The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens

He, You-Wen, Li, Hong, Zhang, Jun, Hsu, Chia-Lin, Lin, Emily, Zhang, Nu, Guo, Jian, Forbush, Katherine A, Bevan, Michael J·2004·Nature Immunology
DOI 10.1038/ni1021

Cited by (172)

Items 101–172 of 172

  1. Mindin is upregulated during colitis and may activate NF-κB in a TLR-9 mediated manner
    Bayasi Guleng · 2010 · World Journal of Gastroenterology
  2. The extracellular matrix protein mindin as a novel adjuvant elicits stronger immune responses for rBAG1, rSRS4 and rSRS9 antigens of Toxoplasma gondiiin BALB/c mice
    Xiaojing Sun, Mei Mei, Xu Zhang, Fusong Han, Boyin Jia, Xiaoyan Wei, Zhiguang Chang, Huijun Lu, Jigang Yin, Qijun Chen et al. · 2014 · BMC Infectious Diseases
  3. Mindin Activates Autophagy for Lipid Utilization and Facilitates White Spot Syndrome Virus Infection in Shrimp
    Jie Gao, Ye-Jia Song, Hao Wang, Bao-Rui Zhao, Xian‐Wei Wang · 2023 · mBio
  4. Upregulation of Spondin-2 protein expression correlates with poor prognosis in hepatocellular carcinoma
    Ying Feng, Yilin Hu, Qinsheng Mao, Yibing Guo, Yifei Liu, Wanjiang Xue, Shuqun Cheng · 2018 · Journal of International Medical Research
  5. PIK3AP1 and SPON2 Genes Are Differentially Methylated in Patients With Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis (PFAPA) Syndrome
    Ema Lovšin, Jernej Kovač, Tine Tesovnik, Nataša Toplak, Daša Perko, Tomaž Rozmarič, Maruša Debeljak, Tadej Avčin · 2020 · Frontiers in Immunology
  6. The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace
    Zhuowei Li, Stavros Garantziotis, Wei Jia, Erin N. Potts, Sikander Lalani, Zhi Liu, You-Wen He, William Michael Foster, John W. Hollingsworth · 2008 · Journal of Leukocyte Biology
  7. Multi-omics analysis reveals the effects of host-rumen microbiota interactions on growth performance in a goat model
    Juncai Chen, Xiaoli Zhang, Xuan Chang, Bingni Wei, Yan Fang, Shanshan Song, Daxiang Gong, Deli Huang, Yawang Sun, Xianwen Dong et al. · 2024 · Frontiers in Microbiology
  8. The clinical significance of spondin 2 eccentric expression in peripheral blood mononuclear cells in bronchial asthma
    Peng Zhou, Caixia Xiang, Jinfeng Wei · 2021 · Journal of Clinical Laboratory Analysis
  9. Role of Mindin in Diabetic Nephropathy
    Maki Murakoshi, Tomohito Gohda, Mitsuo Tanimoto, Kazuhiko Funabïki, Satoshi Horikoshi, Yasuhiko Tomino · 2011 · Experimental Diabetes Research
  10. Characterization of the early molecular changes in the glomeruli of Cd151 −/− mice highlights induction of mindin and MMP-10
    Crystal R. Naudin, Brian C. Smith, Danielle R. Bond, Matthew D. Dun, Rodney J. Scott, Leonie K. Ashman, Judith Weidenhofer, Séverine Roselli · 2017 · Scientific Reports
  11. Cellular gene expression survey of PseudoRabies Virus (PRV) infected Human Embryonic Kidney cells (HEK-293)
    Yannick Blanchard, Nolwenn Le Meur, Martine Le Cunff, Philippe Blanchard, Jean J. Leger, André Jestin · 2006 · Veterinary Research
  12. Jejunal Transcriptomic Profiling for Differences in Feed Conversion Ratio in Slow-Growing Chickens
    Panpradub Sinpru, Cindy Riou, Satoshi Kubota, Chotima Poompramun, Wittawat Molee, Amonrat Molee · 2021 · Animals
  13. Mindin (SPON2) Is Essential for Cutaneous Fibrogenesis in a Mouse Model of Systemic Sclerosis
