Structural insights into the assembly and activation of IL-1β with its receptors

Cited by (162)

Items 101–162 of 162

  1. Allosteric Switching of Agonist/Antagonist Activity by a Single Point Mutation in the Interluekin-1 Receptor Antagonist, IL-1Ra
    Kendra L. Hailey, Dominique T. Capraro, Sulyman Barkho, Patricia Ann Jennings · 2013 · Journal of Molecular Biology
  2. GAG positioning on IL-1RI; A mechanism regulated by dual effect of glycosylation
    Maryam Azimzadeh Irani, Mohammad Reza Ejtehadi · 2019 · Glycobiology
  3. Comparative Analyses of the Conformational Dynamics Between the Soluble and Membrane-Bound Cytokine Receptors
    Chao‐Yie Yang · 2020 · Scientific Reports
  4. Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling
    Jianjie Zhou, Yu Xiao, Yifei Ren, Jiwan Ge, Xinquan Wang · 2022 · iScience
  5. Molecular Interactions in Interleukin and Toll-like Receptor Signaling Pathways
    Greg A. Snyder, Eric J. Sundberg · 2014 · Current Pharmaceutical Design
  6. Inflammatory profiles revealed the dysregulation of cytokines in adult patients of HFMD
    Linghua Yu, Jin He, Linlin Wang, Huixing Yi · 2018 · International Journal of Infectious Diseases
  7. Accessory to inflammation
    John E. Sims · 2010 · Nature Immunology
  8. Association of IL1RAP-related genetic variation with cerebrospinal fluid concentration of Alzheimer-associated tau protein
    Anna Zettergren, Kina Höglund, Silke Kern, Valgeir Thorvaldsson, Johan Skoog, Oskar Hansson, Niels Andreasen, Nenad Bogdanović, Kaj Blennow, Ingmar Gr. Skoog et al. · 2019 · Scientific Reports
  9. Effects of Interleukin-1β in Glycinergic Transmission at the Central Amygdala
    Jocelyn Solorza, Carolina A. Oliva, Karen Castillo, Gabriela Amestica, Maria Constanza Maldifassi, Xaviera A. López-Cortés, Rafael Barra, Jimmy Stehberg, Matthias Piesche, Patricio Sáez‐Briones et al. · 2021 · Frontiers in Pharmacology
  10. A Synthetic Human Antibody Antagonizes IL-18Rβ Signaling Through an Allosteric Mechanism
    Shusu Liu, Shane Miersch, Ping Li, Bingxin Bai, Chunchun Liu, Wenming Qin, Jie Su, Haiming Huang, James Pan, Sachdev S. Sidhu et al. · 2020 · Journal of Molecular Biology
  11. Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling
    Jiwan Ge, Soumya G. Remesh, Michal Hammel, Si Yuan Pan, Andrew D. Mahan, Shuying Wang, Xinquan Wang · 2019 · Structure
  12. X‐ray crystal structure localizes the mechanism of inhibition of an IL‐36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains
    Eric T. Larson, Debra L. Brennan, Eugene R. Hickey, Rajkumar Ganesan, Rachel Kroe‐Barrett, Neil A. Farrow · 2020 · Protein Science
  13. Monoclonal antibodies targeting ST2L Domain 1 or Domain 3 differentially modulate IL-33-induced cytokine release by human mast cell and basophilic cell lines
    Natalie Fursov, Jin Lü, Catherine Healy, Sheng‐Jiun Wu, Eilyn R. Lacy, Angela Filer, Yawei Li, Changbao Liu, Roberta J. Lamb, Brian H. Jones et al. · 2016 · Molecular Immunology
  14. Glycan-mediated functional assembly of IL-1RI: structural insights into completion of the current description for immune response
    Maryam Azimzadeh Irani, Mohammad Reza Ejtehadi · 2020 · Journal of Biomolecular Structure and Dynamics
  15. Dermatologic Manifestations of Noninflammasome-Mediated Autoinflammatory Diseases
    Dörte Symmank, Carina Borst, Mathias C. Drach, Wolfgang Weninger · 2022 · JID Innovations
