 by Gfi1b and Its Co-Factors LSD1 and CoREST
Asif H. Chowdhury, Johnny R. Ramroop, Ghanshyam Upadhyay, Ananya Sengupta, Anna Andrzejczyk, Shireen Saleque · 2013 · PLoS ONE
Gfi1.1 regulates hematopoietic lineage differentiation during zebrafish embryogenesis
Wei Wei, Lu Wen, Peng Huang, Zheng Zhang, Yuanyuan Chen, An Xiao, Haigen Huang, Zuoyan Zhu, Bo Zhang, Shuo Lin · 2008 · Cell Research
GABP transcription factor is required for myeloid differentiation, in part, through its control of Gfi-1 expression
Zhong-Fa Yang, Karen C. Drumea, James Cormier, Junling Wang, Xuejun Zhu, Alan G. Rosmarin · 2011 · Blood
Zinc Finger Protein Gfi1 Controls the Endotoxin-Mediated Toll-Like Receptor Inflammatory Response by Antagonizing NF-κB p65
Ehssan Sharif‐Askari, Lothar Vaßen, Christian Kosan, Cyrus Khandanpour, Marie‐Claude Gaudreau, Florian Heyd, Taro Okayama, Jianmin Jin, Meghan E. B. Rojas, H. Leighton Grimes et al. · 2010 · Molecular and Cellular Biology
The zinc finger protein Gfi1 acts upstream of TNF to attenuate endotoxin‐mediated inflammatory responses in the lung
Jianmin Jin, Hui Zeng, Kurt‐Werner Schmid, Martin Tötsch, Stefan Uhlig, Tarik Möröy · 2006 · European Journal of Immunology
Gfi-1 takes center stage in hematopoietic stem cells
Zhijun Duan, Marshall S. Horwitz · 2005 · Trends in Molecular Medicine
Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1
Jurgen A. F. Marteijn, Laurens T. van der Meer, Liesbeth van Emst, Simon V. van Reijmersdal, Willemijn M. Wissink, Théo de Witte, Joop H. Jansen, Bert A. van der Reijden · 2007 · Blood
Effective, Long-Term, Neutrophil Depletion Using a Murinized Anti-Ly-6G 1A8 Antibody
Patricia A. Olofsen, Marjolein C. Stip, J.H. Marco Jansen, Chilam Chan, Maaike Nederend, Ralph Geoffrey Tieland, Maria Tsioumpekou, Jeanette H.W. Leusen · 2022 · Cells
Growth Factor Independence 1B-Mediated Transcriptional Repression and Lineage Allocation Require Lysine-Specific Demethylase 1-Dependent Recruitment of the BHC Complex
David McClellan, Mattie J. Casey, Diana Bareyan, Helena Lucente, Christopher Ours, Matthew Velinder, Jason Singer, Mehraju Din Lone, Wenxiang Sun, Yunuen Coria et al. · 2019 · Molecular and Cellular Biology
Role of GFI1 in Epigenetic Regulation of MDS and AML Pathogenesis: Mechanisms and Therapeutic Implications
Tarik Möröy, Cyrus Khandanpour · 2019 · Frontiers in Oncology
Combined inhibition of JAK/STAT pathway and lysine-specific demethylase 1 as a therapeutic strategy in CSF3R/CEBPA mutant acute myeloid leukemia
Theodore P. Braun, Cody Coblentz, Brittany M. Curtiss, Daniel J. Coleman, Zachary Schonrock, Sarah A. Carratt, Rowan L. Callahan, Breanna N. Maniaci, Brian J. Druker, Julia E. Maxson · 2020 · Proceedings of the National Academy of Sciences
Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis
Jeffrey D. Cooney, Gordon J. Hildick-Smith, Ebrahim Shafizadeh, Paul F. McBride, Kelli J. Carroll, Heidi Anderson, George Shaw, Owen J. Tamplin, Diana S. Branco, Arthur J. Dalton et al. · 2012 · Developmental Biology
Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts
D.J. Young, Angela Stoddart, Joy Nakitandwe, S.-C. Chen, Zhen Yu Qian, James R. Downing, Michelle M. Le Beau · 2014 · Haematologica
LSD1-mediated repression of GFI1 super-enhancer plays an essential role in erythroleukemia
Goichi Tatsumi, Masahiro Kawahara, Ryusuke Yamamoto, Masakatsu Hishizawa, Katsuyuki Kito, Takayoshi Suzuki, Akifumi Takaori‐Kondo, Akira Andoh · 2019 · Leukemia
The transcription factors GFI1 and GFI1B as modulators of the innate and acquired immune response
Jennifer Fraszczak, Tarik Möröy · 2021 · Advances in immunology
Solution Structure of Gfi-1 Zinc Domain Bound to Consensus DNA
Soojin Lee, Kiran Kumar Doddapaneni, Amber Hogue, Laura McGhee, Shari Meyers, Zhengrong Wu · 2010 · Journal of Molecular Biology
