Cited by 1,071Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyMultiple Sclerosis Research Studies

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The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

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El-Behi, Mohamed, Ciric, Bogoljub, Dai, Hong, Yan, Yaping, Cullimore, Melissa, Safavi, Farinaz, Zhang, Guang-Xian, Dittel, Bonnie N, Rostami, Abdolmohamad·2011·Nature Immunology

DOI 10.1038/ni.2031PMC PMC3116521

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Abstract

Interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells) require exposure to IL-23 to become encephalitogenic, but the mechanism by which IL-23 promotes their pathogenicity is not known. Here we found that IL-23 induced production of the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) in T(H)17 cells and that GM-CSF had an essential role in their encephalitogenicity. Our findings identify a chief mechanism that underlies the important role of IL-23 in autoimmune diseases. IL-23 induced a positive feedback loop whereby GM-CSF secreted by T(H)17 cells stimulated the production of IL-23 by antigen-presenting cells. Such cross-regulation of IL-23 and GM-CSF explains the similar pattern of resistance to autoimmunity when either of the two cytokines is absent and identifies T(H)17 cells as a crucial source of GM-CSF in autoimmune inflammation.

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Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,553
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · cited 1×
“The initial development of T H 17 cells from naive CD4 + T cells is directed by transforming growth factor-β (TGF-β) in combination with IL-6, IL-21 or IL-9 (refs”
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T. B., Oukka, M., & Kuchroo, V. K. (2007) · Nature · doi:10.1038/nature05970 · Cited by 1,896
TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology
McGeachy, M. J., Bak-Jensen, K. S., Chen, Y., Tato, C. M., Blumenschein, W., McClanahan, T., & Cua, D. J. (2007) · Nature Immunology · doi:10.1038/ni1539 · Cited by 1,520
Generation of pathogenic TH17 cells in the absence of TGF-β signalling
Ghoreschi, K., Laurence, A., Yang, X.-P., Tato, C. M., McGeachy, M. J., Konkel, J. E., Ramos, H. L., Wei, L., Davidson, T. S., Bouladoux, N., et al. (2010) · Nature · doi:10.1038/nature09447 · Cited by 1,388
C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
Reboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1716 · Cited by 1,206 · cited 1×
“The CCR6-CCL20 axis is essential for the entry of T H 17 cells into the CNS in the early phase of EA”

Show all 44 references

Research works printed but not linked: 6

McGeachy, M.J. et al. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat. Immunol. 10, 314–324 (2009). · DOI · Paper page
Park, L.S., Friend, D., Gillis, S. & Urdal, D.L. Characterization of the cell surface receptor for granulocyte-macrophage colony-stimulating factor. J. Biol. Chem. 261, 4177–4183 (1986). · DOI
Fleetwood, A.J., Lawrence, T., Hamilton, J.A. & Cook, A.D. Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation. J. Immunol. 178, 5245–5252 (2007). · DOI · Paper page
Hirota, K. et al. Fate mapping of IL-17-producing T cells in inflammatory responses. Nat. Immunol. 12, 255–263 (2011). · DOI · Paper page
Yang, X.O. et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and RORγ. Immunity 28, 29–39 (2008). · DOI · Paper page
Yamazaki, T. et al. CCR6 regulates the migration of inflammatory and regulatory T cells. J. Immunol. 181, 8391–8401 (2008). · DOI