    Isha Rana, Sunny Kataria, Tuan Lin Tan, Edries Yousaf Hajam, Deepak Kumar Kashyap, Dyuti Saha, Johan Ajnabi, Sayan Paul, Shashank Jayappa, Akhil SHP Ananthan et al. · 2022 · Journal of Investigative Dermatology
  14. Deconvolution of RNA-Seq Analysis of Hyperbaric Oxygen-Treated Mice Lungs Reveals Mesenchymal Cell Subtype Changes
    Yuan Yuan, Yilu Zhou, Yali Li, Charlotte Nicole Hill, Rob M. Ewing, Mark G. Jones, Donna E. Davies, Zheng‐Lin Jiang, Yihua Wang · 2020 · International Journal of Molecular Sciences
  15. Microbiota Alters Urinary Bladder Weight and Gene Expression
    Blanka Milić Roje, Anamaria Elek, Vinko Palada, Joana Bom, Aida Iljazović, Ana Šimić, Lana Sušak, Katarina Vilović, Till Strowig, Kristian Vlahoviček et al. · 2020 · Microorganisms
  16. Vocal Fold Fibroblasts in Reinke’s Edema Show Alterations Involved in Extracellular Matrix Production, Cytokine Response and Cell Cycle Control
    Magdalena Grill, Isaac Lazzeri, Andrijana Kirsch, Nina Steurer, Tanja Grossmann, Michael Karbiener, Ellen Heitzer, Markus Gugatschka · 2021 · Biomedicines
  17. Intrinsic disorder in spondins and some of their interacting partners
    Oluwole Alowolodu, Gbemisola Johnson, Lamis Alashwal, Iqbal Addou, Irina V. Zhdanova, Vladimir Nikolaevich Uversky · 2016 · Intrinsically Disordered Proteins
  18. PRELP Enhances Host Innate Immunity against the Respiratory Tract Pathogen Moraxella catarrhalis
    Guanghui Liu, David Ermert, Martin Johansson, Birendra Singh, Yu‐Ching Su, Magnus Paulsson, Kristian Riesbeck, Anna Marie Blom · 2017 · The Journal of Immunology
  19. Hyperlipidemia and Allograft Rejection
    Jessamyn Bagley, Linus Williams, Michael Hyde, Christian Rosa Birriel, John Iacomini · 2019 · Current Transplantation Reports
  20. The evolution of the immune-type gene family Rhamnospondin in cnidarians
    Javier A. López, Matthew G. Fain, Luis Fernando Cadavid · 2010 · Gene
  21. Mindin serves as a tumour suppressor gene during colon cancer progression through MAPK/ERK signalling pathway in mice
    Xiao‐Shen Cheng, Ya‐Ni Huo, Yanyun Fan, Chuanxing Xiao, Xiao‐Mei Ouyang, Lai‐Ying Liang, Ying‐Chi Lin, Jianfeng Wu, Jianlin Ren, Bayasi Guleng · 2020 · Journal of Cellular and Molecular Medicine
  22. Expression of Small Leucine-Rich Proteoglycans During Experimental Fungal Keratitis
    Xiaoyong Yuan, Xia Hua, Kirk R. Wilhelmus · 2010 · Cornea
  23. Spondin-2 is a novel diagnostic biomarker for laryngeal squamous cell carcinoma
    Haosheng Ni, Tingting Ni, Jia Feng, Tingting Bian, Yifei Liu, Jianguo Zhang · 2018 · Pathology - Research and Practice
  24. Study of Human T21 Placenta Suggests a Potential Role of Mesenchymal Spondin-2 in Placental Vascular Development
    Pascale Gerbaud, Padma Murthi, Jean Guibourdenche, Fabien Guimiot, Benoît Sarazin, Danièle Evain‐Brion, Josette Badet, Guillaume Pidoux · 2019 · Endocrinology
  25. Role of C-mannosylation in the secretion of mindin
    Yoko Inai, Kana Ueda, In-Sook Lee Matsui, Michiko Tajiri, Shiho Minakata, Yoshinao Wada, Yoshito Ihara · 2020 · Biochimica et Biophysica Acta (BBA) - General Subjects
  26. PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment
    Sarah Johnson, Yaroslava D. Karpova, Danping Guo, Atreyi Ghatak, Dmitriy A. Markov, Alexei V. Tulin · 2022 · BMC Cancer
  27. Mindin the fort