Severe congenital neutropenia: new genes explain an old disease
Georg Bohn, Karl Welte, Christoph Klein · 2007 · Current Opinion in Rheumatology
Characterization of the colorectal cancer–associated enhancer MYC-335 at 8q24: the role of rs67491583
Sari Tuupanen, Jian Yan, Mikko M. Turunen, Alexandra E. Gylfe, Eevi Kaasinen, Li Li, Charis Eng, Daniel A. Culver, Matthew F. Kalady, Michael J. Pennison et al. · 2012 · Cancer Genetics
Goldfish (Carassius auratus L.) as a model system to study the growth factors, receptors and transcription factors that govern myelopoiesis in fish
Barbara A. Katzenback, Fumihiko Katakura, Miodrag Belosevic · 2015 · Developmental & Comparative Immunology
Transcriptional Repressor Gfi1 Integrates Cytokine-Receptor Signals Controlling B-Cell Differentiation
Chozhavendan Rathinam, Christoph Klein · 2007 · PLoS ONE · Retracted
Gfi-1B Promoter Remains Associated with Active Chromatin Marks Throughout Erythroid Differentiation of Human Primary Progenitor Cells
Benoît Laurent, Voahangy Randrianarison-Huetz, Zahra Kadri, Paul‐Henri Roméo, Françoise Porteu, Dominique Dumènil · 2009 · Stem Cells
The Corepressor Rcor1 Is Essential for Normal Myeloerythroid Lineage Differentiation
Huilan Yao, Devorah C. Goldman, Guang Fan, Gail Mandel, WH Fleming · 2015 · Stem Cells
A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A
Q Liu, S Basu, Ying Qiu, F Tang, Fan Dong · 2010 · Oncogene
Growth factor independent-1 Maintains Notch1-Dependent Transcriptional Programming of Lymphoid Precursors
James D. Phelan, Ingrid Saba, Hui Zeng, Christian Kosan, Malynda S. Wynn, H. Andre Olsson, Jennifer Fraszczak, David A. Hildeman, Bruce J. Aronow, Tarik Möröy et al. · 2013 · PLoS Genetics
Zebrafish microRNA miR-210-5p inhibits primitive myelopoiesis by silencing foxj1b and slc3a2a mRNAs downstream of gata4/5/6 transcription factor genes
Wenshuang Jia, Dong Liang, Nan Li, Meijing Liu, Zhangji Dong, Jingyun Li, Xiaohua Dong, Yunyun Yue, Ping Hu, Jihua Yao et al. · 2018 · Journal of Biological Chemistry
Gene Ontology-driven transcriptional analysis of CD34+cell-initiated megakaryocytic cultures identifies new transcriptional regulators of megakaryopoiesis
Peter G. Fuhrken, Chi Chen, Pani A. Apostolidis, Min Wang, William M. Miller, Eleftherios Terry Papoutsakis · 2008 · Physiological Genomics
Role of Erk1/2 Signaling in the Regulation of Neutrophil Versus Monocyte Development in Response to G-CSF and M-CSF
Nan Hu, Yaling Qiu, Fan Dong · 2015 · Journal of Biological Chemistry
Genetic Insights into Congenital Neutropenia
Christoph Klein, Karl Welte · 2009 · Clinical Reviews in Allergy & Immunology
A somatic mutation of GFI1B identified in leukemia alters cell fate via a SPI1 (PU.1) centered genetic regulatory network
Eduardo Anguita, Rajeev Gupta, Victor Olariu, Peter J.M. Valk, Carsten Peterson, Ruud Delwel, Tariq Enver · 2016 · Developmental Biology
Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes
Jurgen A. F. Marteijn, Laurens T. van der Meer, Liesbeth van Emst, Théo de Witte, Joop H. Jansen, Bert A. van der Reijden · 2006 · Blood
SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis
Li Zhang, Alan D. Friedman · 2011 · Blood
Gfi-1 inhibits the expression of eosinophil major basic protein (MBP) during G-CSF-induced neutrophilic differentiation
Qingquan Liu, Fan Dong · 2012 · International Journal of Hematology
Early cellular interactions and immune transcriptome profiles in human factor VIII‐exposed hemophilia A mice
Jesse D. Lai, D. Cartier, Robin B. Hartholt, Laura L. Swystun, Alice S. van Velzen, Joke M. M. den Haan, Christine A. Hough, Jan Voorberg, David Lillicrap · 2017 · Journal of Thrombosis and Haemostasis
Loss of MicroRNA Targets in the 3′ Untranslated Region as a Mechanism of Retroviral Insertional Activation of Growth Factor Independence 1