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Self-citation
Studies of Mast Cells: Adventures in Serendipity
Brown, M. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00520 · Cited by 9
Estradiol enhances capacity of TLR-matured splenic dendritic cells to polarize CD4+ lymphocytes into IL-17/GM-CSF-producing cells in vitro
Stojić-Vukanić, Z., Bufan, B., Pilipović, I., Vujnović, I., Nacka-Aleksić, M., Petrović, R., Arsenović-Ranin, N., & Leposavić, G. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.09.001 · Cited by 4
Modeling the Dynamics of T Helper 17 Induction and Differentiation
Josep, B. R. (2015) · MOJ Immunology · doi:10.15406/moji.2015.02.00038 · Cited by 4
“For example, intestinal IL-17A+ IL-10+ Th17 cells are known to induce an immunosuppressive environment [16], however, in the onset of IBD, increased IL-17A expression has been reported [17] and Th17 cells expressing IFNγ or GM-CSF can accumulate during gut inflammatory disorders [18-20].”
Background
DAB389IL-2 suppresses autoimmune inflammation in the CNS and inhibits T cell-mediated lysis of glial target cells
Bhopale, M. K., Hilliard, B. A., Constantinescu, C. S., Fujioka, T., Ventura, E. S., Phillips, S. M., & Rostami, A. M. (2013) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2013.07.004 · Cited by 5
“, 1995–1996), IL-17 (Jadidi-Niaragh and Mirshafiey, 2011) and GMCSF (El-Behi et al., 2011), produced by pathogenic CD4 T cells, residential glial cells or non-specific immune cells recruited from blood.”
BackgroundSelf-citation
T Cells and Their Subsets in Autoimmunity
Burkett, P. R., Pawlak, M., Peters, A., & Kuchroo, V. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812102-3.00006-3 · Cited by 2
Single-cell RNA sequencing indicates AP-1 as a potential therapeutic target for autoimmune uveitis.
Zhao, S., Wu, D.-T., Lu, Y., Zhu, L., Wang, S.-H. E., Li, Z.-H., Peng, X., Li, H., Xu, X.-F., & Su, W.-R. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116945 · Cited by 3
Molecular mechanisms of long non-coding RNAs in differentiation of T Helper17 cells
Saadh, M. J., Arellano, M. T. C., Saini, R. S., Amin, A. H., Sharma, N., Arias‐Gonzáles, J. L., Alsandook, T., Cotrina-Aliaga, J. C., & Akhavan‐Sigari, R. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110728 · Cited by 3
Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cellsPreprint
Parween, F., Singh, S. P., Zhang, H. H., Kathuria, N., Otaizo-Carrasquero, F. A., Shamsaddini, A., Gardina, P. J., Ganesan, S., Kabát, J., Lorenzi, H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.25.525561 · Cited by 3
“To manifest pathogenicity in mice these cells have been reported to require IL-23 15, 47, 48 and the transcriptional regulators ROR  t and T-bet 36 , JunB and BATF 49 , BHLHE40 50 , and EOMES 51 .”
Genetic and Environmental Determinants of T Helper 17 Pathogenicity in Spondyloarthropathies
Simone, D., Stingo, A., & Ciccia, F. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.703242 · Cited by 3
Gene Regulatory Network of Human GM-CSF-Secreting T Helper Cells
Éliás, S., Schmidt, A., Gómez-Cabrero, D., & Tegner, J. N. (2021) · Journal of Immunology Research · doi:10.1155/2021/8880585 · Cited by 4
RORα enforces stability of the T-helper-17 cell effector programPreprint
Lee, J.-Y., Hall, J., Pokrovskii, M., Kroehling, L., Wu, L., & Littman, D. (2020) · bioRxiv · doi:10.1101/2020.12.15.422921 · Cited by 3
“(B and C) Normalized counts of autoimmune disease-associated (Il1r1, Il23r, Bhlhe40), pathogenic (Csf2) genes (B) and Rorc (C) in TWT and TAKO Il17aeGFP+ Th17 cells from the DLN (TWT (n = 3) and TAKO (n = 3)) and SC (TWT (n = 3) and TAKO (n = 2)) at peak of EAE.”
BackgroundInfluential
B cells in autoimmune diseases of the central nervous system
Noto, D., & Miyake, S. (2020) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12603 · Cited by 4