    Christine McDonald, Gabriel Núñez · 2003 · Nature Immunology
  28. The structure of the Ca2+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein
    Kemin Tan, Jack Lawler · 2011 · BMC Structural Biology
  29. Retracted: The Role of the Extracellular Matrix Protein Mindin in Airway Response to Environmental Airways Injury
    Sarah Frush, Zhuowei Li, Erin N. Potts, Wenjuan DU, Jerry P. Eu, Stavros Garantziotis, You-Wen He, William Michael Foster, John W. Hollingsworth · 2011 · Environmental Health Perspectives · Retracted
  30. Role of intestinal extracellular matrix-related signaling in porcine epidemic diarrhea virus infection
    Yuchen Li, Jianda Li, Xiuyu Wang, Qingxin Wu, Qian Yang · 2021 · Virulence
  31. Comprehensive analysis of the oncogenic and immunological role of SPON2 in human tumors
    Jiali Tang, Qing Yu Huang, Xuanwen Li, Shinong Gu · 2023 · Medicine
  32. Protein C-Mannosylation and Its Prospective Functions in the Cell
    Yoshito Ihara, Yoko Inai, Midori Ikezaki · 2011 · Trends in Glycoscience and Glycotechnology
  33. Extracellular Matrix Protein Mindin is Required for the Complete Allergic Response to Fungal-Associated Proteinase
    Robert M. Tighe, Erin N. Potts · 2011 · Journal of Allergy & Therapy
  34. Carbon monoxide down-regulates α4β1 integrin-specific ligand binding and cell adhesion: a possible mechanism for cell mobilization
    Alexandre Chigaev, Yelena Smagley, Larry A. Sklar · 2014 · BMC Immunology
  35. Grundregulation – Eine Synthese medizinischen Denkens
    H. Heine · 2004 · Deutsche Zeitschrift für Akupunktur
  36. Mindin is essential for cutaneous fibrogenesis in a new mouse model of systemic sclerosis
    Isha Rana, Sunny Kataria, Tuan Lin Tan, Edries Yousaf Hajam, Deepak Kashyap, Dyuti Saha, Johan Ajnabi, Sayan Paul, Shashank Jayappa, Akhil SHP Ananthan et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  37. Structure of the Lipopolysaccharide from Paenalcaligenes hominis: A Chemical Perspective on Immune Recognition
    Ferran Nieto‐Fabregat, Marcello Mercogliano, Alessandro Cangiano, Giuseppe Vitiello, Emanuela Andretta, Luke A. Clifton, Adele Vanacore, Lorena Buono, María Asunción Campanero‐Rhodes, Dolores Solı́s et al. · 2025 · JACS Au
  38. MINDIN Exerts Protumorigenic Actions on Primary Prostate Tumors via Downregulation of the Scaffold Protein NHERF-1
    Luis Álvarez‐Carrión, Irene Gutiérrez-Rojas, María Rosario Rodríguez-Ramos, Juan Antonio Ardura, Verónica Alonso · 2021 · Cancers
  39. Deficiency of mindin reduces renal injury after ischemia reperfusion
    Tao Bai, Xiong Wang, Cong Qin, Kang Yang, Zhi-guo Duan, Zhixiu Cao, Jiaqian Liang, Lei Wang, Jingdong Yuan, Pengcheng Luo · 2022 · Molecular Medicine
  40. A Multilayered Imaging and Microfluidics Approach for Evaluating the Effect of Fibrinolysis in Staphylococcus aureus Biofilm Formation
    Raffaella Parente, Maria Rita Fumagalli, Alessia Di Claudio, Cindy Lorena Cárdenas Rincón, Marco Erreni, Damiano Zanini, G. Iapichino, Alessandro Protti, Cecília Garlanda, Roberto Rusconi et al. · 2023 · Pathogens
  41. Overexpression of Spondin-2 Is Associated with Recurrence-Free Survival in Patients with Localized Clear Cell Renal Cell Carcinoma
    Huimin Ma, Meng Yu, Cong Wu, Houbao Huang, Yawei Li, Peng Zhang, Jianjun Huang, Long Cheng, Gang Ling Feng, Guorong Li · 2020 · Disease Markers