Magdalena Julia Dabrowska, Karen Dybkær, Hans Erik Johnsen, Bruce Wang, Matthias R. Wabl, Finn Skou Pedersen · 2009 · Journal of Virology
New insights into the regulation by RUNX1 and GFI1(s) proteins of the endothelial to hematopoietic transition generating primordial hematopoietic cells
Roshana Thambyrajah, Rahima Patel, Milena M. Mazan, Michael Lie‐A‐Ling, Andrew J. Lilly, Alexia Eliades, Sara Menegatti, Eva García-Alegría, Magdalena Florkowska, Kiran Batta et al. · 2016 · Cell Cycle
A Focused Review of Ras Guanine Nucleotide-Releasing Protein 1 in Immune Cells and Cancer
Tu Chun Hsu, Gisele Olinto Libanio Rodrigues, Hila Y. Winer, Julie A. Hixon, Wenqing Li, Nadya I. Tarasova, Scott Kenneth Durum · 2023 · International Journal of Molecular Sciences
Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice
Jennifer Fraszczak, Charles Vadnais, Marissa Rashkovan, Julie Ross, Hugues Beauchemin, Riyan Chen, Damien Grapton, Cyrus Khandanpour, Tarik Möröy · 2018 · Leukemia
Interferon Lambda's New Role as Regulator of Neutrophil Function
Amariliz Rivera · 2019 · Journal of Interferon & Cytokine Research
microRNA-22 promotes megakaryocyte differentiation through repression of its target, GFI1
Cary N. Weiss, Keisuke Ito · 2019 · Blood Advances
SUMOylation Regulates Growth Factor Independence 1 in Transcriptional Control and Hematopoiesis
Daniel Andrade, Matthew Velinder, Jason Singer, Luke Devon Maese, Diana Bareyan, Hong N. Nguyen, Mahesh B. Chandrasekharan, Helena Lucente, David McClellan, David Jones et al. · 2016 · Molecular and Cellular Biology
The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling
Benoît Desnues, Amanda B. Macedo, Diana Ordoñez‐Rueda, Annie Roussel‐Queval, Bernard MALISSEN, Pierre Bruhns, Marie Malissen, Lena Alexopoulou · 2016 · European Journal of Immunology
Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation
Sven Geißler, Martin Textor, Sabine Stumpp, Sebastian A Seitz, Anja Lekaj, Sabrina Brunk, Sabine Klaassen, Thorsten Schinke, Christoph Klein, Stefan Mundlos et al. · 2018 · PLoS ONE
The zinc finger protein and transcriptional repressor Gfi1 as a regulator of the innate immune response
Tarik Möröy, Hui Zeng, Jianmin Jin, Kurt Werner Schmid, Alexander Carpinteiro, Erich Gulbins · 2008 · Immunobiology
Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells
Lewis Z. Shi, Nishan S. Kalupahana, Meghan E. Turnis, Geoffrey A. M. Neale, Hanno R. Hock, Dario A.A. Vignali, Hongbo Chi · 2013 · Proceedings of the National Academy of Sciences
Sphingolipids in Acute Lung Injury
Stefan Uhlig, Yang Yang · 2013 · Handbook of experimental pharmacology
correspondence: Cyclic neutropenia associated with T cell immunity to granulocyte proteases and a double de novo mutation in GFI1, a transcriptional regulator of ELANE
Paul M. Armistead, Eric Wieder, Olanike Akande, Gheath Alatrash, Kathryn Quintanilla, Shoudan Liang, Jeffrey J. Molldrem · 2010 · British Journal of Haematology
Regulation of proliferation and functioning of transplanted cells by using herpes simplex virus thymidine kinase gene in mice
Mari Tsujimura, Kosuke Kusamori, Chihiro Oda, Airi Miyazaki, Hidemasa Katsumi, Toshiyasu Sakane, Makiya Nishikawa, Akira Yamamoto · 2018 · Journal of Controlled Release
A gene trap transposon eliminates haematopoietic expression of zebrafish Gfi1aa, but does not interfere with haematopoiesis
Roshana Thambyrajah, Deniz Ucanok, Maryam Sadat Jalali, Yasmin Hough, Robert N. Wilkinson, Kathryn McMahon, Chris Moore, Martin Gering · 2016 · Developmental Biology
Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML
Lacramioara Botezatu, Lars Michel, Anne Helness, Charles Vadnais, Hideki Makishima, Judith Maria Hönes, François Robert, Lothar Vaßen, Aniththa Thivakaran, Yahya Saleh Al-Matary et al. · 2016 · Experimental Hematology