Comprehensive Analysis of the Immune and Stromal Compartments of the CNS in EAE Mice Reveal Pathways by Which Chloroquine Suppresses Neuroinflammation
Thomé, R., Boehm, A., Ishikawa, L. L. W., Casella, G., Munhoz, J., Ćirić, B., Zhang, G., & Rostami, A. M. (2020) · Brain Sciences · doi:10.3390/brainsci10060348 · Cited by 3
“GM-CSF production in Th17 cells is induced through stimulation of the IL-23 receptor [7,9].”
BackgroundSelf-citation
Expression and role of granulocyte macrophage colony-stimulating factor receptor (GM-CSFR) and granulocyte colony-stimulating factor receptor (G-CSFR) on Ph-positive acute B lymphoblastic leukemia
Tan, M., Chen, M., Chen, Y.-Z., & Wu, Y. (2018) · Hematology · doi:10.1080/10245332.2018.1426540 · Cited by 3
DIRECT EFFECTS OF GM-CSF ON THE FUNCTIONS OF HUMAN MONOCYTES/MACROPHAGES
Gazatova, N., Meniailo, M. E., Malashchenko, V., Goncharov, A., Melashchenko, O., Morozova, E. M., & Seledtsov, V. (2019) · Medical Immunology · doi:10.15789/1563-0625-2019-3-419-426 · Cited by 3
“В частности, GM-CSF способен поддерживать дифференцировку и выживаемость дендритных клеток, запускающих антигензависимую пролиферацию и дифференцировку Т-лимфоцитов [14, 17] и регулирующих иммунные реакции на всем их протяжении [4, 7].”
Multiple Sclerosis
Hernandez, A., O’Connor, K. C., & Hafler, D. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-384929-8.00052-6 · Cited by 6
Effect of Dipyridamole on Experimental Autoimmune Uveitis: Reprogrammed Immune Cell Landscape and Reduced Th17 Pathogenicity
Chen, B., Huang, Z., Chen, J., Wu, Y. M., Lv, J., Wen, Y., Wu, X., Zhang, X., Lin, H., & Su, W. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.15.16 · Cited by 2
Activation of the MyD88-JNK pathway promotes pathogenetic Th17 differentiation by induction of activin-A secretion and enhances experimental autoimmune encephalomyelitis
Jin, X., & Zhang, N. (2025) · Neuroreport · doi:10.1097/wnr.0000000000002183 · Cited by 2
Regulatory T cells suppress GM-CSF-producing T helper cells via IL-2 modulation to restrain immunopathology
Costa-Pereira, S., Lanzinger, M., Andreadou, M., Nuñez, N., Villar-Vesga, J., Prisco, F., Häne, P., Roussel, E., Krishnarajah, S., Lindemann, R. C., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115642 · Cited by 3
CD11c+ CD8 T cells cause IFN-γ-dependent autoimmune neuroinflammation that is restrained by PD-1 signaling
Hwang, D., Ishikawa, L. L. W., Seyedsadr, M. S., Jang, S., Kasimoglu, E., Rostami, A., Zhang, G.-X., & Ciric, B. (2025) · bioRxiv · doi:10.1101/2025.02.23.639743 · Cited by 2
“GM-CSF is essential for CD4-EAE development [23], but its role in CD8-EAE is unknown.”
Self-citation
Pin1 maintains the effector program of pathogenic Th17 cells in autoimmune neuroinflammation
Fan, G., Li, G., Li, L., & Da, Y. (2024) · Journal of Autoimmunity · doi:10.1016/j.jaut.2024.103262 · Cited by 5
Immune-responsive gene 1: The mitochondrial key to Th17 cell pathogenicity in CNS autoimmunity
Nematullah, M., Fatma, M., Zhou, G., Prajapati, B., Rashid, F., Ayasolla, K., Ahmed, M. E., She, R., Sajad, M., Zahoor, I., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2427052122 · Cited by 2
“…and is known to include two distinct subsets (22): the pathogenic Th17 (pTh17) subset, which produces high levels of inflammatory mediators, such as IL17a and GMCSF, and induces EAE disease (23–25), and the second nonpathogenic Th17 (npTh17) subset, which has a mild inflammatory profile (26, 27).”
Autotaxin in encephalitogenic CD4 T cells as a therapeutic target for multiple sclerosis
Petersen‐Cherubini, C. L., Murphy, S. P., Xin, M. K., Liu, Y., Deffenbaugh, J. L., Jahan, I., Rau, C. N., Yang, Y., & Lovett‐Racke, A. E. (2023) · European Journal of Immunology · doi:10.1002/eji.202350561 · Cited by 2
“These cytokines were chosen based on their known contributions to encephalitogenicity [28–30].”