  42. Low EGR1 expression predicts poor prognosis in clear cell renal cell carcinoma
    Zhengyan Zhang, Shilong Zhang, Huiling Chen, Yuqin Mao, Chao‐Yue Kong, Zhanming Li, Li‐Shun Wang, Ming Ma, Bing Han · 2021 · Pathology - Research and Practice
  43. Relation of serum spondin-2 levels with cardiac morphology and inflammatory parameters in hemodialysis patients
    İbrahim Doğan, Mücahit Yetim, Tolga Doğan, Hüseyin Kayadibi, Mehmet Bertan Yılmaz, Barış Eser, Macit Kalçık, Yusuf Karavelioğlu · 2018 · International Urology and Nephrology
  44. CITE-Seq Analysis Reveals a Differential Natural Killer Cell SPON2 Expression in Cardiovascular Disease Patients Impacted by Human-Cytomegalovirus Serostatus and Diabetes
    Sujit Silas Armstrong Suthahar, Daniel G. Chen, Sunil Kumar, James R. Heath, Matthew J. Feinstein, John R. Greenland, Daniel R. Calabrese, Lewis L. Lanier, Klaus F. Ley, Avishai Shemesh · 2025 · International Journal of Molecular Sciences
  45. Caenorhabditis elegans: A Tool for Antimicrobial Drug Discovery
    Kitlangki Suchiang, Ramatchandirane Mahesh · 2020 · Springer eBooks
  46. Downregulation of the biological macromolecule Spondin-2 disrupts maternal-fetal immune tolerance and trophoblast invasion, driving unexplained recurrent pregnancy loss
    Xue Zhang, Ping-Fen Li, Yan’e Gao, Peng‐Sheng Zheng · 2025 · International Journal of Biological Macromolecules
  47. Antigenic variation of microbial surface glycosylated molecules
    Daniel C. Stein, Volker Briken · 2010 · Elsevier eBooks
  48. Mindin your own business
    Friedrich Cameron Luft · 2012 · Journal of Molecular Medicine
  49. Transcriptome Changes Associated with Protective Immunity in T and B Cell-Deficient Rag1-/- Mutant Zebrafish
    Aparna Krishnavajhala · 2017 · International Journal of Immunology
  50. The role of roof plate-specific spondins in liver homeostasis and disease
    Le Yang, Wenhui Yue, Hang Zhang, Yue Gao, Lin Yang, Liying Li · 2022 · Liver Research
  51. Mindin promotes the production of reactive oxygen species to regulate intestinal microbiota in kuruma shrimp Marsupenaeus japonicus
    Kaimin Zhou, Bao-Rui Zhao, Jie Gao, Yongzhen Zhao, Yueling Zhang, Xian‐Wei Wang · 2025 · Comparative Immunology Reports
  52. Integrated Functional and scRNA-Seq Analyses Reveal Convergence of M-CSF– and GM-CSF–Derived Macrophages Following IL-27 Polarization
    Tomozumi Imamichi, Jun Yang, Qian Chen, Udeshika Kariyawasam, Jeanette Higgins, Mayra Marquez, Jordan B. Metz, Homa Nath Sharma, Michael Baseler, Hongyan Sui · 2026 · Cells
  53. Liver cancer recurrence predicted by immune-cell location and gene expression
    Christian M. Schürch · 2025 · Nature
  54. INITIATION OF EXPERIMENTAL ACUTE PANCREATITIS AND MODULATION OF INFLAMMATORY RESPONSE
    Jakob BF Axelsson · 2008 · Lund University Publications (Lund University)
  55. CITE-seq analysis reveals human cytomegalovirus and diabetes-associated adaptive NK cell alterations in cardiovascular disease
    Sujit Silas Armstrong Suthahar, Daniel G. Chen, Sunil Kumar, James R. Heath, Matthew J. Feinstein, John R. Greenland, Daniel R. Calabrese, Lewis L. Lanier, Klaus F. Ley, Avishai Shemesh · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  56. SPON2 and its implication in epithelial-mesenchymal transition
