The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria
Open accessAbstract
Natural killer T cells (NKT cells) recognize glycolipid antigens presented by CD1d. These cells express an evolutionarily conserved, invariant T cell antigen receptor (TCR), but the forces that drive TCR conservation have remained uncertain. Here we show that NKT cells recognized diacylglycerol-containing glycolipids from Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, and group B Streptococcus, which causes neonatal sepsis and meningitis. Furthermore, CD1d-dependent responses by NKT cells were required for activation and host protection. The glycolipid response was dependent on vaccenic acid, which is present in low concentrations in mammalian cells. Our results show how microbial lipids position the sugar for recognition by the invariant TCR and, most notably, extend the range of microbes recognized by this conserved TCR to several clinically important bacteria.
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Cites
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Type 2 immunity in the skin and lungs
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Tissue-specific functions of invariant natural killer T cells
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Self-citationIL-7 Licenses Activation of Human Liver Intrasinusoidal Mucosal-Associated Invariant T Cells
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Metadata
- Authors
- Kinjo, Y., Illarionov, P., Vela, J. L., Pei, B., Girardi, E., Li, X., Li, Y., Imamura, M., Kaneko, Y., Okawara, A., Miyazaki, Y., Gómez-Velasco, A., Rogers, P., Dahesh, S., Uchiyama, S., Khurana, A., Kawahara, K., Yesilkaya, H., Andrew, P. W., Wong, C.-H., Kawakami, K., Nizet, V., Besra, G. S., Tsuji, M., Zajonc, D. M., & Kronenberg, M.
- Venue
- Nature Immunology
- Published
- 2011-09-04
- Volume
- 12
- Issue
- 10
- Pages
- 966-974
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2122130567
- Cited by
- 358
- References
- 42
- FWCI
- 13.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Kinjo, Y., Illarionov, P., Vela, J. L., Pei, B., Girardi, E., Li, X., Li, Y., Imamura, M., Kaneko, Y., Okawara, A., Miyazaki, Y., Gómez-Velasco, A., Rogers, P., Dahesh, S., Uchiyama, S., Khurana, A., Kawahara, K., Yesilkaya, H., Andrew, P. W., . . . Kronenberg, M. (2011). Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nature Immunology. https://doi.org/10.1038/ni.2096
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