Background
A Compass to Guide Insights into TH17 Cellular Metabolism and Autoimmunity
Wilson, A., Mosure, S., & Solt, L. A. (2021) · Immunometabolism · doi:10.20900/immunometab20220001 · Cited by 2
“The “pathogenic fate” of TH17 cells depends on the cytokine milieu present at the time of T cell activation; IL-6 and TGFβ steer TH17 cells toward a “non-pathogenic” fate, whereas the addition of IL-1β and IL-23 increase TH17 cell pathogenicity [4,6,8].”
Background
Gene regulatory network of human GM-CSF secreting T helper cells
Éliás, S., Schmidt, A., Gómez-Cabrero, D., & Tegnér, J. (2019) · bioRxiv · doi:10.1101/555433 · Cited by 2
[Recurrent postpartum pyoderma gangrenosum and fatal cardiomyopathy].
Naciri, I., Meziane, M., Benzekri, L., Ghaouti, M., Senouci, K., & Hassam, B. (2017) · Annales de dermatologie et de vénéréologie · doi:10.1016/j.annder.2017.11.006 · Cited by 2
A Promising Target in Rheumatoid Arthritis Treatment: Granulocyte-Macrophage Colony-Stimulating Factor
Avcı, A., Feist, E., & Burmester, G. (2015) · Current Treatment Options in Rheumatology · doi:10.1007/s40674-015-0031-6 · Cited by 2
Analysis of TGF-β1 and TGF-β3 as regulators of encephalitogenic Th17 cells: Implications for multiple sclerosis
Lee, P. W., Yang, Y., Racke, M. K., & Lovett‐Racke, A. E. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.12.007 · Cited by 37
T ‐bet is essential for T h1‐mediated, but not T h17‐mediated, CNS autoimmune disease
O’Connor, R. A., Cambrook, H., Huettner, K., & Anderton, S. M. (2013) · European Journal of Immunology · doi:10.1002/eji.201343689 · Cited by 44
T-Helping Colitis.
Mucida, D. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.023 · Cited by 2
Comparison of Peripheral Blood Th17 Cells and Associated Cytokines in Fingolimod-Receiving and Untreated Multiple Sclerosis Patients
Eken, A., Yetkin, M., Okuş, F. Z., Erdem, Ş., Çakır, M., Haliloğlu, Y., Azizoğlu, Z. B., Donmez-Altuntas, H., Mirza, M., & Canatan, H. (2019) · Turkish Journal of Immunology · doi:10.25002/tji.2019.1007 · Cited by 2
Serotonergic system as a therapeutic target in multiple sclerosis
Sviridova, A. A., Melnikov, M., Belousova, O., Rogovskii, V., Pashenkov, M. V., & Boyko, A. N. (2019) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20191192264 · Cited by 2
Role of Cytokine-Mediated Crosstalk between T Cells and Nonimmune Cells in the Pathophysiology of Multiple Sclerosis
Kamimura, D., Arima, Y., Atsumi, T., Meng, J., Sabharwal, L., Bando, H., Ogura, H., Jiang, J., Huseby, E. S., & Murakami, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800763-1.00006-3 · Cited by 1
Cellular Immunity and Multiple Sclerosis: Current Understanding
Sato, W., & Yamamura, T. (2016) · Springer eBooks · doi:10.1007/978-4-431-55594-0_1 · Cited by 2
IL-23 in Health and Disease
Sherlock, J. P., Zuniga, L. A., & Cua, D. J. (2013) · Springer eBooks · doi:10.1007/978-4-431-54442-5_7 · Cited by 1
PPARα deficiency exacerbates atherosclerosis progressing through enhancing pTh17 cells-macrophage crosstalk.
Ren, T., Jiang, X.-L., Wu, J., Yan, C.-S., Peng, L., Chen, C.-X., Li, W., Wang, W.-Y., Jin, X., & Yang, L.-C. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179247 · Cited by 1
The role of Th17 cells in the pathogenesis of Parkinson's disease: From immune dysregulation to neurodegeneration
Zhao, J., Liang, H., & Bi, Y. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.111990 · Cited by 1
Histamine H4 receptor in neuroinflammation: Dual roles in multiple sclerosis and Parkinson's disease
Yan, W.-J., Yang, Y.-L., Yan, W., Tian, S.-Y., Zi, Y., Liu, G.-J., Yi, Z.-A., Shao, R.-X., Shi, C.-Y., Shan, L., et al. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107400 · Cited by 1
Epithelial MLCK deficiency alleviates alcohol-associated liver disease via dendritic–Th17 cell axis