  16. A New and Robust Method of Tethering IgG Surrogate Antigens on Lipid Bilayer Membranes to Facilitate the TIRFM Based Live Cell and Single Molecule Imaging Experiments
    Shaosen Zhang, Liling Xu, Xingwang Zhao, Xin Chen, Yilin Fan, Zhengpeng Wan, Yinsheng Xu, Wanli Liu · 2013 · PLoS ONE
  17. Macrophage-derived IL-1β directs fibroblast progenitor cell fate via metabolic reprogramming in wound healing
    Huanyu Luo, Xiaoyi Yu, Tianmeng Sun, Zewen Sun, Tianyuan Zhao, Li Chen, Ana Angelova Volponi, Fabian Flores‐Borja, Hongchen Sun, Zhengwen An · 2025 · Communications Biology
  18. Structural and dynamic properties of IL1 receptors
    Julia Zhukova, Julia Lopatnikova, Sergey Vitalievich Sennikov · 2025 · Frontiers in Immunology
  19. Circular permutation of chicken interleukin-1 beta enhances its thermostability
    Wenting Chen, Ting Chen, Chao‐Sheng Cheng, Wen-Yang Huang, Xinquan Wang, Hsien-Sheng Yin · 2014 · Chemical Communications
  20. Synthesis, in silico Studies and Pharmacological Evaluation of a New Series of Indanone Derivatives as Anti-Parkinsonian and Anti-Alzheimer’s Agents
    Ranju Bansal, Ranjit Singh, Pratibha Rana · 2022 · Current Computer - Aided Drug Design
  21. Interleukin-1α activation and localization in lipopolysaccharide-stimulated human monocytes and macrophages
    Thomas Gelsing Carlsen, Pernille Kjærsgaard, Trine Lykke Jørgensen, Rasmus Foldbjerg, Mads Lausen, Thomas Bouet Guldbæk Poulsen, Katarzyna Zabieglo, Gunna Christiansen, Svend Birkelund · 2015 · Journal of Immunological Methods
  22. In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex
    Karoliina Hassi, Timir Weston, Giulia Rinaldi, Joseph Chi-Fung Ng, Asma Smahi, Sophie Twelves, Camilla S. A. Davan-Wetton, Dana Fakhreddine, Franca Fraternali, Francesca Capon · 2023 · Journal of Investigative Dermatology
  23. Characterization and Validation of Arg286 Residue of IL-1RAcP as a Potential Drug Target for Osteoarthritis
    Angela Dailing, Kelsey C. Mitchell, Ngoc Vuong, Kyung Hyeon Lee, Reva Joshi, Virginia A. Espina, Amanda Haymond Still, Carter J. Gottschalk, Anne M. Brown, Mikell A. Paige et al. · 2021 · Frontiers in Chemistry
  24. Preclinical Efficacy of a Capsid Virus-like Particle-Based Vaccine Targeting IL-1β for Treatment of Allergic Contact Dermatitis
    Louise Goksøyr, Anders B. Funch, Anna Kathrine Okholm, Thor Grundtvig Theander, Willem Adriaan de Jongh, Charlotte Menne Bonefeld, Adam Frederik Sander · 2022 · Vaccines
  25. Structural Perturbations Present in the Folding Cores of Interleukin-33 and Interleukin-1β Correlate to Differences in Their Function
    V. V. Hemanth Giri Rao, Shachi Gosavi · 2015 · The Journal of Physical Chemistry B
  26. Beyond Negative Regulation: IL‐1R8 and IL‐1R2 as Novel Immune Checkpoints
    Domenico Supino, Roberto Garuti, Cecília Garlanda · 2025 · European Journal of Immunology
  27. Immunomodulatory Activity of Water Extract of Ulmus macrocarpa in Macrophages
    Da Hye Kwon, Hye-Joo Kang, Yung Hyun Choi, Kyung Tae Chung, Jong Hwan Lee, Kyung Hwa Kang, Sook Kyung Hyun, Byung Woo Kim, Hye Jin Hwang · 2016 · Journal of Life Science
  28. Molecular Docking Studies
    2018 · BENTHAM SCIENCE PUBLISHERS eBooks
  29. The Interleukin-1 Family
    Cecília Garlanda, Sébastien Jaillon · 2016 · Elsevier eBooks
  30. Safety, tolerability, and preliminary efficacy of nadunolimab, an anti-IL- 1 receptor accessory protein monoclonal antibody, in combination with pembrolizumab in patients with solid tumors