    Artur Muradyan · 2010 · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver
  57. Microbes mind out!
    Jenny Buckland · 2004 · Nature reviews. Immunology
  58. Immunomodulating Lactobacilli in Chicken
    Marjorie E. Koenen · 2004 · RePub (Erasmus University Rotterdam)
  59. Insights into the Holobiont of the Early Branching Metazoan Vaceletia sp. and its Biomineralization Strategy
    Juliane Germer · 2017 · eDiss (Georg-August-Universität Göttingen)
  60. The Relationship Between Diabetic Retinopathy and Serum and 24-Hours Urine Mindin Levels in Patients with Type 2 Diabetes Mellitus
    İbrahim Doğan, Çağatay Çağlar, Ahmet Gursoy, Hüseyin Kayadibi · 2022 · Research Square
  61. Faculty Opinions recommendation of The C. elegans F-spondin family protein SPON-1 maintains cell adhesion in neural and non-neural tissues.
    Oliver Hobert · 2008 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  62. In Brief
    2004 · Nature Reviews Microbiology
  63. Phosphorylation of the inner core oligosaccharide of lipopolysaccharide mediates recognition and phagocytosis of Gram-negative bacteria by Brain Angiogenesis Inhibitor 1 (BAI1)
    Emily A. Billings, Linda M. Columbus, James E. Casanova · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  64. Additional file 1 of Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC
    Chengmei Huang, Ruizhang Ou, Chen, Xiaoning, Yaxin Zhang, Jiexi Li, Yihao Liang, Xiaohui Zhu, Lei Liu, Mingzhou Li, Dagui Lin et al. · 2021 · Figshare
  65. Mindin orchestrates the macrophage-mediated resolution of liver fibrosis in mice
    Yongdong Huang, Xian-Ling Zhao, Ying‐Chi Lin, Xiao-mei Ouyang, Xiao‐Shen Cheng, Lai-Ying Liang, Ya-Ni Huo, Gui-Jing Xie, Junhui Lin, Amarsanaa Jazag et al. · 2025 · Hepatology International
  66. Identification of Effector Candidates in Fall Armyworm ( Spodoptera frugiperda ) via Secretome Prediction and Infestation Assay
    Sundaram Shilpi, Chhavi Choudhary, Keshav Kumar Meghwanshi, Vivek Verma, Jayendra Nath Shukla · 2025 · Journal of Applied Entomology
  67. Additional file 1 of PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment
    Johnson, Sarah, Yaroslava D. Karpova, Guo, Danping, Atreyi Ghatak, Dmitriy A. Markov, Alexei V. Tulin · 2022 · Figshare
  68. MINDIN as a mediator of tumor-bone interaction: involvement of integrins in prostate cancer metastatic progression
    Verónica Alonso Rodríguez, Luis Álvarez‐Carrión, Irene Gutiérrez-Rojas, Juan Antonio Ardura · 2026 · Revista de Osteoporosis y Metabolismo Mineral
  69. Serum and urinary mindin as a potential biomarker for diabetic retinopathy: a prospective cross-sectional study
    İbrahim Doğan, Çağatay Çağlar, Ahmet Gursoy, Hüseyin Kayadibi · 2026 · BMC Ophthalmology
  70. Immunomodulatory role of MINDIN in bone microenvironment under inflammatory conditions
    Verónica Alonso Rodríguez, Luis Álvarez‐Carrión, Martina Romeo, Irene Gutiérrez-Rojas, Gonzalo García de Casasola-Rodríguez, Juan Antonio Ardura Rodríguez · 2026 · Revista de Osteoporosis y Metabolismo Mineral
  71. Decoding the glycan architecture of Fusobacterium gonidiaformans rough-type lipopolysaccharide: implications for lectin recognition and immune response
    Francesca Olmeo, Marcello Mercogliano, M. Martin, Stefania De Chiara, Luca De Simone Carone, Alessandro Cangiano, Noemi Gallucci, Amanda L. Lewis, Warren G. Lewis, Magali Coccimiglio et al. · 2026 · Carbohydrate Polymers
  72. Pathogens mind out!
    Jenny Buckland · 2004 · Nature Reviews Microbiology