Wang, X., Wang, J., Xiong, L., Tang, S., Wu, S., Zhao, J., Wang, Z., Zhu, J.-Y., Li, Y.-Q., Zhuang, J.-L., et al. (2026) · JHEP Reports · doi:10.1016/j.jhepr.2026.101849 · Cited by 1
“47,48 To directly validate Th17 cell functional polarization in vivo , we performed flow cytometry analysis of intestinal CD4 + T cells and found that alcohol exposure increased the proportion of pathogenic Th17 cells (IL-17A + GM-CSF + ), while reducing nonpathogenic Th17 cells (IL-17A + IL-10 +…”
ZIP3 is essential for the encephalitogenic function of pTh17 cells by regulating intracellular zinc levels
Drmic, D., Wang, L. H., Noyer, L., Zhong, L., & Feske, S. (2026) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2026.127819 · Cited by 2
Comparative Analysis of Mouse CSF Proteins in Experimental Autoimmune Encephalomyelitis Model and Cuprizone-Induced Demyelination Model by Olink Proteomics
Bernaerts, E., Rutten, M., Visscher, A. D., Beliën, J., Berghmans, N., Mitera, T., Somer, L. D., Matthys, P., & Vandooren, J. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05905-w · Cited by 1
Localized Delivery of Anti‐CD40/PD‐1 Immunotherapy via a Polymeric Implant is Efficacious, Remodels the Tumor Immune Microenvironment and Improves Safety in a PDAC Mouse Model
Minaei, E., Wade, S. J., Penney, C., Ranson, M., Aghmesheh, M., Sluyter, R., & Vine, K. L. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202503780 · Cited by 1
Bergenin, the main active ingredient of Bergenia purpurascens , attenuates Th17 cell differentiation by downregulating fatty acid synthesis
He, Y., Xu, D., Zhang, J., Liu, Y., Liao, M., Xia, Y., Wei, Z., & Dai, Y. (2024) · The FASEB Journal · doi:10.1096/fj.202400961r · Cited by 1
Role of Neutrophils in the Development of Steatotic Liver Disease
Choi, Y., Kim, Y. S., & Hwang, S. (2024) · Seminars in Liver Disease · doi:10.1055/s-0044-1789207 · Cited by 2
“122 Further studies are needed to elucidate the role of IL-23 in ALD.”
Normal value and changes in CRP values on maternal and fetal umbilical cord blood with the labor and intrapartum interventions
Siriwardhana, D., & Lanerolle, S. (2023) · Sri Lanka Journal of Obstetrics and Gynaecology · doi:10.4038/sljog.v45i3.8101 · Cited by 1
“…at the University of Philadelphia on the variation of maternal serum and vaginal fluid CRP levels identified that both maternal serum and vaginal fluid CRP determinations after pre-labor preterm rupture of the membrane are of poor predictive value in neonatal early-onset infection prediction 11 .”
Background
Antigen-independent IL-17A production by bystander-activated CD4+IL-1R1+ cells in patients with multiple sclerosis
Kim, S. Y., Kim, Y., Kim, S., Han, S.-M., Park, H., Payumo, R. M. P., Kim, H. E., Hyun, J., Kim, K. H., Lee, E. J., et al. (2023) · Human Immunology · doi:10.1016/j.humimm.2022.12.004 · Cited by 1
Granulocyte-macrophage colony-stimulating factor suppresses induction of type I interferon in infants with severe pneumonia
Luo, Z., Wei, H., & Li, X. (2022) · Pediatric Research · doi:10.1038/s41390-022-02059-y · Cited by 1
Targeting interferon-λ signaling promotes recovery from central nervous system autoimmunity
Manivasagam, S., Williams, J. L., Vollmer, L., Bollman, B., Bartleson, J. M., Ai, S.-J., Wu, G., & Klein, R. (2021) · doi:10.1101/2021.08.17.456642 · Cited by 1
Specialized subsets of innate-like T cells and dendritic cells protect from lethal pneumococcal infection in the lungPreprint
Murray, M. P., Crosby, C., Marcovecchio, P. M., Hartmann, N., Chandra, S., Zhao, M., Khurana, A., Zahner, S., Clausen, B., Coleman, F., et al. (2021) · bioRxiv · doi:10.1101/2021.07.25.453697 · Cited by 1
“Further, IL-23 has been shown to stimulate GM-CSF production by CD4+ Th17 cells, although it is not known if this is true for iNKT cells (Codarri et al., 2011; El-Behi et al., 2011; Rothchild et al., 2014).”
Background