    Roger B. Cohen, Antonio Jimeno, Jennifer Hreno, Lova Sun, Marie Wallén‐Öhman, Camilla Rydberg Millrud, Annika Sanfridson, Ignacio Garcia‐Ribas · 2025 · Investigational New Drugs
  31. Therapeutic targeting of inflammasome signaling by blocking interleukin-1
    Rebecca C. Coll · 2022 · Elsevier eBooks
  32. IL-1 Receptor Accessory Protein-Ig/IL-1 Receptor Type II-Ig Heterodimer Inhibits IL-1 Response More Strongly than Other IL-1 Blocking Biopharmaceutical Agents
    Haruo Hanawa, Yoshimi Ota, Limin Ding, He Chang, Kaori Yoshida, Keita Otaki, Kazuhisa Hao, Sou Kasahara, Makoto Kodama, Mikio Nakazawa et al. · 2010 · Journal of Clinical Immunology
  33. The Interleukin-1 Family
    Charles Anthony Dinarello, Mihai Gheorghe Netea · 2013 · Springer eBooks
  34. Computational Cosolvent Mapping Analysis Leads to Identify Salicylic Acid Analogs as Weak Inhibitors of ST2 and IL33 Binding
    Xinrui Yuan, Krishnapriya Chinnaswamy, Jeanne A. Stuckey, Chao‐Yie Yang · 2022 · The Journal of Physical Chemistry B
  35. Identification of critical regions within the TIR domain of IL-1 receptor type I
    Jürgen Radons, Werner Falk, Stefan Dove · 2015 · The International Journal of Biochemistry & Cell Biology
  36. Cytokine Receptors and Their Ligands
    Karen S. Cheung Tung Shing, Winnie L. Kan, Tracy L. Nero, Timothy R. Hercus, Denis Tvorogov, Riley D. Metcalfe, Michael D. W. Griffin, Nicole A. de Weerd, Mark A. Guthridge, Paul J. Hertzog et al. · 2022 · Elsevier eBooks
  37. Neuroprotective potential of 17-oximino-16-arylidene steroids: In vivo and in silico investigations
    Ranjit Singh, Prerna Prerna, Ranju Bansal · 2025 · European Journal of Pharmacology
  38. NEMO recruitment at single cytokine-receptor complexes shows quantized dynamics independent of ligand affinity
    A Hyun Kim, Benjamin Krummenacher, Jason Yeung, David Ryan Koes, Robin Lee · 2025 · Cell Reports
  39. Case Study of Hydrogen Bonding in a Hydrophobic Cavity
    Yi-Chen Chen, Chao‐Sheng Cheng, Siu-Cin Tjong, Hsien-Sheng Yin, Shih‐Che Sue · 2014 · The Journal of Physical Chemistry B
  40. Semi-synthetic approaches to bile acids and preclinical evaluation of chenodeoxycholic acid in acute and chronic cutaneous inflammation with docking insights
    Juan Carlos Barragán‐Gálvez, Maria L. González-Rivera, Lorena Vanessa Bolaños Sáenz, Sabino de Jesús García Barajas, Abraham Vidal-Limon, Juan Ramón Zapata‐Morales, Mario Alberto Isiordia‐Espinoza, David Cruz Cruz, Angel Josabad Alonso-Castro, Clarisa Villegas Gómez · 2026 · Results in Chemistry
  41. Regulation of Immunity and Disease by the IL-1 Receptor Family Members IL-1R2 and IL-1R8
    Martina Molgora, Domenico Supino, Cecília Garlanda · 2018 · Springer eBooks
  42. Quantitative assessment of extracellular IL-1 regulation
    Luis F. Ponce, Karina García‐Martínez, Kalet León · 2019 · Journal of Theoretical Biology
  43. Structural basis of pro-inflammatory signaling via the Interleukin-36 receptor (IL-36R) mediated by IL-36γ and IL-37
    Julie Andries, Martin Toul, Jan Félix, Danielle M. Clancy, Savvas N. Savvides · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  44. The Interleukin-1 Family
    Cecília Garlanda, Irene Di Ceglie, Sébastien Jaillon · 2025 · Elsevier eBooks
  45. Characterization of System xc -, a Cystine-Glutamate Amino Acid Transporter, as an Effector of Interleukin-1β-Mediated Injury and Neuroprotection
