Development, cytokine profile and function of human interleukin 17-producing helper T cells
Abstract
T(H)-17 cells are a distinct lineage of proinflammatory T helper cells that are essential for autoimmune disease. In mice, commitment to the T(H)-17 lineage is dependent on transforming growth factor-beta and interleukin 6 (IL-6). Here we demonstrate that IL-23 and IL-1beta induced the development of human T(H)-17 cells expressing IL-17A, IL-17F, IL-22, IL-26, interferon-gamma, the chemokine CCL20 and transcription factor RORgammat. In situ, T(H)-17 cells were identified by expression of the IL-23 receptor and the memory T cell marker CD45RO. Psoriatic skin lesions contained IL-23-producing dendritic cells and were enriched in the cytokines produced by human T(H)-17 cells that promote the production of antimicrobial peptides in human keratinocytes. Our data collectively indicate that human and mouse T(H)-17 cells require distinct factors during differentiation and that human T(H)-17 cells may regulate innate immunity in epithelial cells.
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Produced IL-6 further induces Th17 cell differentiation through STAT3 in the presence of TGFβ, IL-1β and IL-23, which are rich in inflammatory lesions and tumor microenvironments.
“The produced IL-6 further induces Th17 cell differentiation through STAT3 in the presence of TGFβ, IL-1β and IL-23, all of which are rich in inflammatory lesions and tumor microenvironments (164, 166, 169–171, 174, 175).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [170]
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References 52 · Cited by 2,035
- Authors
- Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., Lecron, J.-C., Kastelein, R. A., Cua, D. J., McClanahan, T. K., Bowman, E. P., & de Waal Malefyt, R.
- Affiliations
- Université de Poitiers (FR)
- ORCID
- Venue
- Nature Immunology
- Published
- 2007-08-05
- Volume
- 8
- Issue
- 9
- Pages
- 950-957
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2151566115
- Cited by
- 2,035
- References
- 52
- Citations by year
- 2026: 23 · 2025: 37 · 2024: 52 · 2023: 54 · 2022: 81 · 2021: 66 · 2020: 90 · 2019: 69 · 2018: 66 · 2017: 94 · 2016: 98 · 2015: 109 · 2014: 119 · 2013: 153 · 2012: 169
- FWCI
- 71.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- Th17 cells, IL-17, IL-17A, IL-17F, IL-23, IL-1β, RORγt, Th17 cell differentiation, IL23R, CD45RO, psoriasis, dendritic cells, keratinocytes, antimicrobial peptides, innate immunity, epithelial cells, cytokine profile
- MeSH terms
- Cell Differentiation, Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Epithelial Cells, Flow Cytometry, T-Lymphocytes, Helper-Inducer, Humans, Immunohistochemistry, Psoriasis, Polymerase Chain Reaction, T-Lymphocyte Subsets, Cytokines, Interleukin-17, Antimicrobial Cationic Peptides, Interleukin-23
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