Authors: El-Behi, M., Ciric, B., Dai, H., Yan, Y., Cullimore, M., Safavi, F., Zhang, G.-X., Dittel, B. N., & Rostami, A.
Affiliations: Thomas Jefferson University (US)
Versiti Blood Center of Wisconsin (US)
Corresponding author: Rostami, Abdolmohamad
ORCID: Yan, Yaping
Cullimore, Melissa
Safavi, Farinaz
Zhang, Guang-Xian
Dittel, Bonnie N
Rostami, Abdolmohamad
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2011-04-24
Volume: 12
Issue: 6
Pages: 568-575
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni.2031
PMC: PMC3116521
OpenAlex: W2084388036
Cited by: 1,071
References: 44
Citations by year: 2026: 25 · 2025: 38 · 2024: 38 · 2023: 58 · 2022: 62 · 2021: 72 · 2020: 82 · 2019: 71 · 2018: 74 · 2017: 96 · 2016: 82 · 2015: 108 · 2014: 91 · 2013: 80 · 2012: 73
FWCI: 37.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Multiple Sclerosis Society
Mary E. Groff Surgical and Medical Research and Education Charitable Trust
National Institute of Neurological Disorders and Stroke (R01NS046782)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: Th17 cells, experimental autoimmune encephalomyelitis, IL-23, GM-CSF, interleukin-1, encephalitogenicity, autoimmune disease, antigen-presenting cells, positive feedback loop, T helper cells
MeSH terms: Animals, Antibodies, Cells, Cultured, Encephalomyelitis, Autoimmune, Experimental, Female, Flow Cytometry, Glycoproteins, Interleukin-1, Mice, Inbred C57BL, Mice, Transgenic, Peptide Fragments, CD4-Positive T-Lymphocytes, Granulocyte-Macrophage Colony-Stimulating Factor, Transforming Growth Factor beta, Mice, Knockout, Th1 Cells, Coculture Techniques, CD11c Antigen, Mice, Interleukin-1beta, Interleukin-23, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells, Myelin-Oligodendrocyte Glycoprotein

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The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

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