    Nicole A. Jackman · 2013 · OpenCommons at University of Connecticut (University of Connecticut)
  46. Cytokine Receptors and Their Ligands
    Urmi Dhagat, Tracy L. Nero, Winnie L. Kan, Timothy R. Hercus, Sophie E. Broughton, Nicole A. de Weerd, Brendan John Jenkins, Ashley S. Mansell, Mark A. Guthridge, Paul J. Hertzog et al. · 2015 · Elsevier eBooks
  47. A genetic and functional analysis of novel chicken interleukin-1 gene family members
    Mark S. Gibson · 2012 · UCL Discovery (University College London)
  48. Regulation of ABCB1 expression and activity in porcine brain endothelial cells
    Pablo Vergara · 2016 · Research Explorer (The University of Manchester)
  49. Structural Insights into the Assembly of Large Oligomeric Signalosomes in the Toll-Like ReceptorInterle ukin-1 Receptor Superfamily
    Rev I Ew · 2016
  50. Microscale thermophoresis in the investigation of biomolecular interactions
    2020 · Journal of Chinese Pharmaceutical Sciences
  51. Autoinflammatory Disorders
    Yoshiro Maru · 2016 · Springer eBooks
  52. Autoinflammatory Disorders
    Yoshiro Maru · 2021 · Springer eBooks
  53. Identification of molecular pathways and protein-protein interactions in adipose tissue-derived mesenchymal stromal cells (ASCs) under physiological oxygen concentration in a diabetic rat model.
    Luis-Miguel Paco-Meza, Maria Dolores Carmona-Luque, Sagrario Cañadillas, Ana Lopez-Diaz, Francisco Muñoz-López, Álvaro Jiménez-Arranz, Ipek Guler, Concha Herrera · 2022 · PubMed Central
  54. Molecular mechanism of glycosylated IL-1RII counteraction with IL-1RI in regulation of the immune response
    Narges Jamshidi Khameneh, Maryam Azimzadeh Irani, Mohammad Reza Ejtehadi · 2023 · Molecular Simulation
  55. The role of the interleukin family in neuroinflammation caused by substance dependence
    Xuan Fan · 2024
  56. Unveiling Antibody-Mediated Allostery in Interleukin-1ß Via Conformational Sampling and Machine Learning
    Arzu Uyar · 2025 · Black Sea Journal of Engineering and Science
  57. Perturbation in gene expression in arsenic-treated human epidermal cells
    Kalu Udensi Udensi · 2013 · Unisa Institutional Repository (University of South Africa)
  58. Antagonist Binding Actively Disrupts Interleukin-1 Receptor Dynamics to Block Co-receptor Recruitment
    Chandran Nithin, Ayomide Fasemire, Sebastian Kmiecik · 2026 · bioRxiv
  59. Integrative Computational Prediction Strategy for Antibody–Antigen Binding: A Case Study on Interleukin-1 Beta
    Mehmet Emin Aygen, Arzu Uyar · 2026 · Journal of Chemical Information and Modeling
  60. IL-18 derived from microwave-ablated osteosarcoma facilitates antitumor response
    Jielong Zhou, Yunhui Zhang, Wenjie Yang, X G Wang, M Li, Yao Mengyu, Wenhan Huang, Xiao Chu, Christopher Schliehe, Manzhi Zhao et al. · 2026 · Journal for ImmunoTherapy of Cancer
  61. A novel cyprinid-specific IL-1 family cytokine activates inflammatory responses
    Zhaosheng Sun, Mingxue Sun, Kaizheng Wu, Yawen Niu, Jun Zhu, Zhengyang Wang, Qianjiu Yuan, Hui Yan, Yixin Ji, Xinran Tao et al. · 2026 · Developmental & Comparative Immunology
  62. Integrating multi-omics and machine learning to reveal IL1R2-driven macrophage-fibroblast spatial interactions in polycyclic aromatic hydrocarbon-induced pulmonary fibrosis
    Xin Tang, Peiyi Bai, Qinyang Du, Wulin Yang, Gaopeng Li · 2026 · Frontiers in Immunology